A group of Houstonians have launched a virtual tutoring platform for students in Kindergarten through eighth grade. Image via teachingtogive.org

Seven local high schoolers took lessons from their own schooling challenges in 2020 to launch a free, virtual tutoring program last month with the goal of helping younger students close learning gaps of their own during this unprecedented academic year ahead.

Dubbed Teaching To Give, the project matches kindergarten through eighth grade students with honor roll high schoolers from Kinder High School for the Performing and Visual Arts, Strake Jesuit, and Bellaire High School for 30- to 45-minute teaching sessions in core subjects, languages, debate, and arts via Zoom.

Kinder HSPVA sophomore Weillison Hsu, who now serves as president of Teaching to Give, first proposed the idea to fellow piano major and Vice President Hayden Miller at the end of the 2019-20 school year. The 15-year-olds are bright, talented, and artistic, but their freshman years had not come without challenges: First, several of their teachers were required to take a leave of absence, leaving them with long-term substitutes. Then COVID-19 hit, making traditional learning impossible.

It took time to adjust, Miller says, but eventually he and his peers found their stride in the tech-based schooling style that Houston Independent School District has been following for months. Still, they feared the transition for younger students had not been as smooth.

"We have been used to that independence, where in elementary school, and middle school even, you do a lot hands on and in person," Miller says. So, they decided to help in a way that was safe, affordable, and approachable.

"During these times, it's just not possible to make sure that everyone is fully striving," Miller says. "We wanted to make it as easy as possible for parents to use us and to have a stress-free environment, to provide a successful education and set up."

Today, Teaching to Give has held more than 100 free web-based tutoring sessions for kids around the city in subjects from science to piano. They ask on-boarding students to complete a personality and learning style questionnaire and place them with one of their 29 tutors who they predict will work best with for their subject matter and interests. Miller says the minor age difference has allowed their sessions to have real impact.

"It provides a more relatable experience," he says. "A lot of the time we'll have the same interests as our students. We can use that to foster mutual excitement for the subject material."

Still, the group is learning how to teach in a virtual setting as they go.

"It really forces you to think of how you say things to get the result that you want," Miller says. "I think we will all come out of this as better communicators."

Miller, Hsu, and the five other board members — Lina Wu, Amy Park, Fiona Condron, Rushil Chetty, and Ashley Chu — plan to continue to focus on virtual tutoring sessions even after the pandemic ends and limitations on in-person learning lift. Again pulling from their own experience, they know that virtual options can provide big benefits for busy parents and students like themselves.

And in the meantime, they're hoping to start partnerships with a few local lower schools, are accepting applications for additional tutors, and are raising awareness for their new initiative, Project Pencil, which will donate art supplies to the Gregory-Lincoln Education Center in the Fourth Ward.

"Art is something that is universal. It takes away the stress of learning. Also, art lessons and music lessons are very expensive," Miller adds. "We wanted to incorporate that into our classes because that's what our biggest strengths lie in. We wanted to share that passion and provide a way to spread more unity between people. Art has a way of doing that."

Teaching to Give founders (Weillison, Hayden and Lina) virtually meeting with Thomas Porter, HISD Magnet Coordinator for Gregory Lincoln. Image courtesy of Teaching to Give

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”