Amplifying startup success is key for the energy transition, Houston experts say

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The future energy system will be made up of countless new technologies that are actively being developed and scaled by climate and energy startups around the world. Photo via Getty Images

The global energy landscape is undergoing unprecedented challenges, influenced by post-pandemic work trends, geopolitical events like the Ukraine crisis, and the urgent need to reduce carbon emissions.

To achieve net-zero goals by 2050 and address climate change, a significant investment of $5 trillion by 2030 to USD $4.5 trillion by 2050 is required, necessitating a rapid transformation in traditional energy production, distribution, storage, and consumption methods.

High-tech energy and climate startups are pivotal for a robust economy, driving innovation, economic growth, and enhanced productivity. These startups foster healthy competition, attract crucial investments, and contribute significantly to job creation, outpacing larger companies in terms of employment generation. The U.S., a startup leader, generated over 3.7 million new jobs in 2022, showcasing the adaptability of startups to market trends. Globally, India, with the third-largest startup ecosystem, has contributed to the creation of860,000 jobs since the stand-up of Startup India, emphasizing the importance of nurturing startups for sustained economic dynamism and innovation.

The future energy system will be made up of countless new technologies that are actively being developed and scaled by climate and energy startups around the world. These founding teams require access to scaling resources to accelerate and amplify their impact. Human talent, financial investment, demonstration opportunities and physical facilities are scaling resources that often require significant time and capital to build from scratch. This inefficient resource deployment can be particularly pronounced for hard-tech entrepreneurs. Startup community participants are organized around providing entrepreneurs with the needed access to these resources.

"Our mission is to enable hydrogen adoption by solving the key challenges in hydrogen storage and transportation," says Ayrton CEO, Natasha Kostenuk. "With Halliburton's strategic engineering and manufacturing support, we can scale our technology, execute pilot demonstrations and accelerate towards commercialization."

Halliburton Labs, is highlighted for its diverse team and the support it provides to global entrepreneurs in sustainable ventures. The future energy system is envisioned to be composed of numerous new technologies developed and scaled by climate and energy startups worldwide. These startups require access to scaling resources mentioned above, where Halliburton Labs serves as a conduit between established practitioners and startup entrepreneurs, accelerating the latter's impact by providing access to these critical resources.

Infosys launched the Infosys Innovation Fund to invest in entrepreneurial ventures around the world. Their investment philosophy is geared toward supporting innovation and purposeful solutions that are relevant to the strategic priorities of their clients. This differentiates the Infosys Innovation Fund from most other venture capital institutions, in that they have a strong motivation to create long term value for the end users of the technology and to the companies building these solutions.

Infosys actively collaborates with emerging technology startups through its Infosys Innovation Fund. Employing a Desirability, Feasibility, Viability (DFV) framework, Infosys strategically selects startups and offers advantages such as market, financial and technical scale. The Infosys Innovation Fund stands out for its motivation to create long-term value for end users and the companies building innovative solutions. Infosys also operates an incubation center called ‘Infosys Center for Emerging Technology Solutions’ (iCETS), focusing on NextGen services and offerings through collaboration with clients, startup partnerships, university collaborations, and more.

Startups working with Infosys benefit from accessing the company's know-how, market knowledge, and strategic advisors from the consulting arm of business, Infosys Consulting, who are focused on creating business value through technology innovation. The combined expertise guides entrepreneurs from idea to qualification, proof-of-concept, prototype, minimum viable product (MVP), scale, and continuous discovery and delivery.

Open innovation and trusted partnerships in the energy transition era

In the energy transition era, open innovation and trusted partnerships are becoming essential components of amplifying success for startups. Collaborative cultures and trusted partnerships with companies like Infosys and Halliburton Labs are crucial for supporting and scaling startups in this rapidly evolving energy landscape. This shift towards ‘open innovation’ reflects a broader trend in the industry toward collaboration and shared expertise as key drivers for success to accelerate and achieve global energy transition aspirations.

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Scott Gale is the executive director of Halliburton Labs. Jason Till is partner of Experience Transformation & Innovation at Infosys Consulting. Rima Thakkar is principal - Americas Energy Transition at Infosys Consulting. Laura Sacchi, Mandar Joshi, and Sonali Sakhare of Infosys Consulting contributed to this article.

This article originally ran on EnergyCapital.

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New 'living pharmacy' biotech company launches out of Rice venture studio

fighting cancer

Rice University’s biotech venture studio RBL LLC has launched a new “living pharmacy” company, Duracyte, designed to make cancer treatment easier on patients.

Backed by an up to $45 million Advanced Research Projects Agency for Health (ARPA-H) award, Duracyte aims to commercialize implantable biohybrid pharmacy devices that are designed to produce therapeutic proteins inside the human body around the clock, replacing the need for regular injections and infusions for some cancer patients.

The company’s main platform is its Hybrid Advanced Molecular Manufacturing Regulator (HAMMR), a rechargeable, implantable device that can sense biological signals, monitor tumor environments and adjust therapeutic output in real time. HAMMR has wireless communication capabilities, which allow patients and clinicians to remotely monitor results through an app every five minutes and make changes to treatment plans without a hosptial visit. Additionally, the device can generate its own oxygen supply, which is key for the therapeutic cells’ survival.

“Biologic medicines such as monoclonal antibodies, cytokines and metabolic regulators already account for a significant share of modern therapeutics, but the way we deliver them today often requires frequent injections or infusions that can be demanding for patients and lead to inconsistent drug levels,” Daniel Anderson, MIT professor and co-founder of Duracyte, said in a news release. “Our vision is to enable a continuous, stable therapy by producing these medicines directly inside the body, which could improve treatment consistency, reduce side effects and ultimately transform how biologic therapies are delivered across many diseases.”

Duracyte’s first clinical trial is slated to begin by the end of 2026 and will focus on recurrent ovarian cancer. The Phase I study will build upon existing work on encapsulated cytokine pharmacy technology, and the company hopes that within a few years this treatment can reach clinical application.

The development of Duracyte is supported by ARPA-H's Targeted Hybrid Oncotherapeutic Regulation (THOR) project, which supports a multidisciplinary research consortium co-led by Omid Veiseh, a professor of bioengineering at Rice. The consortium also includes others at Rice, The University of Texas MD Anderson Cancer Center, Stanford University, Carnegie Mellon University, Northwestern University and the University of Houston, plus industry collaborators like Chicago-based CellTrans.

“What we are building is the culmination of years of progress in cell engineering, biomaterials and implantable device technology,” Veiseh added in the release. “By combining these advances with real-time sensing and adaptive drug delivery, we are working with the support of RBL to create a true ‘living pharmacy’ that can deliver continuous, precisely controlled biologic therapies and fundamentally change how these treatments reach patients.”

RBL launched in 2024 and is based out of Houston’s Texas Medical Center Helix Park. Duracyte is the third company launched by RBL, including Sentinel BioTherapeutics, a clinical-stage immunotherapy company developing localized cytokine therapies for solid tumors, and SteerBio, a regenerative medicine company targeting lymphedema.

“Duracyte exemplifies the kind of breakthrough that Houston’s ecosystem is built to produce,” Paul Wotton, managing partner of RBL LLC and co-founder of Duracyte, added in the release. “With world-class clinical infrastructure, exceptional engineering talent and initiatives like the Texas Biotech Task Force driving alignment across industry, investment and talent, this region is uniquely positioned to move the most ambitious ideas in medicine from concept to patient, faster than anywhere else.”

Houston energy hub opens new fundraising cohort to fuel startups

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EnergyTech Cypher has opened applications for its second Liftoff fundraising program.

Applications close May 20 for the 10-week virtual fundraising sprint. The program is geared toward energy and climatech founders preparing to raise their first institutional round. It will cover fundraising requisites, like pitch materials, term sheet negotiation and round closing, according to a release from EnergyTech Cypher.

The program kicks off June 1 and runs every Monday from 1-3 p.m. CST. It will conclude with an in-person capstone simulation in Houston on August 3, where founders will work to close a mock round.

Jason Ethier, EnergyTech Cypher founder and CEO, will lead the program with Payal Patel, an EnergyTech fellow and entrepreneur in residence.

The program is available through Cephyron, EnergyTech Cypher's new investor relationship management platform, built specifically for energy and climatech founders. Users must have a Cephyron Boost membership to participate in the Liftoff program.

The Cephyron IRM app recently went live and is available to founders at any point in their fundraising process, according to the news release. The platform aggregates investor data, tracks market signals and delivers curated weekly recommendations.

EnergyTech Cypher launched Liftoff last year. The inaugural cohort included 19 startups, including Houston-based AtmoSpark Technologies, The Woodlands-based Resollant and others. Each participant closed at least one fundraising deal, according to EnergyTech Cypher.

EnergyTech Cypher rebranded from EnergyTech Nexus earlier this year. It also launched its CoPilot accelerator in 2025. The inaugural group presented its first showcase during CERAWeek last month.

EnergyTech Cypher's annual Pilotathon Pilot Pitch and Showcase applications also opened this month. Find more information here.

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This article originally appeared on EnergyCaptialHTX.com.

Cancer diagnostics startup wins top prize at annual Rice competition​

winner, winners

Rice University student-founded companies took home a total of $115,000 in equity-free funding at the annual Liu Idea Lab for Innovation and Entrepreneurship's H. Albert Napier Rice Launch Challenge last week.

2025 Rice Innovation Fellow Alexandria Carter won the top prize and $50,000 for her startup Bionostic. The startup offers personalized diagnostics for cancer patients by using 3D culturing through its Advanced Tumor Landscape Analysis System (ATLAS) platform.

Carter is working toward her PhD in bioengineering in Professor Michael King's laboratory. She recently completed the Rice Innovation Fellows program and plans to commercialize ATLAS, according to a news release from Rice.

Actile Technologies, founded by another former Rice Innovation Fellow, Barclay Jumet, won second place and $25,000. The company is developing and commercializing textile-integrated technologies. InnovationMap first covered Jumet's wearable technology back in 2023.

Kairos took home the third-place prize and $15,000, plus the $2,000 audience choice award and the $5,000 undergraduate business award. Founded last year by Sanjana Kavula and Adhira Tippur, Kairos is an AI-powered patient intake platform built specifically for independent dental practices.

The NRLC features top startups founded by undergraduate, graduate and MBA students at Rice each year. The top three finishers were named among a group of five finalists earlier this year, which also included HAAST Autonomous and Project Kestrel.

HAAST is developing an unmanned aircraft for organ transport, while Kestrel uses machine learning to organize bird photographers’ photo collections.

Teams presented multiple five-minute pitches throughout the application process over Zoom and in-person before the five finalists presented at the NRLC Championships April 21 at the Rice Memorial Center. Each finalist walked away with an equity-free investment.


Other awards went to:

UnitCode

  • $5,000 MBA Venture Award

HAAST Autonomous

  • $2,500 Chan-Kang Family Prize for Bold Ambition
  • $1,000 Healthcare Innovations Prize

Telstar Networks

  • $2,500 Outstanding Undergraduate Startup Award

Multiplay

  • $1,500 Frank Liu Jr. Prize for Creative Innovation in Music, Fashion, & the Arts

Butterfly Books

  • $1,500 Social Impact Award

SOOZ

  • $1,000 Interdisciplinary Innovation Prize sponsored by OURI

Dooly

  • $1,000 Consumer Goods Prize

Project Kestrel

  • $1,000 AI Prize

Veloci Running won the NRLC last year for its naturally shaped running shoe. Founder and CEO Tyler Strothman recently told InnovationMap that the company has gone on to sell roughly 10,000 pairs of its flagship Ascent shoe, designed to relieve lower leg tightness and absorb impact. Read more here.

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