6 Houston startups disrupting industries with innovative technology

meet the finalists

A concept design rendering of Persona AI's humanoid robot. The company is one of the finalists for the 2025 Houston Innovation Awards in the Deep Tech Business category. Rendering courtesy Persona AI.

Houston is no stranger to technology that's shaping the future. As the longtime location of NASA Johnson Space Center to home base for new ventures disrupting industries with their technology, the Bayou City has had its finger on the pulse of what's new and next for decades.

The Deep Tech Business category in our 2025 Houston Innovation Awards will honor an innovative startup providing technology solutions based on substantial scientific or engineering challenges, including those in the AI, robotics and space sectors.

Six deep tech companies have been named finalists for the 2025 award. They range from a company developing predictive software to accelerate the energy transition to a new venture that's developing humanoid robots.

Read more about these businesses, their founders and their breakthrough technologies below. Then join us at the Houston Innovation Awards on Nov. 13 at Greentown Labs, when the winner will be unveiled.

Tickets are now on sale for this exclusive event celebrating Houston Innovation.

ARIX Technologies

Industrial and robotics company ARIX Technologies is an integrated robotics and data analytics company that delivers inspection services. Its ARIX VENUS robot combines aerospace-grade engineering, advanced non-destructive testing (NDT) and AI-powered analytics to detect hidden corrosion under insulation for the downstream energy, petrochemical, and chemical processing sectors.

ARIX was founded in 2017 by Dianna Liu, a former ExxonMobil engineer. Craig Mallory serves as CEO. The company reports that it is scaling deployments with major Gulf Coast refineries, expanding its analytics platform to include predictive corrosion modeling and growing a global partner program.

Little Place Labs

Space tech company Little Place Labs is developing an AI, machine-learning software across a network of satellites that can provide insights from space in under seven minutes.

The company was founded in 2022 by CEO Bosco Lai and CTO Gaurav Bajaj. The company recently received an award from the U.S. Space Force that will support it in deploying multiple applications and products onto more than 55 satellites over the next 36 months for both national security and commercial use cases. The company won the Security, GovTech & Space competition at the SXSW Pitch showcase last year.

Newfound Materials

Newfound Materials has developed a predictive synthesis software platform for accelerating the discovery of novel materials for critical energy applications, such as batteries, magnets, catalysts, and more. It guides users on the best experiments to try in the lab to optimize the synthesis of their materials.

Newfound Materials was founded in 2024 by CEO Matthew McDermott and participated in the inaugural Activate cohort. The company plans to release a public web app soon. It also has plans to raise a pre-seed or angel round.

Paladin Drones

Paladian develops drone-as-first-responder (DFR) systems for public safety. Its technology gives first responders live aerial video before teams arrive, enabling quicker decisions, better resource allocation and reduced false alarms.

The company was founded in 2018 by Divyaditya Shrivastava and participated in the Y Combinator accelerator that year. The company raised a $5.2 million seed round in 2024 and another round for an undisclosed amount earlier this year. In the future, it plans to expand its DFR deployments into more cities, offer new payload delivery capabilities (like delivering Narcan and life vests), and enhance deconfliction features.

Persona AI

Persona AI is building modularized humanoid robots that aim to deliver continuous, round-the-clock productivity and skilled labor for "dull, dirty, dangerous, and declining" jobs.

The company was founded by Houston entrepreneur Nicolaus Radford, who serves as CEO, along with CTO Jerry Pratt and COO Jide Akinyode. It raised eight figures in pre-seed funding this year and also expanded its operations at the Ion. The company is developing its prototype of a robot-welder for Hyundai's shipbuilding division, which it plans to unveil in 2026.

Tempest Droneworx

Tempest Droneworx provides real-time intelligence collected through drones, robots and sensors. Its Harbinger software platform shares data through a video game engine and aims to provide teams with early warning and insight to help them make decisions faster.

The company was founded in 2021 by CEO Ty Audronis and COO Dana Abramovitz. It participated in the Mass Challenge Air Force Labs and won the Best Speed Pitch at SXSW earlier this year. The company is currently raising a $2.5M seed round.

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A concept design rendering of Persona AI's humanoid robot. The company is expanding at the Ion and plans to deliver prototype humanoids by the end of 2026 for complex shipyard welding tasks. Rendering courtesy Persona AI.

Houston humanoid robotics startup inks new deal to deploy its rugged robots

big deal

Houston-based Persona AI announced the expansion of its operations at the Ion and a major milestone in deploying its humanoid robots.

The company will establish a state-of-the-art development center in the prominent corner suite on the first floor of the Ion, and is slated to begin expansion in June.

“We chose the Ion because it’s more than just a building — it’s a thriving innovation ecosystem,” CEO Nicolaus Radford said in a news release. “This is where Houston’s tech future is being built. It’s a convergence point for the people, energy, and ideas that power our mission to redefine human-machine collaboration. For an industrial, AI-driven robotics company, there’s no better place to scale than in the heart of Houston.”

Persona AI’s new development center will be located in the suite utilized by the Ion Prototyping Lab, managed by TXRX Labs. The IPL will transition its operations to the expanded TXRX facility in the East End Maker Hub, which will allow the lab to grow its team and meet increased demand.

At the start of the year, Persona AI closed $25 million in pre-seed funding. Earlier this month, the company announced a memorandum of understanding with HD Korea Shipbuilding & Offshore Engineering, HD Hyundai Robotic, and Korean manufacturing firm Vazil Company to create and deploy humanoid robots for complex welding tasks in shipyards.

The project will deliver prototype humanoids by the end of 2026, with field testing and full commercial deployment scheduled to begin in 2027.

"As heavy industry faces growing labor constraints—especially in high-risk trades like welding—the need for rugged, autonomous humanoid robots is more urgent than ever,” Radford added in a separate statement. “This partnership with HD Hyundai and Vazil is more than symbolic—deploying to the shipyard is one of the largest real-world proving grounds for Persona's tough, humanoid robots.”

A concept design rendering of Persona AI's humanoid robot. Co-founder and CEO Nic Radford expects customers to take delivery of its first robot in 18 to 24 months. Rendering courtesy Persona AI.

Humanoid robotics, prestigious prizes, and more Houston innovation news to know

Trending News

Editor's note: The first half of February has been full of fresh funding and prestigious accolades for Houston innovators. Here are the five most-read InnovationMap stories from February 1-13, featuring Dr. Peter Hotez, Persona AI, and more.

1. Houston Nobel Prize nominee earns latest award for public health research

Dr. Peter Hotez with Dr. Maria Elena Bottazzi. Photo courtesy of TMC

Houston vaccine scientist Dr. Peter Hotez can add one more prize to his shelf. Hotez — dean of the National School of Tropical Medicine and professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine, co-director of the Texas Children’s Center for Vaccine Development (CVD) and Texas Children’s Hospital Endowed Chair of Tropical Pediatrics — is no stranger to impressive laurels. In 2022, he was even nominated for a Nobel Peace Prize for his low-cost COVID vaccine. His first big win of 2025 is this year’s Hill Prize, awarded by the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST). Continue reading.

2. Houston humanoid robotics startup secures millions in pre-seed funding

A concept design rendering of Persona AI's humanoid robot. Rendering courtesy Persona AI.

A Houston-based startup developing AI-powered humanoid robots for manufacturers and other businesses has raised more than $10 million in pre-seed funding less than a year after its founding. Nic Radford, co-founder and CEO of Persona AI, declines to disclose the amount raised. However, he tells InnovationMap that it was an eight-figure total. Continue reading.

3. 10+ can't-miss Houston business and innovation events for February

Don't miss these February Houston business events. Photo courtesy of Rice University

From talks with the hall-of-fame beauty business founders to agtech and AI summits, Houston will host a number of events focused on innovation and innovators in February. Here’s what not to miss and how to register. Continue reading.


4. 2 Houston professors earn prestigious presidential awards for excellence in STEM

UH physics professor Donna Stokes and Allison Master, an assistant professor in the UH College of Education, were recognized by the Biden Administration for excellence in STEM fields. Photos courtesy UH.

Allison Master, an assistant professor at the University of Houston, is the first from the college to be awarded the Presidential Early Career Award for Scientists and Engineers. The White House also recently recognized UH physics professor Donna Stokes for outstanding mentoring in STEM disciplines with the Presidential Awards for Excellence in Science, Mathematics and Engineering Mentoring. Continue reading.

5. Houston firm invests $150M in leading 'lab on a chip' medical diagnostics co.

Patho Care LLC says its technology is more cost-effective and provides results faster than traditional diagnostic methods. Photo via Getty Images

Houston-based health technology investment firm Hamershlag Private Capital Management Limited (HPCM) announced a $150.15 million venture investment in Patho Care LLC. The “lab on a chip” medical diagnostics company known for its noninvasive point-of-care testing platforms, such as its Raman spectroscopy-based platform. Continue reading.

A concept design rendering of Persona AI's humanoid robot. Co-founder and CEO Nic Radford expects customers to take delivery of its first robot in 18 to 24 months. Rendering courtesy Persona AI.

Houston humanoid robotics startup secures millions in pre-seed funding

my robot

A Houston-based startup developing AI-powered humanoid robots for manufacturers and other businesses has raised more than $10 million in pre-seed funding less than a year after its founding.

Nic Radford, co-founder and CEO of Persona AI, declines to disclose the amount raised. However, he tells InnovationMap that it was an eight-figure total.

While not providing names, Radford says Persona AI’s first outside investors include VC firms, institutions and high-net-worth individuals in the U.S., London and Singapore. One of the high-net-worth investors was among the first employees at SpaceX, Elon Musk’s Brownsville, Texas-based aerospace company, according to Radford.

No Houston investors have participated in the funding round yet. However, Radford says he’s working on bringing aboard one local investor before the round closes.

“Houston’s the perfect city to do a company like this in,” Radford says. “It’s just not the perfect investor climate, but it's the perfect city from a customer aspect.”

Persona AI’s pre-seed funding comes amid a dramatic surge in investment capital chasing AI startups. Global funding for AI-related companies exceeded $100 billion in 2024, up more than 80 percent from the 2023 total, Crunchbase data shows.

Radford and co-founder Jerry Pratt, the startup’s chief technology officer, bootstrapped Persona AI. The third co-founder, Jide Akinyode, serves as Persona AI’s chief operating officer. Radford and Akinyode helped develop NASA’s six-foot-two-inch Valkyrie humanoid robot and both are former employees of Webster-based Nauticus Robotics, a provider of autonomous subsea robots.

Persona AI launched last June in what Radford calls “anti-stealth mode.” The startup is close to announcing its first customer, which does business in the industrial sector. Persona AI expects customers to take delivery of its first robot in 18 to 24 months, Radford says.

Persona AI will operate primarily as a robotics-as-a-service provider, with the company retaining ownership of the lifelike robots and selling the labor that they supply. Radford says the startup’s robots will help alleviate a shortage of skilled labor in sectors like manufacturing.

A report released last year by consulting firm Deloitte and the Manufacturing Institute declared that as many as 1.9 million manufacturing jobs in the U.S. could go unfilled between 2024 and 2033 due to a skills gap and a tight labor market.

Persona AI competes in a market with enormous potential. In November, analysts at Citi Global Insights projected that the global market for humanoid robots could soar to $7 trillion by 2050, with 650 million of the robots tackling all sorts of jobs.

Radford says Personal AI is developing a “rugged” five-foot-eight-inch humanoid robot that’s able to survive tough indoor and outdoor conditions and take on tasks like carting around sheet metal, tending to metal-stamping machines, moving storage bins and handling order fulfillment. He likens his company’s robot prototype to a Ford F-150 pickup truck, compared to the less-sturdy versions produced by robotics competitors, which he calls the Toyota Camry or Volkswagen Beetles of the field.

Radford says he and his team “are building a really compelling startup in one of the hottest markets and one of the greatest cities.” Employees work at Persona AI’s headquarters in Houston or its satellite office in Pensacola, Florida, where Pratt is located.

“We don’t hire anybody that’s not a rock star or superstar,” says Radford, “and I think the city is going to benefit tremendously from our efforts at Persona.”

Radford saw his last company, Nauticus Robotics, from founding to IPO, left the company in January and previously told InnovationMap that he couldn't get the idea of advancing humanoid robotics out of his head. Read more here.

Nicolaus Radford, who founded Nauticus Robotics and took it all the way to IPO, shares details of his new company, PersonaAI. Image via LinkedIn

Houston innovator bets on humanoid robotics with new startup

back in the founder seat

For his next act, Houston entrepreneur Nicolaus Radford has started — in what he describes as an "anti-stealth" capacity — a new company that hopes to bring humanoid robotics out of science fiction novels and into manufacturing floors.

Radford, who saw his last company, Nauticus Robotics, from founding to IPO, left the company in January. He tells InnovationMap that he started receiving some compelling offers at other robotics companies, but none of them felt like a fit. However, he just couldn't get the idea of advancing humanoid robotics out of his head.

"Humanoids are the holy grail of all of robotics," Radford says. "It's what every science fiction writer's always dreamed about.

"It is the future," he continues. "And now with this generative AI moment of 2022 where these machines look a lot more capable, flexible, reprogrammable — they can reason in real time. That's a huge deal."

Radford says he got a call from his friend, Jerry Pratt, who was the CTO at humanoid robotics company Figure AI. Pratt and Radford both worked in robotics at NASA and each have decades of experience in the tech world. The conversation really sealed the deal for Radford, and the two officially launched Persona AI in a LinkedIn post that Radford says shocked him with how much interest the community had.

Radford says that with all this interest, he wants to open up the company to more co-founders than just himself and Pratt, who's based in Florida.

"We're going to give a significant amount of the company out to the early joiners, more so than is probably typical," Radford says. "And it's because we know it takes a village, and we want to highlight that to everybody."

"We're trying to crowdsource the company," he continues. "We've coined that we're anti stealth."

Specifically, Radford says he's looking at growing the team to about 25 people in the next year, alongside raising early funding. He's looking for people with a diverse tech background with well-rounded experience.

"Robotics and humanoids in particular are just so multidisciplinary," Radford says. "Humanoids are a hundred-thousand-piece puzzle, and you're trying to put this puzzle together."

And for Radford, assembling that puzzle in Houston is of utmost importance. The company is headquartered here, and Radford is currently working with The Ion to set up an office there.

"We're exceptionally excited to put (the company) in Houston," he says. "It would be incredible for the city — there's a lot of industrial manufacturing here and a lot of warehousing. ... I still have this desire to shine a light on Houston's tech scene because I believe it is unsung, underappreciated, and quite capable."

The potential for this technology is huge — Radford estimates it as a $3 trillion market — but the first industry he plans on tackling is automotive, but he also sees promise in the medical, energy, and home industries.

"We think automotive is going to be a first-mover market. There's a lot of publicly announced partnerships between advanced robotics companies and humanoid companies and automotive," he says. "These folks are showing a willingness to put something out in the press that says they're developing a humanoid or piloting a humanoid. That's huge.

With this expressed interest, technology advancement, and large labor shortage, Radford is convinced now is the time for humanoid robotics — and for Persona AI.

"We're at a technology tipping point where it makes sense that these machines can do this, and there's an investment community willing to finance it," Radford says. "I think the first time in all of robotic history we're closer than we've ever been to making this a reality."

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.

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