8 Houston entrepreneurs recognized on annual EY awards program

regional winners

Eight Houston entrepreneurs are among 16 recipients of EOY’s Gulf South Award, which recognizes leaders of high-growth companies in Central Texas, South Texas, Louisiana, and Mississippi. Photo via Getty Images

Eight Houston-area entrepreneurs have been named regional winners in Ernst & Young’s 2024 Entrepreneur Of The Year program.

The eight entrepreneurs are among 16 recipients of EOY’s Gulf South Award, which recognizes leaders of high-growth companies in Central Texas, South Texas, Louisiana, and Mississippi.

A panel of judges chose the winners based on factors such as:

  • Creation of long-term value through entrepreneurship.
  • Commitment to the purpose of their business.
  • Demonstration of growth and “substantial impact.”

“The 2024 Entrepreneur Of The Year Gulf South Award winners are exceptional business leaders fueling innovation within their industries and growth within their companies,” says Anna Horndahl, an EY partner who is co-director of EOY’s Gulf South program.

The Houston area’s Gulf South winners for 2024 are:

  • Hal Brumfield of Tachus Fiber Internet, a provider of fiber-to-the-home internet service based in The Woodlands.
  • Stuart Hinchen and Peter Jenkins of QuVa Pharma, a Sugar Land-based provider of ready-to-administer injectables.
  • Andrew Levy of Avelo Airlines, a low-cost airline based in Houston.
  • Derek Maetzold of Castle Biosciences, a Friendswood-based provider of diagnostic tests.
  • Shannon Payne of Allied Fire Protection, a Pearland-based provider of fire prevention products and services.
  • John Poindexter of JB Poindexter & Co., a Houston-based provider of automotive and manufacturing goods and services.
  • Ting Qiao of Wan Bridge, a Houston-based developer and operator of build-to-rent communities.

“These entrepreneurs are shining examples of how to lead a scaling business and also care for their employees, customers and communities,” says Travis Garms, an EY partner who is co-director of EOY’s Gulf South program.

The regional winners now qualify for consideration in the EOY national awards program. The national awards are scheduled to be presented in November.

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Gaurab Chakrabarti and Sean Hunt were originally named regional winners in this year's competition this summer along with nine other Houston entrepreneurs. Photos via solugen.com

Houston founders named winners for 2023 Entrepreneur of the Year awards

winner, winner

Houston’s Gaurab Chakrabarti and Sean Hunt, the founders of the transformative chemical manufacturing company Solugen, have been named EY’s US National Award winners for Entrepreneur of the Year.

Solugen, also recently named a finalist in the 2023 Houston Innovation Awards, is an environmentally friendly approach that relies on smaller chemical refineries that helps in reducing costs and transportation-related emissions. Some of their noted accomplishments includes innovations like the proprietary reactor, dubbed the Bioforge, which is a carbon-negative molecule factory and manufacturing process produces zero wastewater or emissions compared with traditional petrochemical refineries.The Bioforge uses a chemienzymatic process in converting plant-sourced substances into essential materials that can be used instead of fossil fuels.

Chakrabarti and Hunt were originally named regional winners in this year's competition this summer along with nine other Houston entrepreneurs.

Founded in 2016 by Hunt and Gaurab Chakrabarti, Solugen has raised over $600 million from investors like Sasol that believe in the technology's potential. The company is valued at reportedly over $2 billion. Solugen is headquartered in Houston, not because it is the hometown of Chakrabarti, but for what Houston brings to the company.

“There’s no way our business could succeed in the Bay Area," Chakrabarti said in a 2023 interview at SXSW where he detailed the offers Hunt and he received to move the business out of state. “For our business, if you look at the density of chemical engineers, the density of our potential customers, and the density of people who know how to do enzyme engineering, Houston happened to be that perfect trifecta for us.”

Even though they are headquartered in Houston, Solugen recently secured plans to expand to the Midwest, as in November they announced its newest strategic partnership with sustainable solutions company ADM (NYSE:ADM) in Marshall, Minnesota. The partnership includes plans for Solugen to build a 500,000-square-foot biomanufacturing facility next to an existing ADM facility , with the two companies working together on producing biomaterials to replace fossil fuel products.

“The strategic partnership with ADM will allow Solugen to bring our chemienzymatic process to a commercial scale and meet existing customer demand for our high-performance, cost-competitive, sustainable products,” Chakrabarti said in a news release. “As one of the few scaled-up and de-risked biomanufacturing assets in the country, Solugen’s Bioforge platform is helping bolster domestic capabilities and supply chains that are critical in ensuring the U.S. reaches its ambitious climate targets.”

For Chakrabarti and Hunt, Solugen was born out of a 12-year friendship, and the journey began after a friendly card game. After an entrepreneurship contest at MIT, which earned them second place and a $10,000 prize, they invested the winnings to work on what would become Solugen, a proof-of-concept reactor with materials bought from a local home improvement store.

"We had a conviction that we were building something that could be impactful to the rest of the world,” Chakrabarti said at SXSW in 2023.

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Rice launches 'brain economy' initiative at World Economic Forum

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Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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