The four volunteer crew members spent more than 12 months inside NASA's first simulated Mars environment at Johnson Space Center in Houston. Photo via NASA

The crew of a NASA mission to Mars emerged from their craft after a yearlong voyage that never left Earth.

The four volunteer crew members spent more than 12 months inside NASA's first simulated Mars environment at Johnson Space Center in Houston, coming out of the artificial alien enviroment Saturday around 5 p.m.

Kelly Haston, Anca Selariu, Ross Brockwell and Nathan Jones entered the 3D-printed habitat on June 25, 2023, as the maiden crew of the space agency's Crew Health and Performance Exploration Analog project.

Haston, the mission commander, began with a simple, “Hello.”

“It’s actually just so wonderful to be able to say ‘hello’ to you all,” she said.

Jones, a physician and the mission medical officer, said their 378 days in confinement “went by quickly.”

The quartet lived and worked inside the space of 1,700 square feet (157 square meters) to simulate a mission to the red planet, the fourth from the sun and a frequent focus of discussion among scientists and sci-fi fans alike concerning a possible voyage taking humans beyond our moon.

The first CHAPEA crew focused on establishing possible conditions for future Mars operations through simulated spacewalks, dubbed “Marswalks,” as well as growing and harvesting vegetables to supplement their provisions and maintaining the habitat and their equipment.

They also worked through challenges a real Mars crew would be expected to experience including limited resources, isolation and delays in communication of up to 22 minutes with their home planet on the other side of the habitat's walls, NASA said.

Two additional CHAPEA missions are planned and crews will continue conducting simulated spacewalks and gathering data on factors related to physical and behavioral health and performance, NASA said.

Steve Koerner, deputy director of Johnson Space Center, said most of the first crew's experimentation focused on nutrition and how that affected their performance. The work was “crucial science as we prepare to send people on to the red planet,” he said.

“They've been separated from their families, placed on a carefully prescribed meal plan and undergone a lot of observation,” Koerner said.

“Mars is our goal,” he said, calling the project an important step in America's intent to be a leader in the global space exploration effort.

Emerging after a knock on the habitat's door by Kjell Lindgren, an astronaut and the deputy director of flight operations, the four volunteers spoke of the gratitude they had for each other and those who waited patiently outside, as well as lessons learned about a prospective manned mission to Mars and life on Earth.

Brockwell, the crew's flight engineer, said the mission showed him the importance of living sustainably for the benefit of everyone on Earth.

“I’m very grateful to have had this incredible opportunity to live for a year within the spirit of planetary adventure towards an exciting future, and I’m grateful for the chance to live the idea that we must utilise resources no faster than they can be replenished and produce waste no faster than they can be processed back into resources," Brockwell said.

“We cannot live, dream, create or explore on any significant timeframe if we don’t live these principles, but if we do, we can achieve and sustain amazing and inspiring things like exploring other worlds," he said.

Science officer Anca Selariu said she had been asked many times why there is a fixation on Mars.

“Why go to Mars? Because it’s possible,” she said. "Because space can unite and bring out the best in us. Because it’s one defining step that ‘Earthlings’ will take to light the way into the next centuries.”

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.