University of Houston: Navigating incident reporting in the lab

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Innovation isn't always the safest field. Here's what to consider within incident reporting. Graphic by Miguel Tovar/University of Houston

Exploding refrigerator? Chemical splash on the face? These are not just personally devastating lab incidents, they are also expensive.

For instance, awhile back, the University of Hawaii faced a total $115,500 fine for 15 workplace safety violations after a laboratory explosion where a postdoctoral researcher lost one of her arms. Beryl Lieff Benderly wrote in Science that the accident “resulted from a static electricity charge that ignited a tank containing a highly flammable, pressurized mixture of hydrogen, oxygen and carbon dioxide.”

Referred to as “incidents,” they are defined by University of California Santa Barbara (UCSB) in this way: “An incident is an event that results in or causes injury or damage to someone or something, or an event that has the potential to result in or cause injury or damage.”

But when asked which incidents are reportable, the answer is uniform across all research universities: all incidents must be reported.

Incidentally...

There are websites dedicated to laboratory accidents, like this one at UCSB. It lists the two accidents mentioned in this blog’s first sentence. University of Michigan Environment, Health and Safety’s website said, “Being safe at the University of Michigan requires a positive safety culture where we learn from mistakes and near-misses in order to improve and prevent future occurrences. It is vital that you report all ‘incidents’ including near- misses, injuries resulting from your activities, non-compliance with safety and environmental rules, and general unsafe work conditions so that we can learn and grow.” Northwestern University’s website on Research Health and Safety said, “Always report ‘near-misses’ just as you would an incident that causes injury or harm to property.”

Near-missing

You may be asking, what constitutes a “near-miss”? At Western Kentucky University, for example: “A laboratory “near-miss” is an unplanned situation, where with minor changes to time or setting, could have easily resulted in damage or injury to person or property. A near-miss is characterized as having little, if any, immediate impact on individuals, processes, or the environment, but provides insight into accidents that could happen.” Laboratory near misses may cause chemical spills, explosions and bodily injury, but can be treated with first-aid.

Form finding

Most universities have a form to fill out if there is an incident that could have led to a severe injury or death. The form asks for a description of the incident and even asks, in some instances, “Why did it happen?” These should be made out comprehensively and quickly.

OSHA

The Occupational Safety and Health Administration (OSHA) has a reporting process, aside from what each university requires. They need information when you call. The OSHA website states: “Be prepared to supply: Business name; names of employees affected; location and time of the incident, brief description of the incident; contact person and phone number.”

There are even time limits for how quickly one must report a severe injury that requires an in-patient hospitalization, amputation or loss of an eye (24) or fatality.

(It’s eight hours.)

The fact that “losing an eye” is one of just four reasons to contact OSHA, you may wonder, “Are a lot of people blinded in the lab, often?” Also, “Where can I buy safety goggles?”

“Are a lot of people blinded in the lab, often? Also, where can I buy safety goggles?”

The big idea

There are many websites which detail lab disasters. Some are cautionary tales, some are avoidable situations. Just be sure to wear your Personal Protective Equipment (PPE) and be safe out there. Or rather, in there.

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This article originally appeared on the University of Houston's The Big Idea. Sarah Hill, the author of this piece, is the communications manager for the UH Division of Research.

Here's some advice for going green in the lab. Graphic by Miguel Tovar/University of Houston

Houston expert shares tips for shrinking your lab's carbon footprint

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Trying to make your lab greener? Here are some practical examples of how to reduce your lab's carbon footprint and increase sustainability. Since China stopped accepting certain types of plastic waste from the United States and Europe in 2017, the need to dispose of hundreds of single-use plastic vials and other materials (per researcher, each year!) has created an avalanche of waste.

The "single use" problem

COVID-19 has led to even more single-use plastics in labs – and in our everyday lives. The sheer number of gloves, testing kits and even masks we throw away is incredible. "The majority of masks are manufactured from long-lasting plastic materials, and if discarded can persist in the environment for decades to hundreds of years," wrote authors from the University of Portsmouth at the Conversation.com.

Reduce, reuse, recycle

Labs are full of other single-use plastics such as pipette tips, weighing boats, tubes, flasks, reagent bottles, cuvettes, and more. 'Reduce, reuse and recycle' is a fine mantra, but how do researchers cut down on plastics when the sterility of equipment is a concern?

According to the UK's Chemical and Engineering News magazine, "Different users have optimized washing protocols to get pipette tips clean enough for different lab techniques, including mass spectrometry or toxicology and immunology assays.

Earlier this year, for example, researchers at the National Institutes of Health's National Center for Advancing Translational Sciences found their washed pipettes gave the same results as new tips for preparing small-interfering-RNA screening libraries." Customers of Grenova, a lab equipment firm, have reported that some tips can reused 25-40 times.

Baby it's cold

In Nature, Jyoti Madhusoodanan wrote: "Scientists are increasingly aware of the disproportionate environmental footprint of their research. Academic research facilities consume three to six times as much energy as commercial buildings, much of that due to refrigeration and ventilation systems." The has led some third-party "green companies" employed by labs to hold entire conferences around ultra-low temperature freezers. In a feature advertisement in Nature Portfolio, a statistic read: "An average Ultra-Low Temperature freezer consumes as much energy as a single-family home (~20 kWh/day)."

Help for scientists

There are non-profits that will help you mitigate the amount of waste produced by your lab. One of these, My Green Lab, said on its website: "Run 'for scientists, by scientists,' we leverage our credibility and track record to develop standards, oversee their implementation, and inspire the many behavioral changes that are needed throughout the scientific community."

And it offers a free training course for "ambassadors" – those who would like to guide their lab toward sustainable practices.

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This article originally appeared on the University of Houston's The Big Idea. Sarah Hill, the author of this piece, is the communications manager for the UH Division of Research.

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Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Texas-based 'DoorDash for laundry' startup tumbles into Houston market

No Scrubs

Laundry may seem like an endless task that piles up, but a new service offers a solution to overwhelmed Houston families.

NoScrubs, an Austin-based home laundry pickup service has just expanded to Houston. Described by the company as "DoorDash — but for laundry," they wash customer's clothes at local laundromats and return them the same day, folded and ready to be put away.

The service took off like gangbusters in Austin, making an expansion to the state's largest city an obvious choice. It's not universal coverage just yet.

For now, only the following ZIP codes have NoScrubs service available: 77002, 77004, 77005, 77006, 77007, 77008, 77009, 77010, 77018, 77019, 77024, 77025, 77027, 77046, 77056, 77057, 77081, 77098, 77401, 77030, 77003.

A single pickup starts at $40 for 20 pounds of laundry, while the basic monthly subscription is $60 for two pickups. All services use hypoallergenic detergents.

The average American family spends about 240 hours a year on laundry, making it a very time-consuming chore. For people with disabilities, difficult work schedules, and other circumstances, it can be a real help, says co-founder Matt O'Connor.

"Some of our favorite customer stories simply revolve around saving people time when they have something challenging going on," he writes in an email. "For example, one customer reviewed NoScrubs saying 'So happy I could cry! (Partially because I'm pregnant and my emotions are heightened!)...1000% recommend if you have time restrictions or physical restrictions! ' So, whether it’s saving time, the affordability, or the pleasantly surprising turnaround time, NoScrubs has a variety of benefits for any customer."

NoScrubs is also a new opportunity for Houston's gig workers. Because there are no passengers, it can be a safer alternative to driving ride share for women and other people apprehensive about having strangers in their cars. As NoScrubs partners with local laundromats, drivers are also going to centralized locations rather than all over the map, leading to less wear and tear on their cars. The laundromats benefit as well, since NoScrubs loads are ones that would otherwise be done at home.

"Our model makes driving a tiny fraction of the time, so folks who don’t want to wear down their vehicles and spend a ton on gas love working at NoScrubs," added O'Connor.

Here's what's next for Houston’s Tempest Droneworx after SXSW Speed Pitch win

winner, winner

It’s not easy to be a standout at South by Southwest, especially during SXSW Interactive, which is the subsection of the festival that focuses on new media, technology and entrepreneurship.

But it’s even more difficult to win at SXSW Pitch, the competition for startups and entrepreneurs that showcases innovative new technology to a panel of industry experts, high-profile media professionals, venture capital investor, and angel investors.

Tempest Droneworx, a Houston-based company that provides real-time intelligence collected through drones, robots and sensors, did just that last month, taking home the Best Speed Pitch award. It was also named a finalist and alternate in the full SXSW Pitch competition. The company is known for it flagship product, Harbinger, a software solution that agnostically gathers data at virtually any scale and presents that data in easy-to-understand visualizations using a video game engine.

Tempest CEO and founder Ty Audronis says his company won based on its merits and the impact it’s making and will make on the world. Audronis founded the company after his hometown of Paradise, California, was destroyed by a wildfire in 2018.

“(SXSW) was a huge moment for our team,” says Audronis, whose background is in science visualization, data visualization and visual effects for the movie industry. “This is about what everyone at Tempest Droneworx has created, and our mission to make sure that issues—like the one that befell Paradise, California, my hometown, and the inspiration for our Harbinger software—don’t become the full-blown (disasters)."

Audronis shares that the company is working to release an agriculture beta this summer and is raising a Tactical Funding Increase (TACFI) round through the AFWERX, the Department of the Air Force’s innovation arm.

Tempest’s Harbinger is impressing investors and clients alike, but what is it exactly and what does it do?

The best way to explain the solution is in how it’s redefining the agriculture space. Tempest has deployed the product at Grand Farm in North Dakota, an agtech operation that seeks to promote sustainable, climate-resilient farming using applied technology.

“We decided to go down the road of agriculture,” Audronis says. “We're currently installed at the Grand Farm in North Dakota, which is a farm that is very closely tied to Microsoft. They do third-party verification of new soils and fertilizers, and we are helping them with visualizing the data that they're getting from their sensors.”

Additionally, Audronis and his co-founder and wife, Dana Abramovitz, spearhead a pilot program at Doubting Thomas Farms, an organic farm in Minnesota, where the company has installed 22 in-ground sensors that can measure volatile organic emissions.

To further optimize their solutions approach, Tempest Droneworx will also train artificial intelligence to look for overspray from neighboring non-organic farms. This will help maintain organic certification and reduce insurance claims for lost crops.

“This will save Doubting Thomas Farms and other organic farms a boatload of cash,” Audronis says.

During an exclusive tour with InnovationMap, Audronis pulled up a live feed of sensors buried around the Minnesota farm up on the conference room display. The feed did, in fact, look like a video game, with the sensors giving real-time data about the farm’s temperature, moisture level, humidity, CO2 and nitrogen.

Harbinger will collect, extract and extrapolate all of the data and later provide a digital almanac for farmers to track the history of their crops.

As the office tour continued, Audronis pointed out the company’s expanding partnership with the U.S. Military.

As a retired U.S. Navy veteran with over two decades of experience designing, building and piloting drones, Audronis understands that Harbinger has multiple military applications that will ultimately save lives—a core tenet of his company’s mission.

The company has launched a robotic dog known as UBU, developed by Tempest partner Ghost Robotics, that enables faster, more accurate ground surveys for explosive devices. This task previously required multiple airmen and hours to complete, Audronis says.

With agriculture and military initiatives in progress and making an impact, Audronis hopes to one day bring his original vision for Tempest Droneworx and Harbinger full circle by getting the call to combat California’s next catastrophic wildfire.

“We're proving our technology in military and in agriculture right now,” Audronis says. “Eventually, I would like to still save some lives with wildfire. That's really the purpose of the company … Whether it's agriculture, smart cities, the bottom line is saving lives through real-time situational awareness."

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