Houston expert: New technologies are improving lives of those living with type 1 diabetes

Guest column

Last month was National Diabetes Awareness Month and Houston-based JDRF Southern
Texas Chapter has some examples of how technology is helping people with type 1 diabetes. Photo courtesy of JDRF

Type 1 diabetes (T1D) is an autoimmune disease where insulin-producing beta cells in the pancreas are mistakenly destroyed by the body's immune system. Insulin is vital in controlling blood-sugar or glucose levels. Not only do you need proper blood-sugar levels for day-to-day energy, but when blood-sugar levels get too high (hyperglycemia) or too low (hypoglycemia), it can cause serious problems and even death. Because of this, those with T1D are dependent on injections or pumps to survive.

The causes of T1D are not fully known, and there is currently no cure; however, advancing technologies are making it easier to live with T1D.

Monitoring

Those who have had T1D for decades might recall having to pee into a vial and test reagent strips in order to check their blood-sugar levels. Thankfully, this evolved into glucometers, or glucose meters. With a glucometer, those with T1D prick their finger and place a drop on the edge of the test strip, which is connected to the monitor that displays their results. Nowadays, glucometers, much like most T1D tech, can be Bluetooth enabled and sync with a smartphone.

From there, scientists have developed the continuous glucose monitor (CGM) so that those with T1D can monitor their blood sugar 24/7. All you need to do is insert a small sensor under the skin. The sensor then measures glucose levels every few minutes, and that information can then be transmitted to smartphones, computers and even smart watches.

Monitoring blood-sugar levels is vital for those with T1D, particularly because it helps them stay more aware of their body, know what to do and even what to expect, but they also have to actively control those levels by injecting insulin. Think of a monitor as the "check engine" light. It can tell you that there may be a problem, but it won't fix it for you. To fix it, you would need an injection or a pump.

Pumps and artificial pancreas

The development of insulin pumps has made a huge impact on the lives of those with T1D and parents of children with T1D by making it easier to manage their blood-sugar levels. 50 years ago, the prototype of the insulin pump was so large, it had to be a backpack, but with today's technology, it is about the size of a smartphone. The pump is worn on the outside of the body, and it delivers insulin through a tube which is placed under the skin. Insulin pumps mimic the way a pancreas works by sending out small doses of insulin that are short acting. A pump can also be manipulated depending on each person's needs. For example, you can press a button to deliver a dose with meals and snacks, you can remove it or reduce it when active and it can be programmed to deliver more at certain times or suspend delivery if necessary.

One of the most recent and trending developments in T1D research is the artificial pancreas, or more formally referred to as the automated insulin delivery (AID) systems. Essentially, the artificial pancreas is an insulin pump that works with a CGM. The CGM notifies the insulin pump of your blood-sugar reading, which acts accordingly to restore your blood sugar to the target level. The artificial pancreas allows those with T1D to be even more hands off, as it does essentially everything: It continuously monitors blood-sugar levels, calculates how much insulin you would need, which can be done through smart devices, and automatically delivers insulin through the pump.

Living with T1D is a 24/7/365 battle; however, the advances in technology make it easier and safer to live with the disease. Organizations like JDRF play a huge role in investing in research, advocating for government support and more.

November was National Diabetes Awareness Month, and this year is particularly special for JDRF, as it is the 50th year of the organization. JDRF was founded in 1970 by two moms. The community grew to include scientists, lobbyists, celebrities and children—all determined to improve lives and find cures.

Bound by a will stronger than the disease, this year during National Diabetes Awareness Month (NDAM), JDRF celebrates "The Power of Us." We are reflecting on the power of our community and reminding ourselves and the public of how far we've come in the fight against T1D.


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Rick Byrd is the executive director of the JDRF Southern Texas Chapter.
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Exclusive: Hardtech-focused program announces Houston expansion, seeks local leader

changing the world

An organization that directs support to scientists developing impactful technology has decided on Houston for its fifth program.

Activate was founded in Berkeley, California, in 2015 to bridge the gap between the federal and public sectors to deploy capital and resources into the innovators creating transformative products. The nonprofit expanded its programs to Boston and New York before launching a virtual fellowship program — Activate Anywhere, which is for scientists 50 or more miles outside one of the three hubs.

"Our mission is to empower scientists to reinvent the world by bringing their research to market," Aimee Rose, executive managing director of Activate, tells InnovationMap. "There's so much technical talent that we educate in this country every year and so many amazing inventions that happen, that combining the two, which is the sort of inventor/entrepreneur, and giving them the support mechanisms they need to get on their feet and be successful, has the potential to unlock an incredible amount of value for the country, for the environment, and to address other social problems."

This year, Activate is planting seeds in Houston to grow a presence locally and have its first set of fellows in 2024. While Activate is industry agnostic, Rose says a big draw from Houston is the ability to impact the future of energy.

"We're super excited about Houston as an emerging ecosystem for the clean energy transition as being the energy capital of the world, as well as all the other emerging players there are across the landscape in Houston," Rose says. "I think we can move the needle in Houston because of our national footprint."

The first order of business, Rose says, is hiring a managing director for Activate Houston. The job, which is posted online, is suited for an individual who has already developed a hardtech business and has experience and connections within Houston's innovation ecosystem.

"We want to customize the program so that it makes the most sense for the community," Rose says about the position. "So, somebody that has the relationships and the knowledge of the ecosystem to be able to do that and somebody that's kind of a mentor at heart."

The program is for early-stage founders — who have raised less than $2 million in funding — working on high-impact technology. Rose explains that Activate has seen a number of microelectronics and new materials companies go through the program, and, while medical innovation is impactful, Activate doesn't focus on pharmaceutical or therapeutic industries since there are existing pathways for those products.

Ultimately, Activate is seeking innovators whose technologies fall through the cracks of existing innovation infrastructure.

"Not every business fits into the venture capital model in terms of what investors would expect to be eventual outcomes, but these these types of businesses can still have significant impact and make the world a better place," Rose says, explaining how Activate is different from an incubator or accelerator. "As opposed as compared to a traditional incubator, this is a very high touch program. You get a living stipend so you can take a big business technical risk without a personal risk. We give you a lot of hands on support and mentoring."

Each of the programs selects 10 fellows that join the program for two years. The fellows receive a living stipend, connections from Activate's robust network of mentors, and access to a curriculum specific to the program.

Since its inception, Activate has supported 104 companies and around 146 entrepreneurs associated with those companies. With the addition of Houston, Activate will be able to back 50 individuals a year.

Four Houston scientists named rising stars in research

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Four Houston scientists were named among a total of five Texas rising stars in research by the Texas Academy of Medicine, Engineering, Science & Technology, or TAMEST, last month.

The group will be honored at the 2023 Edith and Peter O’Donnell Awards by TAMEST in May. According to Edith and Peter O’Donnell Committee Chair Ann Beal Salamone, the researchers "epitomize the Texas can-do spirit."

The Houston winners include:

Medicine: Dr. Jennifer Wargo

A physician and professor of surgical oncology and genomic medicine at The University of Texas MD Anderson Cancer Center, Wargo was named a 2023 honoree for her discoveries surrounding the "important connection between treatment outcomes and a patient’s gut microbiome," according to a statement from TAMEST.

Engineering: Jamie Padgett

The Stanley C. Moore Professor of Engineering at Rice University, Padgett was honored for her work that aims to "enhance reliability and improve the sustainability of critical community infrastructure" through developing new methods for multi-hazard resilience modeling.

Physical sciences: Erez Lieberman Aiden

As a world-leading biophysical scientist and an associate professor of molecular and human genetics at Baylor College of Medicine, is being honored for his work that has "dramatically impacting the understanding of genomic 3D structures." He is working with BCM to apply his findings to clinical settings, with the hope that it will eventually be used to treat disease by targeting dark matter in the body.

Technology innovation: Chengbo Li

As a geophysicist at ConocoPhillips, Li is being recognized for innovations in industry-leading Compressive Seismic Imaging (CSI) technology. "This CSI technology allows the oil and gas industry to produce these seismic surveys in less time, with less shots and receivers, and most importantly, with less of an environmental impact," his nominator Jie Zhang, founder and chief scientist of GeoTomo LLC, said in a statement.


James J. Collins III at UT Southwestern Medical Center in Dallas was also named this year's rising star in the biological sciences category for his research on schistosomiasis, a disease that impacts some of the world’s poorest individuals.

The O'Donnell Awards have granted more than $1.5 million to more than 70 recipients since they were founded in 2006. Each award includes a $25,000 honorarium and an invitation to present at TAMEST’s Annual Conference each year, according to TAMEST's website.

The awards expanded in 2002 to include both a physical and biological sciences award each year, thanks to a $1.15 million gift from the O’Donnell Foundation in 2022.

Following a pivot, this Houston founder is ready make her mark on the creator economy

houston innovators podcast episode 171

When Madison Long started her company with her co-founder and friend, Simone May, she knew she wanted to do one thing: Provide a platform for young people to have reliable access to payment for their skills and side hustles. Through starting a business, making a name change, launching a beta, going through a pivot, completing an accelerator, and more — that mission hasn't changed. And now, young people across the country can opt into the platform.

Houston-based creator economy platform Clutch celebrated its nationwide launch earlier this month. The platform connects brands to its network of creators for reliable and authentic work — everything from social media management, video creation, video editing, content creation, graphic design projects, and more.

When the company first launched its beta in Houston, the platform (then called Campus Concierge) rolled out at three Houston-area universities: Texas Southern University, Rice University, and Prairie View A&M. The marketplace connected any students with a side hustle to anyone on campus who needed their services.

Long shares on this week's Houston Innovators Podcast that since that initial pilot, they learned they could be doing more for users.

"We recognized a bigger gap in the market," Long says. "Instead of just working with college-age students and finding them side hustles with one another, we pivoted last January to be able to help these young people get part-time, freelance, or remote work in the creator economy for businesses and emerging brands that are looking for these young minds to help with their digital marketing presence."

Once focusing on the gig economy, Clutch changed its focus to the creator economy. The founders launched a new beta after closing $1.2 million in seed funding last year.

"Even though we did have to pivot, we're excited to be at the place now where we do deeply understand how to service both sides of our marketplace — the next-gen creatives and the emerging brands — so that they can really empower each other to meet their goals," Long says on the show.

Clutch, which went through the DivInc Houston accelerator, credits a part of the company's ability to survive the challenges from making pivots on being founded in Houston.

"We attribute a lot of Clutch's success — especially early on — to being located in Houston," Long says, explaining that she moved to Houston from California in 2021 to focus on the company. "It was physically being in the tech ecosystem that was blossoming in the Houston network that allowed us to feel safe making the pivots we were making and get a lot of guidance from mentors we were meeting."

She shares more about what's next for Clutch on the podcast. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.

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