The Ion taps John Reale for startup and investor role

new hire

Houston startup and investment leader John "JR" Reale has a new role at the Ion. Photo courtesy Rice Alliance.

The Ion has named John "JR" Reale as its director for startups and investor engagement.

In his new role, Reale, a longtime leader in Houston’s startup ecosystem, will work to strengthen the innovation district's founder and investor network.

"Here’s what I’ve come to believe: the Ion is not just a building, not just a real estate play, and not just another innovation district. COVID, remote work, and shifting market dynamics changed the rules. Key ingredients like co-working, events, and community, while impactful, are no longer enough on their own," Reale shared on a LinkedIn post announcing the move. "What’s needed are advantages ... We need to intentionally design a system that repeatedly delivers advantages so founders can pull forward their visions."

Reale previously served as executive in residence and venture partner at TMC Venture Fund and co-founded Station Houston. He also serves as managing director of Integr8d Capital. He's an investor and serves on the board of directors for a number of venture-backed companies, including Cart.com, Lionguard and others.

The Ion will host "Today Is Day One – A conversation with John (JR) Reale" to welcome Reale to the role on Tuesday, Oct. 21. Reale will be joined at the event by Heath Butler, partner at Mercury, to discuss their thoughts on shaping Houston's founders ecosystem, as well as the Ion’s Founder Advantage Platform.

"On top of this connected architecture, we will build product. That product will be the Founder Advantage Platform to remove friction, compress time, and compound outcomes," Reale continued on LinkedIn. "This is the system that will drive repeatable experiences, and naturally, make these journeys so much more fun."

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The new two-story wall in Station Houston's space represents Station's promise to its startup members as well as showcases the city's stewards for innovation. Natalie Harms/InnovationMap

Mayor, Station CEO: Houston's innovation ecosystem has arrived

forget up and coming

For Gaby Rowe, Houston's not just an up-and-coming innovation leader.

"Houston's tech ecosystem is here. It exists now. It will continue to grow and gain momentum. It is not a thing of the future; it is here now," Rowe, CEO of Station Houston, tells InnovationMap.

At Station's third anniversary party on January 30, Mayor Sylvester Turner agreed with that sentiment.

"I don't want to say that we're looking to just build this robust, integrated ecosystem," Turner says. "Let me just be bold enough to say that it is done. We've already done it, and we are just expanding on it."

In a week full of announcements — from $2.5 million grants bringing in an international accelerator program to Midtown innovation hub announcing its new name and construction plans — Station, not to be out done, announced its programming expansion plans.

Station's Houston VR Lab made its debut at the celebration, which is an AR/VR space where members can use to showcase their technology to potential partners and investors. Station is also a short ways away from finishing up its robotics lab, something that the organization is partnering with TXRX Labs to work on.

When it comes to investors, Station acts as a sort of matchmaker with its member startups. In 2019, the organization will have 15 different investors with weekly, monthly, or quarterly office hours in the Station space — nine of which are already on board, Rowe says.

Station will also be launching a foreign development accelerator aimed at attracting startups from around the world. The program will help educate and transition the companies into business here in the United States over a one- to three-week session.

"Our belief is that there's no better city for an international startup to come to," Rowe says. "It's so easy to assimilate and there's such a global footprint. And, there's such an open community when it comes to the warmth of the people. There's no one here that I've worked with that won't give you one meeting."

Visually, Station Houston's biggest unveiling was the wall that spans two floors of the office. On the wall is four stewards, as Rowe describes them, that have partnered to progress Houston's innovation. On the wall are the logos of Houston Exponential, TMC Innovation Institute, Rice University, and the University of Houston.

"Those four entities have committed through their stewardship tp make sure that this ecosystem a reality, and today we can say it's here," Rowe says.

The historic Sears building in Midtown will transform into The Ion, a Rice University-backed hub for innovation. Courtesy of Rice University

Rice University's Midtown innovation hub dubbed The Ion takes shape

Eye on Ion

Houston's innovation district is one step closer to the Midtown hub it was promised early last year. Rice University announced the construction details of the historic Sears building's transformation into The Ion, as it's now called.

"We chose the name Ion because it's from the Greek ienai, which means 'go'" says Rice University president David Leebron in the release. "We see it as embodying the ever-forward motion of discovery, the spark at the center of a truly original idea. It also represents the last three letters in many of the words that define the building's mission, like inspiration, creation, acceleration and innovation."

Construction on the 270,000-square-foot building will begin in May, according to Rice's release, and is expected to conclude by the end of next year. The cost of the project wasn't disclosed with the announcement. The building will serve as a coworking space, provide resources for entrepreneurs and startups, and host events, the release says, as well as offer retail space for restaurants and entertainment amenities.

"I gleefully applaud this next giant step in the creation of an innovation hub that will take Houston closer to becoming a world leader in data science and digital technologies" says Houston Mayor Sylvester Turner in the release. "As I said last year when the idea was unveiled, we have to leap, not stroll, into the economic frontier. Now the physical transformation of The Ion will help get us there."

Leading the project is the Rice Management Company, and Rice will provide academic programming, along with other educational institutions including the University of Houston, UH-Downtown, the University of St. Thomas, Houston Community College, Texas Southern University, Houston Baptist University, San Jacinto College, and the South Texas College of Law. Station Houston has been named as the programming partner and will have a huge presence in the hub.

"The Ion will inspire open innovation between universities, global corporations and investors," says Gabriela Rowe, CEO of Station Houston, in the release. "Students and faculty members from institutions like Rice University and the University of Houston will coexist and collaborate with scientists from Houston's other great institutions. Investors and corporations will meet face to face with startup entrepreneurs. Together, at The Ion, they will transform Houston into a thriving, connected, high-tech ecosystem."

Houston-based Hines was listed as the developer, and other dealmakers include New York-based SHoP Architects, James Carpenter Design Associates, James Corner Field Operations, and Gensler's Houston office. The Ion's transformation will include removing the '60s-era metal cladding, but the structure will maintain its original art deco façade.

This is the first phase of development for Houston's innovation district — a 16-acre plan for Midtown, according to the release, and the district will also feature housing, public spacing, and important infrastructure.

"We are eager to contribute to an enhanced quality of life for residents and visitors of Midtown Houston," said Matt Thibodeaux, executive director of Midtown Houston. "The Midtown innovation district is an embodiment of our shared community vision to give professionals and families a means of seizing opportunity as Houston continues to grow as a leading city in technology."

Courtesy of Rice University

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Johnson Space Center and UT partner to expand research, workforce development

onward and upward

NASA’s Johnson Space Center in Houston has forged a partnership with the University of Texas System to expand collaboration on research, workforce development and education that supports space exploration and national security.

“It’s an exciting time for the UT System and NASA to come together in new ways because Texas is at the epicenter of America’s space future. It’s an area where America is dominant, and we are committed as a university system to maintaining and growing that dominance,” Dr. John Zerwas, chancellor of the UT System, said in a news release.

Vanessa Wyche, director of Johnson Space Center, added that the partnership with the UT System “will enable us to meet our nation’s exploration goals and advance the future of space exploration.”

The news release noted that UT Health Houston and the UT Medical Branch in Galveston already collaborate with NASA. The UT Medical Branch’s aerospace medicine residency program and UT Health Houston’s space medicine program train NASA astronauts.

“We’re living through a unique moment where aerospace innovation, national security, economic transformation, and scientific discovery are converging like never before in Texas," Zerwas said. “UT institutions are uniquely positioned to partner with NASA in building a stronger and safer Texas.”

Zerwas became chancellor of the UT System in 2025. He joined the system in 2019 as executive vice chancellor for health affairs. Zerwas represented northwestern Ford Bend County in the Texas House from 2007 to 2019.

In 1996, he co-founded a Houston-area medical practice that became part of US Anesthesia Partners in 2012. He remained active in the practice until joining the UT System. Zerwas was chief medical officer of the Memorial Hermann Hospital System from 2003 to 2008 and was its chief physician integration officer until 2009.

Zerwas, a 1973 graduate of the Houston area’s Bellaire High School, is an alumnus of the University of Houston and Baylor College of Medicine.

3 Houston innovators who are making headlines right now

Featured Innovators

Editor's note: Houston innovators have kicked off the new year with big developments, from an immune-boosting nanodrug to NSF research funding and more. Below, meet three local innovators who have recently been in the headlines.

Kirsten Adam, Rice University

Kirsten Adam. Courtesy photo.

Rice University psychologist Kirsten Adam has received a $600,000 National Science Foundation CAREER Award to research how visual distractions like phone notifications, flashing alerts, crowded screens and busy workspaces can negatively impact focus—and how the brain works to try to regain it. Adam’s work will aim to clarify how the brain refocuses in the age of screens, instant gratification and other lingering distractions. The funding will also be used to train graduate students in advanced cognitive neuroscience methods, expand access to electroencephalography (EEG) and for public data sharing. Read more.

Houston lab-test startup seeks $1M for nationwide expansion

Jim Gebhart, founder and CEO of TheLabCafe.com. Courtesy photo.

Driven by the desire to knock down lab-test barriers, health care industry veteran Jim Gebhart founded Houston-based TheLabCafe.com in 2024. The platform provides access to low-cost medical tests without requiring patients to carry health insurance. It currently serves patients in six states and is poised for major U.S. expansion early this year. Read more.

Wei Gao, University of Houston College of Pharmacy

Wei Gao (center). Photo courtesy UH.

Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to regulatory B cells (Bregs) which block the body's natural immunity and are found in pancreatic and lung cancers. Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight these cancers. Read more.

Texas booms as No. 3 best state to start a business right now

Innovation Starts Here

High employment growth and advantageous entrepreneurship rates have led Texas into a triumphant No. 3 spot in WalletHub's ranking of "Best and Worst States to Start a Business" for 2026.

Texas bounced back into the No. 3 spot nationally for the first time since 2023. After dropping into 8th place in 2024, the state hustled into No. 4 last year.

Ever year, WalletHub compares all 50 states based on their business environment, costs, and access to financial resources to determine the best places for starting a business. The study analyzes 25 relevant metrics to determine the rankings, such as labor costs, office space affordability, financial accessibility, the number of startups per capita, and more.

When about half of all new businesses don't last more than five years, finding the right environment for a startup is vital for long-term success, the report says.

Here's how Texas ranked across the three main categories in the study:

  • No. 1 – Business environment
  • No. 11 – Access to resources
  • No. 34 – Business costs

The state boasts the 10th highest entrepreneurship rates nationwide, and it has the 11th-highest share of fast-growing firms. WalletHub also noted that more than half (53 percent) of all Texas businesses are located in "strong clusters," which suggests they are more likely to be successful long-term.

"Clusters are interconnected businesses that specialize in the same field, and 'strong clusters' are ones that are in the top 25 percent of all regions for their particular specialization," the report said. "If businesses fit into one of these clusters, they will have an easier time getting the materials they need, and can tap into an existing customer base. To some degree, it might mean more competition, though."

Texas business owners should also keep their eye on Houston, which was recently ranked the 7th best U.S. city for starting a new business, and it was dubbed one of the top-10 tech hubs in North America. Workers in Texas are the "third-most engaged" in the country, the study added, a promising attribute for employers searching for the right place to begin their next business venture.

"Business owners in Texas benefit from favorable conditions, as the state has the third-highest growth in working-age population and the third-highest employment growth in the country, too," the report said.

The top 10 best states for starting a business in 2026 are:

  • No. 1 – Florida
  • No. 2 – Utah
  • No. 3 – Texas
  • No. 4 – Oklahoma
  • No. 5 – Idaho
  • No. 6 – Mississippi
  • No. 7 – Georgia
  • No. 8 – Indiana
  • No. 9 – Nevada
  • No. 10 – California
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This article originally appeared on CultureMap.com.

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