Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Houston scientists are developing a soft sleep cap that tracks and stimulates the brain's "cleaning cycles" linked to Alzheimer’s disease and other dementias. Photo via Getty Images.

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”
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The gift will create the John M. O’Quinn Foundation Neurodegenerative Disorders Laboratory at Houston Methodist. Photo via houstonmethodist.org

Houston hospital lands $10 million grant to launch new neurological lab

research incoming

Houston Methodist announced that it has received a $10 million gift from the The John M. O’Quinn Foundation to support research into neurological disorders, including Alzheimer’s disease, Parkinson’s disease and others.

The gift will create the John M. O’Quinn Foundation Neurodegenerative Disorders Laboratory at Houston Methodist, which will be led by Dr. Jun Li, who chairs the department of neurology at the Houston Methodist Neurological Institute. The NIH-backed researcher and his team will provide care, clinical trial opportunities and subspecialty programs through the lab, according to a release from Houston Methodist.

The funds will also be used to recruit neurodegenerative disorders specialists to lab by creating endowed research chairs, research fellowships and funding for pilot studies.

"Many neurodegenerative diseases are chronic and significantly impact the quality of life, causing pain, weakness, loss of ambulation and sensory loss,” Li says in a statement. “Our team is committed to working with patients to help make their lives better through treatment, and this generous gift fuels our determination to do even more and to help find therapies for these neurological diseases. This commitment from The John M. O’Quinn Foundation will support an interdisciplinary team of neurologists and neuroscientists to further explore treatment options.”

The O'Quinn Foundation has been a long-time supporter of the hospital group, according to Houston Methodist, and has had members of its organization suffer from neurodegenerative disorders.

"As our population continues to live longer, we believe it’s critical to help now, and we know Houston Methodist is best positioned with its renowned researchers and clinicians like Dr. Li to help those with neurodegenerative diseases to have a better quality of life, and ultimately, a treatment for these diseases that impact so many,” President and Executive Director of the foundation Robert C. Wilson III says in the statement.

Earlier this year, Houston Methodist also received a $1 million grant from Susan and William “Dub” Henning, Jr. to support Alzheimer’s research at the Nantz National Alzheimer Center at the hospital. It created the Susan and William Henning Jr. Neurodegenerative Research Endowment.

Meanwhile, over the summer, a Houston clinical-stage biotech that treats neurodegenerative diseases company went public. The company, Coya Therapeutics (Nasdaq: COYA), has developed a biologics therapy that prevents further spreading of neurodegenerative diseases by making regulatory T cells functional again and closed a $15.25 million IPO in January. Click here to learn more about the company's treatments for ALS and Alzheimer's.

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Global summit spotlights Houston's growing role in brain health, innovation

where to be

The Center for Houston’s Future and UTMB are bringing the Texas Brain Economy Summit back to Houston this summer to continue to position the region as a global leader in brain health.

The summit, held June 9-10 at the Texas Medical Center's Helix Park, will bring together more than 500 executives, researchers, policymakers and innovators from around the world to discuss the global brain economy.

Attendees can expect to hear from leaders of global institutions, including the World Economic Forum, U.S. Chamber of Commerce, McKinsey Health Institute, Global Brain Economy Initiative, Davos Alzheimer’s Collaborative, Business Collaborative for Brain Health (UsAgainstAlzheimer’s), Rice University, Memorial Hermann, MD Anderson and many others.

Day 1 of the conference will focus on "Enabling Human Flourishing & Economic Growth." Day 2 will focus on "Scaling Innovation & AI Solutions in the Brain Economy."

Keynotes will be delivered by:

  • Lexi Branson, vice president of health policy at the U.S. Chamber of Commerce
  • Kana Enomoto, director of the McKinsey Health Institute
  • Megan Henshall, founder of Google Experience Institute (Xi)
  • Ryan Howard, co-lead of Google Experience Institute (Xi)
  • Dr. Hani Jneid, John Sealy Distinguished Centennial Chair in Cardiology and vice president of cardiovascular operations at UTMB
  • Steve Kean, president and CEO of the Greater Houston Partnership
  • Dan Patrick, Lieutenant Governor of Texas
  • Jochen Reiser, president of UTMB
  • Thomas Seitz, senior partner of the McKinsey Health Institute

Other significant speakers include:

  • Rym Ayadi, founder and president of the Euro-Mediterranean Economists Association (EMEA) and co-founder of the Brain Capital Alliance
  • Arthur Evans, CEO and executive vice president of the American Psychological Association
  • David Gow, president and CEO of the Center for Houston’s Future (Gow is the founder and chairman of Gow Media, InnovationMap's parent company)
  • Bill McKeon, president and CEO of the Texas Medical Center
  • Jeff Merritt, head of urban transformation at the World Economic Forum
  • Joanne Pike, president and CEO of the Alzheimer’s Association
  • George Vradenburg, founding chairman of Davos Alzheimer’s Collaborative and co-founder, chairman and CEO of Us Against Alzheimer’s

The event is supported through Project Metis, which was launched by the Center for Houston’s Future last year. Led by Rice Brain Institute, The University of Texas Medical Branch's Moody Brain Health Institute and Memorial Hermann’s comprehensive neurology care department, the initiative aims to advance the understanding, prevention and treatment of the brain. It was developed on the heels of Texas voters overwhelmingly approving a ballot measure to launch the $3 billion, state-funded Dementia Prevention and Research Institute of Texas (DPRIT).

“Texas voters, by approving the state-funded Dementia Prevention Institute, have shown a strong commitment to brain health, as scientific advances continue daily. [Project Metis] aims to harness the Houston region’s unique strengths: its concentration of leading medical and academic institutions, a vibrant innovation ecosystem, and a history of entrepreneurial leadership in health and life sciences,” Gow said at the time.

Learn more about The Texas Brain Economy Summit and purchase tickets here.

Texas solar power poised to surpass coal for the first time in 2026

Powering Texas

Solar power promises to shine even brighter in Texas this year.

A new forecast from the U.S. Energy Information Administration (EIA) indicates that for the first time, annual power generation from utility-scale solar will surpass annual power generation from coal across the territory covered by the Electric Reliability Council of Texas (ERCOT).

Solar generation is expected to reach 78 billion kilowatt-hours in 2026 in the ERCOT grid, compared with 60 billion kilowatt-hours for coal, the EIA forecast says. The ERCOT grid supplies power to about 90 percent of Texas, including the Houston area.

“Utility-scale solar generation has been increasing steadily in ERCOT as solar capacity additions help meet rapid electricity demand growth,” the forecast says.

Although natural gas remains the dominant source of electricity generation in ERCOT, accounting for an average 44 percent of electricity generation from 2021 to 2025, solar’s share of the generation mix rose from four percent to 12 percent. During the same period, coal’s share dropped from 19 percent to 13 percent.

EIA predicts about 40 percent of U.S. solar capacity, or 14 billion kilowatt-hours, added in 2026 will come from Texas.

Although EIA expects annual solar generation to exceed annual coal generation in 2026, solar surpassed coal in ERCOT on a monthly basis for the first time in March 2025, when solar generation totaled 4.33 billion kilowatt-hours and coal’s totaled 4.16 billion kilowatt-hours. Solar generation continued to exceed that of coal until August of that year.

“In 2026, we estimate that solar exceeded coal for the first time in March, and we forecast generation from solar installations in ERCOT will continue to exceed that from coal until December, when coal generation exceeds solar,” says EIA. “We expect solar generation to exceed that of coal for every month in 2027 except January and December.”

For 2027, EIA forecasts annual solar generation of 99 billion kilowatt-hours in the ERCOT grid, compared with 66 billion kilowatt-hours of annual coal generation.

In April, ERCOT projected almost 368 billion kilowatt-hours of demand in ERCOT’s territory by 2032. ERCOT’s all-time peak demand hit 85.5 billion kilowatt-hours in August 2023.

“Texas is experiencing exceptional growth and development, which is reshaping how large load demand is identified, verified, and incorporated into long-term planning,” ERCOT President and CEO Pablo Vegas said. “As a result of a changing landscape, we believe this forecast to be higher than expected … load growth.”

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This article first appeared on EnergyCapitalHTX.com.

Intuitive Machines strikes $49.3M deal to expand lunar communications network

space deal

Houston-based Intuitive Machines is bulking up its space-to-ground data network with the acquisition of United Kingdom-based Goonhilly Earth Station and its U.S. arm, COMSAT.

The $49.3 million cash-and-stock deal would add 44 antennas to Intuitive Machines’ network. The acquisition is expected to close in the third quarter.

Intuitive Machines, a space infrastructure and services company, designs, builds, and operates spacecraft and data networks for lunar and deep-space missions. Goonhilly operates a satellite Earth station in Cornwall, England.

Intuitive Machines says Goonhilly’s and COMSAT’s civil, commercial, and government customers will complement its current customer base and broaden its reach into related sectors.

“Customers have been clear that they want a single, integrated, and resilient solution for their communications and [position, navigation, and timing] needs as they accelerate missions at an unprecedented pace,” Steve Altemus, co‑founder and CEO of Intuitive Machines, said in a news release.

Kenn Herskind, executive chairman of Goonhilly, says the acquisition “will allow us to scale that capability globally and directly support the next era of lunar exploration. Together, we will be creating a commercial lunar communications network that is interoperable, resilient, and ready to support Artemis and international missions.”
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