Houston entrepreneurial community builder teams up with startup to provide AI-powered founder tools

howdy, partner

The Cannon, a coworking community with locations across Houston, and nstAI, a newly launched suite of services for founders, announced a new partnership. Photo courtesy of The Cannon

A new Houston company has launched to provide a new platform of resources for entrepreneurs powered by artificial intelligence, and the new business already has its first partner.

The Cannon, a coworking community with locations across Houston, and nstAI, a newly launched suite of services for founders, announced a new partnership.

“The opportunity for The Cannon to partner with nstAI to bring a value-driven service offering to growth stage startup organizations is huge for our community. We are constantly looking for areas where we can support every startup, no matter where they are in their journey,” Jon Lambert, The Cannon’s CEO, says in a statement. “The nstAI offering, delivered through The Cannon's platform, will bring tremendous value to emerging companies who are in perhaps the most critical stage of their journey, garnering true market presence and customer share.”

Founded by seasoned entrepreneurs, nstAI's support is targeted aid startup founders during the early phases of business development, including securing non-dilutive funding, creating pitch decks and other materials, as well as making meaningful connections with mentors and potential customers.

"The journey from post-Seed funding to Series B funding is often one of the most challenging phases for founders," John Cooper, a founding partner at nstAI, adds. "We've designed nstAI to be a trusted resource in that process, offering hands-on guidance, leveraging AI-powered tools, and providing access to an unmatched global network of experts and investors."

The nstAI platform will be integrated into The Cannon's digital platform, Cannon Connect, for its members.

"nstAI is more than just a service provider; we're a community of successful entrepreneurs dedicated to supporting each other's growth and success," Mark Voytek, founding partner at nstAI, says in the release.

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This week's roundup of Houston innovators includes Jon Lambert of The Cannon, Ken Cowan of Enchanted Rock, and Richard Wilson of the University of Houston. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a podcast with the CEO of a community-focused coworking space, a professor joining a major health care research project, and a guest columnist with advice on navigating the energy transition.

Jon Lambert, CEO of The Cannon

Jon Lambert, CEO of The Cannon, joins the Houston Innovators Podcast to discuss the growth of The Cannon, including its newest location. Photo courtesy of The Cannon

For the past five years as CEO, Jon Lambert has faced some challenges leading The Cannon — from navigating a global pandemic to the subsequent evolved real estate market. But now, the coworking and community building company is poised for even more growth — especially with its ninth location opening up this month — thanks to its community-driven mission.

The Cannon Memorial opens its doors on Monday, May 13, with a week of free coworking and events. And while the new space, developed in partnership with MetroNational, is open for leasing, Lambert says on the Houston Innovators Podcast the first and foremost, The Cannon is a community.

"The Cannon wasn't created as a real estate play — we got into coworking because as we started supporting the community and asking the question of, 'what can we do for you?,' one of the highlights was, 'hey, we need space to work,'" he says on the show. "For us, we were going to provide space because that's one of the key needs of this community.

"Our measurement of success is not the buildings we have or the occupancy even — it's what's the success of the companies that are part of the community," he continues. Click here to read more.

Ken Cowan, senior vice president of Enchanted Rock

Ken Cowan writes a guest column for InnovationMap. Photo courtesy

As senior vice president of Enchanted Rock, a Houston-based provider of microgrid technology, Ken Cowan has seen how energy resilience has emerged as a key strategy for businesses across industries, as he writes in a guest column for InnovationMap.

"Executives must recognize the strategic imperative of investing in resilient energy infrastructure like microgrid systems, which can provide a competitive advantage against organizations that do not have similar measures in place," he writes. "In doing so, they can navigate uncertainty with confidence, set their business up for future success, and emerge stronger and more resilient than ever before."

In the piece, he explores the value proposition and other benefits to making these changes. Click here to read more.

Richard Willson, Huffington-Woestemeyer Professor of chemical and biomolecular engineering at the University of Houston

Richard Willson (center) and his team are working to develop a mix-and-read antibody measurement system that uses fluorescent materials to determine the amount of antibody present in a sample. Photo via UH.edu

An engineering project at the University of Houston has been selected to join a $10 million effort to bring biopharmaceutical manufacturing into the future. The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) chose the lab of Richard Willson, Huffington-Woestemeyer Professor of chemical and biomolecular engineering at UH, as one of eight development projects that it will fund.

Willson and his team are working to develop a mix-and-read antibody measurement system that uses fluorescent materials to determine the amount of antibody present in a sample. The funding for this project is $200,000. This is the first grant UH has received from NIIMBL.

“In the course of the manufacturing processes, it's important to know the concentration of antibody in your sample and this measurement needs to be made many times in a typical manufacturing process,” said Willson in a press release. In the realm of fluorescents, he is also working to pioneer the use of glow sticks to detect biothreats for the U.S. Navy. His discoveries include a fluorescent material that emits one color of light when excited with another color of light. Click here to read more.

Jon Lambert, CEO of The Cannon, joins the Houston Innovators Podcast to discuss the growth of The Cannon, including its newest location. Photo courtesy of The Cannon

How this community-focused coworking concept plans to continue growth around Houston and beyond

HOUSTON INNOVATORS PODCAST EPISODE 235

"Our measurement of success is not the buildings we have or the occupancy even — it's what's the success of the companies that are part of the community," he continues.

Lambert shares more about The Cannon's community-focused growth by giving Fulshear as an example. The new community west of Houston isn't currently working on developing a coworking facility yet, but from a programming and digital perspective, The Cannon has established a presence.

"The first phase of the project is to just mobilize the startup and early-stage business community in Fulshear and see what kind of energy and vibe we can create there and connect them to The Cannon's resources and community," Lambert says. "That's our big-picture vision. We can build a new node of community — through a new real estate opportunity, economic development or university relationship — that's beneficial in itself, but that node gets connected to everything else."

With a recent acquisition, The Cannon has further grown its ability to engage its communities digitally. In February, Village Insights, a community management platform, was acquired by The Cannon, onboarding its core employees and further integrating the platform it was already using.

When it comes to its next expansion, The Cannon has a lot of opportunity both around and beyond Houston, Lambert says.

"Any direction is an opportunity and possibility," he says. "I would project that by the end of the year, we'll probably be having another conversation about what The Cannon's doing in other cities as well — for the benefit of The Cannon Community in Houston."

Introducing — The Cannon Memorial, which is opening its doors on Monday, May 13. Photo courtesy of The Cannon

Photos: The Cannon announces opening of newest location in Memorial

ready to cowork

The Cannon is gearing up to open its latest location featuring coworking and community events and programming.

The coworking concept, which announced The Cannon Memorial earlier this year, will officially open the new location on Monday, May 13, with a full week of community-focused events. The new location was developed in partnership with MetroNational, the real estate developer behind 300-acre mixed-use development in West Houston.

“MetroNational has long been recognized for offering exceptionally located, high quality, well amenitized office space,” says Anne Marie Ratliff, vice president of Asset Management at MetroNational, in a news release. “The Cannon Memorial diversifies our existing office portfolio to provide flexible space solutions for the evolving needs of the business community.”

The Cannon Memorial has 39 furnished offices, flex user space, dedicated seating, lockable storage, a fully stocked kitchen with complimentary coffee, and five bookable meeting rooms. Members will also receive 24/7-access to the facilities and free parking in the attached garage.

Beginning May 13 and running through May 17, potential members can try out the coworking space for free, as well as attend daily events:

Monday, May 13: Coffee & Community (2 to 3 pm)
Tuesday, May 14: Community Lunch (11:30 am to 12:30 pm)
Wednesday, May 15: Open House and Happy Hour (4 – 6 pm)
Thursday, May 16: Therapeutic Thursday with 15-minute massages (noon to 2 pm)
Friday, May 17: Cowboy Breakfast (9 to 10 am)

"As we open the doors to our next innovation focused workspace, we couldn't be more thrilled to share this moment with our community," says Jon Lambert, CEO of The Cannon. "This week marks not just the inauguration of a new physical space, but the realization of a shared vision and the culmination of an exceptional partnership with our partners at MetroNational. More than just a space, The Cannon Memorial will be an environment where innovation thrives.”

The Cannon Memorial has 39 furnished offices.

Photo courtesy of The Cannon

With seven locations across the Houston area, The Cannon's digital technology allows its members a streamlined connection. Photo courtesy of The Cannon

Houston coworking company acquires digital community platform

M&A moves

After collaborating over the years, The Cannon has acquired a Houston startup's digital platform technology to become a "physical-digital hybrid" community.

Village Insights, a Houston startup, worked with The Cannon to create and launch its digital community platform Cannon Connect. Now, The Cannon has officially acquired the business. The terms of the deal were not disclosed.

“The combined commitment to support innovation communities—large and small—is evident,” Andrew Ramirez, who served as CEO for Village Insights ahead of the acquisition, says in a news release. “Village Insights and The Cannon merged to align efforts and cultivate local, regional and global innovation communities. Combining our value propositions represents a significant leap forward for the populations that we serve.”

With seven locations across the Houston area, The Cannon's digital technology allows its members a streamlined connection.

“The Cannon’s hub network stretches from The Woodlands to Galveston and across the 13-county region, with a membership base of more than 900 companies and 3,000 employees,” Jon Lambert, CEO of The Cannon, adds. “The digital extension of our physical footprint brings comprehensive innovation and business development support to communities that need it the most. Cannon Connect’s virtual- connection capabilities stand to remarkably expand our universe of ecosystem opportunities.”

Village Insights was founded in 2020. According to the release, the acquisition began in December, and members of the Village Insights core leadership team have rolled onto new roles at The Cannon.

“The integration of a world-class onsite member experience and Cannon Connect’s superior virtual resource network creates a seamless, streamlined environment for member organizations,” Clemmie Martin, The Cannon’s newly appointed chief of staff, says in the release. “Cannon Connect and this acquisition have paved new pathways to access and success for all.”

The Cannon is opening a new location just down the road from its headquarters. Photo courtesy of The Cannon

Houston coworking concept expands with new location

coming soon

The Cannon has announced its latest coworking location, and it's not too far from where the company's original facility launched.

The Cannon Memorial is expected to open this spring in Two Memorial City Plaza (820 Gessner) within MetroNational's Memorial City, a 265-acre planned development in west Houston. The coworking concept will take up one floor with 21,960 square feet of space.

"We are delighted to unveil The Cannon Memorial as a pivotal addition to Houston's dynamic business landscape," Jon Lambert, CEO of The Cannon, says in a news release. "Our expansion into Two Memorial City Plaza aligns seamlessly with our mission to cultivate innovation, collaboration, and success within the business community. We eagerly anticipate welcoming entrepreneurs and professionals to experience the unparalleled environment we've created."

The new location is less than three miles from The Cannon West Houston (1334 Brittmoore Rd) and will feature:

38 private office spaces
accomodations for over 60 flex users
24/7 access for members
free covered parking in the attached garage
programmed events, workshops, and networking sessions

“MetroNational is thrilled that The Cannon Memorial is opening and is another exciting milestone in our continued commitment to constantly elevate and enhance the services and experiences at Memorial City,” Anne Marie Ratliff, vice president of Asset Management at MetroNational, says in the release. “This partnership represents not just a collaboration but a testament to our dedication to staying at the forefront of innovation.”

The Cannon — founded in 2017 by Lawson Gow, the son of David Gow, founder of InnovationMap's parent company, Gow Media — has a presence in seven of Houston's regions, including west Houston, downtown, uptown, Fish Creek, The Woodlands, Pearland, and Galveston.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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