Houston physical therapist designs medical device to better treat joint injuries

hot and cold

Thermocuff has several patents and expects FDA approval at the end of the year. Image via thermocuff.com

A great idea can strike anytime — and for Sam Sabbahi, his concept cooked up six years ago while defrosting a chicken for his son’s dinner.

Sabbahi, a physical therapist by trade, knew there had to be a better way to heat and cool common joint injuries — elevating the traditional way of using ice or heat packs.

“In the field, we were always getting people coming in trying to get us to purchase different medical devices and we wondered, ‘who knows what we need better than we do?’” he says. “A patient asked me ‘what a cold pack does’ and I was thinking in my head that a cold pack just cools the skin to three millimeters depth.”

Sabbahi then developed and invented a portable convection-based heating and cooling system device that could be used for joint injury rehabilitation – the device, dubbed Thermocuff, works much in the way that an air fryer circulates the air to get an even temperature.

“It just clicked for me like a light. You know what people say,” he says. “I just got the idea and thought ‘let’s just try this out and see if it would work.”

The device uses air that goes over top of the thermoelectric unit and cycles in a closed loop system. After some proof concept testing, Sabbahi determined that Thermocuff could cool a joint more than twice as quick as the traditional water circulating system that’s currently available on the market now.

The attached tablet connects through Bluetooth to the unit, which allows the patient to increase or decrease the temperature and adjust for heating or cooling.

“You're trying to get the range of motion back,” he says. “We are addressing pain and range of motion now – trying to reduce the swelling inside of a joint to help in function.”

Because the disposable cuff kind of looks like a Chinese finger trap, Sabbahi says it’s not something that you could just make a mold of and then mass produce.

Fast forward to today, Sabbahi and his team of eight have acquired four patents in the U.S., Canada, China and Japan and are waiting on Europe and Mexico.

The team is working toward FDA approval at the end of the year. Thermocuff also has received a grant from the U.S. military. The device is part of the Southwest Pediatric Medical Device Consortium and received grants for production and research from the Medical Technology Enterprise Consortium, which helps startups in the medical field source grants.

The team is targeting business to business, physical therapy clinics, universities, and sports training associations with the hope to move into the consumer market in the coming years.

“We all have ideas is the hardest part, is trying to figure out how to turn your idea into actual product,” he says. “It's fun, actually — kind of like a big puzzle. You know, you're trying to get all, find all the pieces and put them together.”

Stroke patients have a new hope for arm rehabilitation thanks to a team from UH. Photo courtesy of UH

Robotic device created at the University of Houston helps stroke patients to rehabilitate

next-gen recovery

Almost 800,000 people in the United States suffer from a stroke annually — and the affliction affects each patient differently. One University of Houston researcher has created a device that greatly improves the lives of patients whose stroke affected motor skills.

UH engineering professor Jose Luis Contreras-Vidal developed a next-generation robotic arm that can be controlled by the user's brainwaves. The portable device uses a brain-computer interface (BCI) developed by Contreras-Vidal. Stroke patient Oswald Reedus, 66, is the first person to use a device of this kind.

Reedus lost the use of his left arm following a stroke that also caused aphasia, or difficulty speaking. While he's been able to recover his ability to speak clearly, the new exoskeleton will help rehabilitate his arm.

When strapped into the noninvasive device, the user's brain activity is translated into motor commands to power upper-limb robotics. As patients like Reedus use the device, more data is collected to improve the experience.

“If I can pass along anything to help a stroke person’s life, I will do it. For me it’s my purpose in life now,” says Reedus in a news release from UH. His mother and younger brother both died of strokes, and Reedus is set on helping the device that can help other stroke patients recover.

Contreras-Vidal, a Hugh Roy and Lillie Cranz Cullen distinguished professor, has led his device from ideation to in-home use, like with Reedus, as well as clinical trials at TIRR Memorial Hermann. The project is funded in part from an $813,999 grant from the National Science Foundation’s newly created Division of Translational Impacts.

"Our project addresses a pressing need for accessible, safe, and effective stroke rehabilitation devices for in-clinic and at-home use for sustainable long-term therapy, a global market size expected to currently be $31 billion," Contreras-Vidal says in the release. "Unfortunately, current devices fail to engage the patients, are hard to match to their needs and capabilities, are costly to use and maintain, or are limited to clinical settings."

Dr. Gerard E. Francisco, chief medical officer and director of the Neuro Recovery Research Center at TIRR Memorial Hermann, is leading the clinical trials for the device. He's also chair and professor in the Department of Physical Medicine and Rehabilitation at McGovern Medical School at UTHealth Houston. He explains that TIRR's partnership with engineering schools such as the Cullen College of Engineering at UH and others around the nation is strategic.

“This is truly exciting because what we know now is there are so many ways we can induce neuroplasticity or how we can boost recovery,” says Francisco in the release. “That collaboration is going to give birth to many of these groundbreaking technologies and innovations we can offer our patients.”

Both parts of the device — a part that attaches to the patient's head and a part affixed to their arm — are noninvasive. Photo courtesy of UH

Houston-based CorInnova is gearing up to pitch at a prestigious event. Photo via CorInnova.com

Houston health tech company tapped for prestigious pediatric medical device competition

ready to pitch

Houston-based medtech company CorInnova is gearing up for what could be a big payday.

CorInnova is among five medtech companies that have been invited to present pitches in October for the National Capital Consortium for Pediatric Device Innovation’s “Make Your Medical Device Pitch for Kids!” competition.

CorInnova and the four other finalists now have access to a four-month pediatric accelerator program led by MedTech Innovator and will vie for a share of $150,000 in grant funding from the U.S. Food and Drug Administration (FDA). The pitch event is part of the 10th annual Symposium on Pediatric Device Innovation.

“Addressing unmet needs across pediatric populations is critical to advancing children’s health, and we are delighted to once again work with pioneering companies that seek to bridge this care gap,” says Kolaeh Eskandanian, president and chief innovation officer at Children’s National Hospital and principal investigator for the pediatric device consortium.

CorInnova has developed a minimally invasive device for the treatment of congestive heart failure. Specifically, CorInnova’s soft, flexible device can be inserted through a 1-inch incision to increase the amount of blood pumping in the heart by 50 percent.

The device’s primary benefit is that there’s no contact with blood, thus minimizing complications when the device is being used. Blood contact during a heart procedure can increase the risk of health problems such as stroke and kidney disfunction.

“The device is collapsible, allowing it to be delivered and secured to the heart in a minimally invasive manner. The device conforms to the heart’s surface, and gently compresses the heart to increase cardiac output using an external pneumatic driver that operates in synchrony with the heartbeat,” CorInnova explains on its website.

In the U.S., around 40,000 babies are born each year with congenital heart defects. About one-fourth of these newborns have critical defects, often prompting the need for surgery or other procedures.

Since being founded in 2004, CorInnova has raised at least $6.3 million, according to Crunchbase. This includes a $6.1 million investment from Wellcome Trust, a London-based charitable foundation that focuses on biomedical research.

Aside from the MedTech Innovator accelerator, CorInnova has participated in the TMC Accelerator’s fall 2019 accelerator program for medical device makers and the fall 2018 gBETA Medtech accelerator program.

The four other finalists in the medtech pitch competition are:

La Palma, California-based Innovation Lab, whose mechanical elbow brace stabilizes tremors in some pediatric patients with cerebral palsy.
Biddeford, Maine-based Prapela, whose vibrating pad helps treat apnea in newborns.
Richmond, Virginia-based Tympanogen, whose nonsurgical procedure takes the place of surgery for eardrum repair.
Xpan of Concord, Ontario, Canada, whose universal trocar (a surgical instrument) improves safety, access, and flexibility during various procedures.

BiVACOR named Thomas Vassiliades as CEO effective immediately. Photo courtesy of BiVACOR

Former Medtronic exec takes the helm of Houston med device startup

mover and shaker

A Houston-based preclinical artificial heart device company has a new head honcho as it grows its team and further develops its technology.

BiVACOR named Thomas Vassiliades as CEO effective immediately. He replaces the company's founder, Daniel Timms, in the position. BiVACOR is on track to head toward human clinical trials and commercialization, and Vassiliades is tasked with leading the way.

“BiVACOR led an extensive CEO search, and Tom was the clear choice given his experience, background, leadership style, and exceptional track record,” says Timms in a news release. “Tom has the skillset and credibility to guide BiVACOR through its next chapter of transformation and advancement as we undertake the next stage of clinical activities leading up to First in Human early feasibility studies.”

Vassiliades has over 30 years of experience within the medical device industry as well as cardiothoracic surgery. He was most recently the general manager of the surgery and heart failure business at Abiomed and held several leadership roles at Medtronic. Dr. Vassiliades received his MD from the University of North Carolina, and his MBA was achieved with distinction at Emory University.

“I am excited and honored to join the BiVACOR team, working closely with Daniel and the entire team as we look forward to bringing this life-changing technology to the market,” says Dr. Vassiliades in the release. “Throughout my career, I’ve been guided by the goal of bringing innovative cardiovascular therapies to the market to improve patient care and outcomes – providing solutions for those that don’t have one. BiVACOR is uniquely well-positioned to provide long-term therapy for patients with severe biventricular heart failure.”

Timms will take over BiVACOR's technical team working on the Total Artificial Heart system as CTO. The device, billed as the first long-term therapy for patients with severe heart failure, is an implantable artificial heart based on rotary blood-pump technology. Similar in size to an adult fist, it is small enough to be implanted in many women and some children yet capable of delivering enough cardiac power to a man who's exercising. Unlike the two-chamber human heart, BiVACOR's device features a single chamber.

The medical device company, which has operations in Houston and Australia, recently announced the addition of eight new employees doubling their team. The growth comes following its series B raise last year.

“It is a testament to the great progress the team has made and to the importance of the unmet clinical need addressed by the Total artificial Heart technology," Timms says on the appointment of Vassiliades. "We look forward to Tom’s leadership as BiVACOR navigates the path to commercialization.”

Proxima Clinical Research has its New Year's resolution and is ready to start working hands on with health tech startups. Graphic via proximacro.com

Houston organization plans to launch health tech accelerator in 2022

ready to grow

A contract research organization based in Houston has announced its new accelerator program aimed at helping startups quickly grow their health tech businesses.

Proxima Clinical Research released details of M1 MedTech, which expects to launch early next year. The CRO has raised funds to launch and invest in members of the inaugural cohort.

“Our goal is to move these companies substantially forward in a short amount of time,” says Kevin Coker, CEO of Proxima, in a news release. “Proxima is in a unique position to leverage our experienced team of regulatory, quality, and clinical experts. We won’t be working at arm’s length from these companies. We will be a big part of what they do every day.”

The program will focus on a small group of companies and the Proxima team will provide hands-on support, including instruction, workshops, and one-on-one mentoring.

“This will be a unique experience for all parties involved, as Proxima is also a young, yet established, company that is now creating a program to assist companies at an earlier stage,” says Larry Lawson, co-founder of Proxima, in the release. “Our experience in the CRO realm and ability to provide coaching in clinical, regulatory, quality, and go-to-market strategies will only strengthen M1 MedTech’s ability to support the success of emerging companies and provide more life-saving technology to the public.”

Kevin Coker and Larry Lawson co-founded Proxima in 2017. Photos courtesy

The accelerator will target Class II and III medical devices for its initial cohort. In the future, Proxima plans to expand to include an even more extensive incubator focused solely on Class III devices, according to the release.

“M1 will be a place where startups can go to receive concrete resources to further their development. The participant success is our sole focus, and the ultimate goal is to have a substantial impact on the ideation-to-market process for Class II and Class III medical devices,” says Isabella Schmitt, director of regulatory affairs at Proxima and a principal at M1, in the release. “Proxima’s specific expertise alongside our M1 partners will provide resources for all key areas of a medical device entrepreneur’s journey to market and beyond.”

The M1 MedTech applications will open online in the spring.

“We don’t view M1 as competitive to other accelerators, rather we believe it will offer a different experience. Our team will strive to create a personalized program where companies have a dedicated touch point throughout the process,” says Sean Bittner, director of programs at M1 MedTech, in the release. “We will also provide specific, tailored connections and resources vetted by our team through professional partnerships, not just a general list of industry contacts.”

James Reinstein joins the Houston Innovators Podcast to discuss what's next for growing medical device company, Saranas. Photo courtesy

Health tech executive leads Houston startup into its next generation following $12.8M series B

houston innovators podcast episode 103

When James Reinstein took the helm of Houston-based Saranas in March 2020, he was tasked with taking the medical device company through its series B funding round and into larger clinical trials. Navigating these tasks during a global pandemic wasn't part of the plan.

"There was just so much uncertainty," Reinstein says on this week's episode of the Houston Innovators Podcast. "All of the funds didn't know which end was up, what hospitals would be doing, what procedures were going to begin again."

Saranas received FDA approval and began its clinical trials for its Early Bird Bleed Monitoring System in 2019. The device is designed to detect and track bleeding complications related to endovascular procedures. These medical procedures treat problems, such as aneurysms, that affect blood vessels. Around 20 percent of patients suffer a bleeding complication during endovascular procedures.

Reinstein explains that the way health tech funding trended over the past 18 months greatly affected Saranas. The device fell outside the parameters of what investors were looking for during this pandemic time. However, Reinstein explains, the Early Bird worked and had FDA approval — that made all the difference.

"We are very confident that the product does work and it can have a significant impact for hospitals and patients," Reinstein says. "Eventually, the term sheets came in."

Saranas announced in July that it closed a $12.8 million series B investment led by Wisconsin-based Baird Capital, the venture capital and global private equity arm of Baird, a global company with a location in Houston. Austin-based S3 Ventures also supported the round.

The funds will propel Saranas into its next phase, which includes growing its team, larger trials, and a next-generation product.

Reinstein has had decades in health care innovation all over the world, with a large chunk of his career at Boston Scientific. He's seen Houston's innovation ecosystem evolve.

"I do think that there's a great potential for Houston to really develop the industry," Reinstein says. "There's just two areas that need to get fortified. One is the funding and getting the funds directed to Houston companies — with the idea that the company stays in Houston. ... The other side of the coin is really finding the talent to come in and run the companies, take on leadership positions."

Reinstein shares more details on what's next for Saranas, as well as his advice for med tech entrepreneurs and observations on Houston's innovation ecosystem on the show. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.

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2 Houston suburbs roll onto top-15 spots on U-Haul’s list of growing cities

on the move

More movers hauled their belongings to Texas than any other state last year. And those headed to the Greater Houston area were mostly pointed toward Missouri City and Conroe, according to a new study.

In its recently released annual growth report, U-Haul ranks Missouri City and Conroe at No. 13 and No. 19, respectively among U.S. cities with the most inbound moves via U-Haul trucks in 2022. Richardson was the only other Texas cities to make the list coming in at No. 15.

Texas ranks No. 1 overall as the state with the most in-bound moves using U-Haul trucks. This is the second year in a row and the fifth year since 2016 that Texas has earned the distinction.

“The 2022 trends in migration followed very similar patterns to 2021 with Texas, Florida, the Carolinas and the Southwest continuing to see solid growth,” U-Haul international president John Taylor says in a news release. “We still have areas with strong demand for one-way rentals. While overall migration in 2021 was record-breaking, we continue to experience significant customer demand to move out of some geographic areas to destinations at the top of our growth list.”

U-Haul determines the top 25 cities by analyzing more than 2 million one-way U-Haul transactions over the calendar year. Then the company calculated the net gain of one-way U-Haul trucks entering a specific area versus departing from that area. The top U-Haul growth states are determined the same way.

The studies note that U-Haul migration trends do not directly correlate to population or economic growth — but they are an “effective gauge” of how well cities and states are attracting and maintaining residents.

Missouri City is known for its convenient location only minutes from downtown Houston. The city’s proximity to major freeways, rail lines, the Port of Houston, and Bush and Hobby Airports links its businesses with customers “around the nation and the world,” per its website.

The No. 19-ranked city of Conroe is “the perfect blend of starry nights and city lights,” according to the Visit Conroe website. Conroe offers plenty of outdoor activities, as it is bordered by Lake Conroe, Sam Houston National Forest and W. Goodrich Jones State Forest. But it also has a busy downtown area with breweries, theaters, shopping and live music.

To view U-Haul’s full growth cities report, click here.

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This article originally ran on CultureMap.

Houston-based creator economy platform goes live nationally

so clutch

An app that originally launched on Houston college campuses has announced it's now live nationwide.

Clutch founders Madison Long and Simone May set out to make it easier for the younger generation to earn money with their skill sets. After launching a beta at local universities last fall, Clutch's digital marketplace is now live for others to join in.

The platform connects brands to its network of creators for reliable and authentic work — everything from social media management, video creation, video editing, content creation, graphic design projects, and more. With weekly payments to creators and an inclusive platform for users on both sides of the equation, Clutch aims to make digital collaboration easier and more reliable for everyone.

“We’re thrilled to bring our product to market to make sustainable, authentic lifestyles available to everyone through the creator economy," says May, CTO and co-founder of Clutch. "We’re honored to be part of the thriving innovation community here in Houston and get to bring more on-your-own-terms work opportunities to all creators and businesses through our platform.”

In its beta, Clutch facilitated collaborations for over 200 student creators and 50 brands — such as DIGITS and nama. The company is founded with a mission of "democratizing access to information and technology and elevating the next generation for all people," according to a news release from Clutch. In the beta, 75 percent of the creators were people of color and around half of the businesses were owned by women and people of color.

“As a Clutch Creator, I set my own pricing, schedule and services when collaborating on projects for brands,” says Cathy Syfert, a creator through Clutch. “Clutch Creators embrace the benefits of being a brand ambassador as we create content about the products we love, but do it on behalf of the brands to help the brands grow authentically."

The newly launched product has the following features:

Creator profile, where users can share their services, pricing, and skills and review inquiries from brands.
Curated matching from the Clutch admin team.
Collab initiation, where users can accept or reject incoming collab requests with brands.
Collab management — communication, timing, review cycles — all within the platform.
In-app payments with a weekly amount selected by the creators themselves.
Seamless cancellation for both brands and creators.

Clutch raised $1.2 million in seed funding from Precursor Ventures, Capital Factory, HearstLab, and more. Clutch was originally founded as Campus Concierge in 2021 and has gone through the DivInc Houston program at the Ion.

Madison Long, left, and Simone May co-founded Clutch. Photo courtesy of Clutch

Houston expert: Space tourism is the future — do we have the workforce to run it?

guest column

Throughout history, humans have always been fascinated in exploring and traveling around the world, taking them to many exotic places far and away. On the same token, ever since the dimension of space travel has been inaugurated with multiple private companies launching rockets into space, it has become an agenda to make space travel public and accessible to all. We believe that space travel is the next frontier for tourism just like for our forefathers world travel to faraway places was the next frontier, for recreational and adventure purposes.

In a world racing on technology, we can picture flying cars, invisible doors, and international cuisine in space. With this rapid expansion of the land, the idea of space tourism has stirred the space industry to think about running businesses, start trade, and set up universalization beyond the ring of the earth. It is no longer science fiction but our immediate future. However, the true question remains. Who will be responsible for all of it? Are we training the right workforce that is needed to build and run all of this?

Space tourism is an exciting idea in theory, traveling to extra-terrestrial destinations, exploring new planets, all by being in an anti-gravitational environment. Through these diminishing borders and rapid advancements soon we'll be living the space life, all the virtual, metaverse gigs coming to reality. But before that let's explore space tourism and how the solar system will welcome humans.

What is Space tourism?

Ever since 1967, Apollo opened the getaway of space travel and the technological intervention spun to rise. Just like nomad tourism, space tourism is human space travel for commercializing interstellar for leisure or pleasurable adventures of the unknown. Space has different levels of horizons, according to research, orbital space has high speeds of 17,400 mph to allow the rocket to orbit around the Earth without falling onto the land. While lunar space tourism goes into subcortical flights and brings people back at a slower speed.

Studies have shown that in the upcoming years, commercial space exploration will hike up the economical database, by generating more than expected revenue. On these grounds, space tourism won't be limited to suborbital flights but rather take onto orbital flights, this revolutionary expenditure will change the future.

Everything aligns when the right team works together endlessly to reach the stars. The space exploration will only take place with enthusiastic and empowered individuals catering towards their roles.

Astronomers, space scientists, meteorologists, plasma physicists, aerospace engineers, avionics technicians, technical writers, space producers, and more will work in the field to make this space dream come true.

The attraction of Space exploration

Curiosity is the gateway to the seven wonders of the world. Humans are born with novelty-seeking, the drive to explore the unknown and push boundaries. This exploration has benefited society in a million ways, from making bulbs to jets.

The attraction towards exploring the space stems from the same desire for novelty seeking. We want to answer the most difficult questions about the universe, is there only darkness beyond that sky? Can we live on another planet if ours die? To address the challenges of space and the world, we have created new technologies, industries, and a union worldwide. This shows how vital space exploration is to humans. Many astronauts dwell on the idea of seeing the iconic thin blue outline of our planet, the quintessential experience makes the astronaut go back and back. However, are we entering this dimension with the right skills? Is our future workforce ready to take need the best

Who will lead the path?

The main question that still goes unanswered is who will run space tourism. When it comes to the future, there are infinite options. One decision and you will fly into an endless sky.

This expenditure has opened multiple career opportunities for the future workforce to take on for diversification and exploration of space. Currently, we cannot predict how people will find meaning and improve their lives through space tourism, but it will be a soul-awakening experience. According to experts, travelers would prefer a livelihood in space for which companies are working day and night to figure out accommodation and properties. The ideas include having space hotels, offices, research labs, and tents for operations.

Lastly, space tourism is just a start, we are moving into a dimensional field of physics and astronomy to create new opportunities and ground-breaking inventions to explore the untouchable. The new era of more refined and thoroughly accessed careers are on the rise, let's see how the world evolves in the next 10 years.