Australia-based Moonshot has opened a Houston chapter. Miriam Espacio / Pexels

It's almost an understatement to say that Houston's space economy is taking off like a rocket.

On May 28, four companies in the Houston area — Axiom Space Inc., Boeing Co., KBRwyle, and NanoRacks LLC — were tasked with helping chart NASA's course in the space economy, whose global value is projected to climb as high as $3 trillion by 2040. Three days later, Houston-based Intuitive Machines LLC was awarded a $77.2 million contract to send as many as five NASA payloads to the moon.

And a month later, on June 26, officials broke ground on the first phase of Houston Spaceport, a 450-acre project at Ellington Airport that will serve as a sort of control center for aerospace research and manufacturing, and commercial space operations.

Then, on July 19 — a day ahead of the 50th anniversary of Apollo 11 man-on-the-moon mission — Australia-based startup Moonshot Space Co. launched a chapter in Houston to help foster the region's multibillion-dollar space economy. Through its programming, which will kick off this fall, Moonshot seeks to corral entrepreneurs, students, job seekers, business executives, investors, university researchers, government officials, and others in an effort to nurture and promote Houston's space economy.

Troy McCann, founder and CEO of Moonshot, believes Houston — home to NASA's Johnson Space Center — can emerge as the epicenter of the global space economy.

"You'd have to have been living under a rock for the past 50 years not to be aware of Houston's stellar aerospace ecosystem," McCann says. "It's got both the historical credibility and a suite of … successful commercial space ventures based there."

"We want to help fine-tune Houston's space economy by providing a proven framework to elevate people and their ideas into successful teams and scalable businesses," McCann adds, "and to create the industries of the future and solve humanity's greatest challenges."

The Houston chapter, a nonprofit venture, is Moonshot's first in the U.S. and second outside Australia. Nathan Johnson, a Houston attorney who specializes in space law and business development, has been tapped to direct it.

"We're in the process of starting chapters across the globe because we believe that the next Nikola Tesla or Marie Curie is out there somewhere, but they don't have access to the resources they need to change the world for the better," McCann says. "Today, the average person has the ability to start a commercial space program for less than the cost of a fast-food franchise."

Johnson says Houston's prominence as NASA's hub for human spaceflight, its status as the "Energy Capital of the World," and the presence of the Texas Medical Center combine to make Space City a potent force in the space economy.

"My hope is to see Houston continue to lead in space and become a hub for the next wave of space commercialization," Johnson says. "We have a wide breadth of industries, and I would like to see that terrestrial expertise extend to new market applications in space."

If Houston does evolve into a nucleus for the global space economy, it stands to reap sky-high financial rewards. Various analysts forecast the global space economy will soar to between $1 trillion and $3 trillion by 2040, up from an estimated $415 billion in 2018.

"Space is and will be a global endeavor, depending on a strong economy, smart industries, and a talented workforce," Johnson says. "Houston already has all of those things, continues to actively develop them at all levels of the community, and does so in a way that reflects the world's population."

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

---

This article first appeared on EnergyCapitalHTX.com.