From a low-cost vaccine to an app that can help reduce exposure, here are the latest COVID-focused and Houston-based research projects. Photo via Getty Images

While it might seem like the COVID-19 pandemic has settled down for the time being, there's plenty of innovative research ongoing to create solutions for affordable vaccines and tech-enabled protection against the spread of the virus.

Some of that research is happening right here in Houston. Here are two innovative projects in the works at local institutions.

UH researcher designs app to monitor best times to shop

A UH professor is putting safe shopping at your fingertips. Photo via UH.edu

When is the best time to run an errand in the pandemic era we currently reside? There might be an app for that. Albert Cheng, professor of computer science and electrical and computer engineering at the University of Houston, is working on a real-time COVID-19 infection risk assessment and mitigation system. He presented his plans at the Institute of Electrical and Electronics Engineers conference HPC for Urgent Decision Making and will publish the work in IEEE Xplore.

Cheng's work analyzes up-to-date data from multiple open sources to see when is the best time to avoid crowds and accomplish activities outside the home.

"Preliminary work has been performed to determine the usability of a number of COVID-19 data websites and other websites such as grocery stores and restaurants' popular times and traffic," Cheng says in a UH release. "Other data, such as vaccination rates and cultural factors (for example, the percentage of people willing to wear facial coverings or masks in an area), are also used to determine the best grocery store to shop in within a time frame."

To use the app, a user would input their intended destinations and the farthest distance willing to go, as well as the time frame of the trip. The risk assessment and mitigation system, or RT-CIRAM, then "provides as output the target location and the time interval to reach there that would reduce the chance of infections," said Cheng.

There's a lot to it, says Cheng, and the process is highly reliant on technology.

"We are leveraging urgent high-performance cloud computing, coupled with time-critical scheduling and routing techniques, along with our expertise in real-time embedded systems and cyber-physical systems, machine learning, medical devices, real-time knowledge/rule-based decision systems, formal verification, functional reactive systems, virtualization and intrusion detection," says Cheng.

2 Houston hospitals team up with immunotherapy company for new vaccine for Africa

The new vaccine will hopefully help mitigate spread of the disease in Sub-Saharan Africa. Photo via bcm.edu

Baylor College of Medicine and Texas Children's Hospital have teamed up with ImmunityBio Inc. — a clinical-stage immunotherapy company — under a licensing agreement to develop a safe, effective and affordable COVID-19 vaccine.

BCM has licensed out a recombinant protein COVID-19 vaccine candidate that was developed at the Texas Children's Hospital Center for Vaccine Development to ImmunityBio. According to the release, the company engaged in license negotiations with the BCM Ventures team, about the vaccine that could address the current pandemic needs in South Africa.

"We hope that our COVID-19 vaccine for global health might become an important step towards advancing vaccine development capacity in South Africa, and ultimately for all of Sub-Saharan Africa," says Dr. Peter Hotez, professor and dean of the National School of Tropical Medicine at Baylor and co-director of the Texas Children's Hospital Center for Vaccine Development.

ImmunityBio, which was founded in 2014 by Dr. Patrick Soon-Shiong, is working on innovative immunotherapies that address serious unmet needs in infectious diseases, according to a news release from BCM.

"There is a great need for second-generation vaccines, which are accessible, durable and offer broad protection against the emerging variants," says Soon-Shiong. "ImmunityBio has executed on a heterologous ("mix-and-match") strategy to develop a universal COVID-19 vaccine. To accomplish this, we have embarked upon large-scale good manufacturing practices and development of DNA (adenovirus), RNA (self-amplifying mRNA) and subunit protein (yeast) vaccine platforms. This comprehensive approach will leverage our expertise in these platforms for both infectious disease and cancer therapies."

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12+ can't-miss Houston business and innovation events for September

where to be

Editor's note: Houston's business and innovation events are back in session. From the return of Houston Energy and Climate Startup Week to a send-off for an impactful innovation leader and several health conferences, here's what not to miss and how to register. Please note: this article may be updated to include additional event listings.

Sept. 5-7 — Houston Hackathon

Impact Hub Houston is bringing back the Houston Hacakthon this month, where developers of all skill sets can work together to propose solutions to some of the Bayou City’s most pressing issues. The event is focused on ideating, designing, and developing both policy-based and tech solutions to improve Houston.

This event starts Saturday, Sept. 5, at noon at the Ion. Register here.

Sept. 8 — Community Celebration: A Send-Off for Paul Cherukuri

Come out to the Ion to celebrate Paul Cherukuri, Rice’s first chief innovation officer, whose visionary leadership has left a lasting impact on Houston’s innovation ecosystem. Cherukuri is leaving the university to accept a position at the University of Virginia. Hear remarks from Cherukuri and enjoy a networking reception following the talk.

This event is Monday, Sept. 8, from 2:30-5:00 p.m. at the Ion. Register here

Sept. 11 — Houston Methodist Leadership Speaker Series – Dr. Evan Collins

The Houston Methodist Tech Hub at the Ion will host its recurring leadership speaker series, this time featuring Dr. Evan Collins, chief of the Houston Methodist Hand & Upper Extremity Center at Houston Methodist and the Houston Methodist Center for Innovation's first innovator-in-residency. Collins will present on the creative process of innovation.

This event is Thursday, Sept. 11, from 4:45-6 p.m. at the Ion. Register here.

Sept. 12 — Future of Space

The Greater Houston Partnership’s 2025 Future of Space event will feature a keynote address by Vanessa E. Wyche, acting associate administrator of NASA. In her new role, Wyche serves as NASA’s chief operating officer, leading more than 18,000 employees and overseeing an annual budget exceeding $25 billion. Discussions will highlight how Houston’s space ecosystem is driving economic growth, technological innovation and new opportunities across the region and the nation.

The event is Friday, Sept. 12, from noon-1:30 p.m. at the Royal Sonesta. Find more information here.

Sept. 15-19 — Houston Energy and Climate Startup Week

Houston Energy and Climate Startup Week returns for its second year, with panels, happy hours and pitch days focused on the energy transition. The week features major events, including the Energytech Nexus Pilotathon, the Rice Alliance Energy Tech Venture Forum, Halliburton Labs Finalists Pitch Day and many others. See a preview of the week on our sister site EnergyCapitalHTX.com and learn more in the event listings below.

This event starts Monday, Sept. 15. The Ion District will host many of the week's events. Find more information here.

Sept. 16 — Energytech Nexus Pilotathon

Grab breakfast and take in keynotes and panels by leaders from New Climate Ventures, V1 Climate, Halliburton, Energy Tech Nexus and many others during Houston Energy & Climate Week. Then hear pitches during the Pilotathon, which targets startups ready to implement pilot projects within six to 12 months.

This event is Tuesday, Sept. 16, from 8 a.m.-5 p.m. at GreenStreet. Get tickets here.

Sept. 16 — Meet the Activate Houston Cohort 2025 Fellows

Meet Activate's latest cohort, which was named this summer, and also learn more about its 2024 group during Houston Energy & Climate Week.

This event is Tuesday, Sept. 16, at 5 p.m. at the Ion. Register here.

Sept. 17 — Green ICU Conference: Sustainability in Health Care for a Healthier Future

Houston Methodist will host its inaugural Green ICU Conference during Houston Energy & Climate Week. The conference is designed to bring together healthcare professionals, industry leaders, policymakers and innovators to explore solutions for building a more sustainable healthcare system.

This event is Wednesday, Sept. 17. from 8 a.m.-3 p.m. at TMC Helix Park. Register here.

Sept. 18 — Rice Alliance Energy Tech Venture Forum

Hear from clean energy startups from nine countries and 19 states at the 22nd annual Energy Tech Venture Forum during Houston Energy & Climate Week. The 12 companies that were named to Class 5 of the Rice Alliance Clean Energy Accelerator will present during Demo Day to wrap up their 10-week program. Apart from pitches, this event will also host keynotes from Arjun Murti, partner of energy macro and policy at Veriten, and Susan Schofer, partner at HAX and chief science officer at SOSV. Panels will focus on corporate innovation and institutional venture capital.

This event is Thursday, Sept. 18, from 7:30 a.m.-5 p.m. at Rice University’s Jones Graduate School of Business. Register here.

Sept. 18 — ACCEL Year 3 Showcase

Celebrate Advancing Climatetech and Clean Energy Leaders Program, or ACCEL, an accelerator program for startups led by BIPOC and other underrepresented founders from Greentown Labs and Browning the Green Space. Two Houston companies and one from Austin are among the eight startups to be named to the 2025 group. Hear startup pitches from the cohort, and from Greentown's Head of Houston, Lawson Gow, CEO Georgina Campbell Flatter and others. This event is part of Houston Energy & Climate Week.

This event is Thursday, Sept. 18, from 5-8 p.m. at Greentown Labs. Get tickets here.

Sept. 19 — Halliburton Labs Finalists Pitch Day

Hear from Halliburton Labs' latest cohort of entrepreneurs during Houston Energy & Climate Week. The incubator aims to advance the companies’ commercialization with support from Halliburton's network, facilities and financing opportunities. Its latest cohort includes one company from Texas.

This event is Friday, Sept. 19, from 8 a.m.-noon at The Ion. Register here.

Sept. 21-25 — AI in Health Conference

The Ken Kennedy Institute at Rice University will present the fourth annual AI in Health Conference, which aims to bridge the gap between artificial intelligence and real-world health outcomes. The event will explore the current landscape of artificial intelligence in health and present a research-driven outlook for the future of computational health innovation.

This conference is from Tuesday, Sept. 23, to Wednesday, Sept. 24. Additional workshops will be offered on Monday, Sept. 22, and Thursday, Sept. 25. The events will be held at the BioScience Research Collaborative at Rice University. Find more information here.

Sept. 25 — Industrial AI Nexus Connect

InnovateEnergy and Industrial AI Nexus will host a talk by Matthew Alberts, manager of innovation and emerging technologies at Southern Company and author of "The Gen AI Manufacturing Revolution: Smarter Factories, Enhanced Products, and Reduced Costs." Alberts will present “The Gen AI Revolution," followed by happy hour and a complimentary book signing.

This event is Thursday, Sept. 25, from 5:30-7:30 p.m. at the Ion. Register here.

Texas is the 4th hardest working state in America, report finds

Ranking It

It's no secret that Texans are hardworking people. To align with the Labor Day holiday, a new WalletHub study asserts that the Lone Star State is one of the five most hardworking states in America for 2025.

The report ranked Texas the fourth most hardworking state this year, indicating that its residents are working harder than ever after the state fell into seventh place in 2024. Texas previously ranked No. 4 in 2019 and 2020, slipped into No. 5 in 2021 and 2022, then continued falling into sixth place in 2023. But now the state is making its way back to the top of the list.

WalletHub's analysts compared all 50 states based on "direct" and "indirect" work factors. The six "direct" work factors included each state's average workweek hours, employment rates, the share of households where no adults work, the share of workers leaving vacation time unused, and other data. The four "indirect" work factors consisted of workers' average commute times, the share of workers with multiple jobs, the annual volunteer hours per resident, and the average leisure time spent per day.

North Dakota landed on top as the most hardworking state in America for 2025 for another year in a row, earning a score of 66.17 points out of a possible 100. For comparison, Texas ranked No. 4 with 57.06 points. Alaska (No. 2), South Dakota (No. 3), and Hawaii (No. 5) round out the top five hardest working states.

Across the study's two main categories, Texas ranked No. 5 in the "direct" work factors ranking, and earned a respectable No. 18 rank for its "indirect" work factors.

Broken down further, Texans have the second-longest average workweek hours in America, and they have the 12th best average commute times. Texans have the 6th lowest amount of average leisure time spent per day, the report also found.

According to the study's findings, many Americans nationwide won't take the chance to not work as hard when presented with the opportunity. A 2024 Sorbet PTO report found 33 percent of Americans' paid time off was left unused in 2023.

"While leaving vacation time on the table may seem strange to some people, there are plenty of reasons why workers choose to do so," the report's author wrote. "Some fear that if they take time off they will look less dedicated to the job than other employees, risking a layoff. Others worry about falling behind on their work or are concerned that the normal workflow will not be able to function without them."

The top 10 hardest working states are:

  • No. 1 – North Dakota
  • No. 2 – Alaska
  • No. 3 – South Dakota
  • No. 4 – Texas
  • No. 5 – Hawaii
  • No. 6 – Virginia
  • No. 7 – New Hampshire
  • No. 8 – Wyoming
  • No. 9 – Maryland
  • No. 10 – Nebraska
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This story originally appeared on CultureMap.com.