Houston needs to lighten up a little, sheesh. Photo by Rome Wilkerson on Unsplash

Not-so-happy news for Texans living in Houston – they're living in one of the "unhappiest" cities in the nation.

A recent SmartAsset study ranked Houston the No. 81 happiest city in the U.S., based on an analysis of 90 large cities for their residents' quality of life, well being, and personal finances.

The city's rank in the bottom 10 — alongside Texas neighbors Dallas (No. 80), El Paso (No. 83), and Laredo (No. 89) – shows not everything about Houston is as easygoing as people think it is. We can hear Ken Hoffman's disagreement from here.

The study found 28.5 percent of all Houston households make a six-figure salary or more, and 16.2 percent of residents are burdened by their housing costs. Houston's poverty rate is 20.7 percent, so maybe it really is more difficult to live comfortably in the city, after all.

Houston has a marriage rate of 39.4 percent, and its residents have a life expectancy of 79 years old. Nearly 76 percent of residents have health insurance, and a Houstonian has nearly five "mentally unhealthy" days per month on average.

Our beloved city has had some bad press recently: H-Town isn't exactly revered for having the best drivers; the city and its suburbs are apparently less appealing for new residents making the move to Texas; and its popularity in the tech industry seems to be waning.

It's not all doom and gloom, though. There's always plenty of new restaurants to try, our city's inventive art scene remains unmatched, and plenty of hometown hero celebrities, Hall of Fame athletes, and talented musicians praise Houston for its culture and hospitality.

While money can't necessarily buy happiness, SmartAsset suggests that having a higher quality of life can influence a person's financial decisions, therefore leading to a greater probability of beneficial outcomes. Of course, that's assuming high financial literacy and strong money management skills.

"Depending where you live, certain quality of life factors, including metrics like life expectancy, infrastructure and the rate of marriage, can ultimately impact your happiness," the report's author wrote.

Elsewhere in Texas, the Dallas suburb of Plano soared to the top as the No. 2 happiest city in the nation. More than half (52.5 percent) of all Plano households make a six-figure salary or more, and only 12.1 percent of residents are burdened by their housing costs. Plano's poverty rate is less than five percent, its marriage rate is 56 percent, and nearly 90 percent of Plano residents have health insurance.

Other Texas cities that earned spots in the report, that notably aren't as happy as Plano, include: Fort Worth (No. 38), Arlington (No. 47), Irving (No. 64), Austin (No. 65), San Antonio (No. 70), Corpus Christi (No. 77), and Lubbock (No. 78).

The top 10 happiest cities in the U.S. are:

  • No. 1 – Arlington, Virginia
  • No. 2 – Plano, Texas
  • No. 3 – Fremont, California
  • No. 4 – San Jose, California
  • No. 5 – Seattle, Washington
  • No. 6 – Boise City, Idaho
  • No. 7 – Raleigh, North Carolina
  • No. 8 – Chesapeake, Virginia
  • No. 9 – San Francisco, California
  • No. 10 – Anchorage, Alaska
The report ranked the 90 most populous U.S. cities based on data from the U.S. Census Bureau 1-Year American Community Survey for 2022 and from the County Health Rankings and Roadmaps for 2023. Data that factored into each city's ranking included a city's household income, poverty level, life expectancy, health insurance rates, marriage rates, overcrowding rates, and more.The full report and its methodology can be found on smartasset.com

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This article originally ran on CultureMap.

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.