The Welch Foundation, a Houston-based nonprofit, has doled out fresh funding to research organizations, with over a third being deployed to Houston-area institutions. Photo via Getty Images

Five schools in the Houston area have landed $10.8 million in research grants from the Houston-based Welch Foundation.

The 36 grants were awarded to Rice University, Texas A&M University, the University of Houston, the Baylor College of Medicine, and the University of Texas Medical Branch in Galveston.

In all, the foundation announced nearly $28 million in Texas research grants for 2023. All of the money — in the form of 91 grants for 15 Texas colleges and universities — goes toward chemical research. This year’s total for grant funding matches last year’s total.

“The Welch Foundation continues to emphasize the creative pursuit of basic chemical research,” Adam Kuspa, the foundation’s president and a former dean at the Baylor College of Medicine, says in a news release. “Our funding allows investigators throughout the state to follow their curiosity and explore the foundations chemical processes.”

Since its establishment in 1954, the Welch Foundation has contributed about $1.1 billion to the advancement of chemistry in Texas.

One of this year’s local grant recipients is Haotian Wang, assistant professor in Rice’s chemical and biomolecular department. The professor’s grant-funded research will focus on the conversion of carbon dioxide into useful chemicals, such as ethanol.

Last year, Rice reported that Wang’s lab in the George R. Brown School of Engineering had replaced rare, expensive iridium with ruthenium, a more abundant precious metal, as the positive-electrode catalyst in a reactor that splits water into hydrogen and oxygen.

The lab’s addition of nickel to ruthenium dioxide resulted in production of hydrogen from water electrolysis for thousands of hours.

“There’s huge industry interest in clean hydrogen,” Wang says. “It’s an important energy carrier and also important for chemical fabrication, but its current production contributes a significant portion of carbon emissions in the chemical manufacturing sector globally.”

“We want to produce it in a more sustainable way,” he adds, “and water-splitting using clean electricity is widely recognized as the most promising option.”

Here's what researchers raked in the cash to support their research. Photo via Getty Images

Fresh funds: 2 Houston organizations dole grants to advance research

research roundup

Funding fuels the research that supports the innovations of tomorrow. Two Houston-based scientific organizations announced funding recipients that are working on advancing research in space health and chemistry.

4 research teams receive funds to advance space health work

The Translational Research Institute for Space Health, known as TRISH, at Baylor College of Medicine has announced almost $4 million in grants to four research teams. As more and more plans to launch humans into space continue to develop, TRISH is working to support research addressing human health in space.

TRISH's Biomedical Research Advances for Space Health initiative looked for new ways to reduce potential damage from the environment through manipulation of human metabolism and the normal state-of-being at the cellular or whole organism level, according to a press release.

"These outstanding awardees brought cutting-edge proposals to the table. Each project provides a unique opportunity to advance human health research on the bleeding edge of science fiction," says TRISH Executive Director, Dorit Donoviel, in the release. "This creative research has the potential to protect all humans through advancing tissue transplantation or helping patients that have medical conditions such as heart or brain damage that could be aided by reducing cellular activity."

The awardees, who will begin their TRISH-funded research in April 2022, for BRASH 2101 included:

  • Clifton Callaway, M.D., Ph.D., University of Pittsburgh, Pennsylvania
    • Cold-Sleep for Long Duration Spaceflight
  • Tammy Chang, M.D., Ph.D., University of California, San Francisco
    • The Effect of Isochoric Supercooling on Human Liver Metabolic Function
  • Allyson Hindle, Ph.D., University of Nevada, Las Vegas
    • Can Humans Hibernate at Warm Temperatures?
  • Christopher Porada, Ph.D., Wake Forest University, Winston-Salem, North Carolina
    • Using Human Organoids and Fossilized Remains from Extinct Hominins to Unlock the Secrets of Torpor/Hibernation

Houston organization names 2021 award recipient

The Welch Foundation has named professor Chi-Huey Wong as the 2021 recipient of the Robert A. Welch Award in Chemistry. Wong is a leader in synthetic chemistry and chemical biology. Specifically, the award recognizes Wong for his development of new methods for the synthesis of complex carbohydrates and glycoproteins and the elucidation of carbohydrate-mediated biological recognition associated with disease progression, according to a press release.

"The mission of The Welch Foundation is to improve the lives of others through the advancement of chemical research, and Dr. Wong has been working towards that goal for decades," says Carin Barth, chair and director of The Welch Foundation Board of Directors. "Not only has he made revolutionary advances in chemistry and biology, but his methodologies will facilitate new drug and vaccine developments for years to come."

Wong is the Scripps Family Chair Professor in the Department of Chemistry at The Scripps Research Institute. He will receive $500,000 to advance his research. Houston-based Welch Foundation has contributed more than $1.1 billion to the advancement of chemistry since 1954.

Both Rice University and the University of Houston were selected by the Department of Energy to receive funds for ongoing research projects. Photo via Getty Images

Houston researchers snag government funds for net-zero emissions projects

seeing green

Rice University and the University of Houston were two of four national institutions to receive sizable grants from the Department of Energy last month to go toward the research and development of projects that will improve CO2 storage to help move the country toward the goal of net-zero emissions by 2050.

Each of the four projects works to advance long-term, commercial-scale geologic sequestration of CO2. According to a release from the DOE, the process of carbon capture and storage (known as CSS) separates and captures CO2 from the emissions of industrial processes before it is released into the atmosphere. Once captured, the CO2 is then injected into deep underground geologic formations, known as caprock.

However, during seismic events, like an earthquake or volcanic eruption, the CO2 can leak through the ground and contaminate the water supply.

"Large scale carbon capture efforts are vital to getting America emissions free by 2050, and how we store this CO2 must be safe, secure and permanent," said U.S. Secretary of Energy Jennifer M. Granholm. "The R&D investments in new tools and technology to monitor underground activity near CO2 storage sites will help us minimize risk from natural events like earthquakes, safeguard the environment and water supply, and get us that much closer to our clean energy goals."

Rice was awarded nearly $1.2 million from the DOE for its project that aims to develop a new strategy for monitoring seal integrity in the CCS process. The project "has the potential to provide a powerful platform for identifying CO2 leakage through reactivated faults or fracture zones," the statement said.

UH received a nearly $800,000 grant for its project that will work to determine cost-effective seismic data processing technologies that will automatically detect faults on 3D seismic migration images.

The project is being developed by Yingcai Zheng at the University of Houston in collaboration with Los Alamos National Lab and Vecta Oil and Gas and aims will help not only estimate seismic activity, but will also be able to estimate the fluid leakage pathways in certain regions, according to a separate release from UH.

"Most think of applied geophysics as linked to the oil and gas industry," Zheng said in the statement. "While that is true, when we think of the energy transition and how to achieve our goals, it is important to realize that this cannot happen without studying the geophysics of the subsurface – in a way, it literally holds the well-being of humanity's future."

The remaining two projects that received grants from the DOE come from the Battelle Memorial Institute in Ohio and The New Mexico Institute of Mining and Technology. In total the DOE issues $4 million to support the projects.

A number of Houston energy leaders are looking at smarter ways to store CO2. This spring, Joe Blommaert, the Houston-based president of ExxonMobil Low Carbon Solutions, said that he envisions creating a $100 billion carbon-capture hub along the Houston Ship Channel. And that same month Occidental's venture arm, Oxy Low Carbon Ventures, announced plans to construct and operate a pilot plant that would convert carbon dioxide into feedstocks.

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Rice University scientists invent new algorithm to fight Alzheimer's

A Seismic Breakthrough

A new breakthrough from researchers at Rice University could unlock the genetic components that determine several human diseases such as Parkinson's and Alzheimer's.

Alzheimer's disease affected 57 million people worldwide in 2021, and cases in the United States are expected to double in the next couple of decades. Despite its prevalence and widespread attention of the condition, the full mechanisms are still poorly understood. One hurdle has been identifying which brain cells are linked to the disease.

For years, it was thought that the cells most linked with Alzheimer's pathology via DNA evidence were microglia, infection-fighting cells in the brain. However, this did not match with actual studies of Alzheimer's patients' brains. It's the memory-making cells in the human brain that are implicated in the pathology.

To prove this link, researchers at Rice, alongside Boston University, developed a computational algorithm called “Single-cell Expression Integration System for Mapping Genetically Implicated Cell Types," or SEISMIC. It allows researchers to zero in on specific neurons linked to Alzheimer's, the first of its kind. Qiliang Lai, a Rice doctoral student and the lead author of a paper on the discovery published in Nature Communications, believes that this is an important step in the fight against Alzheimer's.

“As we age, some brain cells naturally slow down, but in dementia — a memory-loss disease — specific brain cells actually die and can’t be replaced,” said Lai. “The fact that it is memory-making brain cells dying and not infection-fighting brain cells raises this confusing puzzle where DNA evidence and brain evidence don’t match up.”

Studying Alzheimer's has been hampered by the limitations of computational analysis. Genome-wide association studies (GWAS) and single-cell RNA sequencing (scRNA-seq) map small differences in the DNA of Alzheimer's patients. The genetic signal in these studies would often over-emphasize the presence of infection fighting cells, essentially making the activity of those cells too "loud" statistically to identify other factors. Combined with greater specificity in brain regional activity, SEISMIC reduces the data chatter to grant a clearer picture of the genetic component of Alzheimer's.

“We built our SEISMIC algorithm to analyze genetic information and match it precisely to specific types of brain cells,” Lai said. “This enables us to create a more detailed picture of which cell types are affected by which genetic programs.”

Though the algorithm is not in and of itself likely to lead to a cure or treatment for Alzheimer's any time soon, the researchers say that SEISMIC is already performing significantly better than existing tools at identifying important disease-relevant cellular signals more clearly.

“We think this work could help reconcile some contradicting patterns in the data pertaining to Alzheimer’s research,” said Vicky Yao, assistant professor of computer science and a member of the Ken Kennedy Institute at Rice. “Beyond that, the method will likely be broadly valuable to help us better understand which cell types are relevant in different complex diseases.”

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This article originally appeared on CultureMap.com.

5 incubators and accelerators fueling the growth of Houston startups

meet the finalists

Houston is home to numerous accelerators and incubators that support founders in pushing their innovative startups and technologies forward.

As part of our 2025 Houston Innovation Awards, the new Incubator/Accelerator of the Year category honors a local incubator or accelerator that is championing and fueling the growth of Houston startups.

Five incubators and accelerators have been named finalists for the 2025 award. They support startups ranging from hard-tech companies to digital health startups.

Read more about these organizations below. Then join us at the Houston Innovation Awards on Nov. 13 at Greentown Labs, when the winner will be unveiled.

Get your tickets now on sale for this exclusive event celebrating Houston Innovation.

Activate

Hard tech incubator Activate supports scientists in "the outset of their entrepreneurial journey." The Houston hub was introduced last year, and joins others in Boston, New York, and Berkley, California—where Activate is headquartered. It named its second Houston cohort this summer.

This year, the incubator grew to include its largest number of concurrent supported fellows, with 88 companies currently being supported nationally. In total, Activate has supported 296 fellows who have created 236 companies. Those companies have raised over $4 billion in follow-on funding, according to Activate. In Houston, it has supported several Innovation Awards finalists, including Solidec, Bairitone Health and Deep Anchor Solutions. It is led locally by Houston Managing Director Jeremy Pitts.

EnergyTech Nexus

Cleantech startup hub EnergyTech Nexus' mission is to accelerate the energy transition by connecting founders, investors and industrial stakeholders and helping to develop transformative companies, known as "thunderlizards."

The hub was founded in 2023 by CEO Jason Ethier, Juliana Garaizar and Nada Ahmed. It has supported startups including Capwell Services, Resollant, Syzygy Plasmonics, Hertha Metals, EarthEn Energy and Solidec—many of which are current or past Innovation Awards finalists. This year Energy Tech Nexus launched its COPILOT Accelerator, powered by Wells Fargo Innovation Incubator (IN²) at the National Renewable Energy Laboratory (NREL). COPILOT partners with Browning the Green Space, a nonprofit that promotes diversity, equity and inclusion (DEI) in the clean energy and climatech sectors. Energy Tech Nexus also launched its Liftoff fundraising program, its Investor Program, and a "strategic ecosystem partnership" with Greentown Labs.

Greentown Labs

Climatetech incubator Greentown Labs offers its community resources and a network to climate and energy innovation startups looking to grow. The collaborative community offers members state-of-the-art prototyping labs, business resources and access to investors and corporate partners. The co-located incubator was first launched in Boston in 2011 before opening in Houston in 2021.

Greentown has seen major changes and activity this year. In February, Greentown announced Georgina Campbell Flatter as its new CEO, along with a new Board of Directors. In July, it announced Lawson Gow as its Head of Houston, a "dedicated role to champion the success of Greentown Houston’s startups and lead Greentown’s next chapter of impact in the region," according to Greentown. It has since announced numerous new partnerships, including those with Energy Tech Nexus, Los Angeles-based software development firm Nominal, to launch the new Industrial Center of Excellence; and Houston-based Shoreless, to launch an AI lab onsite. Greentown Houston has supported 175 startups since its launch in 2021, with 45 joining in the last two years. Those startups include the likes of Hertha Metals, RepAir Carbon, Solidec, Eclipse Energy (formerly GoldH2) and many others.

Healthtech Accelerator (TMCi)

The Healthtech Accelerator, formerly TMCx, focuses on clinical partnerships to improve healthcare delivery and outcomes. Emerging digital health and medical device startups that join the accelerator are connected with a network of TMC hospitals and seasoned advisors that will prepare them for clinical validation, funding and deployment.

The Healthtech Accelerator is part of Texas Medical Center Innovation, which also offers the TMCi Accelerator for Cancer Therapeutics. The Healthtech Accelerator named its 19th, and latest, cohort of 11 companies last month.

Impact Hub Houston

Impact Hub Houston supports early-stage ventures at various stages of development through innovative programs that address pressing societal issues. The nonprofit organization supports social impact startups through mentorship, connections and training opportunities.

There are more than 110 Impact Hubs globally with 24,000-plus members spanning 69 countries, making it one of the world’s largest communities for accelerating entrepreneurial solutions toward the United Nations' Sustainable Development Goals (SDGs).

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The Houston Innovation Awards program is sponsored by Houston City College Northwest, Houston Powder Coaters, FLIGHT by Yuengling, and more to be announced soon. For sponsorship opportunities, please contact sales@innovationmap.com.



Rice University launches  engineering-led brain science and health institute

brain research

Rice University has announced the creation of a new interdisciplinary center known as the Rice Brain Institute (RBI).

The new hub will aim to use engineering, natural sciences and social sciences to research the brain and reduce the burden of neurodegenerative, neurodevelopmental and mental health disorders.

“The Rice Brain Institute reflects Rice’s strength in collaboration without boundaries,” Rachel Kimbro, dean of the School of Social Sciences, said in a news release. “Our researchers are not only advancing fundamental science but they’re also ensuring that knowledge reaches society in ways that promote human flourishing.”

RBI researchers will work in thematic clusters focusing on neurodegeneration, mental health, brain injury and neurodevelopment. The clusters will work toward goals such as significantly improving key brain health outcomes, reducing mortality and mental health disorders and improving quality of life for patients living with brain injuries and neurodevelopmental disorders, according to Rice.

The institute will focus on “engineering-driven innovation,” rather than traditional neuroscience, to design tools that can measure, model and modulate brain activity based around Rice’s expertise in soft robotics, neuroimaging, data science and artificial intelligence—making it unique among peer organizations, according to Rice.

Additionally, RBI will be structured around three collaborative Rice “pillars”:

  • The Neuroengineering Initiative, launched in 2018, brings together neuroscience, engineering, and related fields experts
  • The Neuroscience Initiative, a new initiative that brings together cell biologists, neurobiologists, biochemists, chemists and physicists to explore fundamental mechanisms of the brain and nervous system
  • The Brain and Society Initiative, also a new initiative, considers brain research within the broader social and policy landscape

Rice’s Neuroengineering Initiative has already garnered more than $78 million in research funding, according to Rice, and has established major partnerships, like the Rice-Houston Methodist Center for Neural Systems Restoration.

“Rice is uniquely equipped to bridge and connect scientific understanding of the brain and behavior sciences with the technologies and policies that shape our world,” Amy Dittmar, the Howard R. Hughes Provost and executive vice president for academic affairs, added in the news release. “By uniting faculty in neuroengineering, neuroscience and psychological sciences, this interdisciplinary hub embodies the kind of bold, nimble collaboration that allows Rice to turn discovery into societal impact to save lives and enhance human flourishing.”

The formation of the RBI coincides with recent support of the Dementia Prevention Research Institute of Texas (DPRIT), which landed voter approval earlier this week and aims to make Texas the center for dementia research via brain-health tech. According to the World Economic Forum, brain disorders and mental health disorders cost the global economy an estimated $5 trillion per year and could be as high as $16 trillion by 2030.

“Few areas of research have as direct and profound an impact on human well-being as brain health,” Rice President Reginald DesRoches added in the news release. “As rates of Alzheimer’s, dementia and other neurological diseases rise in our country and around the world, universities have a responsibility to lead the discovery of solutions that preserve memory, movement and quality of life. We all know someone who has been affected by a brain-related health issue, so this research is personal to all of us.”