Baylor College of Medicine's Jessica Watts, Dr. Jerome Pollet, and Dr. Paul Ling with Tess. Photo by Jackelin Reyna/Houston Zoo

An innovative team from Baylor College of Medicine and Texas Children’s Hospital has worked with the Houston Zoo to develop a first-of-its-kind treatment for elephants, which has been administered to its first patient.

Tess, the beloved, 40-year-old matriarch of the Houston Zoo’s elephant herd, is recovering well after receiving the first-ever mRNA vaccine against elephant endotheliotropic herpesvirus (EEHV) 1A on Tuesday, June 18. The veterinary staff at the Houston Zoo will monitor Tess in the coming weeks to check her reaction and the efficacy of the vaccine.

EEHV 1A is a deadly infection for Asian Elephants. While generally benign in African Elephants, Asian Elephants can develop fatal hemorrhages. The fatality rate is a whopping 80 percent, making it one of the most serous threats to elephant populations outside of humans.

Anti-viral drugs have some effect on the disease, but two-thirds show no improvement. This has led to a search for a vaccine. For 15 years, the Houston Zoo and Dr. Paul Ling at Baylor College of Medicine’s Department of Virology and Microbiology have partnered to develop the drug. They have been helped by worldwide research from zoos and animal specialists, as well as graduate student Jessica Watts and Dr. Jeroen Pollet at Houston's Texas Children’s Hospital. The research has been funded by private donations, research partnerships, and grants.

Before being inoculated, the mRNA vaccine was exhaustively tested, with the dosage being extrapolated from data involving horses.

Houston Zoo veterinarians will periodically test Tess to see if she is developing the appropriate antibodies. If she is and there are no adverse reactions, the next step will be to administer the vaccine to the rest of the Houston herd. Many of these are Tess’s own children (Tucker, Tupelo, Tilly, and Teddy) and grandchildren (Winnie).

Should the vaccine prove effective, the doses will be made available worldwide to zoos and private elephant sanctuaries. It is likely to have a significant benefit on protecting and preserving the Asian Elephant population. As of January, there are fewer than 50,000 of the animas left in the wild. They are currently listed as endangered, and breeding programs and research done through the Houston Zoo are essential to keeping the animals from going extinct.

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This article originally ran on CultureMap.

The immersive new exhibit will now open next year. Image courtesy of Houston Zoo

Houston Zoo delays new, immersive island exhibit due to supply chain issues

journey delayed

Houstonians eager to meet sea lions, giant tortoises, sharks, and Humboldt penguins at the Houston Zoo will have to wait a bit longer, the zoo announced.

Galápagos Islands, the highly immersive Houston Zoo experience showcasing one of the most pristine, ecologically rich areas in the world, will not open until early 2023.

The Galápagos exhibit is part of the zoo’s 100th anniversary celebration and was slated to open fall of this year. Zoo officials cite supply chain issues for key construction materials — such as acrylic viewing panels for the state-of-the-art sea lion habitat — as the reason for the delay.

This planned exhibit is the first of its kind to showcase the wildlife of the legendary island chain that Charles Darwin studied and made famous.Guests can dive into an environment evoking the archipelago’s unique landscapes and oceanic habitats — all meant to inspire intrigue and preservation.

One major draw should be the Galápagos penguins, which are threatened by overfishing, ocean pollution, and climate change and are highly protected by the Ecuadorian government. It is the most threatened penguin species in the world, the zoo notes, with an estimated population of less than 2,000 individuals.

The Galápagos is often heralded as the planet’s ultimate area spotlighting unique species, the delicate balance of ecosystems, and the pressing need for conservation action, the zoo notes.

“We’re disappointed that the project has been delayed, but we know we’re not alone in experiencing supply chain problems,” said Houston Zoo president and CEO Lee Ehmke in a statement. “Our commitment to conservation in the Galápagos Islands, our animal residents, and our guests here in Houston remain unwavering. A short delay in our exhibit opening will not deter us from our mission of connecting communities to animals, inspiring action to save wildlife.”

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This article originally ran on CultureMap.

Memorial Park, which is currently undergoing a master plan renovation, and other Houston parks can be a great opportunity for introducing urban conservation inside the city limits. Rendering courtesy of Nelson Byrd Woltz

Houston conservationist is helping to find new ways to protect local species and ecosystems

Living on a prairie

The Houston toad is a species that was discovered in Harris County in the 1950s. It has a very distinct, loud call that reverberates at quite a high pitch. But the Houston toad's call hasn't been heard in the city of Houston for almost 50 years. The species is locally extinct and critically endangered elsewhere. In fact, it's the most endangered amphibian in North America, says Cassidy Brown Johnson, a Rice University lecturer and president of the Coastal Prairie Partnership.

"When we think about extinction, we think of the dodo bird or the woolly mammoth," Johnson says. "But extinction is happening right underneath our noses."

The Houston Zoo has a breeding facility for Houston toad, but other than that, it's extremely unlikely that the Houston toad will ever reside naturally in its namesake city.

"We have modified the environment so heavily, that it'd be a bit of a dicey thing to do [to reintroduce the species] because there are so few of them, it's better to focus on an environment where it's still OK for them," Johnson says. The largest population of the Houston toad is actually in Bastrop, however due to the Bastrop fires in 2011, the species is only just recently back to a good place even there.

Johnson is giving a free lecture in April at Rice regarding extinction, where she'll bring her Astros-named Houston toads, Springer and Julia Morales, as her teacher aids.

Changing tides in conservation
As cities like Houston continue to be developed, scientists and researchers are challenged with finding new ways to effect conservation. Johnson says within the industry, there's been a shift in thinking when it comes to preserving nature.

"There's a new burgeoning movement in conservation called urban conservation," she says. "For a long time, if you talked to the traditional conservationists, the idea of conservation is to protect big spaces — the national and state park systems are the perfect example."

But large parks are expensive and a huge undertaking. It's still the strongest form of conservation, but introducing conservation efforts in a city — perhaps in some of Houston's parks, like Memorial Park or Hermann Park — helps not only the species of animals involved, but also educates the local population and forms a connection with residents.

"That has a twofold kind of benefit," Johnson says. "It protects the greenspace so species to live with us, and then also it makes the connection to this place we try to protect."

Of course, this type of effort is new, and there's not a lot of data to show how this would affect the ecosystem and its species, from the migratory and genetic diversity standpoints. Despite the lack of data, Johnson says this type of effort needs to happen.

"We're going to continue to manipulate the world, and maybe if we started thinking about this now, that we can get to a point were we understand enough were we can make these some sort of functioning ecosystem," she says.

Part of the shift in thinking about these ecosystems has to do with new ways of tracking species and understanding their environments.

"Technology is helping us ask a lot of these questions," Johnson says. "Ecology is surprisingly complicated. There's so many variables. ... I think technology and our advance with computing is definitely going to help us understand it."

Using preservation to solve flooding
The educational component is also very important to conservation, and Johnson is making strides on campus with her class. Last year, her department and her class introduced a pocket prairie right on the Rice campus.

Before it was the fourth largest city in America, Houston was a prairie. That type of ecosystem — thick with prairie grass — is very absorbing when it comes to rain water.

"It's really surprising to people that the trees and all this lushness is actually all artificial," Johnson says. "We know that this ecosystem evolved with the cyclical flooding events that happened here."

This movement to bring back Houston's ancient ecosystem is a new focus on a few prairie conservationist groups — and even the Harris County Flood Control. This has been going on for a while, but recent flooding events have opened the eyes of people now looking for reliable solutions to flooding problems.

"After Hurricane Harvey, people started realizing that this might be one of the solutions we could actually investigate and see if it can help us," Johnson says. "A green space is going to absorb way more water than a parking lot."

Of course, there are other flood solutions being discussed — some even incorporating tech or even a tube system underground.

"Historically, there has been some budding of heads between the environment and technology, but I really think moving forward, those two fields have to work together. We need to use technology to save the environment," Johnson says. "I think Houston is one of the places where that conversation is starting to happen."

Missing the toads

Courtesy of Cassidy Brown Johnson

The Houston toad has been locally extinct since the 1970s.

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New UH survey reveals concerns over AI data center growth in Houston

data findings

A new report out of the University of Houston shows that area residents remain wary of the long-term effects of operating data centers.

The recent survey from the University of Houston’s latest SPACE City Panel, conducted by the Center for Public Policy at the Hobby School of Public Affairs, shows that while 85 percent of Houston-area residents use AI, nearly 63 percent oppose the construction of AI data centers within 1 mile of their homes.

Respondents’ concerns centered around data centers’ high energy demand and the area’s power grid reliability. According to the survey, 32 percent of residents who oppose local data center projects would be more likely to support the centers if they relied on renewable energy over fossil fuels.

“Respondents understand that AI can bring economic and educational benefits, but they are also concerned about the physical infrastructure needed to fuel AI, especially data centers,” Soran Mohtadi, post-doctoral fellow at the Hobby School and a researcher on the report, said in a news release. “This physical infrastructure demands more electricity and water, leading to environmental impacts.”

Experts estimate that 6.5 gigawatts of data center capacity will be added to the Texas grid by 2030. And Houston’s data center capacity is predicted to more than double by 2028.

The Electric Reliability Council of Texas also projects electricity demand could reach 218 gigawatts by 2031, which would be more than double the record peak set in August 2023. Data centers are expected to account for 86 gigawatts of that new demand.

Survey respondents also said they are concerned about the state's future water supply, given the large amounts of water that data centers need to stay cool.

In terms of who’s responsible for that issue, 57.6 percent of respondents said they put the onus on Texas lawmakers, while 31.5 percent say tech companies should be responsible.

Additionally, more than 75 percent of respondents believed that data center developers and technology companies—not residents—should bear the cost of infrastructure upgrades to support data centers.

“Every decision legislators make has implications on residents’ everyday lives and local infrastructure now and in the future,” Maria P. Perez Arguelles, lead researcher on the report and research assistant professor at the Hobby School, added in the news release. “This issue is going to become more important in years to come, so this is just the beginning.”

Read the full report here.

Houston-born Cemvita makes breakthrough in sustainable fuel production

clean fuels

Houston-based biotech company Cemvita announced that it recently reached a critical milestone in the development of its FermOil product, which can be used to create Sustainable Aviation Fuel (SAF) and other renewable fuels at industrial scale.

The company shared in a news release that it completed a 75,000-liter industrial fermentation run at Belgium's Bio Base Europe Pilot Plant.

The campaign achieved target technical metrics for the production of FermOil, Cemvita’s renewable natural oil (RNO). FermOil is produced from industrial crude glycerin, an industrial byproduct, as opposed to traditional sugar-based feedstocks used in many bio-oil fermentation processes. It's designed to be a drop-in feedstock for creating SAFs.

Cemvita had previously advanced its FermOil production process through multiple scale-up stages before successfully reaching the 75,000-liter demonstration campaign, according to the company.

“This is not just a fermentation milestone,” Moji Karimi, CEO at Cemvita, said in the release. “It is a blueprint for how existing industrial infrastructure can evolve into circular bioeconomy infrastructure. Every biodiesel plant generating crude glycerin is a potential platform for renewable natural oil production.”

The milestone also supports the deployment of Cemvita’s industrial biomanufacturing platform, FermWorks, which integrates with existing energy and industrial infrastructure to turn waste carbon streams into SAFs and other materials. According to the release, Cemvita plans to move forward with commercial deployment discussions with partners in Brazil, Europe and in the UK. Cemvita already has a partnership with the Brazilian sustainable research institution REMA.

“We are proud to support innovative companies like Cemvita in scaling breakthrough industrial biotechnology solutions,” Hendrik Waegeman, head of business operations at Bio Base Europe Pilot Plant, added in the release. “Successfully operating at the 75,000-liter scale using a feedstock such as crude glycerin highlights both the maturity of the technology and the quality of the scale-up execution achieved by the Cemvita team.”

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Eli Lilly scoops up Houston biotech startup in $300 million deal

big pharma deal

Pharmaceutical giant Eli Lilly has acquired Houston biotech startup CrossBridge Bio, which develops antibody-drug conjugates for cancer, in a deal worth up to $300 million. The deal was celebrated by TMC Venture Fund and the University of Texas Health Science Center at Houston last week.

CrossBridge, founded in 2023, is developing ADCs based on research by Kyoji Tsuchikama and Zhiqiang An, both of UT Health Houston. Tsuchikama is an associate professor of medicinal chemistry and a globally recognized ADC pioneer, and An is a professor of molecular science and vice president of drug discovery.

Antibody-drug conjugates (ADCs) are a potent combination of targeted therapy and chemotherapy that kills cancer cells while saving healthy tissue.

Clinical trials for CrossBridge’s primary ADC candidate, CBB-120, are expected to start this year, pending approval from the U.S. Food and Drug Administration (FDA).

“I’m proud of how well our team has executed and advanced our platform in such a short time since the company’s founding,” Michael Torres, co-founder and CEO of CrossBridge, said in a news release. “By becoming a part of Lilly, a leader in patient-focused therapeutic development, we are well-positioned to further accelerate the clinical potential of this approach.”

Under the Lilly deal, CrossBridge shareholders were expected to receive an upfront payment along with a follow-up payment based on the achievement of certain milestones.

In 2024, CrossBridge closed a $10 million seed round. Among the investors in CrossBridge are the Texas Medical Center Venture Fund, CE-Ventures, Alexandria Venture Investments, Portal Innovations, Linden Lake Labs, and the Cancer Prevention and Research Institute of Texas (CPRIT). It was formed in TMC Innovation’s Accelerator for Cancer Therapeutics program."Built within the TMC ecosystem, CrossBridge Bio grew with the support, funding, and resources that helped shape its trajectory. TMC led the company's early financing and watched it evolve from its earliest days to its acquisition by Eli Lilly," William McKeon, president and CEO of the Texas Medical Center, shared in a LinkedIn post. "[This is a] strong reminder that breakthrough science and the right early backing can change what’s possible."