Houston innovation team wins global award for painless heart technology

heart of gold

A medical device coming out of the Texas Heart Institute has been recognized for its innovation. Photo via THI

Houston's Texas Heart Institute's pain-free defibrillation technology was named the top future medical product design worldwide last month as part of the annual Create the Future Design contest.

The tiny technology aims to change the way cardiac arrhythmias are managed and remove the often traumatizing pain associated with their treatment. Developed by THI's Electrophysiology Clinical Research & Innovations team in conjunction with scientists at Rice University and UCLA, the technology allows doctors to place up to 12 tiny nodes around the heart to pace and defibrillate the heart without using a shock.

The technology will be most useful for atrial fibrillation and ventricular fibrillation, which can lead to sudden death, stroke, and congestive heart failure, according to Dr. Mehdi Razavi, the head investigator on this project and leader of the THI team. Razavi says winning the award "speaks to the need" of a new solution in the field as the shocks associated with traditional implantable cardioverter-defibrillators, or ICDs, can cause severe PTSD among patients.

"It's extremely painful. It's like someone takes a two by four and just pounds you from the inside in the chest, or a horse kicking you in the chest," Razavi says. He went on to add: "I have actually one patient who was a Vietnam veteran. He said nothing that he faced in battle was as disconcerting—not just because of the pain, but the fact that you don't know when the pain is when the shock is about to happen. That anxiety is just overwhelming."

Instead of shocking the patient's heart in a central location, the nodes spread energy needed to pace the heart at the correct rate throughout the muscle based on their location. This dilutes the feeling of a sudden jolt, and Razavi says, defibrillation using his technology could go unnoticed in patients.

In addition to this game-changing possibility, the new technology is physically safer in many ways, too. The miniaturized battery-less pacing system is free of traditional wires that send electrical pulses to the heart, known as leads. These leads can dislodge and fracture within the body and can cause infection.

The technology's wireless and miniature nature also allows doctors to better access regions of the heart that currently are difficult to reach with bulkier ICDs. Each node can be individually programmed and can stimulate different regions of the heart in different ways, as well.

A cross disciplinary team developed the device. Aydin Babakhani, an associate professor in physical and wave electronics at UCLA first developed the nodes to stimulate electricity for non-medical purposes. Behnaam Aazhang, the J.S. Abercrombie Professor of Electrical and Computer Engineering and the Director of the Rice Neuroengineering Initiative, first introduced Razavi to Babakhani, and the trio worked together to bring the technology to the medical arena, along with about 15 to 20 other medical professionals and students.

The team at Rice is continuing to develop the hardware for clinical use. And studies on the use of defibrillation through these nodes across the heart are being conducted out to the Texas Heart Institute's research lab. Razavi and his team are currently conducting preclinical studies on the new form of treatment and aims to roll it out for clinical use in the next three to five years.

Diane Yoo, who was hospitalized due to COVID-19 earlier this year, created a VC fund that's investing in health tech solutions for the disease. Photo courtesy of Medingenii

Houston investor recovers from COVID-19 — then funds startups innovating solutions for the disease

money moves

While so many of Houston's venture capital groups and entrepreneurs have been figuring out the best ways to navigate fundraising amid a pandemic, Diane Yoo managed to close an oversubscribed initial fund and deployed investments into health tech startups during COVID-19 — while also recovering from the disease itself.

Entrepreneur turned investor Diane Yoo launched her health tech-focused venture capital fund, Medingenii Capital, last year, but didn't start fundraising for its initial fund until this year.

Yoo says she and her partners, entrepreneur and investor Greg Campbell, neurologist Dr. Eddie Patton, Dr. Sreedhar Mandayam, and investor Gen Fukunaga, were virtually meeting with over a dozen potential investors weekly and closed the round in under two months.

It was right around closing when Yoo says she caught COVID-19.

"It ravaged every part of my body, and I ended up having to be hospitalized because I couldn't breathe," she says.

Yoo recovered after a month and a half of enduring the disease, only to come out of that experience to fund innovative Houston companies working on COVID-19 solutions. Medingenii focuses on early stage health tech, including genomics, health IT, medical devices, and patient engagement.

"The pandemic has really validated some of the business models we're invested in," she tells InnovationMap.

One example from Medingenii's portfolio is Houston-based medical device company, Vitls. The company's technology includes a wearable device that can monitor vital signs and sync with a smartphone app and sends key information to doctors remotely.

As Yoo thinks back to her COVID-19 treatment, Vitls could have helped her and her fellow patients get out of the crowded hospital wing and home to recover sooner — with the peace of mind of remote care thanks to the device.

"When I was in the ER room, it was overcrowded," Yoo says. "If you were not seriously ill, they would dismiss you because there was just no room. But if you went home with Vitls, you could have sent all your vitals to your doctor from home."

Fueled by a mission to find more health tech solutions like Vitls and with the quick pace of her first fund — Yoo says she's already deployed the capital into Houston-based startups and is looking toward the second fund, which will again focus on Houston startups.

"We really love Houston," Yoo says. "We want to invest a lot of our fund here, and we continue to do that and plan to do that. We see a lot of opportunity in Houston and look forward to working with the innovation ecosystem here."
Chris Dupont, CEO of Galen Data, has seen his share of challenges and opportunities amid the COVID-19 pandemic. Photo via galendata.com

With increased awareness in need for connected medical devices, this Houston startup fills the gap

Houston innovators podcast episode 41

For decades, medical device innovation has been improving the way patients are cared for, but only recently are innovators enabling important connectivity applications.

"Most legacy medical devices are not connected to the internet," says Chris DuPont, CEO and founder of Galen Data Inc. "All the new companies that are coming to us — the emerging wearable tech — connectivity is vital in their product roll out."

But with this internet connectivity, adhering to safety regulations adds costly and challenging obstacles for medical device companies. That's where Galen Data comes into play, and the Houston startup is seeing more of a need for its medical device cloud services now more than ever.

"COVID-19 has created all kinds of challenges — and I think in the long run, a lot of opportunities for Galen," DuPont shares on this week's episode of the Houston Innovators Podcast. "I think there will be a heightened awareness for the need for connected medical devices."

Galen Data's technology enables better communication between the device, the patient, and the medical provider, and DuPont equates it to being able to have a system similar to a check engine light on your vehicle.

"Wouldn't you want to know if your drug pump was starting to have problems or if the electro mechanical systems were starting to fail?" DuPont asks on the podcast.

The company's technology also provides important medical data and information that can be crucial for detecting trends and predictability.

"There's far greater risk in not having access to certain critical data to that device," DuPont says when asked about the hesitation some people have regarding medical data in terms of privacy.

DuPont shares more about his company's recent growth, his most recent partnership with an Austin-based medical device company, and how he's observed Houston emerging medical device innovation ecosystem evolve over his decades of experience. Listen to the full interview below — or wherever you get your podcasts — and subscribe for weekly episodes.
Houston-based Galen Data is collaborating with an Austin health device company on a cloud-based platform that monitors vital signs. Photo via galendata.com

Houston startup teams up with Austin company on medical device amid COVID-19 crisis

texans teaming up

Two Texas companies with NASA roots are joining forces on a technology that can be used to monitor vital signs of seniors or others that are at-risk of contracting COVID-19.

Houston-based Galen Data Inc., which has developed a cloud platform for medical devices, and Austin-based Advanced TeleSensors Inc., the creator of the Cardi/o touchless monitor. Together, the two health tech companies are collaborating to take ATS's device and adding Galen Data's cloud technology.

"We wish we had found Galen Data sooner. We had been building our own cloud for six months, thinking a custom solution would best meet our needs," says Sajol Ghoshal, CEO and president of ATS, in a news release. "Getting up-and-running with them was very easy, and it allowed us to focus on our core competency — which is data-signal processing."

ATS's technology uses radio frequency in its remote, touchless monitoring. The company's founders developed the core technology at NASA's Jet Propulsion Lab. Initially, the technology was intended for assisted living facilities. Now, amid the COVID-19 crisis, monitoring isolated seniors or at-risk patients is even more relevant.

Galen Data, which launched in 2016, also has NASA roots as the founders met as software contractors working on NASA's safety systems. The company has developed and marketed its cloud-based platform for connecting medical devices to the internet, including pacemakers and glucose monitors.

Chris DuPont, co-founder and CEO, has led the company to meet compliance standards set by the U.S. Food and Drug Administration (FDA), the Health Insurance Portability and Accountability Act of 1996 (HIPPA), cybersecurity organizations, and others.

"We knew that our platform would be a great fit for Cardi/o," Chris DuPont, CEO of Galen Data, says. "Speed was critical, accentuated by the COVID-19 crisis. We were well positioned to address ATS' needs, and help those at-risk in the process."

Sajol Ghoshal (left), CEO and president of ATS, and Chris Dupont, (CEO of Galen Data), are bringing together their technologies. Photos courtesy
TMCx will select its 2020 cohort from the 19 startups it has invited to attend a bootcamp this month. Courtesy of TMC

TMCx names 19 startups to be considered for 2020 cohort

that x-factor

The Texas Medical Center is one step closer to narrowing down its next TMCx cohort. It will be the first group of startups for the accelerator following an overhaul and redesign of the program that was announced last year.

TMCx has identified 19 companies from around the world to attend a two-week bootcamp within the TMC. At the conclusion of the two weeks, TMCx will select its 2020 cohort, which will then go through a six-month accelerator program.

While TMCx has been accelerating digital health and medical device startups for five years, this is the first year the program has taken this approach. The TMCx team first announced these changes on its last demo day in November. The program redesign was put into motion in order to find startups and technologies that solve the problems and challenges that TMC institutions face.

"The TMCx team is razor-focused on ensuring X companies find a landing spot here in the TMC," says Lance Black, associate director at TMCx. "Our north star metric is agreements between the startup and the member institution. With this as our determiner of success, we need to be intimately familiar with not only what the startups are doing but with what our hospitals need."

The TMCx team selected this batch of 19 startups based on their ability to hit the ground running at TMC, Black explains, and the two-week bootcamp will be filled with customer meetings, in-hospital exploration, social events, and educational programming.

"From these bootcamp participants, we are looking for companies who are ready to have meaningful conversations with their customers on day 1," Black says. "The access to enterprise health systems here in Houston is like no other place in the world, so TMCx is focused on curating these conversations and subsequent relationships so our member institutions are truly able to remain cutting edge."

Ultimately, Black says, his team is looking for the companies ready to "show up" for the TMC's member institutions.

"One of the most exciting aspects of TMCx's new phase is how we are now working hand-in-hand with the offices of innovation and internal champions of our member institutions to investigate needs and scour the globe for the best solutions," Black explains. "This community is one of collaborators and TMCx is a proud partner in improving the quality of life for patients."

Here are the health tech startups participating in the TMCx bootcamp this month:

  • San Francisco-based Atlas Health connects patients with payment resources.
  • Austin-based CareStarter automates and scales care management.
  • Houston-based CaseCtrl is a surgical case management platform.
  • San Francisco-based DeepScribe is an autonomous medical scribe.
  • Austin-based Diligent Robotics created a clinical robot assistant.
  • Los Angeles-based Elly allows users to live healthier through positivity.
  • San Francisco-based Ferrum reduces preventable medical errors.
  • San Antonio-base GaitIQ evaluates gait in primary care.
  • Toronto-based HelpWear is a clinical grade wearable heart monitor.
  • Pessac, France-based inHEART combines imaging and electrocardiology technologies.
  • London-based Lantum is a total workforce solution for healthcare.
  • Denver-based Manatee has created connected, everyday therapy for kids.
  • Cupertino, California-based Pyrames is a continuous, non-invasive blood pressure monitoring system.
  • Copenhagen-based Radiobotics automates analysis of routine medical X-rays.
  • Philadelphia-based Repisodic is a discharge planning solution.
  • Evanston, Illinois-based Rheos is a wearable shunt monitor.
  • College Station-based Solenic Medical eliminates biofilm on metallic implants.
  • Melbourne-based TALi can assess and strengthen attention in early childhood.
  • New York-based Yosi is creating the waiting room of the future.
Houston, home to the largest medical center in the world, had a lot of trending health tech stories this year. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Top 5 Houston health tech stories of 2019

2019 in review

Editor's note: As 2019 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. Within the health category, top stories included new details from the Texas Medical Center's ongoing TMC3 project, health tech and medical device startups in Houston, and more.

Texas Medical Center reveals new details and renderings for its TMC3 campus

The design and construction team has been announced for TMC3. Courtesy of Elkus Manfredi Architects

The Texas Medical Center just announced the dream team of architects and designers that are making TMC3 into a reality.

Elkus Manfredi Architects, Transwestern, and Vaughn Construction are the three companies that will serve as the architectural and development team for the 37-acre research campus. TMC3's founding institutions — TMC, Baylor College of Medicine, Texas A&M University Health Science Center, The University of Texas Health Science Center at Houston, and The University of Texas MD Anderson Cancer Center — decided on the three entities.

"Texas Medical Center is eager to move forward with a bold, imaginative and dynamic new design vision for the TMC3 Master Plan," says TMC CEO and president, Bill McKeon, in a press release. "With the combined talents of Elkus Manfredi Architects, Transwestern, and Vaughn Construction on-board, I couldn't be more confident that this dream team will flawlessly execute the totality of the project's vision and fulfill its mission to bring together leading researchers and top-tiered expertise from the private sector to create the number one biotechnology and bioscience innovation center in the entire world."

TMC3 was first announced just over a year ago and is planned to open in 2022. The campus will incorporate research facilities, retail space, residential plans, a hotel and conference center, and green space. Parking will be underground to optimize surface area. To continue reading this top story, click here.

5 Houston medical device companies changing the industry

As medicine and technology both advance, these Houston startups are at the forefront of the industry. Getty Images

With the Texas Medical Center at the heart of Houston, health advancement opportunities are endless. Medical breakthroughs are happening across town, but as technology advances, the industry is seeing more and more startups popping up to take new tech tools and applying them to traditional medical devices and procedures.

These five Houston startups are developing the future of the industry — one device at a time. To continue reading this top story, click here.

Houston medical device company gains FDA approval

Houston-based Saranas has received de novo distinction from the FDA for its bleed monitoring technology. Courtesy of Saranas

When it comes to early bleeding detection, Houston-based Saranas, which closed $2.8 million in funding last year, is ahead of the game with its Early Bird Bleed Monitoring System. The Food and Drug Administration has recognized the medical device company and granted it De Novo distinction.

"Gaining FDA approval for the Early Bird is a significant milestone for Saranas as it demonstrates our continued commitment to address an unmet need for real-time detection and monitoring of endovascular bleed complications," says Saranas president and CEO, Zaffer Syed in a release. "As the first and only device on the market for early bleed detection, we have the potential to significantly reduce bleeding complications and related healthcare costs, while improving clinical outcomes in patients undergoing endovascular procedures."

The Early Bird technology is designed to detect bleeding from vessel injury caused by a surgery, for instance. One in five patients experienced a bleed complication in over 17,000 large-bore transcatheter procedures, according to the release which cites the National Inpatient Sample Database. To continue reading this top story, click here.

5 Houston biotech companies taking health care to new levels

With the Texas Medical Center in their backyard, these Houston biotech companies are creating breakthrough technologies. Getty Images

Houston is the home of the largest medical center in the world, so it comes as no surprise that the Bayou City is also home to breakthrough technologies. Here are five Houston companies developing some of this biotech advancements. To continue reading this top story, click here.

TMCx announces its next medical device cohort with 5 startups hailing from Houston

The next TMCx cohort begins August 5. Courtesy of TMC

The Texas Medical Center's startup accelerator, TMCx, has added 19 companies from all around the world to join its medical device family.

The TMC Innovation Institute team narrowed down 140 applications to 40 for the second round of the process, which includes face-to-face interviews, according to a release. After those, 18 companies were selected to join the TMCx09 class, which focuses on medical devices. The last cohort, which specialized in digital health, concluded on June 6.

Out of the 18 companies, five are from Houston. Four other startups hail from other corners of the United States, while 10 international companies also made the cohort. The program commences on August 5, and will run for four months before concluding in a demo day event in November. To continue reading this top story, click here.
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Texas named a top state for women-led startups

this one's for the ladies

Who runs the world? According to Merchant Maverick's inaugural Best States for "Women-Led Startups'' study, Texas is a great place for women to be in charge.

The Lone Star state cracked the top 10 on the list, earning a No. 6 spot according to the small business reviews and financial services company, which based the study on eight key statistics about this growing segment of the economy. Colorado (at No. 1), Washington, Virginia, Florida, and Montana were the only states to beat out Texas on the rankings—leading the Merchant Maverick team to conclude that "the part of the country that lies west of the Mississippi is great for startups led by women entrepreneurs."

Women-led startups in Texas received $365 billion in VC funding in the last five years, the report found. This is the seventh largest total among U.S. states. Too, about 20 percent of Texans are employed at woman-led firms, which is the fifth highest percentage among states. Roughly 35 percent of employers in Texas are led by women.

A few other key findings that work in female founders' favor: The startup survival rate in Texas is nearly 80 percent. And a lack of state income tax "doesn't hurt either," the report says.

Still there are shortcomings. On a per capita basis, only 1.27 percent of Texas women run their own business. The average income for self-employed women is also relatively low ranking among states, coming in around $55,907 and landing at 31st among others.

This is not the first time Texas has been lauded as a land of opportunity for women entrepreneurs. A 2019 study named it the best state for business opportunities for women. Houston too has proven to support success for the demographic. The Bayou City was named in separate studies a best city for female entrepreneurs to start a business and to see it grow.

Still, as many findings have concluded, the realities of the pandemic loom for all startups and small business owners. The Merchant Maverick study was careful to add: "The pandemic has changed the economic landscape over the past year, and often for the worse.

"This means that not every metric may be able to accurately gauge how a state might fare amidst the pandemic," the report continues. "To help factor in COVID's impact, we included some metrics that take 2020 into account, but it will be a while until we get a full picture of the pandemic's devastation.""

New downtown office tower will rise in bustling Discovery Green

new to hou

A new office tower will soon loom over the popular Discovery Green as the anchor of a new downtown district. Global development and construction firm, Skanksa, announced the new building at 1550 Lamar St. and its anchor tenant on January 13. The new 28-story, 375,000-square-foot Class-A office structure is dubbed 1550 on the Green, per a Skanska statement.

Global law firm Norton Rose Fulbright will relocate its Houston office in 2024 and acquire naming rights upon occupancy, according to a press release.

Bound by La Branch, Lamar, Crawford, and Dallas Streets, 1550 on The Green will feature extra-wide pedestrian zones with a canopy of trees, two tenant outdoor roof terraces, and wide views of the surrounding greenery.

International design firm BIG-Bjarke Ingels Group led the building's design; it is the company's first foray into Texas. BIG's design promises sustainability, energy efficiency, and an "airy" office environment for tenants, a release describes.

Some 7,000 square feet of retail space will greet first-floor guests. Michael Hsu Office of Architecture has been tapped to design the interior amenity spaces; those include a fitness center, rooftop event space and terrace, and community spaces.

The new 1550 on the Green tower is part of a new envisioned district that will be branded as Discovery West. The district will consist of 3.5 acres of mixed-use development boasting restaurants, retail, green space, and "world-class architecture," per a release.

Working with Central Houston Inc., Discovery Green, Bike Houston, the Kinder Foundation, as well as several brokers, Skanska and design firm of record, BIG-Bjarke Ingels Group, completed the master plan for Discovery West in early 2020.

Skanska has been noticeably active in the Houston office market, specifically with the development of Bank of America Tower, West Memorial Place I and II, and the future Discovery West. The company is behind the acquisition of a buzzy strip center in Montrose. Skanska also plans to multifamily to its Houston portfolio, the firm notes.

"As an organization that prides itself on building what matters to our communities, our team, made up of Houstonians, has been working alongside local stakeholders to develop a plan and a building that will transform this side of downtown Houston while still meeting the needs of the city," said Matt Damborsky, executive vice president for Skanska USA commercial development's Houston market, in a statement.

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This article originally ran on CultureMap.

5 most popular innovation stories in Houston this week

WHAT'S TRENDING

Editor's note: Another week has come and gone, and it's time to round up the top headlines from the past few days. Trending Houston tech and startup news on InnovationMap included top a female-founded startup that helps busy families manage, Housotn innovators to know, and more.

3 female Houston innovators to know this week

This week's roundup of Houston innovators includes Nicole Rogers of Validere, Allie Danziger of Ampersand, and Ashley Small of Medley Inc. Courtesy photos

In the week's roundup of Houston innovators to know, I'm introducing you to three female innovators across industries — from energy tech to business entrepreneurship. Continue reading.

Rice University teams up with Chase for new small business initiative

The Susanne M. Glasscock School of Continuing Studies at Rice University has a new partnership with Chase that will offer professional resources. Photo via rice.edu

A school at Rice University has been tapped by Chase for Business to help provide free, online courses to small businesses.

Rice's Susanne M. Glasscock School of Continuing Studies will be offering short courses as a part of a Small Business Series.

"Chase for Business is committed to our small-business partners and their ongoing success," says James Connolly, Houston market manager for Chase Business Banking, in a news release. "We're providing tools and resources that will not only help them survive our current economy, but also thrive in the months and years to come. Partnering with the Glasscock School presents a great educational opportunity from a trusted source right here in our community." Continue reading.

Female-founded Houston startup helps busy families do it all

Bevy co-founders and working moms Carissa Janeway (left) and Lynda Attaway wanted to create a service for helping busy families keep things moving smoothly. Photo courtesy of Bevy

So much to do and so little time? We feel you. In a 2018 Pew Research Center survey, 60 percent of U.S. adults said they sometimes felt too busy to enjoy life. Bevy, an organization company serving greater Houston, is helping the overwhelmed and active do it all.

"Bevy was actually born from our-real life experiences," explains Lynda Attaway, co-founder and CEO of Bevy.

As the former co-founder and chief strategy officer of Sunnova Energy, she led a complex schedule until the demands of doing it all got to her. While climbing the corporate ladder for 18 years, she would "do whatever it took and stay as late as it took," to succeed.

While trying to raise her three children and balance a large role, she soon realized that many of her male colleagues had a stay-at-home wife who managed the at-home projects that can take so much time.

"I finally came to the realization that I could not be everything to everybody, which is a very common kind of syndrome that we tend to have as women," she shares. "Something needed to change." Continue reading.

Houston venture group closes $64M fund and rebrands with new name

Montrose Lane managing partners, Ryan Gurney (left) and Jeremy Arendt, have announced a rebrand and the closing of the new fund. Photos via montroselane.com

A Houston venture investment group has announced today that it has a new name to go along with the recent closing of its second fund.

Cottonwood Venture Partners, a Houston-based firm focused on funding startups with software solutions for the energy industry, has closed its $64 million Fund II and renamed itself Montrose Lane.

"Our mission is to uphold a creative and fast-moving approach to partnering with software companies that help make energy affordable, safe, and environmentally friendly," says Jeremy Arendt, managing partner, in a news release. "For several reasons, 'Montrose Lane' captures that vision for us." Continue reading.

TMCx company recognized internationally, Cannon acquires Houston fintech startup, and more innovation news

From startup pitch competitions seeking applications to Houston startups with big news, here are the latest short stories of Houston innovation. Photo courtesy TMC Innovation

Houston's innovation ecosystem has been booming with news fresh out of the gate for 2021, and it's likely some might have fallen through the cracks.

For this roundup of short stories within Houston innovation, a TMCx startup gets called out by Time Magazine, pitch competitions seek entries for thousands of dollars of investment prizes, and more. Continue reading.

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