3 Houston energy innovators to know this week

who's who

This week's roundup of Houston innovators includes Juliana Garaizar of Greentown Labs, Trevor Best of Syzygy Plasmonics, and Nathan Ough of VoltaGrid. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across the energy industry recently making headlines in Houston innovation.

Juliana Garaizar, head of the Houston incubator and vice president of innovation at Greentown Labs

Juliana Garaizar joins the Houston Innovators Podcast to discuss the incubator's upcoming Climatetech Summit. Photo courtesy of Juliana Garaizar

This week, Greentown Labs is hosting a two-day summit focused on elevating the conversation around clean energy and the energy transition in Houston and beyond, as well as serving as a showcase for emerging technologies coming out of Greentown's member companies.

"The main theme for this Climatetech Summit is commercialization, and we're trying to explore it in different ways," Juliana Garaizar, head of the Houston incubator and vice president of innovation for Greentown, says on this week's Houston Innovators Podcast. "We're going to have some great panels on rapid commercialization and Houston and the energy transition."

Last year, Houston played a role in Greentown's annual Climatetech Summit. The two-day streamed event in 2021 attracted over 2,500 viewers from 38 different countries. This year's event will return to in-person but keep the streaming element to maintain this opportunity to reach people all over the world. The summit kicks off on November 2 in Houston and continues on November 3 in Boston. (InnovationMap is a partner for the Houston portion of the summit.) Click here to read more.

Trevor Best, co-founder and CEO of Syzygy Plasmonics

Trevor Best, CEO of Syzygy Plasmonics, announced a new tool for clean energy. Photo courtesy of Syzygy

Houston-area energy tech startup Syzygy Plasmonics just released a free online tool at CarbonModel.com that enables users to calculate the greenhouse gas emissions and emission-reduction costs in as little as 60 seconds. It’s a more straightforward way of making those calculations than is offered by Argonne National Laboratory’s Greenhouse gases, Regulated Emissions, and Energy use in Technologies (GREET) model, the startup says.

Syzygy co-founder and CEO Trevor Best calls the Inflation Reduction Act “a major tailwind” for energy transition and hydrogen adoption.

“Existing hydrogen producers now have the fiscal support needed to sanction new projects. And companies that had been mulling hydrogen as a new business are incentivized to move more quickly,” Best says. “Both existing and new entrants in the hydrogen market want to know if their hydrogen is clean enough to qualify for [Inflation Reduction Act] tax credits.” Click here to read more.

Nathan Ough, president and CEO of VoltaGrid

Houston-based VoltaGrid provides small-scale, self-contained microgrids that can operate independently of major power grids or in tandem with other microgrids. Photo via LinkedIn

Bellaire-based VoltaGrid, which provides small-scale, self-contained microgrids that can operate independently of major power grids or in tandem with other microgrids, has hauled in $150 million in equity funding. VoltaGrid’s product consists of natural gas engines, portable energy storage, natural gas processing and grid power connectivity.

VoltaGrid says it will spend the fresh cash to grow its power generation portfolio, along with its low-carbon fuel program in partnership with Pilot. The low-carbon platform features hydrogen and compressed natural gas.

“VoltaGrid continues to set new milestones across multiple sectors and business lines as we execute on our proven strategy with key partners,” Nathan Ough, president and CEO of VoltaGrid, says. Click here to read more.

Houston-based VoltaGrid provides small-scale, self-contained microgrids that can operate independently of major power grids or in tandem with other microgrids. Photo via voltagrid.com

Houston microgrid tech company announces $150 investment

hauling in cash

VoltaGrid, a Bellaire-based startup that specializes in distributed power generation via microgrids, has hauled in $150 million in equity funding.

Founded in 2020, VoltaGrid provides small-scale, self-contained microgrids that can operate independently of major power grids or in tandem with other microgrids. VoltaGrid’s product consists of natural gas engines, portable energy storage, natural gas processing and grid power connectivity.

Investors in the $150 million round include the Canada Pension Plan Investment Board (CPP Investments), Longbow Capital, Walter Ventures, and Pilot Company (operator of more than 800 retail and fueling locations in the U.S. and Canada). The $150 million round comes less than a year after VoltaGrid announced a $100 million round featuring the same investors.

“Our strategy to establish one of the largest asset bases of portable generation, uniquely paired with our low-carbon fueling solutions, has significantly decreased the complexity for our partners to electrify their operations. I am thankful to our team members for the tremendous amount of work that has been contributed to create one of the largest portfolios of contracted low carbon fuels in the industry.”

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

2024 Google search volume for terms related to investing
Number of investors
Number of businesses receiving investments in 2024
Total amount of capital invested in businesses in 2024
Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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