Guide App, a Houston startup, is looking to help its users tap into social media better. Photo via Getty Images

Just look at any smartphone on the market and it becomes evident just how pervasive mobile apps have become, especially social media apps.

As the social networking sphere has revolutionized communication, technology has spawned multitudinous variants in the most organic way. That kind of technological momentum lends itself to why platforms like Guide App have a chance to be the next big thing in the space.

The company's CEO and co-founder, Tim Salau, tells InnovationMap that Guide is a social learning and development platform that aims to revolutionize learning experiences for creators, leaders, and organizations.

“Guide is a social learning platform for creators who are freelancers and work in the entertainment and media industry,” says Salau, Houston native and University of Texas graduate. “And they can use Guide to create and learn production skills. We pivoted in late 2019 as the pandemic hit, and we realized that Guide could be used as a B2B platform and solution for businesses to onboard and train their remote workers.

“So that's really what makes us money, and we really decided to build it because we saw that there was a huge gap in the business space of a bite-sized training platform and solution, and to do what TikTok and Reels was doing in the consumer space, but for professionals with security and privacy in mind for organizations,” he says.

With the pivot, businesses can now use Guide as a platform to onboard and train new hires for their respective companies.

“Ideally, it would be pretty much anyone within the marketing department, the product management division, or even engineers within their organizations who are creators in the sense of migrating to creative work in their own different disciplines,” says Salau. “And they could use Guide to potentially maybe create a video that's 90 seconds or less on everything a new hire needs to know within the first 90 days in the product management role or in the marketing role.”

Tapping into trends

Salau explains how he's got his ear to the ground when it comes to trends within media.

“With the way that things are moving in the entertainment and media industry and what's been happening with these strikes, I see the short-form content becoming even more important because people are not necessarily attending movie theaters at a high engagement rate,” says Salau. “Then there are multiple streaming platforms have so many gates and paywalls up, a lot of people aren't necessarily using all of these streaming platforms and seeing all of the long-form content out."

“I'm starting to see that in the next three to five years, macro content will become more important, and instead of the streaming era that we've seen in the last few years or in the last decade or so led by Netflix, I'm going to use our mock theory, we're going to start seeing a beaming era in which we're going to start seeing content being pushed to creators and consumers, that is literally tailored to what they want.”

According to Salau, platforms such as Instagram and TikTok push content based on their respective algorithms that followers don’t necessarily want to see, and that takes time away from the content they need, when they need it.

“Looking forward, it’s clear that in the sense of taking away all of the distractions that we see on these platforms, at Guide, we want to push content as it comes from the creators,” says Salau. “And for us, that focus will be on microcontent, which is content that’s 90 seconds or less.”

Data shows that the best micro content is video content that clocks in around 15 seconds.

“Content that goes up to 30 seconds is probably even cutting it a little bit too long, but the content that really goes a lot, and goes really viral on those platforms is 15 seconds,” says Salau. “And now that TikTok is becoming a more long-form entertainment platform, you're starting to see them kind of strip away from what really got them popular and buzzworthy.”

Monitoring monetization

Popularity aside, one of the major tenets of content creation is monetization.

“Getting to the point where creators will be able to monetize their content is our goal at Guide,” says Salau. “We have to build up towards that goal, but that’s the intent. We intend on having them be able to create profiles where they can actually list their merch. They can post about merch in their videos, and more importantly, get to a point where people can actually buy the entertaining content that they have.”

Once Guide reaches monetization, creators will be able to list content at the price they want it and have associated merchandise of their brand. This is a huge difference from how TikTok and Instagram and other consumer video platforms get creators paid.

“We see that it's better to actually go the other route and actually allow creators to monetize their own brand, which is what every creator often really wants,” says Salau. “That’s ideal because when a creator brings consumer brands into the picture, they have to play to what they want from an advertisement and dollars type of standpoint. So, we don't want to actually get into that world. We want to really keep everything creator oriented.”

Curating a culture of creators

At this point, Guide has about 150 creators, because they’ve been very selective with their icon program.

“We don’t believe that everyone’s a creator,” says Salau. “Because if everyone is a creator, then no one is a creator.

“And we kind of see this with a lot of the creator platforms out there. Just because anyone can create content with a smartphone doesn't mean it's content that's edifying or beneficial that people are actually enriching and learning from. So, we're really big on learning, because we see ourselves in that space.”

As Salau and team look forward with Guide, they plan on continuing to address the learning and talent development gap for remote and mobile teams. They’ll also remain focused on being the kind of platform where creators can talk about the behind-the-scenes and the process of how to make music or how to approach acting, or how to think about set production when on a set.

“With Instagram and TikTok, it’s really much more about fun and virality, and doing something that gets a reaction, versus helping people learn,” says Salau. “So, with us, the feedback we've received is, ‘I get it,’ and ‘I'm interested.’ And I want to continue learning and growing with y'all. Thank you.”

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.

Elon Musk's SpaceX is about to make its debut on Wall Street

Money Moves

Elon Musk's rocket company SpaceX will make its debut on Wall Street Friday, June 12, and both institutional and retail investors are expected to gobble up the 555.6 million shares going up for sale at $135 apiece. Musk, already the world's richest man, could become its first trillionaire.

SpaceX is likely to become the biggest IPO ever, with proceeds of around $75 billion. SpaceX hopes to become the first company to send people to Mars. In fact, part of Musk’s future compensation depends on SpaceX eventually establishing a colony of at least 1 million people on the red planet.

Why SpaceX is going public now

In a video conference on Musk's social media platform X, he told JPMorgan CEO Jamie Dimon that people have suggested for the last 10 years that he take SpaceX public. He's doing it now because the company plans to put 100,000 next-generation Starlink satellites into orbit. Deploying AI data centers in space is a “massive new growth base and you need capital for that,” he said.

Going public provides access to the capital that SpaceX needs. But it also exposes it to more scrutiny from shareholders and more regulatory oversight. That includes filing quarterly financial reports, which critics say incentivizes short-term thinking over longer-term planning and creates unnecessary costs for a company. Securities regulators are currently soliciting public comment on a proposal to require public companies to file the financial reports only twice every year.

How the IPO impacts the company

Musk will hold the majority of a special class of shares, giving him control over decisions related to company strategy, finances and personnel. On the latter, because of his ownership of most of these Class B shares, the only person who can fire Musk as CEO is Musk.

The company credits Musk with being the “driving force” behind its growth, innovation and success. But what happens if Musk is no longer in the picture? SpaceX warns that the loss of Musk could disrupt its ability to execute its strategy as well as hurt its “reputation and relationships with customers, partners and other stakeholders.”

The company also warns that finding a replacement with the same skills and experience as Musk would be time-consuming, if not nearly impossible. As Wedbush Securities analyst Dan Ives wrote Wednesday, “At the end of the day Musk is SpaceX and SpaceX is Musk.”

What could make or break SpaceX

Currently in the test phase, the gigantic reusable Starship rocket is key to SpaceX realizing Musk's ambitions. Much of the commercial space business hinges on SpaceX developing Starship’s capability to be fully reusable and hearty enough for a quick turnaround between flights. If that doesn't happen, SpaceX warns that putting data centers and satellites in space will take longer and cost more money, meaning it risks customers bailing on the company.

Analysts say that by pioneering reusable rockets, SpaceX has established a clear lead on competitors such as Blue Origin, led by Amazon founder Jeff Bezos. The Starlink satellite business competes with, among others, AST SpaceMobile – which is relying on a SpaceX rocket to send its latest generation of satellites into orbit next week.

The prospectus filed last week says SpaceX’s biggest potential market is the sale of business-oriented artificial intelligence products designed to transform how people get work done. It’s an opportunity SpaceX predicts would be worth $22.7 trillion if it could somehow dominate rivals like Anthropic, OpenAI and Microsoft in a highly competitive industry. But the prospectus shows no clear path to profitability for the xAI business, which merged with SpaceX earlier this year.

Why Wall Street is paying attention

If the SpaceX IPO is as successful, the stock could quickly join the Nasdaq 100, a widely followed index that tracks the 100 largest non-financial companies in the composite. That's important because some popular funds, such as the $460 billion QQQ exchange-traded fund, mimic the index and will automatically buy whatever is listed in the index.

Nasdaq recently changed its rules to allow select companies to enter the Nasdaq 100 after just 15 trading days.

S&P Dow Jones Indices, on the other hand, is sticking to established and more traditional thresholds that will not allow SpaceX or other companies with gargantuan IPOs faster entry into its S&P 500 index. That means even high-profile companies will still need to wait for their stocks to trade a full 12 months before they can enter the index.

Companies want to be in the S&P 500 in particular because it's arguably the most important index on Wall Street, with trillions of dollars either mimicking it exactly or benchmarked against it. Vanguard's VOO fund that tracks the S&P 500 has roughly $950 billion invested in it, for example.