Why this Houston medical device innovator is pumped up for the first total artificial heart

HOUSTON INNOVATORS PODCAST EPISODE 248

Dr. William Cohn is the chief medical officer for BiVACOR, a medical device company creating the first total artificial heart. Photo via TMC

It's hard to understate the impact Dr. William Cohn has had on cardiovascular health as a surgeon at the Texas Heart Institute or on health care innovation as the director of the Center for Device Innovation at the Texas Medical Center. However, his role as chief medical officer of BiVACOR might be his most significant contribution to health care yet.

The company's Total Artificial Heart is unlike any cardiovascular device that's existed, Cohn explains on the Houston Innovators Podcast. While most devices are used temporarily for patients awaiting a heart transplant, BiVACOR's TAH has the potential to be a permanent solution for the 200,000 patients who die of heart failure annually. Last year, only around 4,000 patients were able to receive heart transplants.

"Artificial hearts historically have had bladders that ejected and filled 144,000 times a day. They work great for temporary support, but no one is suggesting they are permanent devices," Cohn says on the show.

The difference with BiVACOR's device is it abandons the bladder approach. Cohn explains that as assist pumps evolved — something his colleague, Dr. Bud Frasier, had a huge impact on — they featured new turbine and rotor technology. Daniel Timms, BiVACOR's founder and CTO, iterated on this technology beginning when he was a postdoctoral student at Queensland University of Technology in Australia.

"BiVACOR is the first artificial heart that leverages what we learned from that whole period — it has no bladders, it has no valves. It has one moving part, and that moving part is suspended in an electromagnetic field controlled by a computer and changed thousands of times a second," Cohn says. "It will never wear out, and that's why we think it's the world's first total artificial heart."

The company is seeing momentum, celebrating its first successful human implantation last month. The device was used for eight days on a patient at Baylor St. Luke’s Medical Center before the patient received a heart transplant.

Cohn says that BiVACOR has plans to use the TAH as "bridge-to-transplant" device in several other surgeries and expects to get FDA approval for that purpose in the next three to four years before working toward clearance for total artificial heart transplants.

Cohn has worked to support medical device startups at CDI at TMC for the seven years it has existed — first under Johnson and Johnson and then under TMC when it took the program over. He describes the center and its location as the ideal place for developing the future of health care, with Houston rising up to compete with regions known for medical device success — both coasts and Minnesota.

"Being in the shadow of the largest medical center on the planet — 106,000 employees show up there every 24 hours," Cohn says, "if you want to innovate, this is the place to do it."

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Revisiting a conversation with Dr. Joseph Rogers, president and CEO of the Texas Heart Institute, on the Houston Innovators Podcast. Photo via texasheart.org

Play it back: How this Houstonian is leading heart health innovation

HOUSTON INNOVATORS PODCAST EPISODE 246

Heart health innovation is at a major moment in history — and Houston is at the center of it.

Last summer, Dr. Joseph Rogers, president and CEO of the Houston-based Texas Heart Institute, joined the Houston Innovators Podcast to share how he came to be at the helm of THI, as well as the incredible technologies the institute is working on to address heart failure, a global epidemic affecting at least 26 million people worldwide, 6.2 million adults in the U.S.

This month, one of THI’s technologies reached a major milestone. BiVACOR, a Houston company successfully implanted the company's first Total Artificial Heart in a human. The device was implanted in the patient on July 9. Eight days later, a donor heart became available and was transplanted into the patient, removing the TAH, establishing the device as a successful bridge-to-heart-transplant solution for patients, THI reported.

In addition to this breakthrough in health tech, THI is focused on addressing Cardiometabolic Syndrome at a new conference on Friday, August 23, in Houston. The full-day symposium will take place in collaboration with Arianna Huffington, the founder and CEO of Thrive Global. Dr. Rogers is co-directing the program with Dr. Stephanie Coulter, medical director for THI Center for Women’s Heart & Vascular Health.


In the episode, Rogers explains why he's bullish on Houston and THI leading heart health innovation alongside other health care organizations — nonprofits, universities, local government — to collaborate in ways never been done before. And THI is dedicated to this mission.

"We should act as a convener," Rogers says. "Houston is the place to do this.

"The reason I think this is such an important community to address this problem is it's the most diverse city in the United States. And I've never lived anywhere or heard of another city that I was so convinced believed they could do anything they set their minds to. It's about making the community aware of the problem and a potential solution — and then working on trying to solve it," he continues. "But I think all of the pieces are here to show the world how to do this at a community level."

Emerson Perin of the Texas Heart Institute, recently published the largest clinical trial of cell therapy for patients with chronic heart failure to-date included 580 patients at 52 sites throughout North America. Photo via texasheart.org

Houston health care leader on a mission to innovate an end to heart failure

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Emerson Perin’s end goal isn’t to treat heart failure. The medical director of The Texas Heart Institute says that he has his sights set firmly on curing the malady altogether. And, with the power of innovation and a strong team, the Houston-based cardiologist has a good chance of meeting his objective.

Perin first came to THI for fellowship training in 1988, following his residency in Miami and medical school in his birthplace of Brazil.

“This is a very special place,” the physician and researcher, whose titles also include director for THI’s Center for Clinical Research and vice president for medical affairs, tells InnovationMap. “It has a worldwide-reaching reputation. I’ve always liked research and this is a great place in terms of innovation and practicing high-level cardiology.”

For decades, Perin has followed in THI founder Denton Cooley’s footsteps with world-changing research. In 2001, the founding medical director of THI’s Stem Cell Center was the first person to inject stem cells into a failing human heart. It led to a trial of 17 patients that year.

“A couple of the patients did remarkably well — more than you could ever expect. These guys who couldn’t’ walk across the room pretty much were jogging on the beach. That gave me the initial insight that this works,” Perin recalls.

What exactly is heart failure? The term refers to the condition of a heart that can’t pump enough blood to sustainably power the body through oxygenation of the tissues from blood flow. It may sound like a death sentence, but with appropriate care, it can usually be managed with medicines and if worsening occurs, devices and, ultimately, heart transplantation.

And Perin is proving that there’s a lot of life ahead for heart failure patients. Earlier this year, he published another groundbreaking clinical trial, DREAM-HF. The largest clinical trial of cell therapy for patients with chronic heart failure to-date included 580 patients at 52 sites throughout North America.

With the goal of getting a new cell therapy approved for heart failure, the primary endpoint was to prove that the therapy could prevent recurrent hospitalizations.

“It was a total negative,” says Perin. That’s because the cells don’t have a decongestant effect such as the medicines currently used to treat heart failure.

But that doesn’t mean that the trial was a failure. Quite the opposite. That’s because Perin and his team proved something else: The trial was able to prove that there was significant improvement in patients with inflammation. After those patients were injected with mesenchymal precursor cells (MPC), they showed a 70-percent reduction in heart attacks and strokes. Cardiovascular deaths also decreased.

These are blockbuster numbers, and big news for patients dealing with heart failure. What it means is that the cells addressed a different aspect of heart failure that until now had been left untreated which was the inflammation — how heart failure starts and what keeps it going.

So what’s next? Going to the FDA.

“They said, ‘We can’t approve it with one trial, but we’ll approve it with two,’” says Perin.

This time, his primary endpoint will be tailored to suit the positive outcome he knows he’ll be able achieve. This next round will begin in 2024.

Once the FDA approves a new catheter system for injecting the heart with stem cells and genes, the team will proceed with new studies. Gene therapy will be another frontier for Perin — and patients with heart failure.

“I think the combination of cells and genes is even more powerful,” he says. “That will help save lives in a completely new way and do away with heart failure.”

Perin's work is just one piece of the puzzle, and Dr. Joseph Rogers, who was appointed president and CEO of THI in 2021, is leading the organization's initiative in several ways. THI, recently buoyed by a $32 million donation from a patient — the largest charitable donation in its history — is exploring several innovative therapeutics, devices, and treatments.

THI recently received a two-year, $1.14 million grant from The National Heart, Lung, and Blood Institute to develop a novel, first-in-class drug to treat the cardiovascular disease that arises from atherosclerosis. Another THI innovator, Camila Hochman-Mendez — along with her research team — is studying the effects of regenerative medicine on hearts.

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Diversity-focused sports tech accelerator opens applications to Houston innovators for the first time

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A global organization has announced it's opening applications to its equity-focused sports tech accelerator to Houston founders for the first time.

Thanks to a collaboration with Impact Hub and Black Ambition, the adidas Community Lab has expanded its footprint and is now accepting applicants from new markets, including Houston, Toronto, Los Angeles, Atlanta, and New York, for its 2024-2025 cohort.

The initiative, which has been running for three years, has a goal of supporting Black and Latino/a/e founders with mentorship, pitch training, event programming, and networking. The eight-month program also has $75,000 in grant funding to dole out to participants as well.

“As Community Lab enters its third year, we are thrilled to cultivate a larger cohort of social entrepreneurs who share our vision of removing barriers to accessing sport for the communities we collectively serve,” Ayesha Martin, senior director of adidas Purpose, says in a news release.

Both the global organization of Impact Hub and the local group, Impact Hub Houston, are involved in the collaboration.

“Impact Hub is thrilled to partner and support this third iteration of adidas Community Lab, empowering visionary leaders who are advancing SDG3 —Good Health and Wellbeing — and SDG10 — Reduced Inequalities," Michelle Avalos, co-founder of Impact Hub Houston, adds. Together, we’re helping entrepreneurs create equitable access to sports and foster healthier, more inclusive communities for all."

Applications are open online now until September 23.

Founded by Pharrell Williams, Black Ambition will also collaborate with the program this year on key programing sessions. The organization invests funding and resources into Black and Hispanic entrepreneur-founded startups.

"Black Ambition was founded to create the space, bespoke opportunities and relationships needed for underrepresented founders to excel, uninterrupted. We are excited to partner with adidas Purpose to extend elements of our renowned, global founder support model to social impact entrepreneurs positively transforming their communities through sports and wellness," says Jermeen Sherman, managing director at Black Ambition.

City of Houston grants $100,000 to 10 innovative arts organizations

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Ten Houston individuals and nonprofits are beneficiaries of grants totaling $100,000 for efforts to furthers cultural tourism and resilience throughout the City of Houston.

The Mayor’s Office of Cultural Affairs (MOCA) awarded the funds through the Initiative, a competitive grant program administered by Houston Arts Alliance (HAA) and funded by a portion of the city’s Hotel Occupancy Tax.

The application period is open three times annually and grant funding falls into three categories: Art + Neighborhood Cultural Destinations, Art + Disaster Resilience Awareness, and Art + Conference Tourism.

Here is a look at the winners and the projects that will be created with these grants.

Art + Conference Tourism

Contemporary Arts Museum Houston
This week, from September 16-19, the museum, in partnership with Houston Freedmen’s Town Conservancy (HFTC) and artist Theaster Gates, hosts Houston’s edition of the renowned Black Artists Retreat (B.A.R). The initiative explores the concept of “Black Land Ownership and Space: Black Stabilization and Determination." The four-day event brings together speakers, panelists, and experts from Houston and across the country to elevate and inspire the brain trust in local Black and BIPOC artists, creatives, and intellectuals. Programming occurs in Houston Freedmen’s Town, POST Houston, and CAMH.

One Sample Cultural Foundation
The organization will use its grant to produce the Ethnography of Afro-Venezuelan Music, a multidisciplinary educational conference that includes videos, music, and dance that exploring the syncretism of African culture and European religious practices in Venezuela through music. This free event will take place twice — at the Institute of Hispanic Culture of Houston on October 10 and at Teatro Bilingüe de Houston on April 13, 2025. The project aims to strengthen ties between the African American and Venezuelan communities and promote a dynamic cultural exchange.

SoulSista Art Foundation
The organization hosts a conference highlighting Houston’s contributions to the new music business at Houston Warehouse Studio on November 11. Free and open to the general public, it will include performances from selected poets and Afrobeats artists who have been recognized over the years in Houston, along with a DJ and food trucks. Donations will be accepted.

Art + Neighborhood Cultural Destinations

DaCamera
The music organization will use its grant for a series of jazz concerts at the historic El Dorado Ballroom in Third Ward. DaCamera at The Eldorado: Rising Jazz Stars features up-and-coming jazz artists from around the country, providing a new opportunity for Houstonians to experience the next generation of outstanding jazz talent. Concerts begin in October and run through May 2025. All performances will be pay-what-you-can.

Dance Afrikana
A curated exhibition, digital dance archive, and a book are planned as part of the organization's Black Dance in Texas multidisciplinary project. Documenting the rich history of Black dance in the state, this project is an extension of the research project by Dance Afrikana’s founder and Scholar-in-Residence for Rice University’s CERCL Program at the African American History Research Center Gregory Campus.

Norma Jo Thomas
The composer's original musical, Carol of the Bells, will have its world premiere on December 14 at the C. Lee Turner Performing Arts Center on the campus of Lone Star College. The holiday offering is part of Thomas' ongoing tradition to bring cultural programming to the community, and is part of an Acres Homes community collaboration.

The Pilot Dance Project

Celebrated Houston-based choreographer Cynthia Garcia presents Loteria, which brings to life the characters of the traditional Mexican board game. In an urban landscape of constant gentrification, often cultural signifiers, customs, and traditions are left behind to show the legacies of cultural communities. The work will be performed at two major cultural events in gentrified neighborhoods that have histories as Mexican and Mexican American neighborhoods, MECA’s Day of the Dead Festival in October and the MD Anderson YMCA’s annual posada in Near Northside in December.

University of Houston Foundation
Seven-time Grammy Award-winner Terence Blanchard will engage communities from Third Ward and downtown Houston in a series of events. In addition to performing a concert, the jazz legend will collaborate with University of Houston and University of Houston-Downtown students. Performance will take place November 7, 8, and 10 at the Wortham Theater Center or at the University of Houston Moores School of Music. A fireside chat and workshop are also part of the visit.

Art + Resilience Awareness

Group Acorde
The organization's Batimento Cardiaco is a new work that depicts Houstonians' mental health before, during, and after a natural disaster occurs. It will premiere at the MATCH October 3 and 4, and feature musicians, two contemporary dance choreographers, and a visual artist who've collaborated on this important work. Sets and costumes are made of recyclable materials. A discussion will follow the performance. Rehearsals streamed on Group Acorde's social media will give audiences a look at the work as it develops.

Lance Flowers
The artists solo exhibit, Take Me As I Am, takes place simultaneously at the Hogan Brown Gallery in Third Ward and Yale University’s Institute for Sacred Music. It's a collection of new 2D works, videography, music, and photography pieces highlighting Third Ward and its community, and all the materials used will be gathered from the Third Ward. It's curated by gallery director Robert Hodge. The Yale portion of this show has received its own funding.

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This article originally ran on CultureMap.

How to prepare your business for severe weather, according to this Houston expert

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Unprecedented severe weather events are becoming more frequent and intense. Proactive business planning is critical to navigating what Mother Nature has in store for us.

In Houston, severe weather can impact operations any time of year, not just hurricane season, so now is the time to incorporate any fresh lessons learned during Hurricane Beryl into your plans. Employers are responsible for safeguarding their employees and assets during these emergencies, which requires establishing an emergency action plan as a foundation of preparedness.

Develop an Emergency Action Plan

If your business does not have an emergency action plan (EAP), today is the perfect time to start it so you are prepared with a response strategy. This clearly written plan is a blueprint for how your business will react and protect employees when severe weather strikes. The more detailed the EAP, the better you and your employees will respond in a time of crisis. Within the EAP, it is important to outline specific protocols, designate key roles and responsibilities and establish communication channels for employees and clients. As power can be an issue during severe weather events, outlining various communication channels is helpful.

Identify Key Employees

During an emergency, you need to know who has the authority to make the decisions that impact your employees and your business. The designated person needs to assess the situation, determine whether employees should work remotely or shelter in place, and communicate these decisions clearly and quickly. This person is usually on the leadership team and can be trusted to make clear decisions, act promptly and communicate effectively to mitigate undue risks.

Implement Regular Emergency Training

Practice makes perfect. A plan on paper is the first step, but it must be practiced and drilled so everyone knows what to do, asks questions and makes any needed adjustments, all when the stakes are not as high. Familiarity with emergency procedures through periodic training and drills allows employees to practice evacuation routes, assembly points and safety protocols.Incorporating local emergency responders in safety drills familiarizes employees with the roles and responsibilities of each group. Through this emergency training, your teams will become confidently prepared to calmly respond to emergencies.

Provide a Swift and Orderly Response

Proactively thinking through and planning for location-specific emergency situations allows business owners to mitigate risks associated with severe weather events and quickly respond when a crisis strikes. When your business is prepared, there is less downtime and disruption to business operations, it protects physical assets, and most importantly, it prioritizes the safety and well-being of employees.

Houston experiences a wild mix of severe weather situations, which makes proactive business planning and preparedness even more critical. Prioritizing EAP development and implementation, designating responsible decision-makers, conducting regular training and drills, and ensuring clear communication channels sets the stage for a resilient organization in severe weather. Additionally, establishing a clear EAP helps foster a culture of safety and readiness that can significantly protect lives and livelihoods during times of crisis.

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Ray Brock is a director of safety services with Insperity, a leading provider of human resources offering the most comprehensive suite of scalable HR solutions available in the marketplace.

This article originally ran on EnergyCapital.

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