The University of Houston has teamed up with Chevron for a new fellowship program, which just announced its first class. Photo courtesy of UH.edu

The University of Houston has named eight graduate students to its first-ever cohort of UH-Chevron Energy Graduate Fellows.

The PhD and doctoral students will each receive a one-year $12,000 fellowship, along with mentoring from experts at UH and Chevron.

“The UH-Chevron Energy Fellowship program is an exciting opportunity for our graduate students to research the many critical areas that impact the energy industry, our communities and our global competitiveness,” Ramanan Krishnamoorti UH's Vice President for Energy and Innovation says in a statement.

“Today’s students not only recognize the importance of energy, but they are actively driving the push for affordable, reliable, sustainable and secure energy and making choices that clearly indicate that they are meaningfully contributing to the change,” he continues.

Their work focuses on energy-related research in fields ranging from public policy to geophysics and math. The fellowship is funded by Chevron.

“We love that Chevron is sponsoring this group of fellows because it’s a fantastic way for us to get involved with the students who are working on some of the biggest problems we’ll face in society,” Chevron Technology Ventures President Jim Gable adds.

The 2023 UH-Chevron Energy Graduate Fellows are:

The PhD and doctoral students will each receive a one-year $12,000 fellowship, along with mentoring from experts at UH and Chevron. Photo via UH.edu

Kripa Adhikari, a Ph.D. student in the Department of Civil and Environmental Engineering in the Cullen College of Engineering. Her work focuses on thermal regulation in enhanced geothermal systems. She currently works under the mentorship of Professor Kalyana Babu Nakshatrala and previously worked as a civil engineer with the Nepal Reconstruction Authority.

Aparajita Datta, a researcher at UH Energy and a Ph.D. candidate in the Department of Political Science. Her work focuses on the federal Low-Income Home Energy Assistance Program (LIHEAP), a redistributive welfare policy designed to help households pay their energy bills. She holds a bachelor’s degree in computer science and engineering from the University of Petroleum and Energy Studies in India, and master’s degrees in energy management and public policy from UH. She also recently worked on a paper for UH about transportation emissions.

Chirag Goel, a Ph.D. student in materials science and engineering at UH. His work focuses on using High Temperature Superconductors (HTS) to optimize manufacturing processes, which he says can help achieve carbon-free economies by 2050. The work has uses in renewable energy generation, electric power transmission and advanced scientific applications.

Meghana Idamakanti, a third-year Ph.D. student in the William A. Brookshire Department of Chemical and Biomolecular Engineering. Her work focuses on using electrically heated steam methane for cleaner hydrogen production. She received her bachelor’s degree in chemical engineering from Jawaharlal Nehru Technological University in India in 2020 and previously worked as a process engineering intern at Glochem Industries in India.

Erin Picton, an environmental engineering Ph.D. student in the Shaffer Lab at UH. Her work focuses on ways to increase the sustainability of lithium processing and reducing wasted water and energy. “I love the idea of taking waste and turning it into value,” she said in a statement. She has previously worked in collaboration with MIT and Greentown Labs, as chief sustainability officer of a Houston-based desalination startup; and as a visiting graduate researcher at Argonne National Lab and at INSA in Lyon, France.

Mohamad Sarhan, a Ph.D. student and a teaching assistant in the Department of Petroleum Engineering. His work focuses on seasonal hydrogen storage and the stability of storage candidates during hydrogen cycling. He holds a bachelor’s degree and a master’s degree in petroleum engineering from Cairo University

Swapnil Sharma, a Ph.D. student in the William A. Brookshire Department of Chemical and Biomolecular Engineering. His work has been funded by the Department of Energy and focuses on thermal modeling of large-scale liquid hydrogen storage tanks. He works with Professor Vemuri Balakotaiah. He holds bachelor's and master’s degrees in chemical engineering from the Indian Institute of Technology (IIT). He also developed one of the world’s highest fiber-count optical fiber cables while working in India and founded CovRelief, which helped millions of Indians find resources about hospital beds, oxygen suppliers and more during the pandemic.

Larkin Spires, who's working on her doctoral research in the Department of Earth and Atmospheric Sciences in the College of Natural Sciences and Mathematics. Her work focuses on a semi-empirical Brown and Korringa model for fluid substitution and the ties between geophysics and mathematics. She works under Professor John Castagna and holds a bachelor’s degree in math from Louisiana State University and a master’s degree in geophysics from UH.

Earlier this month Evolve Houston also announced its first-ever cohort of 13 microgrant recipients, whose work aims to make EVs and charging infrastructure more accessible in some of the city's more underserved neighborhoods.

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This article originally ran on EnergyCapital.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”