Houston's Nobel Prize winner, Jim Allison, is the star of Breakthrough, which premieres on Independent Lens at 9 pm Monday, April 27, on PBS, PBS.org, and the PBS Video App. Photo via SXSW.com
Not all heroes wear capes. In fact, our current coronavirus heroes are donning face masks as they save lives. One local health care hero has a different disease as his enemy, and you'll soon be able to stream his story.
Dr. James "Jim" Allison won the 2018 Nobel Prize in Physiology or Medicine for his work in battling cancer by treating the immune system — rather than the tumor. Allison, who is the chair of Immunology and executive director of the Immunotherapy Platform at MD Anderson Cancer Center, has quietly and often, singularly, waged war with cancer utilizing this unique approach.
The soft-spoken trailblazer is the subject of an award-winning documentary, Jim Allison: Breakthrough, which will air on PBS and its streaming channels on Monday, April 27 at 9 pm (check local listings for channel information). Lauded as "the most cheering film of the year" by the Washington Post, the film follows Allison's personal journey to defeat cancer, inspired and driven by the disease killed his mother.
Breakthrough is narrated by Woody Harrelson and features music by Willie Nelson, adding a distinct hint of Texana. (The film was a star at 2019's South by Southwest film festival.) The documentary charts Alice, Texas native as he enrolls at the University of Texas, Austin and ultimately, cultivates an interest in T cells and the immune system — and begins to frequent Austin's legendary music scene. Fascinated by the immune system's power to protect the body from disease, Allison's research soon focuses on how it can be used to treat cancer.
Viewers will find Allison charming, humble, and entertaining: the venerable doctor is also an accomplished blues harmonica player. Director Bill Haney weaves Allison's personal story with the medical case of Sharon Belvin, a patient diagnosed with melanoma in 2004 who soon enrolled in Allison's clinical trials. Belvin has since been entirely cancer-free, according to press materials.
"We are facing a global health challenge that knows no boundaries or race or religion, and we are all relying on gifted and passionate scientists and healthcare workers to contain and ultimately beat this thing," said Haney, in a statement. "Jim Allison and the unrelenting scientists like him are my heroes – and I'll bet they become yours!"
Jim Allison: Breakthrough premieres on Independent Lens at 9 pm Monday, April 27, on PBS, PBS.org, and the PBS Video App.
Jim Allison, immunotherapy researcher at MD Anderson and Nobel Prize recipient, is the subject of a new film that premiered at SXSW. Photo courtesy of MD Anderson Cancer Center
For most of his career, James Allison has been a cancer research wildcatter fighting an oftentimes lonely battle for the advancement of immunotherapy. The medical community has historically been skeptical of the science, but nonetheless Allison dedicated his life to developing a better treatment to the disease that has claimed so many lives — including his mother's.
Last year, Allison, the chair of Immunology and executive director of the Immunotherapy Platform at MD Anderson, won the 2018 Nobel Prize in medicine, and Breakthrough, a film about Allison's progression from early researcher to Nobel Prize recipient, premiered on March 9 at the 2019 SXSW Interactive festival.
But despite the Nobel Prize and the new film both validating the science to the public, Allison says there's a lot more work to be done in immunotherapy. Allison, his colleague, Padmanee Sharma, and the filmmaker for Breakthrough, Bill Haney, hosted a discussion at SXSW about the future of immunotherapy.
"It's a time of considerable optimism — and we're just at the beginning," says Allison.
The film focuses on the man behind the science — a 70-year-old, harmonica-playing researcher from small-town Alice, Texas. It's both an ode to Allison's career and a thought-provoking take on all the work left to be done in the industry.
Immunotherapy is the process of targeting one's immune system's T-cells, infection-fighting white blood cells, to attack cancer cells. Sharma, a fellow MD Anderson oncology expert and clinician, says their work has received clinical approvals for treating Melanoma, kidney cancer, lung cancer, and bladder cancer. The scientists are now focused on expanding that treatment to other cancer types and building upon the established platform they've created, while also making sure nothing comes in the way of the facts of the science.
"It really requires that we dedicate ourselves to the basic science, understanding it and educating people about it, so we don't allow the facts and science get muddied by things that are political or nonfactual," Sharma says.
In a lot of ways, this is what Breakthrough has been able to do — communicate the facts on a platform where anyone can understand the science.
"We have a revolution on our hands, and thankfully we have people like Bill who can really tell the story well, because maybe as a scientist and a clinician, we're not always equally talented on telling the story to laypeople," Sharma says.
Moving forward, Allison says he's focused on finding out why the treatment fails in some instances, and he's determined to progress immunotherapy's success rate from the 20 to 40 percent rate he says he sees it at now to 100 percent.
"We've got all the basic tools, and we know what the main issues are," Allison says. "There's still a lot to do, but we need to be smart and do fact-based and mechanism-based combinations."
Jim Allison's groundbreaking work with T cells helped him net the award. Photo courtesy of MD Anderson Cancer Center
Allison, who is the chair of Immunology and executive director of the Immunotherapy Platform, is the first MD Anderson scientist to receive the world's most coveted award for discoveries in the fields of life sciences and medicine. Allison won for his work in launching an effective new way to attack cancer by treating the immune system rather than the tumor, according to a release.
"I'm honored and humbled to receive this prestigious recognition," Allison says in a statement. "A driving motivation for scientists is simply to push the frontiers of knowledge. I didn't set out to study cancer, but to understand the biology of T cells, these incredible cells to travel our bodies and work to protect us."
Allison shares the award with Tasuku Honjo, M.D., Ph.D., of Kyoto University in Japan. When announcing the honor, the Nobel Assembly of Karolinska Institute in Stockholm noted in a statement that "stimulating the ability of our immune system to attack tumor cells, this year's Nobel Prize laureates have established an entirely new principle for cancer therapy."
The prize recognizes Allison's basic science discoveries on the biology of T cells, the adaptive immune system's soldiers, and his invention of immune checkpoint blockade to treat cancer. According to MD Anderson, Allison's crucial insight was to block a protein on T cells that acts as a brake on their activation, freeing the T cells to attack cancer. He developed an antibody to block the checkpoint protein CTLA-4 and demonstrated the success of the approach in experimental models.
Allison's work led to the development of the first immune checkpoint inhibitor drug which would become the first to extend the survival of patients with late-stage melanoma. Follow-up studies show 20 percent of those treated live for at least three years, with many living for 10 years and beyond, unprecedented results, according to the cancer center.
"Jim Allison's accomplishments on behalf of patients cannot be overstated," says MD Anderson president Peter WT Pisters, M.D., in a statement. "His research has led to life-saving treatments for people who otherwise would have little hope. The significance of immunotherapy as a form of cancer treatment will be felt for generations to come."
"I never dreamed my research would take the direction it has," Allison adds. "It's a great, emotional privilege to meet cancer patients who've been successfully treated with immune checkpoint blockade. They are living proof of the power of basic science, of following our urge to learn and to understand how things work."
A national startup accelerator has announced its fifth local cohort, which includes five Houston companies participating in the spring 2022 class.
Madison, Wisconsin-based gener8tor has announced today the five participating startups in gBETA Houston. The program will be led by Muriel Foster, the newly named director of gBETA Houston, which originally launched in Houston in 2020 thanks to a grant from from the Downtown Redevelopment Authority.
The program, which is designed to help guide early-stage startups find early customer traction, connect with mentors, and more, is based in the Downtown Launchpad, and is free and does not take equity in the participating companies. The cohort kicked off on April 21 and concludes on June 10.
The new cohort includes:
Founded by CEO Steffie Thomson a year ago, Getaway Sticks has designed a shoe that gives women the painless support they need using athletic foam to create a shoe that gives women the painless support they need. Getaway Sticks provides the solutions to women’s #1 wardrobe complaint of high heel pain. Since launch, the company has earned over $35,000 in revenue from over 150 customers.
Through a combination of software and hardware technology, LocBox is rethinking the shopping experience for online and local purchases. If you shop, ship, or have food delivered to your house, LocBox will make your life easier. Led by CEO Sterling Sansing, LocBox has previously participated in the Texas A&M MBA Venture Challenge.
SpeakHaus is focused on equipping young professionals and entrepreneurs with public speaking skills through its on-demand training platform and group coaching program. Since launching in October 2021, SpeakHaus has facilitated 6 corporate trainings and coached 61 business leaders generating over $49,000 in revenue. The company is led by CEO Christa Clarke.
Led by CEO LaGina Harris, The Us Space is creating spaces intentionally for women of color, women-led businesses, and women-centric organizations. Since launching in June 2021, The Us Space has created partnerships with more than a dozen community organizations, sustainable businesses, and organizations creating positive economic impact in the City of Houston.
Founded in August 2021, Urban Eatz Delivery is a food delivery service app that caters to the overlooked and underrepresented restaurants, food trucks, and home-based food vendors. Urban Eatz Delivery has earned over $88,000 in revenue, delivered to over 2,000 users, and worked with 36 restaurant and food vendors on the app. The company is led by CEO D’Andre Good.
“The five companies selected for the Spring 2022 cohort tackle unique problems that have propelled them to create a business that solves the issues they once faced," Foster says in a news release. "From public speaking, apparel comfort, and food delivery from underrepresented restaurant owners, these founders have found their niche and are ready to continue to make an enormous impact on the Houston ecosystem."
it's Foster's first cohort at the helm of the program. A Houston native, she has her master’s in public administration from Texas Southern University and a bachelor’s in marketing from Oklahoma State University. Her background includes work in the nonprofit sector and international business consulting in Cape Town, South Africa, and she's worked within programming at organizations such as MassChallenge, BLCK VC, and now gener8tor.
The program is housed at the Downtown Launchpad. The five startups will have access to the space to meet with mentors, attend events, and run their companies.
"Creating (the hub) was a little like a moonshot, but it’s paying off and contributing enormous impact to the city’s economy. The five startups selected for the gBETA Houston Spring cohort will continue that legacy,” says Robert Pieroni, director of economic development at Central Houston Inc., in the release. “As these entrepreneurs chase their dreams and create something epic, they will know Downtown Houston is standing behind them. I am so proud of what Downtown Launchpad is already, and what it will become.”
Muriel Foster, a native Houstonian, is the new director of gBETA Houston. Image via LinkedIn
Since 2019,
alliantgroup and the Houston Independent School District have been partnering for the SPARK Award, a program that rewards outstanding HISD science teachers who are increasing student engagement and achievement through innovative lesson plans that emphasize both the importance and fun aspects of science.
The overall winner receives a $3,500 personal award plus $500 for their classroom, and the other five finalists receive $1,300 each plus another $500 to spend on their classrooms.
After working for three years as an accountant,
Lynell Dillard taught a weekly finance class where her students became her inspiration to pursue a full-time career in the classroom.
She secured her first teaching position in 2002 and hasn’t looked back. For three years now, she has been teaching science and giving her students hands-on learning opportunities they may not experience outside of the classroom.
Dillard explains that for many of her students, her role as a teacher is to give them as many opportunities to interact with the natural environment as possible. She knows many of her students and their families would not have access to these resources if it were not for the school district.
"We all learn in a different way, so we have to be willing to help that other person if they don’t get what I get, and there’s no criticism in it," Dillard says. "I tell them they are my future. Every single part of your education is important."
"Before I went to foster care, I was not doing well in my education,"
Ruth Giles says. "My foster mom, Nancy, took the time to figure out how I learned. She figured out I’m good with memorization, flashcards, and practicing. I would not be here without her today."
Sadly, Nancy passed away in January from COVID-19. Now, more than ever, it’s important to Giles that she continue sharing her experiences with her students to keep Nancy’s legacy alive.
Giles says the best part of teaching fifth-grade science is helping her students view the world in a different way, just like Nancy did for her.
Melanie Jenkins has been a fifth grade ESL teacher at Katherine Smith Elementary School for three years, but first got started in substitute teaching. She then went on to fulfill her childhood dream of working in finance, but found it wasn’t all she thought it would be.
"I still had in the back of my mind these kids whose lives I touched and who remembered me and understood what I was trying to teach them," she says.
Now she can't imagine doing anything else. It's challenging that many of her students are learning English for the first time, but she focuses on vocabulary and giving them resources in both English and Spanish is key, along with truly forming relationships with them.
“I try to figure out who likes what and how I can bring that into the classroom,” says Jenkins. “If you are a hands-on learner, we have the opportunities to put our hands on things. If you are a project-based learner, you have the opportunity to do projects. So there’s no one size fits all.”
According to science teacher
Mimi Muñoz, STEM education is important but learning to be kind should be first in any classroom environment.
She also works hard to get her fifth-grade students engaged in their lessons and understand why science is important to their everyday lives.
“They get so excited to do hands-on activities, experiments, and projects,” Muñoz explains. “One thing I really want them to understand is that you need learning every day of your life. And learning science, as well as the world around us, is their real life. The things I’m teaching you [in the classroom] are important.”
Muñoz has been teaching for three years and spent her entire career at Seguin Elementary. She says the last two years were very tough on her students because of the pandemic, but despite virtual learning, it has only strengthened the way she connects to her students.
An educator of 17 years,
Gerjuan O’Neal is following in her family’s footsteps.
"My maternal grandmother was a second and third grade teacher, and my maternal grandfather was a high school government teacher," she says. "My great-aunt was an elementary teacher and then a homebound teacher. My favorite thing is that I teach kindergarten through fifth grade, so every day is different."
She loves teaching STEM to her students because they can see how it applies to the other subjects they are also learning in school.
"I really like for my students to be creative problem solvers, and I like to show them all the different components of STEM," O’Neal explains. "If we are doing a science technology map, everything fits together. If we do a Lego build, we’re doing estimating with numbers. If we are coding, they get to see where math is involved and where they must be critical thinkers."
Although this is her first year teaching at Bonner Elementary School,
Leticia Sifuentes is a veteran of the classroom with 24 years of experience.
Her favorite part about teaching is seeing her students become just as passionate about science as she is.
“I tell my students I’m a science nerd. We watch a movie — where’s the science? We go somewhere — where’s the science? They’re able to bring science to everything they talk about. It’s in reading, it’s in math, it’s just the way we can incorporate science in everyday life.”
Sifuentes was named an honorable mention teacher for alliantgroup’s 2019 SPARK Award, but three years later she says she is a better educator after working through the challenges of a pandemic and virtual learning. She now realizes that as an educator it is not only her responsibility to ensure her students are performing well academically but also emotionally, socially, and mentally.
Known for its diversity, Houston ranks as the third best major metro area in the U.S. for Asian American entrepreneurs, according to a new study.
Personal finance website SmartAsset analyzed data for 52 of the largest metro areas to come up with the ranking. The analysis looked at nine metrics in three categories: prevalence of Asian-owned businesses, success of new businesses, and income and job security.
About 9 percent of the Houston metro area’s residents identify as Asian.
The SmartAsset study puts Houston in fifth place for the number of Asian-owned businesses (nearly 19,900) and in fourth place for the share of Asian-owned businesses (almost 17.9 percent) among all businesses. Furthermore, Houston ranks 14th for the increase (nearly 9.6 percent) in the number of Asian-owned businesses from 2017 to 2019.
Leading the SmartAsset list is the San Francisco metro area, followed by Dallas-Fort Worth. Austin comes in at No. 11 and San Antonio at No. 14.
The largest minority-owned business in the Houston area, as ranked by annual revenue, is Asian-owned private equity firm ZT Corporate.
Founded in 1997 by Chairman and CEO Taseer Bada, who was born in Pakistan, ZT Corporate is valued at more than $1 billion. ZT Corporate generates more than $600 million in annual revenue and employs over 3,000 people.
“As we look ahead, the vision for ZT Corporate is limitless. Our team will continue pushing boundaries and finding the bright spots in the economy that produce consistent financial gains for our investors,” Bada says in a news release marking his company’s 25th anniversary.
ZT Corporate’s flagship businesses are:
Altus Community Healthcare, a provider of health care services.
ZT Financial Services, a wealth management firm.
ZT Motors, which owns and operates auto dealerships. Last year, ZT Motors bought three Ron Carter dealerships in the Houston area.
“ZT Corporate is a vital asset to our citizens as a longtime local employer,” Houston Mayor Sylvester Turner says, “and has positively affected many lives through their health care organizations and philanthropic efforts.”
Muriel Foster, a native Houstonian, is the new director of gBETA Houston. Image via LinkedIn
