This Houston medical device innovator plans to lead a 'paradigm shift' in vascular surgery

HOUSTON INNOVATORS PODCAST EPISODE 199

Tim Boire, CEO and co-founder of VenoStent, shares his company's roadmap on this week's episode of the Houston Innovators Podcast. Photo via LinkedIn

Commercializing a health tech innovation is a long game — fraught with regulatory obstacles, cyclical rounds of funding, and continuous improvement — all fueled by the desire to enhance treatment and save lives.

That's Tim Boire's plan. And it's a thorough one at that. On this week's episode of the Houston Innovators Podcast, Boire — president and CEO of VenoStent, a medical device startup that’s designing a unique material for hemodialysis patients — shares his roadmap for his company.

"We believe we can be pioneers of a paradigm shift in vascular surgery — to not just treat problems after they've already occurred, but actually prevent them from occurring in the first place," he says in the episode.

VenoStent's most recent hurdle cleared is closing a $16 million series A round of venture funding. Two Charleston, South Carolina-based firms — Good Growth Capital and IAG Capital Partners — led the round. The TMC Venture Fund also contributed.

Now, VenoStent is headed for a 200-patient trial in the United States, with an ultimate goal of product launch in 2026. The company's unique medical device is a bioabsorbable wrap that reduces vein collapse by providing mechanical support and promoting outward vein growth.

Boire had the idea for VenoStend when he was completing his PhD at Vanderbilt University. He completed the program, and then joined the HealthWildcatters accelerator in 2017 in Dallas. After that, Boire and his co-founder, Geoff Lucks, decided to take the leap and move to Houston to join JLABS at TMC. The rest, as they say, is history.

“Houston’s been a great place to hire,” Boire says. “We've been I think very fortunate to find our employees who are stellar, true believers in the technology — amazing engineers, and amazing people.”

And, of course, Boire has a plan to continue this hiring success. He says the goal is to grow to a team of 16 by the end of the year. Marketing and sales roles will likely be filled in 2025 ahead of product launch.

“When we think about what our mission is at VenoStent, it’s to ultimately improve patient care — and we are very passionate about this specific problem that patients experience and go through,” Boire says.

“That's what drives everything we're doing as a company to improve quality and length of life for patients who have chronic kidney disease that progresses to a point where they need dialysis to sustain life," he continues. "We believe that we can become the standard care for vascular surgery starting with hemodialysis access."

As VenoStent's trials and growth goes according to plan, Boire says this product can be used for other implications.

Boire shares more on his grand plan, plus how he weathered the storm that is fundraising at a time where so much venture capital activity has slowed. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

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7 Hills Pharma, an innovative immunotherapy company, was awarded a $13.5 million grant from the Cancer Prevention and Research Institute of Texas. Photo via Getty Images

Houston immunotherapy company to use $13.5M grant to further develop cancer treatments

future of pharma

Between Bangalore and Chennai in the Indian state of Andhra Pradesh, you’ll find the town of Tirupati. It’s home to seven peaks that host a Hindu temple complex devoted to a form of Vishnu, Venkateshvara. It is also the region from which Upendra Marathi originally hails. It’s where his father, and many other family members, attended medical school.

“My father’s first job was to take care of the pilgrims,” recalls Marathi.

It's only natural that his groundbreaking Houston company would be named 7 Hills Pharma.

“That sort of selflessness and giving back, I wanted to embody it in the name of the company,” Marathi says.

Now, 7 Hills Pharma is announcing that last month, it was awarded a $13.5 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT). That’s on top of more than $13 million in NIH grants, making the company the second largest recipient of SBIR/STTR grants in Texas.

Launched in 2016, 7 Hills Pharma is working to develop drugs that can overcome the all-too-common problem of immunotherapy resistance. Thanks to the Nobel Prize-winning work of Jim Allison in the realm of immuno-oncology, the field was “very hot” at the time, says Marathi, particularly in Houston.

So what has 7 Hills developed? Oral small molecules that activate integrins — the receptors that allow cells to bind to one another — allowing for the cell-to-cell interactions that create a successful immune response to immune checkpoint inhibitors such as Yervoy. In other words, they have created capsules that increase the effectiveness of drugs that allow the body’s own immune response to fight cancers.

But that’s not all. Tests have shown that the same discovery, called alintegimod, can also augment the effectiveness of vaccines. The pill, which co-founder and co-inventor Peter Vanderslice calls “a beautiful way to amplify the vaccines,” can potentially be applied to anything from influenza to coronavirus.

Their greatest challenge, says Vanderslice, is the very fact that the technology is so novel.

“Most large pharmas are very risk averse,” he explains. “They only want to do ‘me-too’ kinds of drugs.”

7 Hills Pharma is the third company Marathi, both a PhD and an MBA, has helped to found based on technology he co-invented. Vanderslice is director of the molecular cardiology research laboratories at The Texas Heart Institute.

“It’s very much a homegrown company,” Marathi says.

And a small one, at least for now. Working out of JLabs@TMC, the full-time team is currently just Marathi and Siddhartha De, the senior director of development. Marathi convinced De to transplant himself and his family from India for the purpose of assisting 7 Hills with preparing its drugs for clinical readiness.

The CPRIT funds will allow 7 Hills Pharma to hire several long-time team members full-time and with benefits.

“The bringing of talent and bringing of technology to TMC and what was born at Texas Heart Institute is rather remarkable,” says Rob Bent, the company’s director of operations.

The next step for 7 Hills Pharma is a Phase Ib/IIa clinical trial in patients with treatment-resistant solid tumors. And the team just finalized the deck that will help raise another $10 million to $250 million in the company’s series A. And hopefully sooner rather than later, a new set of medical pilgrims will be thanking 7 Hill Pharma for its care.

It's a busy month in Houston. Luis Alvarez/Getty Images

10+ can't-miss Houston business and innovation events for March

Where to be

Editor's note: SXSW has been canceled due to the coronavirus since the publishing on this events roundup. The original version of this article is below.

March is a busy month for Houston in general — but especially when it comes to innovation. The inaugural Houston Tech Rodeo starts out the month and the Rice Business Plan Competition closes out March in a few weeks — and the interactive weekend at SXSW falls right in the middle of the month for those planning the trip to Austin.

But for the Houston innovators in the energy industry, March got a little less busy when CERAWeek by IHS Markit was canceled due to the growing threat of the coronavirus, or COVID19.

Should any other events below have that same fate, this article will be updated.

March 2-6 — Houston Tech Rodeo

A week full of events, the Tech Rodeo is made up of over 30 innovation events across Houston. These are InnovationMap's picks for what to attend during the week. For a complete list of the events (most of which are free), head to the website.

Details: The event is from Monday, March 2, to Friday, March 6 across Houston. Learn more.

March 5 — Space Center Houston's Thought Leader Series: Designing for Human Performance

Learn how human factors engineering relates to spacecraft and spacesuit design while celebrating Women's History Month and the 20th anniversary of the International Space Station. Speakers include Celena Dopart, human factors engineer for Starliner at Boeing, and Katie Spira, NASA flight controller.

Details: The event is at 7 pm on Thursday, March 5, at Space Center Houston (1601 E NASA Pkwy). Learn more.

March 6 — Premier Talks: Women in Innovation & Technology 

Join this panel of accomplished women as they discuss the importance of being a woman in the current workforce and leading among your peers. Be empowered to self-evaluate, inspire those around you, and raise the bar on your professional goals. Discuss the challenges women face in a male dominated technology workforce and why it is important to take the limits off of your thinking.

Details: The event is from 9:15 to 11 am on Friday, March 6, at GA Houston (1301 Fannin St, Floor 21). Learn more.

March 6 — The Greater Houston Partnership’s Rise to the Top

Celebrating International Women's Day, the Greater Houston Partnership and the Partnership's Women's Business Alliance brings the Rise to the Top event. Expect a keynote address from Gretchen Watkins, president atShell Oil Company and executive vice president at Global Unconventionals, Shell Oil Company, and candid conversations from a panel of female executives discussing the challenges and triumphs of succeeding as a woman in today's business environment.

Details: The event is from 10:30 am to 1:30 pm on Friday, March 6, at Hilton Americas (1600 Lamar St.). Learn more.

March 10 — Equinor & Techstars Energy Accelerator Meet & Greet

If you're an energy-focused startup, don't miss this info session with the Equinor & Techstars Energy Accelerator, which is visiting Houston and looking for the 10 best energy companies for its next cohort.

Details: The event is from 6 to 9 pm on Monday, March 10, at The Ion (1301 Fannin Street, Suite 2440). Learn more.

March 10-11 — Energy 2.0: Equality, Environment, and the New Economy

Join over 100,000 people taking part in Energy 2.0 2020; an innovative experience that addresses new frontiers in the energy industry where business, workforce, environment, innovation, and policy intersect. Spread across multiple locations and continents, corporate watch sites around the globe, and simulcast online, Energy 2.0 brings energy professionals and a diverse mix of experts across various disciplines together for learning and networking opportunities.

Details: The event is from Monday, March 10, to Tuesday, March 11, online and at The Westin Houston, Memorial City (945 Gessner Rd.). Learn more.

March 12 — Lunch n' Learn: In Today's Market - Do Patents Even Matter?

Inventors and business professionals are asked to review the claims of their patent application before it is filed. This step is THE critical step that is supposed to ensure that the claims will protect their invention. The decision you make here determines if you will be part of the 97 percent of all patents that never recoup the cost of filing them.

Details: The event is from noon to 1:30 pm on Wednesday, March 12, at The Ion (1301 Fannin Street, Suite 2440). Learn more.

March 19 — Science First: How 3D Printing is Reshaping the Future of Healthcare

Technology is evolving faster than ever – and advancements in 3D printing could revolutionize the delivery of healthcare products and solutions to change the trajectory of health for humanity.

Details: The event is from 11:30 am to 2 pm on Wednesday, March 19, at JLABS @ TMC (2450 Holcombe Blvd.). Learn more.

March 24 — How to Form a Micro VC Fund Workshop at Mercury Fund

Welcoming all angels, previous founders, MBA students, aspiring and current venture capitalists that are interested in learning more about the basic essentials for starting a small venture fund. Speakers are Blair Garrou of Mercury Fund and Justin LaPoten of BADR Investments.

Details: The event is from 10 to 11 am on Tuesday, March 24, at Mercury Fund (3737 Buffalo Speedway, #Suite 1750). Learn more.

March 25 — 2020 H. Albert Napier Rice Launch Challenge - Startup Competition

The H. Albert Napier Rice Launch Challenge Startup Competition is Rice's newest entrepreneurship competition, awarding over $60,000 in prize money to Rice-affiliated teams. Students and alumni enter business ideas (high growth ventures or small business ideas) to compete.

Details: The event is from 6 to 9 pm on Wednesday, March 25, at Liu Idea Lab For Innovation & Entrepreneurship (Rice University - Cambridge Office Building). Learn more.

March 26 — T3CH Workshop: Grow With Google "Using Data to Drive Business Growth"

In this T3CH workshop, you'll learn best practices on data-driven decision making; and get practical guidance on how to find and analyze trends regarding online customer engagement with your business, so you can turn those insights into well-informed, actionable decisions.

Details: The event is from noon to 1 pm on Thursday, March 26, at Impact Hub Houston @ The Cannon Post Oak (675 Bering Drive, #200). Learn more.

March 26-28 — Rice Business Plan Competition

The event — dubbed the "world's richest and largest student startup competition" — begins later this month. The Rice Business Plan Competition will host 42 student teams from all over the world. The three-day contest consists of pitches, judging, and a closing banquet where the winners are revealed.

Details: The event is from Thursday, March 26, to Saturday, March 28, at Rice University and the Hilton Americas. Learn more.

Check out these panels, networking meetups, and more. Getty Images

10+ can't-miss Houston business and innovation events for February

Where to be

Despite the short month, Houston will play host to tons of innovation networking, panel, and meetup events throughout the month of February. And, it's a leap year, so take that as an opportunity to jump into the startup ecosystim in town.

If you know of innovation-focused events for this month or next, email me at natalie@innovationmap.com with the details and subscribe to our daily newsletter that sends fresh stories straight to your inboxes every morning.

February 4 — How AI Can Boost Your Business with Ryan Shirzadi of Tekrevol

How can artificial intelligence help grow your business? Specifically, Ryan Shirzadi of Tekrevol will be covering the social impacts, industries affected, why you need an AI strategy, and how AI can help small businesses grow. Networking will follow the discussion and pizza will be provided by Tekrevol.

Details: The event is from 6 to 7:30 pm on Tuesday, February 4, at Station Houston (1301 Fannin Street, Suite 2440). Learn more.

February 5 — Meet and Greet with Pat Matthews, CEO & Founder of Active Capital

Meet Active Capital's founder and CEO, Pat Matthews. Rakesh Agrawal, founder and CEO of Snapstream, will interview Matthews followed up by an open Q&A and conversation with the audience.

Details: The event is from 5:30 to 6:45 pm on Wednesday, February 5, at WeWork (708 Main Street, 3rd Floor). Learn more.

February 5 — Houston Social Entrepreneurship Meetup

The meetup brings together like-minded individuals from the nonprofit, social enterprise, impact investing, technology and many other fields to understand the concept of social entrepreneurship and be inspired to find new ways to tackle local social issues. At each meetup, you'll get an intro to social entrepreneurship, hear from a social entrepreneur in Houston, and network with other changemakers from across the entrepreneur ecosystem.

Details: The event is from 5:30 to 7:30 pm on Wednesday, February 5, at Impact Hub Houston @ The Cannon Downtown (1801 Main St., 13th Floor). Learn more.

February 6 — Fail Forward presented by Frost Bank

Join BakerRipley and Frost Bank for an evening of #FailForward fun and get real, behind-the-scenes stories straight from entrepreneurs on the challenges they faced trying to access and raise funding for their small business or startups.

Details: The event is from 6 to 8 pm on Thursday, February 6, at BakerRipley Center (4450 Harrisburg Blvd.). Learn more.

February 12 — The Impact of AI on Automation and the Future of the Workforce

Technology and innovation are rapidly changing how we do and think about work. This panel event seeks to bring together respected leaders in the corporate and entrepreneurial worlds to have meaningful conversations on AI, automation and the future of workforce.

Details: The event is from 6:30 to 9 pm on Wednesday, February 12, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 13 — Female Founders Breakfast with Baker Botts and The Artemis Fund

Baker Botts L.L.P. and The Artemis Fund have come together to bring you a breakfast panel discussion on how a good corporate governance system and a little corporate housekeeping can avoid larger messes down the road.

Details: The event is from 8:30 to 10:30 am on Thursday, February 13, at Baker Botts (910 Louisiana St., 32nd Floor). Learn more.

February 18 — How She Got There: Women Leaders in Tech

Join General Assembly for an evening good conversation with a panel of females in tech. These inspirational women will share their stories on how they got to where they are today and share their insights into being a woman in business and tech.

Details: The event is from 6:30 to 9 pm on Tuesday, February 18, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 19 — Houston Angel Summit

Join the Houston Angel Network for its bi-annual summit. Attendees will learn the basics of angel investing as well as hear from experts on the topics of term sheets and tax implication of early stage investing. This event is open to accredited investors, HAN members and individuals from our partnership organizations. The price of attendance — $100 — will be applied to annual membership if attendees decide to join the Houston Angel Network.

Details: The event is from 9 am to 3 pm on Wednesday, February 19, at Liu Idea Lab for Innovation and Entrepreneurship (Cambridge Building at Rice University). Learn more.

February 20 — The Five W's of Holding Your First, First-in-Human Trial

Who, what, when, where and why to hold your first, first-in-human clinical trial? JLABS has tapped into experts in the field from Johnson & Johnson, CROs and agencies to help you answer these questions and more.

Details: The event is from 11:30 am to 2 pm on Thursday, February 20, at JLABS @ TMC (2450 Holcombe Blvd.). Learn more.

February 20 — Bunker Brews Houston: How to be Mentored in Your Business

Lots of entrepreneurs fail to seek out mentors, and struggle in silence and isolation because of it. Some will find great mentors, but fail to recognize the unspoken rules of the road to acquire, activate, and maintain a mentor-mentee relationship. Hear from some great local mentors of business owners.

Details: The event is from 6 to 8 pm on Thursday, February 20, at MassChallenge (1313 Main St., Suite 210). Learn more.

February 20 — Rising Stars in Houston Health Tech

Join General Assembly for an epic night with some of the Houston's most inspiring healthtech founders and leaders. In a candid discussion, they'll share their stories and insights.

Details: The event is from 6:30 to 9 pm on Thursday, February 20, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 24 — Made in Houston: Celebrating Black History Month

In honor of Black History Month, General Assembly has organized an evening with some of Houston's legendary innovators and creators. Each speaker will share their tips and tricks on how to create a unique product, service or brand that's pushing the boundaries while sharing their journey.

Details: The event is from 6:30 to 9 pm on Monday, February 24, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 25 — The Cannon Lunch & Learn: Show me the Money

As an early stage company, raising capital is or will be a significant part of your efforts and can present major challenges. Preparation and an understanding of what drives value is crucial to attracting investors. Join Cannon partner, Baker Tilly, as they provide an overview of the capital raise process and highlight key factors to consider when preparing to raise capital.

Details: The event is from 11:30 am to 1 pm on Tuesday, February 25, at The Cannon (1334 Brittmoore Road). Learn more.

Vivante Health, which uses technology and at-home testing to help users treat chronic digestive health issues, has raised $5.8 million. Getty Images

Digital health startup based in Houston closes $5.8 million round

Money moves

A Houston health technology startup that uses digital solutions and on-demand support to help its users with digestive health has closed a Series A round of funding.

Vivante Health raised $5.8 million in a series A1 round, according to a news release. The round was led by California-based Lifeforce Capital and Athens, Greece-based Big Pi Ventures. Additionally, NFP Ventures, FCA Venture Partners, and Longmont Capital contributed to the round.

"We knew we were onto something when the market responded so positively," says Dr. Kimon Angelides, Vivante Health founder and CEO, in the release, "but support from esteemed, experienced and successful firms like Lifeforce and Big Pi, and the continued strong support from our initial investor partners, give us a very encouraging boost of confidence as we carry out our vision and further develop the GIThrive platform."

With the fresh funds, Vivante will continue to develop its GI health platform, GIThrive. The digital tool has an at-home microbiome test kit for users, as well as a breath tester that monitors food sensitivities. GIThrive also connects users to on-demand support from nutritionists and experts on the GIThrive app.

The startup's Houston headquarters is based out of the Johnson & Johnson Innovation Center, JLabs@TMC, but has offices in Nashville, Chicago, and Athens. Angelides, who honors his Greek heritage by spending a fair about of time in Greece, says in the release how important the Big Pi investment is for him.

"This partnership with Big Pi, a tech-based investment firm who's driven by the desire to support Greek talent, makes perfect sense. What's more, we have partnered with a team who themselves have been very successful entrepreneurs," says Angelides in the release.

Angelides, who has founded three other health tech companies, impressed Big Pi with his entrepreneurial track record and nationwide team

"This is one of those rare investments where the financial upside goes hand in hand with the prospect of radically improving the lives of millions of people across the globe," says Marco Veremis, investment partner with Big Pi, in the release.

Lifeforce Capital has a portfolio of software startups, including Aspire, Cricket Health, Notable Labs, One Medical, and Second Genome, per the news release, and the VC firm is excited for their new addition.

"We were immediately struck by Kim's entrepreneurial passion and big vision," says Sander Duncan, general partner with Lifeforce Capital, in the release. "We are thrilled to work with the Vivante team to build the first platform tackling digestive disease for millions of suffering patients."

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Meet 6 mentors who are helping the Houston startup scene flourish

meet the finalists

Few founders launch successful startups alone — experienced and insightful mentors often play an integral role in helping the business and its founders thrive.

The Houston startup community is home to many mentors who are willing to lend an ear and share advice to help entrepreneurs meet their goals.

The Mentor of the Year category in our 2025 Houston Innovation Awards will honor an individual like this, who dedicates their time and expertise to guide and support budding entrepreneurs. The award is presented by Houston City College Northwest.

Below, meet the six finalists for the 2025 award. They support promising startups in the medical tech, digital health, clean energy and hardware sectors.

Then, join us at the Houston Innovation Awards this Thursday, Nov. 13 at Greentown Labs, when the winner will be unveiled. The event is just days away, so secure your seats now.

Anil Shetty, InformAI

Anil Shetty serves as president and chief medical officer for biotech company Ferronova and chief innovation officer for InformAI. He's mentored numerous medical device and digital health companies at seed or Series A, including Pathex, Neurostasis, Vivifi Medical and many others. He mentors through organizations like Capital Factory, TMC Biodesign, UT Venture Mentoring, UTMB Innovation and Rice's Global Medical Innovation program.

"Being a mentor means empowering early-stage innovators to shape, test, and refine their ideas with clarity and purpose," Shetty says. "I’m driven by the opportunity to help them think strategically and pivot early before resources are wasted. At this critical stage, most founders lack the financial means to bring on seasoned experts and often haven’t yet gained real-world exposure. Mentorship allows me to fill that gap, offering guidance that accelerates their learning curve and increases the chances of meaningful, sustainable impact."

Jason Ethier, EnergyTech Nexus

Jason Ethier is the founding partner of EnergyTech Nexus, through which he has mentored numerous startups and Innovation Awards finalists, including Geokiln, Energy AI Solutions, Capwell Services and Corrolytics. He founded Dynamo Micropower in 2011 and served as its president and CEO. He later co-founded Greentown Labs in Massachusetts and helped bring the accelerator to Houston.

"Being a mentor means using my experience to help founders see a clearer path to success. I’ve spent years navigating the ups and downs of building companies, struggling with cash flow, and making all the mistakes; mentoring gives me the chance to share those lessons and show entrepreneurs the shortcuts I wish I’d known earlier," Ethier says. "At Energytech Nexus, that role goes beyond just helping individual founders — it’s about creating a flywheel effect for Houston’s entire innovation ecosystem."

Jeremy Pitts, Activate Houston

Jeremy Pitts serves as managing director of Activate Houston, which launched in Houston last year. He was one of the founders of Greentown Labs in the Boston area and served in a leadership role for the organization between 2011 and 2015. Through Activate, he has mentored numerous impactful startups and Innovation Awards finalists, including Solidec, Coflux Purification, Bairitone Health, Newfound Materials, Deep Anchor Solutions and others.

"Being a mentor to me is very much about supporting the person in whatever they need. Oftentimes that means supporting the business—providing guidance and advice, feedback, introductions, etc," But just as important is recognizing the person and helping them with whatever challenges they are going through ... Sometimes they need a hype man to tell them how awesome they are and that they can go do whatever hard thing they need to do. Sometimes they just need an empathetic listener who can relate to how hard these things are. Being there for the person and supporting them on their journey is key to my mentorship style."

Joe Alapat, Liongard

Joe Alapat founded and serves as chief strategy officer at Houston software company Liongard and chief information officer at Empact IT, which he also owns. He mentors through Founder Fridays Houston Group, Software Day by Mercury Fund, SUPERGirls SHINE Foundation, Cup of Joey and at the Ion. He's worked with founders of FlowCare, STEAM OnDemand, Lokum and many other early stage startups.

"Being a mentor to me means unleashing an individual’s 10x—their purpose, their ikigai (a Japanese concept that speaks to a person’s reason for being)," Alapat says. "Mentoring founders in the Houston community of early stage, high-growth startups is an honor for me. I get to live vicariously through a founder’s vision of the future. Once they show me that compelling vision, I’m drawn to bring the future forward with them so the vision becomes reality with a sense of urgency."

Neal Dikeman, Energy Transition Ventures

Neal Dikeman serves as partner at early stage venture fund Energy Transition Ventures, executive in residence at Greentown Labs, and offices in and supports Rice Nexus at the Ion. He mentors startups, like Geokiln, personally. He also mentored Helix Earth through Greentown Labs. The company went on to win in the Smart Cities, Transportation & Sustainability contest at SXSW earlier this year. Dikeman has helped launch several successful startups himself, most recently serving on the board of directors for Resilient Power Systems, which was acquired by Eaton Corp for $150 million.

"Founders have to find their own path, and most founders need a safe space where they can discuss hard truths outside of being 'on' in sales mode with their team or board or investors, to let them be able to work on their business, not just in it," Dikeman says.

Nisha Desai, Intention

Nisha Desai serves as CEO of investment firm Intention and mentors through Greentown Labs, TEX-E, Open Minds, the Rice Alliance Clean Energy Accelerator, Avatar Innovations and The Greenhouse. She currently works with founders from Solidec, Deep Anchor Solutions, CLS Wind and several other local startups, several of which have been nominated for Innovation Awards this year. She's served a board member for Greentown Labs since 2021.

"When I first started mentoring, I viewed my role as someone who was supposed to prevent the founder from making bad decisions. Now, I see my role as a mentor as enabling the founder to develop their own decision-making capability," Desai says. "Sometimes that means giving them the space to make decisions that might be good, that might be bad, but that they can be accountable for. At the end of the day, being a mentor is like being granted a place on the founder's leadership development journey, and it's a privilege I'm grateful for."

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The Houston Innovation Awards program is sponsored by Houston City College Northwest, Houston Powder Coaters, FLIGHT by Yuengling, and more to be announced soon. For sponsorship opportunities, please contact sales@innovationmap.com.

Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”

Autonomous truck company with Houston routes goes public

on a roll

Kodiak Robotics, a provider of AI-powered autonomous vehicle technology, has gone public through a SPAC merger and has rebranded as Kodiak AI. The company operates trucking routes to and from Houston, which has served as a launchpad for the business.

Privately held Kodiak, founded in 2018, merged with a special purpose acquisition company — publicly held Ares Acquisition Corp. II — to form Kodiak AI, whose stock now trades on the Nasdaq market.

In September, Mountain View, California-based Kodiak and New York City-based Ares disclosed a $145 million PIPE (private investment in public equity) investment from institutional investors to support the business combo. Since announcing the SPAC deal, more than $220 million has been raised for the new Kodiak.

“We believe these additional investments underscore our investors’ confidence in the value proposition of Kodiak’s safe and commercially deployed autonomous technology,” Don Burnette, founder and CEO of Kodiak, said in a news release.

“We look forward to leading the advancement of the commercial trucking and public sector industries,” he added, “and delivering on the exciting value creation opportunities ahead to the benefit of customers and shareholders.”

Last December, Kodiak debuted a facility near George Bush Intercontinental/Houston Airport for loading and loading driverless trucks. Transportation and logistics company Ryder operates the “truckport” for Ryder.

The facility serves freight routes to and from Houston, Dallas and Oklahoma City. Kodiak’s trucks currently operate with or without drivers. Kodiak’s inaugural route launched in 2024 between Houston and Dallas.

One of the companies using Kodiak’s technology is Austin-based Atlas Energy Solutions, which owns and operates four driverless trucks equipped with Kodiak’s driver-as-a-service technology. The trucks pick up fracking sand from Atlas’ Dune Express, a 42-mile conveyor system that carries sand from Atlas’ mine to sites near customers’ oil wells in the Permian Basin.

Altogether, Atlas has ordered 100 trucks that will run on Kodiak’s autonomous technology in an effort to automate Atlas’ supply chain.

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