A Houston-based software startup received a multimillion-dollar grant from the National Institutes of Health for its work within neurophysiology. Getty Images

Armed with a nearly $3.8 million federal grant, a Houston startup aims to boost neuroscience research around the world.

Vathes LLC, a developer of data management software that collaborates with neuroscience research labs in North America and Europe, recently received the $3.78 million grant from the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative at the National Institutes of Health (NIH). That initiative is part of the National Institute of Neurological Disorders and Stroke.

Vathes says the NIH funding will enable the startup to ramp up its DataJoint Pipelines for Neurophysiology project. The project aims to make open-source software for data science and engineering available to researchers who specialize in neurophysiology, a branch of neuroscience that looks at how the nervous system functions. The pipeline project holds the promise of benefiting research in areas like autism, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease).

The project's principal investigator is Dimitri Yatsenko, vice president of research and development at Vathes. Technologically speaking, neuroscientists are playing catch-up with their counterparts in fields like astrophysics, genomics, and bioinformatics, according to Yatsenko.

Neuroscience "is undergoing a fast transformation in terms of moving toward much more data-centric, data-intensive, computation-intensive, and collaborative projects," Yatsenko says. This means that neuroscientists are "now finding themselves having to quickly adapt to an environment," he adds, "where they have to share big data and computations with their collaborators in very dynamic settings and perform them in a very fluid way."

Yatsenko says the NIH-funded project will help smaller research groups tap into the technical expertise of larger research labs.

Vathes' DataJoint Neuro platform and services, which help create so-called DataJoint pipelines, enable neuroscientists to streamline, analyze, and visualize complex data. Among its customers are Princeton University's Neuroscience Institute and Columbia University's Zuckerman Institute. The federally funded project will empower smaller labs to capitalize on existing DataJoint pipelines as ready-to-go turnkey packages, Yatsenko says.

In essence, Vathes' technology acts as a translator. Big research labs collect data in databases that can vary by computer language and platform. Through the Vathes setup, that data can be incorporated by a lab of any size into algorithmic, machine learning, and artificial intelligence mechanisms, regardless of the computer language or platform.

Edgar Walker, CEO of Vathes, says this simplifies the construction and use of databases, giving scientists "more room to focus on the logic of their data pipeline rather than on the physical implementation of it."

Founded in 2016, Vathes is housed at the Texas Medical Center's Innovation Institute. It employs 10 people. The startup previously received a $100,000 grant from the U.S. Defense Advanced Research Projects Agency (DARPA).

Yatsenko says the project backed by the $3.78 million NIH grant will propel the startup's growth, as it "gives us a big window of opportunity" to provide tools and services that support the startup's open-source software.

"As the NIH and other funding agencies are shifting a lot of their focus to collaborative projects that are distributed among multiple institutions," Walker says, "we've established a reputation as the company that can facilitate such research, be efficient, and actually be cost-effective as well, and make the projects very smooth."

"We expect to continue to grow this business at the same exponential rate," he adds. "We'll keep our fingers crossed and see how things go."


CEO Edgar Walker (left) and Dimitri Yatsenko, vice president of research and development, lead Houston-based Vathes. Photos courtesy of Vathes

Two Houston hospitals — Texas Children's Hospital and Baylor College of Medicine — have received funding from the National Institutes of Health. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Houston researchers receive $3.2 million grant to enhance fetal monitoring technology

Fresh funds

Thousands of cases of fetal growth restriction occur annually that can lead to complications at birth. In order to get a better idea of condition and to develop better monitoring technology, the National Institutes of Health has granted $3.2 million to researchers at Baylor College of Medicine and Texas Children's Hospital.

The researchers are tasked with developing "an improved way to evaluate umbilical venous blood flow using 3D and Doppler ultrasound techniques" in small fetuses, according to a release from Baylor College of Medicine.

"Our research team will initially validate the accuracy and reproducibility of new 3D volume flow measurements and then develop corresponding reference ranges in normal pregnancies," says Dr. Wesley Lee, professor of obstetrics and gynecology at Baylor, in the release.

"Detailed observations of fetal growth, heart function, and circulatory changes will be made in over 1,000 small fetuses with estimated weights below the 10th percentile," Lee continues. "The results will be correlated with pregnancy outcomes to identify prenatal predictors of clinical problems in newborns."

The grant will fund a five-year investigation collaboration between the two Houston hospitals, as well as the University of Michigan, Perinatology Research Branch of the Eunice Kennedy Shriver National Institute of Child Health, and Human Development and GE Healthcare.

FGR is a condition that affects fetuses that are below the weight normal for their gesticular age — usually in the 10th percentile of weight or less, according to Stanford Children's Health. Underlying issues with placenta or umbilical cord can increase the risks of the condition and causes of FGR can range from blood pressure problems to drug and alcohol use.

Affected fetuses can be at risk of stillbirth or neonatal death. Babies that overcome FGR complications at birth are predisposed to developmental delay and the development of adult diseases such as obesity, diabetes, coronary artery disease, and stroke, according to the release.

According to Dr. Lee, identifying these FGR and at-risk fetuses can benefit their health in infancy as well as throughout their lives.

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Chicago-based food delivery app launches to serve Houstonians

introducing chowbus

A new delivery app wants to make it easier for Houstonians to access the best dishes from Chinatown. Chowbus, a nationwide service that focuses on Asian cuisines, has arrived in Houston.

Among the 80-plus restaurants available at launch, diners may use the app to order dishes from Chinatown favorites such as Mala Sichuan Bistro, Arco Seafood, and Ocean Palace as well as relative newcomers like Chengdu Taste, Chongqing Chicken Pot, and Meet Fresh. Deliveries are available from 11 am to 10 pm to points within the Houston city limits as well as to suburbs such as Pearland, Sugar Land, and Katy.

Customers pay a delivery fee that costs between $2.99 and $4.99 depending on their proximity to the restaurant, but the app does provide a bundling option that allows people to order dishes from multiple restaurants without paying an additional fee. True die-hards can subscribe to Chowbus Plus; for $9.99 per month, all deliveries over $25 are free and deliveries between $15 and $25 cost $1.99.

"We are excited to roll out our service to the Houston community," Chowbus co-founder and CEO Linxin Wen said in a statement. "The city is known for its vibrant culinary scene, which includes tons of great authentic Asian restaurants. We're proud to help Space City discover them."

Beyond helping restaurants expand their reach, Chowbus aims to be a good partner to its restaurants by providing them with analysis of best-selling dishes as well as high quality digital photography. On average, Chowbus claims to boost delivery revenue by 25-percent for restaurants on the platform.

"We're thrilled by the opportunity to partner with Chowbus," said Shanjian Li, the owner of Chongqing Chicken Pot, a Szechuan restaurant in Chinatown's Bellaire Food Street complex. "We hope this will help more Houstonians discover the flavorful dishes that we work so hard to create every day."

Based in Chicago, Chowbus has been a growth spurt. The platform now offers delivery from more than 3,000 restaurants in over 20 cities across North America such as Los Angeles, Seattle, New York, and Boston.

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This article originally ran on CultureMap.

Houston fintech software startup expands with new German office

unicorn on the move

A growing Houston fintech software-as-a-service startup has announced that it's opening an additional European office following reaching unicorn status earlier this year.

HighRadius, which has a software that automates key treasury management processes, is opening an office in Frankfurt, Germany, the company announced today.The news comes after the company has posted triple-digit year-over-year growth, according to a press release. HighRadius boasts of 25 new customers and a 250 percent increase in bookings over the past year.

"Frankfurt's position in central Germany makes other parts of the country readily accessible, and its status as the financial center of the country opens up a gateway to a deep pool of talent and relevant partnerships," says Jon Keating, HighRadius' Vice President and General Manager, EMEA, in a news release.

The company, which achieved unicorn status with a $1 billion valuation following a $125 million raise in January, opened an office in Amsterdam last year and has had its London office since 2017. According to the release, Germany, Switzerland, and Austria are territories with major market opportunities. The Frankfurt office will house sales, pre-sales, marketing, and consulting employees.

HighRadius's technology is relevant amid the COVID-19 pandemic more than ever as its clients are in need of safe and easy remote technology and automation to prevent delays in accounts receivable. Last month, the SaaS company launched new technology to help with this need: the RadiusOne A/R Suite for mid-sized businesses.

"We launched the RadiusOne B2B Network to facilitate suppliers and A/R teams to digitally connect with their buyers and A/P teams for faster processing of receivables and payments. Currently, the network has millions of active businesses," says Sashi Narahari, founder and CEO of HighRadius, in a news release. "The RadiusOne A/R Suite will provide the essential apps for A/R teams at mid-sized businesses to instantly plug their ERPs and A/R processes into this network and digitally connect with their buyers across the globe."