3 Houston innovators to know this week

who's who

This week's innovators to know roundup includes Durg Kumar of Knightsgate Ventures, Rand Stephens of Avison Young, and Shail Sinhasane of Mobisoft. Photos courtesy

Editor's note: In today's Monday roundup of Houston innovators, I'm introducing you to three innovators across industries — from commercial real estate to venture capital.

Durg Kumar, managing partner at Knightsgate Ventures

Durg Kumar — along with his New York-based business partner Allen Bryant — join the Houston Innovators Podcast to discuss their second fund. Photos courtesy

As Durg Kumar enters into his venture capital firm's second fund, his focus is not diverted from Knightsgate Ventures' existing portfolio in this unprecedented time. Throughout the pandemic, Houston-based Knightsgate has been offering support to these startups.

"Now's a good time to retrench and focus on building product," Kumar says, "so that in 2021 when travel restrictions ease, then you've got your refined product to go out and take it to the customers."

Kumar and Allen Bryant, the VCs other partner, joined the Houston Innovators Podcast to discuss their second fund and more. Click here to read more and stream the episode.

Rand Stephens, managing director of Avison Young's Houston office

Rand Stephens discusses COVID-19's effect on office and innovation spaces. Durg Kumar (left) and Allen Bryant, partners at Knightsgate Ventures, join the Houston Innovators Podcast to discuss their second fund. Photos courtesy

Since the 1980s, Houston has been increasing focus on diversifying its economy from oil and gas. Rand Stephens has observed this and noted that new innovation centers rising — like The Ion and A&M's new hub in the TMC — are indicators of progress.

"Houston is an incredible diverse city. We have unlimited talent from an engineering standpoint, and I think those types of projects bode well for keeping and attracting top tech talent. I think that's really the key," he says.

He discusses this progress and the effect of the pandemic on CRE in a Q&A. Click here to read more.

Shail Sinhasane, CEO of Mobisoft

This Houston entrepreneur created a new tool can be used to coordinate responsible rides for passengers infected with COVID-19. Photo courtesy

As the pandemic's effects continue to reverberate into aspects of daily life, a Houston software company has pivoted its technology to create an app that can safely transport COVID-19 patients to their quarantine location.

Mobisoft announced the launch of NEMT Pulse, a non-emergency medical transportation app to be used by schools, community health centers, hospitals, and more to easily facilitate isolated rides.

"We pivoted our NEMT software that could be implemented to safely meet the needs of those affected by COVID-19," says Shail Sinhasane, CEO of Mobisoft, in a news release. "This app provides a solution to ensure individuals who have tested positive can get to their quarantine location with one less thing to worry about." Click here to read more.

Rand Stephens, managing director of Avison Young's Houston office, discusses COVID-19's effect on office and innovation spaces. Photo courtesy of Avison Young

Houston real estate expert shares why now's the time for the city's innovation ecosystem to emerge

Q&A

Rand Stephens has been in Houston since the '80s, and he's seen the city evolve from having an economy heavily dominated by oil and gas to a city focused on diversification of industry.

Now, as a technology and innovation ecosystem is emerging with new startup and lab space being developed, Houston is on a good path — even in light of the effects of the pandemic.

"I think that Houston is a very vibrant place and it always has been. It's very entrepreneurial, and it will adjust to the new environment," says Stephens, who's principal at Avison Young and the founding managing director of the company's Houston office.

Stephens discussed the importance of new developments and the effect of the pandemic on the commercial real estate industry in an interview with InnovationMap.

InnovationMap: Why is the timing right for Houston's innovation ecosystem to emerge?

Rand Stephens: Since the '80s, there's been a real emphasis within the city to diversify. Trying to do new things is always difficult because a lot of it has to do with timing — it has to make sense economically. Innovation is a hot thing right now, more so than ever. As a city or company, if you're not constantly innovating, you're going to get left behind.

From a real estate standpoint, we've really had an abundance of low-cost space in an environment that is very entrepreneurial.

IM: Why are emerging innovation campuses like The Ion and Texas A&M Innovation Plaza near the Texas Medical Center so important?

RS: Houston is an incredible diverse city. We have unlimited talent from an engineering standpoint, and I think those types of projects bode well for keeping and attracting top tech talent. I think that's really the key.

You have to have this kind of infrastructure to support the innovation. The more that we can do to make the city walkable and to provide connectivity to the different parts of the city, is important. It's all about the experience. And, I don't think people like getting in the car and fight traffic — I think it's that simple.

IM: Has COVID-19 affected the momentum of innovation development?

RS: It has. But, what I've seen, and it's totally anecdotal, but people are coming to grips with COVID. They are coming to grips with the risks, and, as time goes on, they will see it as a less risky disease as a vaccine and treatment become available.

These innovation spaces are going to be important for collaboration. You lose the spontaneity of innovation and collaboration if you're not around people. But, we're already seeing people in Houston returning to work.

IM: In general, how is the pandemic affecting commercial real estate?

RS: COVID is impacting the office market the most — and I think it will long term as well. There's been a trend for a long time now to use less square footage per person. I think corporations have evolved from looking at their office spaces as a place to put people to work to really trying to create an experiential environment to use the office to re-enforce their culture and brand in order to recruit top talent. COVID has accelerated that trend now.

My gut feeling on that is it's going to depend on the business. Different types of industries function differently, and the size of the business is going to depend on that too. I think the trend of using less square footage per person isn't going to go up. I don't think we're going to see companies taking more space for social distancing. I think what they'll do is give people more flexibility. I think corporates are going to say, "let's ammenitize our space and put people in places where it's experiential and a cool place to work." And I think people are OK with that.

IM: What makes Houston a good city for innovation?

RS: There are three or four reasons off the top of my head, but one is the entrepreneurial spirit and that's pervasive everywhere. Then, we have amazing infrastructure here, with talent and education. Another thing that is key is affordability. Relatively speaking, it's a very affordable city to do business in. The fourth thing would be the diversity and inclusion we have here. Houston is one of the most diverse cities in the country — and a lot of people don't know that. And I have found it to be an incredibly inclusive city. I think if you move here and you have good ideas and work hard, there's nothing to hold you back here.

------

This conversation has been edited for brevity and clarity.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

---

A version of this article first appeared on EnergyCapitalHTX.com.

View All Listings