How this Houston innovator is making AI accessible, personal, and safe

HOUSTON INNOVATORS PODCAST EPISODE 198

Anshumali Shrivastava joins the Houston Innovators Podcast to share the revolutionary work ThirdAI is doing for artificial intelligence. Photo via rice.edu

Anshumali Shrivastava's career has evolved alongside the rise of artificial intelligence. Now, he believes his company represents the future of the industry's widespread implementation.

Shrivastava, who's also a professor at Rice University, founded ThirdAI, pronounced "third eye," in 2021 to democratize artificial intelligence through software innovations. As Shrivastava explains on the Houston Innovators Podcast, AI processes have historically been run on larger, less accessible computing hardware. ThirdAI's tools are able to run on a regular central processing unit, or CPU, rather than the more powerful graphics processing unit, or GPU.

"We focus on the problems that people are facing in the current AI ecosystem," Shrivastava says on the podcast. "Right now, if you are to build some of the large-language models and (linear programming) models, you need a lot of computing power, dedicated engineers to move it, and, even if you are using fully managed services, it's costly and there are a lot of privacy implications because you have to move data around."



These are some of the challenges for AI development, and, as Shrivastava points out, this process isn't even accessible for 90 percent of the world that lacks the infrastructure to do it. And, even for companies that can afford to invest in the dedicated GPU hardware, there's a global chip shortage.

ThirdAI's solution? Enable AI processes on the hardware that is accessible — CPUs.

"That is what our product offerings are — the AI ecosystem on commodity infrastructure," he says, explaining that ThirdAI's goal is also to improve existing AI applications.

One specific AI application that ThirdAI is making more effective for its customers is search tools in ecommerce. The need to make online shopping searches as quick and as accurate as possible directly affects the company's ability to complete the transaction. Wayfair tapped into ThirdAI's tech to address its latency in its on-site searching.

"Their problem was in the domain of making language models and search engines, which are AI based, very efficient," Shrivastava says. "We were able to bring down (latency) significantly with our technology."

One AI application that's taken off over the past few years is the chat-based model — led by OpenAI's ChatGPT. As exciting as the prospect of navigating information via chatbot is, many companies, understandably, have privacy concerns.

ThirdAI created PocketLLM to address this concern. The platform, which ThirdAI offers for free, operates completely on the harddrive of the owner of the data, meaning your data stays with you.

"ChatGPT has shown the world what is possible," Shrivastava says, explaining that 80 or 90 percent of use cases are people or companies wanting to take their knowledge and data and turn it into an AI chat tool. "What people want is a ChatGPT-kind of agent on their data, but they don't want their proprietary data to be leaked to the outer world."

"Because I can build AI where your data is, your data never have to leave your ecosystem. PocketLLM is a demonstration of that capability," Shrivastava continues. "It's a tool that uses our software stack and essentially looks at your data and builds this chat agent and offers you an air-gapped privacy."

Shrivastava explains that the tool can be used for enterprises or even personal applications — like navigating past conversations on email, seeing as no email provider seems to have an optimized search option.

PocketLLM is just one thing ThirdAI is working on. Shrivastava explains that the company is developing an entire ecosystem of tools that can be used on CPUs.

"If AI is going to be an agent, it better be personalized," he says, explaining that no one AI will have the right answer for everyone.

Shrivastava shares more about the future of both AI and ThirdAI, which is growing to keep up with demand. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

ThirdAI's new PocketLLM app is free to use and completely secure. Photo via Getty Images

Houston startup launches innovative chat tool on its mission to democratize AI

smart tech

Artificial intelligence has a big potential to disrupt the technology industry, and one Houston company that was founded by a computer science professor at Rice University, is fast on its way to help lead that future now in a convenient and affordable way.

Founded by Anshumali Shrivastava and Tharun Medini, a recent Ph.D. who graduated under Shrivastava from Rice's Department of Electrical and Computer Engineering, ThirdAI is building AI deep learning tools that aim to be sustainable and scalable to fit the changing needs of the industry. The company is on a mission to democratize AI, Shrivastava tells InnovationMap.

Shrivastava likes to use the word efficiently when describing what makes ThirdAI different, and how its programs can teach AI via multiple avenues to be what he refers to as “1,000 times more efficient.”

“The carbon footprint of these models are off the charts, and so expensive,” Shrivastava. “We believe this could be made efficient. … We use the same ideas that were developed, but we do it on a massive scale.”

ThirdAI's latest tool is a multilingual ChatGPT-like AI training tool PocketLLM app. Announced earlier this month, the tool is free. According to the company, users have access to a personalized chatbot that understands what the user is searching within documents, and can be fine-tuned to help elaborate your thoughts through a neural search.

ThirdAI's PocketLLM app is free to use. Image courtesy of ThirdAI

The app is private and secure and runs on deep-learning algorithms according to Vinod Iyengar, head of product at ThirdAI, and no one — not even ThirdAI — has access to the documents except the user.

“Tools exist to help people search text files, but that requires sharing your data with third parties,” says Iyengar in a news release. “Our solution is private and secure, powered by deep learning algorithms. And it returns results lightning fast.”

The process includes the user installing the app, uploading any text document files, and clicking "train." Minutes later, you have an AI tool that can process the information in those documents.

“The neural search encourages you to elaborate on your thoughts with details in the discover window and see the difference in results,” says Shrivastava in the release. “It can also be fine-tuned to your tastes by selecting the relevant option and hitting the update button to re-train."

In September of 2021, ThirdAI — pronounced "third eye" — raised $6 million in seed funding. The round was invested in by three California-based VCs — Neotribe Ventures and Cervin Ventures, which co-led the round with support from Firebolt Ventures. The technology ThirdAI is working with comes from 10 years of deep learning research and innovation. The company's technology has the potential to make computing 15-times faster, the company reports.

Anshumali Shrivastava is an associate professor of computer science at Rice University. Photo via rice.edu

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Houston researchers develop dissolvable implant for targeted cancer drug delivery

cancer research

Researchers at Houston Methodist have developed a biodegradable implant that can be used to safely and consistently deliver drug treatments to tumors and then dissolve without the need for further surgery.

The implant is only the size of a grain of rice, but its potential is staggering. The biodegradable nanofibrous drug-eluting seed (b-NDES) works as a reservoir parked inside a soft tumor, where it can slowly release immune-stimulating drugs over time. This overcomes a consistent problem with drugs such as immune checkpoint inhibitors. Normal systemic administration sees comparatively little of the drug making its way to the tumor, with most of it circulating throughout the body. The b-NDES is like deploying a small guerrilla fighting force embedded in enemy territory, doing maximum damage to the entrenched tumor.

"To improve cancer treatment, we're trying to start a fire inside the tumor itself," Corrine Chua, associate professor in the Center for BioNanoengineering at Houston Methodist Research Institute, said in a news release. "By activating immune cells directly within the tumor microenvironment, those cells can then travel throughout the body and seek out cancer wherever it exists. The b-NDES platform was developed to help keep therapeutic drugs concentrated inside tumors while minimizing exposure to healthy tissues.”

Chua co-led the study with Alessandro Grattoni, chair and director of the Center for BioNanoengineering at Houston Methodist Research Institute.

The study included support from the Nancy Owens Breast Cancer Foundation and the National Institutes of Health/National Cancer Institute.

Chau and Grattoni used preclinical models of triple-negative breast cancer, an aggressive form of cancer that is estrogen receptor-negative, progesterone receptor-negative and HER2-negative. Because of the receptor negativity, some popular treatments like tamoxifen and trastuzumab are ineffective. Chemotherapy has been shown to be the best course of action.

The b-NDES implant is deployed alongside radiation drugs. It keeps the drugs focused on the tumor, reducing the amount of harmful side effects typically seen when drugs are circulated more widely in the body. In 60 percent of the models, tumors were eliminated and did not cause side effects beyond the tumor site. Once the drugs have been deployed, the implant breaks down naturally.

While promising, more research will have to be done to expand use to other tumor types.

"Although the study focused on triple-negative breast cancer models, the approach could have broader applications for solid tumors," Grattoni added in the release. "It could potentially be used in cancers where there is a tumor lesion accessible for placement, including pancreatic or lung cancers."

New Houston platform Same Day Reels launches for on-demand content creation

In The Moment

If an event doesn't happen on Instagram, did it even really happen? In today's social media-driven age of branding and audience engagement, the answer increasingly is no.

Houston entrepreneur Karen De Amat is looking to fill the online content creation needs of companies with her new venture, Same Day Reels, which launched in early August. It will serve as a platform to connect companies and brands with talent that can help turn an event into a viral moment as it is happening.

"Events move quickly, and social media moves even faster,” said De Amat. “Same Day Reels was built to help brands capture the moment while it still matters. We are creating a more efficient way for businesses and creators to work together. Brands need content faster, and creators need more opportunities to turn their talent into real work. Same Day Reels brings those needs together.”

The company is focused on adding livestreams and concurrent short video content to "activations, launches, fundraisers, grand openings, conferences, hospitality experiences, and private celebrations." Such content can significantly increase the visibility of a product or brand according to digital marketing brands like Wyzowl, whose data found 63 percent of people in 2026 prefer to learn about new products via short video.

Packages offered by Same Day Reels will include filming, editing, and publishing content within hours of the targeted event.

De Amat says that her content creation platform will be a way to preserve the excitement of events and launches by enshrining them with immediate social media-driven memories.

“Event content is no longer just something you post after the fact,” De Amat said. “It is part of how people experience, remember and share the moment.”

Previously, De Amat is also the founder and CEO of Social Behavior, an influencer marketing company she launched from her home in 2014. It quickly garnered an array of clients and thrust De Amat into the spotlight, including numerous appearances on Fox 26's The Isiah Factor. Influencer Marketing Hub named her one of the top CEOs of influencer marketing companies in Houston in 2025.

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This article originally appeared on CultureMap.com.

Bristol Myers Squibb to build $2.3B Houston pharma manufacturing campus

coming soon

New Jersey-based pharmaceutical giant Bristol Myers Squibb Co. has officially named Houston as the home of its new state-of-the-art manufacturing site.

The 60,000-square-foot facility represents a $2.3 billion investment, according to a news release. It is expected to create 500 skilled jobs and will be located in Houston's Generation Park.

BMS first announced that it was considering Houston among 16 other cities for the facility in May. The new hub will manufacture small molecule, biologic and antibody-drug conjugates and is part of a $40 billion commitment to invest in the United States over five years. Construction is slated to begin next year, with the facility coming online in 2030.

"We're building the domestic manufacturing capabilities needed to deliver the next generation of medicines and support future scientific breakthroughs. Houston and the state of Texas offer the talent, infrastructure, and partnership needed to help bring that vision to life," Christopher Boerner, CEO and board chair of BMS, said in the release.

The new facility will feature a modular, multi-modal design, which will allow the company to reconfigure and add to its manufacturing capabilities over time. BMS says it expects the facility to "(grow) in scale and capability well beyond its opening configuration."

"Our decision to build this state-of-the-art manufacturing campus in Houston, Texas, reflects our confidence in the region’s ability to support a world-class, digitally advanced supply operation,” Karin Shanahan, EVP and chief supply chain and operations officer of BMS, added in the release. “This facility is designed to deliver the speed, quality, and reliability that patients depend on, combining flexible, modular manufacturing with advanced digital capabilities to ensure consistent supply across multiple modalities. It strengthens our ability to operate with resilience and positions us to reliably deliver medicines to patients today while adapting future demands.”

Texas Gov. Greg Abbott shared that the state has granted BMS a $4.89 million Texas Enterprise Fund (TEF) grant for the project. TEF grants, administered by the Texas Economic Development & Tourism Office, support business relocation or expansion projects that create "new, good-paying jobs in the community and attract significant new capital investment to the state." The development is also a qualified project under the Texas Jobs, Energy, Technology, and Innovation (JETI) program.

“Texas is a global hub for life sciences, where today’s innovations shape the future of healthcare,” Abbott said in a news release. “This $2.3 billion investment by Bristol Myers Squibb in the dynamic biotech ecosystem in Houston is a testament to the depth of our skilled workforce and the pipeline of talent coming through our nation-leading technical colleges and research universities. With lower operating costs and easy access to markets across the U.S. and the world, Texas drives affordability for consumers.”

"Bristol Myers Squibb’s announcement is a tremendous win for Texas and the Houston region, further reinforcing our position as a premier destination for life sciences and advanced manufacturing,” added Greater Houston Partnership President and CEO Steve Kean.

Last fall, Eli Lilly and Co. selected Generation Park, a 4,300-acre, master-planned commercial district near Lake Houston, for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.