The high-speed train is chugging along. Rendering courtesy of Texas Central

The high-speed railroad from Houston to Dallas has acquired a key new player that will run day-to-day operations.

Renfe, an international railway company based in Spain, has been hired by Texas Central, the project developers, as the train's operating partner. The selection of Renfe as an operating partner marks another major step forward for the Houston-to-North Texas high-speed railroad.

Texas Central CEO Carlos Aguilar says in a statement that Renfe was chosen after a review of the best railroad operators in the world.

"Renfe has established a reputation for excellence in railroad operation in Spain and across the world, and we welcome them aboard," Aguilar says. "With their decades of expertise, they were a natural fit to join our other partners. Having the operator, the design build, and technology teams all on board and able to collaborate will ensure all aspects of the railroad are integrated and efficient."

A release calls Renfe "one of the world's most significant railways operators," running 5,000 trains daily on 7,500 miles of track. The company is integral to the transport system in its home base of Spain, handling more than 487 million passengers and 19.6 million tons of freight moved in 2017.

Renfe, in partnership with Adif, which manages Spanish railway infrastructure, will be responsible for running the trains; maintaining system components, such as engines, signals, and other equipment; and overseeing ticketing, passenger loyalty programs, and other services.

It will also provide technical advice on the design and construction of the Texas train and assist in the further development of Texas Central's operation and maintenance plans, preparing the railroad for passenger service.

Renfe is one of the biggest companies in Spain, employing nearly 14,000 people and recording revenues of 3.6 billion euros in 2017. Its high-speed systems were used by more than 36 million passengers in 2017. In March, Renfe announced that it had posted a net profit of 70 million euros in 2017, thanks in part to a jump in the number of its high-speed passengers, chalking up five consecutive years of growth.

Renfe president Isaías Táboas says the deal is a boon for Texas and for the Spanish railway industry.

"Texas Central represents a large high-speed train project in a country with high-growth potential, for which the Spanish experience will be of great help," he says. "Both Renfe Operadora and Adif have accumulated years and miles of high-speed railway development with professional teams, extensive experience, and specialized knowledge. We are committed to the success of Texas Central in improving the mobility of Texans and others in the U.S."

The agreement comes about a week after Texas Central engaged multinational firm Salini Impregilo ­– operating in the U.S. market with The Lane Construction Corporation – to lead the civil construction consortium that will build the passenger line, including viaducts, embankments, and drainage.

Spain's first high-speed line between Madrid and Seville was dedicated in 1986 and Renfe's first high-speed service connected the cities in 1992.

Its second high-speed line, from Madrid to Barcelona, was completed in 2007. Renfe also operates high-speed service from Barcelona to Paris, Lyon, and Toulouse in France. Among other major international projects, Renfe operates the recently opened high-speed train between Mecca and Medina, in Saudi Arabia.

The 200-mph train will link Houston and Dallas in 90 minutes, with a midway stop in the Brazos Valley.

The Texas train will be based on the latest generation of Central Japan Railway's Tokaido Shinkansen train system, the world's safest mass transportation system. It has operated for more than 54 years with a perfect record of zero passenger fatalities or injuries from operations, and an impeccable on-time performance record.

Texas Central and its partners are refining and updating construction planning and sequencing, guided by the Federal Railroad Administration's recently released draft environmental impact statement. The FRA now is working on a final environmental review that will help determine the project's timeline and final route.

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This story originally appeared on CultureMap.

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.