Rice University students collaborate on COVID-19 solutions

game changers

Rice 360˚ Institute of Global Health's student innovators created projects and devices — from disinfecting devices and optimized intubation tools — that respond to challenges presented by COVID-19. Courtesy of Rice University

An annual program with Rice University and its partners in Africa had to do things differently in light of the COVID-19 pandemic. Not only did operations have to shift to a virtual approach, but the projects themselves instead addressed the needs created by the disease.

Rice 360˚ Institute for Global Health, which collaborates with the Malawi University of Science and Technology (MUST) and the University of Malawi, The Polytechnic (Poly), continued their annual programming virtually over six weeks. The collaboration brings students together to solve global health issues, and this year's issue to address was overwhelmingly COVID-19.

"We had to give a lot of thought to whether we might have to cancel the program, and that was really heartbreaking to think about," says Rice 360˚ Director Rebecca Richards-Kortum, professor of bioengineering, in a news release. "Back in those days of late March and early April, I never really imagined how wonderful the virtual internship program could be."

Thirteen undergraduate interns and eight teaching assistants from Rice and Malawi, worked on six different projects, and three were presented in an online event on July 16. Here were the projects that were presented.

A disinfecting system that has the capability to sterilize multiple N95 masks at once. The system uses ultraviolet lights that can kill the coronavirus in around 30 minutes. Alternatively, the project included a smaller version that could be powered by solar energy. Yankholanga Pelewelo of MUST, Carolyn Gonawamba of Poly, and Andrew Abikhaled and Bhavya Gopinath of Rice developed the technology.
A walk-in decontamination unit that can decontaminate up to 3,000 people per day. The team of interns developed a prototype that consisted of PVC frame covered in plastic with nozzles to spray disinfectant. The project has already received interest from labs and hospitals for the device. Team members included Brenald Dzonzi of Poly, Mwayi Yellewa of MUST, and Kaitlyn Heintzelman, Krystal Cheung, and Sana Mohamed of Rice.
A redesigned intubation box that gives doctors better access to patients during the procedure. More than half of the 3,000 health care workers who have died from the coronavirus were doctors who focused on respiratory procedures, the team pointed out, and this daunting fact calls for redesigned tools. In total, the student innovators pitched three different designs that each included armholes in the sides, with a third hole on top to let a clinician or nurse assist with the procedure. The student team consisted of Chikumbutso Walani of Poly, Ruth Mtuwa of MUST, and Lauren Payne and Austin Hwang of Rice.

The other three projects included in the program but didn't present were designs for face shields, a hand sanitizer station and a contactless temperature monitor. All of the projects were led by teaching assistants Aubrey Chikunda and Chisomo Mukoka from MUST; Hannah Andersen, Nimisha Krishnaswamy, Alex Lammers and Ben Zaltsman of Rice; and Hope Chilunga and Francis Chilomo from Poly.

While pivoting the program to virtual comes with its challenges, Maria Oden — a professor of bioengineering, director of Rice's Oshman Engineering Design Kitchen and director of Rice 360˚ — recognizes the opportunities it provides as well.

"It would have been easy and understandable to cancel this internship, but that's not what happened, and look what the result was," Oden says in the release. "Over 90 people have tuned in to see the work of the interns. That's something we've never achieved with our in-person internships. We can learn from this experience."

Rice 360° Virtual Internship Highlights – Summer 2020www.youtube.com

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

New accelerator joins the Ion and more Houston innovation news to know

Trending News

Editor's note: The Houston innovation scene is buzzing with big news this month, from a new accelerator joining the fold at the Ion to pre-IPO funding and national expansion plans. Below are the five most-read InnovationMap stories from Feb. 1-15, 2026:

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The new AI Native Dual-Use Sports, Health & Wellness Accelerator is expected to launch in March. Photo courtesy of the Ion

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform. The AI Native Dual-Use Sports, Health & Wellness Accelerator is scheduled to formally launch in March. Continue reading.

10+ can't-miss Houston business and innovation events in February

From recurring monthly favorites to the return of annual celebrations and summits, here's what not to miss in February. Photo courtesy the Ion.

February may be a short month, but its event calendar isn’t. From recurring monthly favorites to the return of annual celebrations and summits, here are the Houston business and innovation events not to miss — and how to register. Continue reading.

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