Wellysis is known for its continuous ECG/EKG monitor with AI reporting, known as the S-Patch. Photo via wellysis.com.

Wellysis, a Seoul, South Korea-headquartered wearable biosensing company with its U.S. subsidiary based in Houston, has closed a $13.5 million pre-IPO funding round and plans to expand its Texas operations.

The round was led by Korea Investment Partners, Kyobo Life Insurance, Kyobo Securities, Kolon Investment and a co-general partner fund backed by SBI Investment and Samsung Securities, according to a news release.

Wellysis reports that the latest round brings its total capital raised to about $30 million. The company is working toward a Korea Securities Dealers Automated Quotations listing in Q4 2026 or Q1 2027.

Wellysis is known for its continuous ECG/EKG monitor with AI reporting. Its lightweight and waterproof S-Patch cardiac monitor is designed for extended testing periods of up to 14 days on a single battery charge.

The company says that the funding will go toward commercializing the next generation of the S-Patch, known as the S-Patch MX, which will be able to capture more than 30 biometric signals, including ECG, temperature and body composition.

Wellysis also reports that it will use the funding to expand its Houston-based operations, specifically in its commercial, clinical and customer success teams.

Additionally, the company plans to accelerate the product development of two other biometric products:

  • CardioAI, an AI-powered diagnostic software platform designed to support clinical interpretation, workflow efficiency and scalable cardiac analysis
  • BioArmour, a non-medical biometric monitoring solution for the sports, public safety and defense sectors

“This pre-IPO round validates both our technology and our readiness to scale globally,” Young Juhn, CEO of Wellysis, said in the release. “With FDA-cleared solutions, expanding U.S. operations, and a strong AI roadmap, Wellysis is positioned to redefine how cardiac data is captured, interpreted, and acted upon across healthcare systems worldwide.”

Wellysis was founded in 2019 as a spinoff of Samsung. Its S-Patch runs off of a Samsung Smart Health Processor. The company's U.S. subsidiary, Wellysis USA Inc., was established in Houston in 2023 and was a resident of JLABS@TMC.

Tim Boire, CEO and co-founder of VenoStent, shares his company's roadmap on this week's episode of the Houston Innovators Podcast. Photo via LinkedIn

This Houston medical device innovator plans to lead a 'paradigm shift' in vascular surgery

HOUSTON INNOVATORS PODCAST EPISODE 199

Commercializing a health tech innovation is a long game — fraught with regulatory obstacles, cyclical rounds of funding, and continuous improvement — all fueled by the desire to enhance treatment and save lives.

That's Tim Boire's plan. And it's a thorough one at that. On this week's episode of the Houston Innovators Podcast, Boire — president and CEO of VenoStent, a medical device startup that’s designing a unique material for hemodialysis patients — shares his roadmap for his company.

"We believe we can be pioneers of a paradigm shift in vascular surgery — to not just treat problems after they've already occurred, but actually prevent them from occurring in the first place," he says in the episode.

VenoStent's most recent hurdle cleared is closing a $16 million series A round of venture funding. Two Charleston, South Carolina-based firms — Good Growth Capital and IAG Capital Partners — led the round. The TMC Venture Fund also contributed.

Now, VenoStent is headed for a 200-patient trial in the United States, with an ultimate goal of product launch in 2026. The company's unique medical device is a bioabsorbable wrap that reduces vein collapse by providing mechanical support and promoting outward vein growth.

Boire had the idea for VenoStend when he was completing his PhD at Vanderbilt University. He completed the program, and then joined the HealthWildcatters accelerator in 2017 in Dallas. After that, Boire and his co-founder, Geoff Lucks, decided to take the leap and move to Houston to join JLABS at TMC. The rest, as they say, is history.

“Houston’s been a great place to hire,” Boire says. “We've been I think very fortunate to find our employees who are stellar, true believers in the technology — amazing engineers, and amazing people.”

And, of course, Boire has a plan to continue this hiring success. He says the goal is to grow to a team of 16 by the end of the year. Marketing and sales roles will likely be filled in 2025 ahead of product launch.

“When we think about what our mission is at VenoStent, it’s to ultimately improve patient care — and we are very passionate about this specific problem that patients experience and go through,” Boire says.

“That's what drives everything we're doing as a company to improve quality and length of life for patients who have chronic kidney disease that progresses to a point where they need dialysis to sustain life," he continues. "We believe that we can become the standard care for vascular surgery starting with hemodialysis access."

As VenoStent's trials and growth goes according to plan, Boire says this product can be used for other implications.

Boire shares more on his grand plan, plus how he weathered the storm that is fundraising at a time where so much venture capital activity has slowed. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

7 Hills Pharma, an innovative immunotherapy company, was awarded a $13.5 million grant from the Cancer Prevention and Research Institute of Texas. Photo via Getty Images

Houston immunotherapy company to use $13.5M grant to further develop cancer treatments

future of pharma

Between Bangalore and Chennai in the Indian state of Andhra Pradesh, you’ll find the town of Tirupati. It’s home to seven peaks that host a Hindu temple complex devoted to a form of Vishnu, Venkateshvara. It is also the region from which Upendra Marathi originally hails. It’s where his father, and many other family members, attended medical school.

“My father’s first job was to take care of the pilgrims,” recalls Marathi.

It's only natural that his groundbreaking Houston company would be named 7 Hills Pharma.

“That sort of selflessness and giving back, I wanted to embody it in the name of the company,” Marathi says.

Now, 7 Hills Pharma is announcing that last month, it was awarded a $13.5 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT). That’s on top of more than $13 million in NIH grants, making the company the second largest recipient of SBIR/STTR grants in Texas.

Launched in 2016, 7 Hills Pharma is working to develop drugs that can overcome the all-too-common problem of immunotherapy resistance. Thanks to the Nobel Prize-winning work of Jim Allison in the realm of immuno-oncology, the field was “very hot” at the time, says Marathi, particularly in Houston.

So what has 7 Hills developed? Oral small molecules that activate integrins — the receptors that allow cells to bind to one another — allowing for the cell-to-cell interactions that create a successful immune response to immune checkpoint inhibitors such as Yervoy. In other words, they have created capsules that increase the effectiveness of drugs that allow the body’s own immune response to fight cancers.

But that’s not all. Tests have shown that the same discovery, called alintegimod, can also augment the effectiveness of vaccines. The pill, which co-founder and co-inventor Peter Vanderslice calls “a beautiful way to amplify the vaccines,” can potentially be applied to anything from influenza to coronavirus.

Their greatest challenge, says Vanderslice, is the very fact that the technology is so novel.

“Most large pharmas are very risk averse,” he explains. “They only want to do ‘me-too’ kinds of drugs.”

7 Hills Pharma is the third company Marathi, both a PhD and an MBA, has helped to found based on technology he co-invented. Vanderslice is director of the molecular cardiology research laboratories at The Texas Heart Institute.

“It’s very much a homegrown company,” Marathi says.

And a small one, at least for now. Working out of JLabs@TMC, the full-time team is currently just Marathi and Siddhartha De, the senior director of development. Marathi convinced De to transplant himself and his family from India for the purpose of assisting 7 Hills with preparing its drugs for clinical readiness.

The CPRIT funds will allow 7 Hills Pharma to hire several long-time team members full-time and with benefits.

“The bringing of talent and bringing of technology to TMC and what was born at Texas Heart Institute is rather remarkable,” says Rob Bent, the company’s director of operations.

The next step for 7 Hills Pharma is a Phase Ib/IIa clinical trial in patients with treatment-resistant solid tumors. And the team just finalized the deck that will help raise another $10 million to $250 million in the company’s series A. And hopefully sooner rather than later, a new set of medical pilgrims will be thanking 7 Hill Pharma for its care.

It's a busy month in Houston. Luis Alvarez/Getty Images

10+ can't-miss Houston business and innovation events for March

Where to be

Editor's note: SXSW has been canceled due to the coronavirus since the publishing on this events roundup. The original version of this article is below.

March is a busy month for Houston in general — but especially when it comes to innovation. The inaugural Houston Tech Rodeo starts out the month and the Rice Business Plan Competition closes out March in a few weeks — and the interactive weekend at SXSW falls right in the middle of the month for those planning the trip to Austin.

But for the Houston innovators in the energy industry, March got a little less busy when CERAWeek by IHS Markit was canceled due to the growing threat of the coronavirus, or COVID19.

Should any other events below have that same fate, this article will be updated.

March 2-6 — Houston Tech Rodeo

A week full of events, the Tech Rodeo is made up of over 30 innovation events across Houston. These are InnovationMap's picks for what to attend during the week. For a complete list of the events (most of which are free), head to the website.

Details: The event is from Monday, March 2, to Friday, March 6 across Houston. Learn more.

March 5 — Space Center Houston's Thought Leader Series: Designing for Human Performance

Learn how human factors engineering relates to spacecraft and spacesuit design while celebrating Women's History Month and the 20th anniversary of the International Space Station. Speakers include Celena Dopart, human factors engineer for Starliner at Boeing, and Katie Spira, NASA flight controller.

Details: The event is at 7 pm on Thursday, March 5, at Space Center Houston (1601 E NASA Pkwy). Learn more.

March 6 — Premier Talks: Women in Innovation & Technology 

Join this panel of accomplished women as they discuss the importance of being a woman in the current workforce and leading among your peers. Be empowered to self-evaluate, inspire those around you, and raise the bar on your professional goals. Discuss the challenges women face in a male dominated technology workforce and why it is important to take the limits off of your thinking.

Details: The event is from 9:15 to 11 am on Friday, March 6, at GA Houston (1301 Fannin St, Floor 21). Learn more.

March 6 — The Greater Houston Partnership’s Rise to the Top

Celebrating International Women's Day, the Greater Houston Partnership and the Partnership's Women's Business Alliance brings the Rise to the Top event. Expect a keynote address from Gretchen Watkins, president atShell Oil Company and executive vice president at Global Unconventionals, Shell Oil Company, and candid conversations from a panel of female executives discussing the challenges and triumphs of succeeding as a woman in today's business environment.

Details: The event is from 10:30 am to 1:30 pm on Friday, March 6, at Hilton Americas (1600 Lamar St.). Learn more.

March 10 — Equinor & Techstars Energy Accelerator Meet & Greet

If you're an energy-focused startup, don't miss this info session with the Equinor & Techstars Energy Accelerator, which is visiting Houston and looking for the 10 best energy companies for its next cohort.

Details: The event is from 6 to 9 pm on Monday, March 10, at The Ion (1301 Fannin Street, Suite 2440). Learn more.

March 10-11 — Energy 2.0: Equality, Environment, and the New Economy

Join over 100,000 people taking part in Energy 2.0 2020; an innovative experience that addresses new frontiers in the energy industry where business, workforce, environment, innovation, and policy intersect. Spread across multiple locations and continents, corporate watch sites around the globe, and simulcast online, Energy 2.0 brings energy professionals and a diverse mix of experts across various disciplines together for learning and networking opportunities.

Details: The event is from Monday, March 10, to Tuesday, March 11, online and at The Westin Houston, Memorial City (945 Gessner Rd.). Learn more.

March 12 — Lunch n' Learn: In Today's Market - Do Patents Even Matter?

Inventors and business professionals are asked to review the claims of their patent application before it is filed. This step is THE critical step that is supposed to ensure that the claims will protect their invention. The decision you make here determines if you will be part of the 97 percent of all patents that never recoup the cost of filing them.

Details: The event is from noon to 1:30 pm on Wednesday, March 12, at The Ion (1301 Fannin Street, Suite 2440). Learn more.

March 19 — Science First: How 3D Printing is Reshaping the Future of Healthcare

Technology is evolving faster than ever – and advancements in 3D printing could revolutionize the delivery of healthcare products and solutions to change the trajectory of health for humanity.

Details: The event is from 11:30 am to 2 pm on Wednesday, March 19, at JLABS @ TMC (2450 Holcombe Blvd.). Learn more.

March 24 — How to Form a Micro VC Fund Workshop at Mercury Fund

Welcoming all angels, previous founders, MBA students, aspiring and current venture capitalists that are interested in learning more about the basic essentials for starting a small venture fund. Speakers are Blair Garrou of Mercury Fund and Justin LaPoten of BADR Investments.

Details: The event is from 10 to 11 am on Tuesday, March 24, at Mercury Fund (3737 Buffalo Speedway, #Suite 1750). Learn more.

March 25 — 2020 H. Albert Napier Rice Launch Challenge - Startup Competition

The H. Albert Napier Rice Launch Challenge Startup Competition is Rice's newest entrepreneurship competition, awarding over $60,000 in prize money to Rice-affiliated teams. Students and alumni enter business ideas (high growth ventures or small business ideas) to compete.

Details: The event is from 6 to 9 pm on Wednesday, March 25, at Liu Idea Lab For Innovation & Entrepreneurship (Rice University - Cambridge Office Building). Learn more.

March 26 — T3CH Workshop: Grow With Google "Using Data to Drive Business Growth"

In this T3CH workshop, you'll learn best practices on data-driven decision making; and get practical guidance on how to find and analyze trends regarding online customer engagement with your business, so you can turn those insights into well-informed, actionable decisions.

Details: The event is from noon to 1 pm on Thursday, March 26, at Impact Hub Houston @ The Cannon Post Oak (675 Bering Drive, #200). Learn more.

March 26-28 — Rice Business Plan Competition

The event — dubbed the "world's richest and largest student startup competition" — begins later this month. The Rice Business Plan Competition will host 42 student teams from all over the world. The three-day contest consists of pitches, judging, and a closing banquet where the winners are revealed.

Details: The event is from Thursday, March 26, to Saturday, March 28, at Rice University and the Hilton Americas. Learn more.

Check out these panels, networking meetups, and more. Getty Images

10+ can't-miss Houston business and innovation events for February

Where to be

Despite the short month, Houston will play host to tons of innovation networking, panel, and meetup events throughout the month of February. And, it's a leap year, so take that as an opportunity to jump into the startup ecosystim in town.

If you know of innovation-focused events for this month or next, email me at natalie@innovationmap.com with the details and subscribe to our daily newsletter that sends fresh stories straight to your inboxes every morning.

February 4 — How AI Can Boost Your Business with Ryan Shirzadi of Tekrevol

How can artificial intelligence help grow your business? Specifically, Ryan Shirzadi of Tekrevol will be covering the social impacts, industries affected, why you need an AI strategy, and how AI can help small businesses grow. Networking will follow the discussion and pizza will be provided by Tekrevol.

Details: The event is from 6 to 7:30 pm on Tuesday, February 4, at Station Houston (1301 Fannin Street, Suite 2440). Learn more.

February 5 — Meet and Greet with Pat Matthews, CEO & Founder of Active Capital

Meet Active Capital's founder and CEO, Pat Matthews. Rakesh Agrawal, founder and CEO of Snapstream, will interview Matthews followed up by an open Q&A and conversation with the audience.

Details: The event is from 5:30 to 6:45 pm on Wednesday, February 5, at WeWork (708 Main Street, 3rd Floor). Learn more.

February 5 — Houston Social Entrepreneurship Meetup

The meetup brings together like-minded individuals from the nonprofit, social enterprise, impact investing, technology and many other fields to understand the concept of social entrepreneurship and be inspired to find new ways to tackle local social issues. At each meetup, you'll get an intro to social entrepreneurship, hear from a social entrepreneur in Houston, and network with other changemakers from across the entrepreneur ecosystem.

Details: The event is from 5:30 to 7:30 pm on Wednesday, February 5, at Impact Hub Houston @ The Cannon Downtown (1801 Main St., 13th Floor). Learn more.

February 6 — Fail Forward presented by Frost Bank

Join BakerRipley and Frost Bank for an evening of #FailForward fun and get real, behind-the-scenes stories straight from entrepreneurs on the challenges they faced trying to access and raise funding for their small business or startups.

Details: The event is from 6 to 8 pm on Thursday, February 6, at BakerRipley Center (4450 Harrisburg Blvd.). Learn more.

February 12 — The Impact of AI on Automation and the Future of the Workforce

Technology and innovation are rapidly changing how we do and think about work. This panel event seeks to bring together respected leaders in the corporate and entrepreneurial worlds to have meaningful conversations on AI, automation and the future of workforce.

Details: The event is from 6:30 to 9 pm on Wednesday, February 12, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 13 — Female Founders Breakfast with Baker Botts and The Artemis Fund

Baker Botts L.L.P. and The Artemis Fund have come together to bring you a breakfast panel discussion on how a good corporate governance system and a little corporate housekeeping can avoid larger messes down the road.

Details: The event is from 8:30 to 10:30 am on Thursday, February 13, at Baker Botts (910 Louisiana St., 32nd Floor). Learn more.

February 18 — How She Got There: Women Leaders in Tech

Join General Assembly for an evening good conversation with a panel of females in tech. These inspirational women will share their stories on how they got to where they are today and share their insights into being a woman in business and tech.

Details: The event is from 6:30 to 9 pm on Tuesday, February 18, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 19 — Houston Angel Summit

Join the Houston Angel Network for its bi-annual summit. Attendees will learn the basics of angel investing as well as hear from experts on the topics of term sheets and tax implication of early stage investing. This event is open to accredited investors, HAN members and individuals from our partnership organizations. The price of attendance — $100 — will be applied to annual membership if attendees decide to join the Houston Angel Network.

Details: The event is from 9 am to 3 pm on Wednesday, February 19, at Liu Idea Lab for Innovation and Entrepreneurship (Cambridge Building at Rice University). Learn more.

February 20 — The Five W's of Holding Your First, First-in-Human Trial

Who, what, when, where and why to hold your first, first-in-human clinical trial? JLABS has tapped into experts in the field from Johnson & Johnson, CROs and agencies to help you answer these questions and more.

Details: The event is from 11:30 am to 2 pm on Thursday, February 20, at JLABS @ TMC (2450 Holcombe Blvd.). Learn more.

February 20 — Bunker Brews Houston: How to be Mentored in Your Business

Lots of entrepreneurs fail to seek out mentors, and struggle in silence and isolation because of it. Some will find great mentors, but fail to recognize the unspoken rules of the road to acquire, activate, and maintain a mentor-mentee relationship. Hear from some great local mentors of business owners.

Details: The event is from 6 to 8 pm on Thursday, February 20, at MassChallenge (1313 Main St., Suite 210). Learn more.

February 20 — Rising Stars in Houston Health Tech

Join General Assembly for an epic night with some of the Houston's most inspiring healthtech founders and leaders. In a candid discussion, they'll share their stories and insights.

Details: The event is from 6:30 to 9 pm on Thursday, February 20, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 24 — Made in Houston: Celebrating Black History Month

In honor of Black History Month, General Assembly has organized an evening with some of Houston's legendary innovators and creators. Each speaker will share their tips and tricks on how to create a unique product, service or brand that's pushing the boundaries while sharing their journey.

Details: The event is from 6:30 to 9 pm on Monday, February 24, at GA Houston (1301 Fannin St, Floor 21). Learn more.

February 25 — The Cannon Lunch & Learn: Show me the Money

As an early stage company, raising capital is or will be a significant part of your efforts and can present major challenges. Preparation and an understanding of what drives value is crucial to attracting investors. Join Cannon partner, Baker Tilly, as they provide an overview of the capital raise process and highlight key factors to consider when preparing to raise capital.

Details: The event is from 11:30 am to 1 pm on Tuesday, February 25, at The Cannon (1334 Brittmoore Road). Learn more.

Vivante Health, which uses technology and at-home testing to help users treat chronic digestive health issues, has raised $5.8 million. Getty Images

Digital health startup based in Houston closes $5.8 million round

Money moves

A Houston health technology startup that uses digital solutions and on-demand support to help its users with digestive health has closed a Series A round of funding.

Vivante Health raised $5.8 million in a series A1 round, according to a news release. The round was led by California-based Lifeforce Capital and Athens, Greece-based Big Pi Ventures. Additionally, NFP Ventures, FCA Venture Partners, and Longmont Capital contributed to the round.

"We knew we were onto something when the market responded so positively," says Dr. Kimon Angelides, Vivante Health founder and CEO, in the release, "but support from esteemed, experienced and successful firms like Lifeforce and Big Pi, and the continued strong support from our initial investor partners, give us a very encouraging boost of confidence as we carry out our vision and further develop the GIThrive platform."

With the fresh funds, Vivante will continue to develop its GI health platform, GIThrive. The digital tool has an at-home microbiome test kit for users, as well as a breath tester that monitors food sensitivities. GIThrive also connects users to on-demand support from nutritionists and experts on the GIThrive app.

The startup's Houston headquarters is based out of the Johnson & Johnson Innovation Center, JLabs@TMC, but has offices in Nashville, Chicago, and Athens. Angelides, who honors his Greek heritage by spending a fair about of time in Greece, says in the release how important the Big Pi investment is for him.

"This partnership with Big Pi, a tech-based investment firm who's driven by the desire to support Greek talent, makes perfect sense. What's more, we have partnered with a team who themselves have been very successful entrepreneurs," says Angelides in the release.

Angelides, who has founded three other health tech companies, impressed Big Pi with his entrepreneurial track record and nationwide team

"This is one of those rare investments where the financial upside goes hand in hand with the prospect of radically improving the lives of millions of people across the globe," says Marco Veremis, investment partner with Big Pi, in the release.

Lifeforce Capital has a portfolio of software startups, including Aspire, Cricket Health, Notable Labs, One Medical, and Second Genome, per the news release, and the VC firm is excited for their new addition.

"We were immediately struck by Kim's entrepreneurial passion and big vision," says Sander Duncan, general partner with Lifeforce Capital, in the release. "We are thrilled to work with the Vivante team to build the first platform tackling digestive disease for millions of suffering patients."

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.

Elon Musk's SpaceX is about to make its debut on Wall Street

Money Moves

Elon Musk's rocket company SpaceX will make its debut on Wall Street Friday, June 12, and both institutional and retail investors are expected to gobble up the 555.6 million shares going up for sale at $135 apiece. Musk, already the world's richest man, could become its first trillionaire.

SpaceX is likely to become the biggest IPO ever, with proceeds of around $75 billion. SpaceX hopes to become the first company to send people to Mars. In fact, part of Musk’s future compensation depends on SpaceX eventually establishing a colony of at least 1 million people on the red planet.

Why SpaceX is going public now

In a video conference on Musk's social media platform X, he told JPMorgan CEO Jamie Dimon that people have suggested for the last 10 years that he take SpaceX public. He's doing it now because the company plans to put 100,000 next-generation Starlink satellites into orbit. Deploying AI data centers in space is a “massive new growth base and you need capital for that,” he said.

Going public provides access to the capital that SpaceX needs. But it also exposes it to more scrutiny from shareholders and more regulatory oversight. That includes filing quarterly financial reports, which critics say incentivizes short-term thinking over longer-term planning and creates unnecessary costs for a company. Securities regulators are currently soliciting public comment on a proposal to require public companies to file the financial reports only twice every year.

How the IPO impacts the company

Musk will hold the majority of a special class of shares, giving him control over decisions related to company strategy, finances and personnel. On the latter, because of his ownership of most of these Class B shares, the only person who can fire Musk as CEO is Musk.

The company credits Musk with being the “driving force” behind its growth, innovation and success. But what happens if Musk is no longer in the picture? SpaceX warns that the loss of Musk could disrupt its ability to execute its strategy as well as hurt its “reputation and relationships with customers, partners and other stakeholders.”

The company also warns that finding a replacement with the same skills and experience as Musk would be time-consuming, if not nearly impossible. As Wedbush Securities analyst Dan Ives wrote Wednesday, “At the end of the day Musk is SpaceX and SpaceX is Musk.”

What could make or break SpaceX

Currently in the test phase, the gigantic reusable Starship rocket is key to SpaceX realizing Musk's ambitions. Much of the commercial space business hinges on SpaceX developing Starship’s capability to be fully reusable and hearty enough for a quick turnaround between flights. If that doesn't happen, SpaceX warns that putting data centers and satellites in space will take longer and cost more money, meaning it risks customers bailing on the company.

Analysts say that by pioneering reusable rockets, SpaceX has established a clear lead on competitors such as Blue Origin, led by Amazon founder Jeff Bezos. The Starlink satellite business competes with, among others, AST SpaceMobile – which is relying on a SpaceX rocket to send its latest generation of satellites into orbit next week.

The prospectus filed last week says SpaceX’s biggest potential market is the sale of business-oriented artificial intelligence products designed to transform how people get work done. It’s an opportunity SpaceX predicts would be worth $22.7 trillion if it could somehow dominate rivals like Anthropic, OpenAI and Microsoft in a highly competitive industry. But the prospectus shows no clear path to profitability for the xAI business, which merged with SpaceX earlier this year.

Why Wall Street is paying attention

If the SpaceX IPO is as successful, the stock could quickly join the Nasdaq 100, a widely followed index that tracks the 100 largest non-financial companies in the composite. That's important because some popular funds, such as the $460 billion QQQ exchange-traded fund, mimic the index and will automatically buy whatever is listed in the index.

Nasdaq recently changed its rules to allow select companies to enter the Nasdaq 100 after just 15 trading days.

S&P Dow Jones Indices, on the other hand, is sticking to established and more traditional thresholds that will not allow SpaceX or other companies with gargantuan IPOs faster entry into its S&P 500 index. That means even high-profile companies will still need to wait for their stocks to trade a full 12 months before they can enter the index.

Companies want to be in the S&P 500 in particular because it's arguably the most important index on Wall Street, with trillions of dollars either mimicking it exactly or benchmarked against it. Vanguard's VOO fund that tracks the S&P 500 has roughly $950 billion invested in it, for example.