This week's roundup of Houston innovators includes Isabella Schmitt of Proxima Clinical Research, Rob Schapiro of Microsoft, and Lara Cottingham of Greentown Labs. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from medical device innovation to energy tech— recently making headlines in Houston innovation.

Isabella Schmitt, director of regulatory affairs at Proxima Clinical Research and principal at M1 MedTech

A Houston life science expert shares what she thinks Houston needs to work on to continue growing as an health care innovation ecosystem. Photo courtesy

Houston is home to the world's largest medical center, but it still tends to fall behind other metros when it comes to life science innovation hub rankings. Isabella Schmitt, director of regulatory affairs at Proxima Clinical Research and principal at M1 MedTech, writes in a guest column for InnovationMap about why this is — and what can be done to change that.

"Houston's life sciences sector holds immense growth potential, but addressing funding, talent recruitment, regulatory navigation, and collaboration challenges is needed for continued success," she writes. "By tackling these issues and leveraging its unique strengths, Houston can establish itself as a significant player in the global life sciences arenas. If we wait too long, we won’t be able to truly establish the Third Coast because another player will come into the mix, and we’ll lose companies like BioMatrix to their golden shores." Read more.

Rob Schapiro, Energy Acceleration Program director and Houston site leader for Microsoft

Rob Schapiro of Microsoft joins the Houston Innovators Podcast to discuss DEI initiatives, translating between the tech in the energy sectors, AI, and more. Photo courtesy of Microsoft

At a glance, Rob Schapiro admits his resume might not make the most sense. A trained geologist with decades of experience in the energy sector, Schapiro made the move to Microsoft three years ago.

"I saw this disconnect between technology companies and energy companies — they didn't really speak the same language," he says on this week's episode of the Houston Innovators Podcast. "I thought I could help potentially solve this problem and work between the two as a sort of translator."

Now, as Microsoft’s Energy Acceleration Program director and site leader for the company’s Houston office, which is located in the Ion, Schapiro is deeply embedded in Houston's innovation ecosystem and is dedicated to helping advance Houston's role energy transition in a sustainable and equitable way. Read more.

Lara Cottingham, vice president of strategy, policy, and climate impact at Greentown Labs

Greentown Houston is asking its current and potential members what they want in a wet lab. Photo via GreentownLabs.com

Greentown Labs is in the early stages of building out a wet lab for its members. But first, Lara Cottingham, vice president of strategy, policy, and climate impact at Greentown Labs, says they want to know what their members actually want.

"We want to announce to the community that this is something we're going to build — but we still need a lot of feedback and input from startups so we can learn what exactly they need or want to see from the wet lab," Cottingham tells InnovationMap. "No two wet labs are the same."

Right now, there aren't any details available about timeline or specifics of the new facility. Greentown is prioritizing getting feedback from its members and having conversations with potential sponsors and corporate partners. Read more.

Greentown Houston is asking its current and potential members what they want in a wet lab. Photo via GreentownLabs.com

Greentown Houston announces plans for wet lab, calls for feedback from members

seeing green

Greentown Houston has announced it's building a new wet lab facility — but first, they need some help from the community.

Greentown Labs, which is dual located at their headquarters in Somerville, Massachusetts, and in the Ion District in Houston, has announced that they are building out a wet lab in their Midtown space.

"We have heard from several startups as well as corporate partners in the ecosystem that are looking for wet lab space," says Lara Cottingham, vice president of strategy, policy, and climate impact at Greentown Labs. "Greentown has experience running wet labs from our location in Somerville. We're excited to be able to offer wet lab space to climatetech startups as an additional amenity to the Ion District.

Although Greentown's Boston-area location has wet lab space, Cottingham says the organization is not interested in copying and pasting that same facility. Greentown wants to provide the tools that the Houston ecosystem needs, and that requires getting feedback from its current and potential members.

"We want to announce to the community that this is something we're going to build — but we still need a lot of feedback and input from startups so we can learn what exactly they need or want to see from the wet lab," Cottingham tells InnovationMap. "No two wet labs are the same."

Right now, there aren't any details available about timeline or specifics of the new facility. Greentown is prioritizing getting feedback from its members and having conversations with potential sponsors and corporate partners.

"Corporate partners are a big part of the ecosystem and the community at Greentown. They can be so many things to our startups — mentors, customers, investors," Cottingham says. "And in this space, they can help us sponsor and financially support the wet lab. We're still fundraising — we have some partners that have committed to funding, but we're still looking for more funding."

In addition to monetary contribution, Cottingham says they are looking for other options as well, from partnerships with equipment providers, hazardous materials management, and more.

Startups that need wet lab space are encouraged to fill out the online form, which will be open through the summer, and potential corporate partners can express their interest online as well.

Greentown Houston opened its doors in 2021 and has since grown to house more than 75 energy and climatetech startups, as well as several accelerators, thanks to support from dozens of corporate partners.

A new program is launching to support the next generation of energy innovators. Photo via greentownlabs.com

Greentown Labs launches student-driven entrepreneurship program in Texas

back to school

The country's largest climatetech startup incubator and several schools are teaming up to prepare the next generation of clean energy innovators.

Greentown Labs, based in Boston and Houston, announced its new Texas Entrepreneurship Exchange for Energy (TEX-E) this week. The collaborative initiative aims to strengthen the student-driven entrepreneurship ecosystem in Houston, according to a news release, to focus on energy innovation. Greentown Labs, MIT’s Martin Trust Center for Entrepreneurship, and universities across Texas — including The founding institutions of TEX-E are Rice University, Texas A&M University, Prairie View A&M University, University of Houston, and The University of Texas at Austin — are collaborating on the project.

“Houston has long been known as the energy capital of the world, but to lead the world’s energy transition, the city must create a strong, vibrant innovation ecosystem to support the next generation of entrepreneurs and energy companies,” says Lara Cottingham, chief of staff at Greentown Labs, in the news release. “TEX-E will build upon Texas universities’ deep and long-standing connections to the energy industry by helping to attract and retain the world-class talent needed to supercharge Houston’s innovation ecosystem.”

The program, though based in Texas, will integrate both Greentown Labs locations, providing students with access to mentorship with incubator startups, networking events, career opportunities, and cross-learning with MIT.

“Boston and Houston might seem like an odd pairing, but they complement one another beautifully,” says Ben Soltoff, ecosystem builder and entrepreneur in residence at the Martin Trust Center for MIT Entrepreneurship, in the release. “The Boston area has a strong community-driven ecosystem around climate innovation, including MIT’s pioneering Climate and Energy Ventures Course in Cambridge, which has spawned over 30 companies. But often when MIT startups need to scale up, they look towards Texas, where they can find talent, space, and industry knowhow in spades.

"Together, these two regions are unstoppable,” he adds.

The five schools are just the beginning for the program, which plans to expand the collaboration over time. Locally, Houston area schools have collaborated with Greentown Houston since its opening over a year ago.

“The TEX-E collaboration will provide valuable opportunities to our students, and Houston is a natural location to create such an ecosystem,” says Ramanan Krishnamoorti, vice president for energy and innovation at the University of Houston, in the release. “Training new talent and supporting their pursuit of innovative ideas are vital in addressing the growing global need for affordable, reliable, and environmentally sustainable energy.”

For more information, students and educators should sign up for the TEX-E newsletter and attend an upcoming event at Greentown Houston. The next event at the incubator is the Climatetech Summit on November 2.

Meet five of the many Houston innovators that will be out at SXSW Pitch, Houston House, Founded in Texas, and much more this week and into next week. Photos courtesy

5 Houston innovators headed to SXSW to know this weekend

who's who

Editor's note: It's a special Friday edition of innovators to know this week — well, weekend. SXSW kicks off today and Houstonians will be headed up to Austin for the week or just the weekend. If you're looking out for the best panels and talks to go to, look no further than this guide I created — as well as the five Houston innovators I think you should know who are listed below.

Lara Cottingham, chief of staff for Greentown Labs

Photo via LinkedIn

Calling all energy transition startups, investors, and more. The Greater Houston Partnership is hosting a full day of energy transition discussions at Houston House on Monday, March 14, at the Line Hotel. Lara Cottingham of Greentown Labs will be at the activation site with a must-attend networking hour at 4 pm called Transition on Tap.

Diana Murakhovskaya, co-founder and general partner of The Artemis Fund

Photo via LinkedIn

Who runs the world? Women. And Diana Murakhovskaya knows that based off her work with her Houston-based venture capital fund, The Artemis Fund. Project W, Artemis Fund, HearstLab, and Beam have teamed up at SXSW to present the second Founded in Texas event on Sunday, March 13, at Relay Coworking. Twelve founders selected by application will pitch to investors from across the country . The audience will get a glimpse of the innovation and creativity at work in the growing Texas startup ecosystem.

Pamela Singh, co-founder and CEO of CaseCTRL

Photo courtesy of CaseCTRL

Pamela Singh is the only Houston startup founder to pitch this year at SXSW's pitch competition. Representing her digital health startup, Case CTRL, Singh takes the prestigious stage Saturday, March 12, to compete in the Enterprise & Smart Data Technology category.

Sandy Guitar, managing director of HX Venture Fund

Photo courtesy of Sandy Guitar

The HX Venture Fund is hosting a meetup that all of the Houston startup ecosystem needs to know about. Network with a number of founders from Houston's fastest-growing startups along with several great VCs around the nation to participate in a joint conversation about founding tech startups. The event will take place at 11:30 am to 12:30 pm at Hilton Austin Downtown, Room 408.

Ashley DeWalt, managing director of DivInc

Photo courtesy of DivInc

Ashley DeWalt, managing director of DivInc, is just one of the many Houston innovators featured in Houston House from the GHP. The activation starts Sunday, March 13, at the Line Hotel with a day of programming across industries and topics — from sports tech and diversity (both topics DeWalt specializes in) to health care innovation and space. Catch DeWalt's panel, Game Changers - The Rise of Sports Tech, on Sunday at 11:30 am at Houston House.

This week's roundup of Houston innovators includes Carolyn Rodz of Hello Alice, Kimon Angelides of FemTec Health, and Lara Cottingham of Greentown Labs. Courtesy photos

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from health tech to clean energy — recently making headlines in Houston innovation.

Carolyn Rodz, CEO and founder of Hello Alice

Carolyn Rodz joins the Houston Innovators Podcast this week. Photo courtesy of Hello Alice

Hello Alice exists to serve small business founders through their entrepreneurial journeys — that's why Carolyn Rodz founded the company — and SMBs needed support more than ever last year.

As challenging as the pandemic was for Hello Alice, it was validating too. Rodz says the company had a 700 percent increase in revenue and an 1,100 percent acquisition growth.

"We'd never operated in a downcycle, but what we learned through that process was that we're a really valuable resource for business owners when times are great, but we're also a really valuable resource for them when times are tough," she says on this week's episode of the Houston Innovators Podcast. Click here to read more and stream the episode.

Kimon Angelides, founder, chairman, and interim CEO of FemTec Health,

Dr. Kimon Angelides is also the founder of Houston health tech startups Livongo Health and Vivante Health. Photo via LinkedIn

Kimon Angelides, who has founded a handful of Houston health tech startups, has announced his latest venture launched FemTec Health, a tech-enabled women's health sciences and beauty company focused on transforming the total healthcare experience for women. The company is emerging from stealth mode this week with already 10 million members, two clinical trials in progress, $38 million in funding, and a team of over 150.

"Our platform can be implemented across all areas including specialty care, wellness and prevention, reproductive care, sexual wellness, mental health, chronic care, and beyond," Angelides says in the release. "It is driven by state-of-the-art genomics and digital technologies that empower women to take control of their health at every stage of their life journey, based on their individual health profiles."

FemTec Health's business and growth model is to expand via acquisitions — and the company has several under its belt already, including beauty subscription box Birchbox, universal beauty store Mira Beauty, and beauty industry social marketing platform Liquid Grids, which has over 1.5 million members, according to the release. Click here to read more.

Lara Cottingham, chief of staff for Greentown Labs

As of this week, Lara Cottingham is the chief of staff at Greentown Labs. Photo via LinkedIn

Lara Cottingham is the new chief of staff for Greentown Labs, a Boston-area company that opened in Houston earlier this year. Cottingham previously served as the city of Houston's chief sustainability officer and the chief of staff for the city's Administration and Regulatory Affairs Department for the past seven years. In her new role, Cottingham will oversee the day-to-day operations and communications for Greentown's CEO Emily Reichert, along with key stakeholder engagements and strategic initiatives for the incubator.

"In working with Mayor Turner and Climate Mayors across the U.S., I saw how important partnerships are to helping cities decarbonize," says Cottingham in the release. "There is no better partner or place for climate action at work than Greentown Labs. Greentown is 100 percent committed to attracting and nurturing the energy companies of the future and making Houston the energy transition capital of the world. I'm excited to join the team and see how climatetech can help cities reach their climate goals." Click here to read more.

As of this week, Lara Cottingham is the chief of staff at Greentown Labs. Photo via LinkedIn

Greentown Labs hires former Houston sustainability exec

new hire

The country's largest climatetech startup incubator has made a strategic new hire.

Lara Cottingham is the new chief of staff for Greentown Labs, a Boston-area company that opened in Houston earlier this year. Cottingham previously served as the city of Houston's chief sustainability officer and the chief of staff for the city's Administration and Regulatory Affairs Department for the past seven years. In her new role, Cottingham will oversee the day-to-day operations and communications for Greentown's CEO Emily Reichert, along with key stakeholder engagements and strategic initiatives for the incubator.

"Lara brings a tremendous wealth of knowledge and experience to our team from her dynamic leadership role at the City of Houston," says Reichert in a news release. "Her breadth of knowledge in sustainability, climate, and the energy transition, and her expertise in regulatory and stakeholder aspects of the energy industry, will be incredibly valuable to our team and community."

Under her leadership at the city of Houston, Cottingham was the chief author of Houston's Climate Action Plan, an initiative aimed at reducing greenhouse gas emissions in Houston, and getting the city to a point where it meets the Paris Agreement goal of carbon neutrality by 2050. Cottingham helped the city move to 100 percent renewable electricity, according to the release, and helped turn a 240-acre landfill into the nation's largest urban solar farm.

"In leading the Climate Action Plan, Lara helped spark Houston's leadership in what has become a global energy transition and was a passionate advocate for climate action in Houston," says Houston Mayor Sylvester Turner in the release. "While she will be missed, this new role will only strengthen our partnership with Greentown. I look forward to working with Emily, Lara, and the Greentown team to meet our climate goals and make Houston the energy capital of the future."

Before her work at the city, Cottingham worked at Hill+Knowlton Strategies' Houston office range of clients across the energy sector. Earlier in her career, she served as communications director for two congressmen in the U.S. House of Representatives. She began her work with the city in 2014.

"In working with Mayor Turner and Climate Mayors across the U.S., I saw how important partnerships are to helping cities decarbonize," says Cottingham in the release. "There is no better partner or place for climate action at work than Greentown Labs. Greentown is 100 percent committed to attracting and nurturing the energy companies of the future and making Houston the energy transition capital of the world. I'm excited to join the team and see how climatetech can help cities reach their climate goals."

Greentown Labs first announced its entrance into the Houston market last summer. The new 40,000-square-foot facility in Midtown across the street from The Ion opened its prototyping and wet lab space, offices, and community gathering areas for about 50 startup companies opened in April. Greentown was founded in 2011 in Somerville, Massachusetts, and has supported more than 400 startups, which have raised more than $1.5 billion in funding.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.