Everyone wants to live here. Photo by Kevin Hernandez on Unsplash

Start spreading the news: Houston will eclipse New York City as the 2nd biggest metro area by the year 2100, a new report predicts.

An analysis by moving services site moveBuddha published June 22 says Houston's population could swell to 31.38 million people in the next 77 years.

Based on current population and migration trends, in fact, America’s three biggest metropolitan areas by 2100 will be Dallas-Fort Worth (No. 1), Houston (No. 2), and Austin (No. 3), replacing New York, Los Angeles, and Chicago as the country’s most populous metros, the report predicts.

Dallas-Fort Worth's population is estimated to grow to 33.91 million, and Austin's is projected to jump to 22.29 million.

"The future of America may lie in Texas," the report's author says.

The latest data from the U.S. Census Bureau says Houston-The Woodlands-Sugar Land is currently the No. 5 biggest metro in the country with a population of more than 7.2 million and a 10-year growth rate of about 20 percent.

Houston-The Woodlands-Sugar Land had the second highest numeric increase in population between 2021 and 2022 of any U.S. metro (124,281 residents), following Dallas-Fort Worth-Arlington (170,396 residents), according to the Census Bureau.

There are some risks to continued population booms, including the effects of climate change, moveBuddha points out. While heat will be a major issue, there are much more dangerous possibilities.

"The bigger threat may be more destructive hurricanes from off the Gulf of Mexico," the report's author says. "Hurricane Harvey devastated Houston in 2017, and major storms like that could become more common. A historic flood also nailed the city in 2019. Planning for a future of these climate-induced threats will be critical for Houston."

The study also comes with an obvious caveat: no one is sure what the future looks like in terms of population growth. Academics, scientists, and futurists alike haven't been able to agree on population predictions. Climate change isn't just a risk for Houston, but for the entire world, the report reminds.

"According to one GDP projection through 2099, over three-quarters of U.S. counties will suffer economically because of climate damage," the report says. "That could be from everything from heat-related deaths to sea-level rise to increased natural disasters... But if global warming is held in check, Texas may be America’s haven in 2100. New technologies may help us adapt to extreme weather and heat."

According to the report, the top 10 largest metros and their populations by 2100 will be:

  • No. 1 – Dallas-Fort Worth (33,907,275)
  • No. 2 – Houston (31,384,122)
  • No. 3 – Austin (22,293,980)
  • No. 4 – Phoenix (22,271,212)
  • No. 5 – New York City (20,810,467)
  • No. 6 – Atlanta (18,370,497)
  • No. 7 – Los Angeles (15,502,798)
  • No. 8 – Washington-Arlington, D.C.-Virginia (14,972,830)
  • No. 9 – Orlando (14,172,727)
  • No. 10 – Miami (13,779,843)
These projections were calculated using census data from 2010 and 2020, using annual compound and 10-year population growth rates for U.S. metro areas with over 250,000 people. The study then hypothesized the annual compound growth rates between 2020 and 2100 to find 2100's estimated population numbers for the same cities.The full report and its methodology can be found on movebuddha.com.

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This article originally ran on CultureMap.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.