New travel startup plans the perfect vacations for Houston's busy young professionals

GET THERE NOW

Young professionals can dive into fun travel with this Houston-based company. Photo courtesy of Here and Now Travel

Work-life balance for a young professional is hard. There's the dream of travel but the nightmare of planning. Then there's the challenge of working with limited vacation days and finding a friend whose schedule lines up.

To the rescue comes Houston-based Here & Now Travel, which aims to create a vacation free of stress and full of memorable experiences and offers adventurous group travel specifically for young professionals.

When discussing the inspiration for starting their company, cofounder Alex Coleman tells CultureMap that he and his wife and fellow cofounder, Elise, were caught between the benefits and drawbacks of individual versus group travel.

They loved the freedom of solo traveling but not the potential feelings of isolation and vulnerability. When it came to traveling with friends, they enjoyed the bonding and security in a group but not all the work involved with navigating everyone's schedules and preferences during planning.

"We decided to create a travel company that combined the best of both worlds," Coleman says. "A company that gave people the flexibility of going to their desired destinations at their desired time, without losing the experience of traveling with a group of awesome people."

As young professionals themselves, the Colemans also wanted their company to consider the typically low number of vacation days their target clients have. That's why Here & Now trips take advantage of weekends and holidays so participants only have to take a maximum of three days off from work.

Here & Now Travel currently has six trips planned for 2020: two to Costa Rica, two to Colombia, and two to Mexico. On these trips, the itineraries lean towards adventure activities and cultural experiences.

For example, their next trip scheduled for January 9 to January 13 to Costa Rica includes exploring Juan Castro Blanco National Park, zip lining through the rainforest, learning how to make tortillas with a local family, and more.

"We shy away from crowded tourist attractions. We pride ourselves on showing travelers hidden gems of our destinations, be it the hidden Mayan cenote in Tulum where we have to be blessed by the community's Mayan Shaman before entering, or one of the region's largest waterfall in Costa Rica which sits on the land of a small farming family," says Coleman. "Through these tucked away, amazing places, we get to see things others typically don't, and have true interaction with the communities we are visiting.

Each Here & Now package includes private transportation to and from the airport and for the duration of the trip, shared three or four-star accommodation, all breakfasts and lunches, and all entrance fees and itinerary activity costs. Flights, dinners, and the required travel insurance are not included.

If you decide to join one of their trips, you can expect to be in a group of between six and 14 young professionals — with 14 being the absolute max as Here & Now Travel doesn't want to overrun the visited communities or contribute to the overuse of their resources.

"Large groups in charter buses feel clunky and seem like you are trampling or disrupting the destinations you are visiting," says Coleman. "We cap our trips at 14 people, allowing us to be good stewards of the communities we visit, and maintain our feel as a small group of travelers...and not tourists."

Each travel group is also accompanied by a Here & Now host who handles all the logistics as well as a local guide, which is a feature that Coleman believes sets their company apart from others.

"Travelers on Here & Now trips are always led by someone who calls that destination home," he explains. "Our guides have an emotional bond to the places we explore. Their passion and connection to their homes is something that can't be replicated."

Along with employing these local guides, Here & Now Travel works with local drivers, restaurants, and lodging as a way to ensure the money they spend in each community stays in that community.

As a further testament to their commitment to sustainable tourism, Here & Now Travel plans to offset their carbon footprint, which is mainly caused by airline travel, by donating to the nonprofit Trees for Houston in 2020.

The company also has plans to increase their number of trips to once per month and to eventually include European destinations.

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This article originally ran on CultureMap.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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