How this Houston innovator is making AI accessible, personal, and safe

HOUSTON INNOVATORS PODCAST EPISODE 198

Anshumali Shrivastava joins the Houston Innovators Podcast to share the revolutionary work ThirdAI is doing for artificial intelligence. Photo via rice.edu

Anshumali Shrivastava's career has evolved alongside the rise of artificial intelligence. Now, he believes his company represents the future of the industry's widespread implementation.

Shrivastava, who's also a professor at Rice University, founded ThirdAI, pronounced "third eye," in 2021 to democratize artificial intelligence through software innovations. As Shrivastava explains on the Houston Innovators Podcast, AI processes have historically been run on larger, less accessible computing hardware. ThirdAI's tools are able to run on a regular central processing unit, or CPU, rather than the more powerful graphics processing unit, or GPU.

"We focus on the problems that people are facing in the current AI ecosystem," Shrivastava says on the podcast. "Right now, if you are to build some of the large-language models and (linear programming) models, you need a lot of computing power, dedicated engineers to move it, and, even if you are using fully managed services, it's costly and there are a lot of privacy implications because you have to move data around."



These are some of the challenges for AI development, and, as Shrivastava points out, this process isn't even accessible for 90 percent of the world that lacks the infrastructure to do it. And, even for companies that can afford to invest in the dedicated GPU hardware, there's a global chip shortage.

ThirdAI's solution? Enable AI processes on the hardware that is accessible — CPUs.

"That is what our product offerings are — the AI ecosystem on commodity infrastructure," he says, explaining that ThirdAI's goal is also to improve existing AI applications.

One specific AI application that ThirdAI is making more effective for its customers is search tools in ecommerce. The need to make online shopping searches as quick and as accurate as possible directly affects the company's ability to complete the transaction. Wayfair tapped into ThirdAI's tech to address its latency in its on-site searching.

"Their problem was in the domain of making language models and search engines, which are AI based, very efficient," Shrivastava says. "We were able to bring down (latency) significantly with our technology."

One AI application that's taken off over the past few years is the chat-based model — led by OpenAI's ChatGPT. As exciting as the prospect of navigating information via chatbot is, many companies, understandably, have privacy concerns.

ThirdAI created PocketLLM to address this concern. The platform, which ThirdAI offers for free, operates completely on the harddrive of the owner of the data, meaning your data stays with you.

"ChatGPT has shown the world what is possible," Shrivastava says, explaining that 80 or 90 percent of use cases are people or companies wanting to take their knowledge and data and turn it into an AI chat tool. "What people want is a ChatGPT-kind of agent on their data, but they don't want their proprietary data to be leaked to the outer world."

"Because I can build AI where your data is, your data never have to leave your ecosystem. PocketLLM is a demonstration of that capability," Shrivastava continues. "It's a tool that uses our software stack and essentially looks at your data and builds this chat agent and offers you an air-gapped privacy."

Shrivastava explains that the tool can be used for enterprises or even personal applications — like navigating past conversations on email, seeing as no email provider seems to have an optimized search option.

PocketLLM is just one thing ThirdAI is working on. Shrivastava explains that the company is developing an entire ecosystem of tools that can be used on CPUs.

"If AI is going to be an agent, it better be personalized," he says, explaining that no one AI will have the right answer for everyone.

Shrivastava shares more about the future of both AI and ThirdAI, which is growing to keep up with demand. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

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ThirdAI's new PocketLLM app is free to use and completely secure. Photo via Getty Images

Houston startup launches innovative chat tool on its mission to democratize AI

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Artificial intelligence has a big potential to disrupt the technology industry, and one Houston company that was founded by a computer science professor at Rice University, is fast on its way to help lead that future now in a convenient and affordable way.

Founded by Anshumali Shrivastava and Tharun Medini, a recent Ph.D. who graduated under Shrivastava from Rice's Department of Electrical and Computer Engineering, ThirdAI is building AI deep learning tools that aim to be sustainable and scalable to fit the changing needs of the industry. The company is on a mission to democratize AI, Shrivastava tells InnovationMap.

Shrivastava likes to use the word efficiently when describing what makes ThirdAI different, and how its programs can teach AI via multiple avenues to be what he refers to as “1,000 times more efficient.”

“The carbon footprint of these models are off the charts, and so expensive,” Shrivastava. “We believe this could be made efficient. … We use the same ideas that were developed, but we do it on a massive scale.”

ThirdAI's latest tool is a multilingual ChatGPT-like AI training tool PocketLLM app. Announced earlier this month, the tool is free. According to the company, users have access to a personalized chatbot that understands what the user is searching within documents, and can be fine-tuned to help elaborate your thoughts through a neural search.

ThirdAI's PocketLLM app is free to use. Image courtesy of ThirdAI

The app is private and secure and runs on deep-learning algorithms according to Vinod Iyengar, head of product at ThirdAI, and no one — not even ThirdAI — has access to the documents except the user.

“Tools exist to help people search text files, but that requires sharing your data with third parties,” says Iyengar in a news release. “Our solution is private and secure, powered by deep learning algorithms. And it returns results lightning fast.”

The process includes the user installing the app, uploading any text document files, and clicking "train." Minutes later, you have an AI tool that can process the information in those documents.

“The neural search encourages you to elaborate on your thoughts with details in the discover window and see the difference in results,” says Shrivastava in the release. “It can also be fine-tuned to your tastes by selecting the relevant option and hitting the update button to re-train."

In September of 2021, ThirdAI — pronounced "third eye" — raised $6 million in seed funding. The round was invested in by three California-based VCs — Neotribe Ventures and Cervin Ventures, which co-led the round with support from Firebolt Ventures. The technology ThirdAI is working with comes from 10 years of deep learning research and innovation. The company's technology has the potential to make computing 15-times faster, the company reports.

Anshumali Shrivastava is an associate professor of computer science at Rice University. Photo via rice.edu

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Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

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With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

5+ must-know application deadlines for Houston innovators

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Editor's note: As 2026 ramps up, the Houston innovation scene is looking for the latest groups of innovative startups that'll make an impact. A number of accelerators and competitions have opened applications. Read below to see which might be a good fit for you or your venture. And take careful note of the deadlines. Please note: this article may be updated to include additional information and programs.

Did we miss an accelerator or competition accepting applications? Email innoeditor@innovationmap.com for editorial consideration.

2026 HCC Business Plan Competition

Deadline: Jan. 26

Details: HCC’s annual Business Plan Competition (BPC) is an opportunity for proposed, startup and existing entrepreneurs to develop focused plans to start or grow their businesses. Accepted teams will be announced and training will begin in late February and run through early June, with six free, three-hour training sessions. Advising will be provided to each accepted team. Applicants can apply as a team of up to five persons. Finalists will present to to gudges on May 27, 2026. Last year, $26,000 was awarded in seed money to the top five teams. In-kind prizes were also awarded to all graduating teams including free products, services and memberships, with an estimated in-kind value totaling $147,000. Find more information here.

University of Houston Technology Bridge Innov8 Hub (Spring 2026)

Deadline: Jan . 30

Details: UHTB Innov8 Hub’s immersive, 12-week startup acceleration program designed to help early-stage founders launch and scale their technology startups. Selected participants will gain access to expert mentors and advisors, collaborate with a cohort of peers, and compete for cash prizes during our final pitch event. The cohort begins Feb. 16, 2026. The program culminates in Pitch Day, where participants present their ventures to an audience of investors and partners from across the UH innovation ecosystem. Find more information here.

Rice Business Plan Competition 2026

Deadline: Jan. 31

Details: The Rice Business Plan Competition, hosted by the Rice Alliance for Technology and Entrepreneurship, gives collegiate entrepreneurs real-world experience to pitch their startups, enhance their business strategy and learn what it takes to launch a successful company. Forty-two teams will compete for more than $1 million in cash, investments and prizes on April 9-11, 2026. Find more information here.

Rice Veterans Business Battle 2026

Deadline: Jan. 31

Details: The Rice Veterans Business Battle is one of the nation’s largest pitch competitions for veteran-led startups, providing founders with mentorship, exposure to investors and the opportunity to compete for non-dilutive cash prizes. The event has led to more than $10 million of investments since it began in 2015. Teams will compete April 8-9, 2026. Find more information here.

TEX-E Fellows Application 2026-2027

Deadline: Feb. 10

Details: The TEX‑E Fellowship is a hands-on program designed for students interested in energy, climate, and entrepreneurship across Texas. It connects participants with industry mentors, startup founders, investors and academic leaders while providing practical, "real-world" experience in customer discovery, business modeling, and energy-transition innovation. Fellows gain access to workshops, real-world projects, and a statewide network shaping the future of energy and climate solutions. Participants must be a student at PVAMU, UH, UT Austin, Rice University, MIT or Texas A&M. Find more information here.

2026 Energy Venture Day & Pitch Competition

Deadline: Feb. 13

Details: The Rice Alliance, the Houston Energy Transition Initiative (HETI) and TEX-E will present the annual Energy Venture Day and Pitch Competition during CERAWeek on March 24-25, 2026. Energy Venture Day features two days of presentations by energy tech ventures driving efficiency and advancements toward the energy transition. On March 24, the Pitch Preview at the Ion will feature over 50 companies presenting in front of Rice Alliance's robust network of investors and industry partners. On March 25, the Energy Venture Day and Pitch Competition during CERAWeek will showcase 36 ventures at the George R Brown Convention Center. The pitch competition is divided up into the TEX-E university track, in which Texas student-led energy startups compete for $50,000 in cash prizes, and the industry ventures track. The industry track is subdivided into three additional tracks, spanning materials to clean energy. The top three companies from each industry track will be named. The winner of the CERAWeek competition will also have the chance to advance and compete for the $1 million investment prize at the Startup World Cup. Find more information here.

Greentown Go Make 2026

Deadline: March 10

Details: Greentown Go Make 2026 is an open-innovation program with Shell and Technip Energies. The six-month program is advancing industrial decarbonization by accelerating catalytic innovations. Selected startups will gain access to a structured platform to engage leadership from Shell and Technip Energies and explore potential partnership outcomes, including pilots and demonstrations. They’ll also receive networking opportunities, partnership-focused programming, and marketing visibility throughout the program. The cohort will be selected in May. Find more information here.

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