Houston oncology therapeutics co. raises $11.4M in seed funding

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Diakonos Oncology Corp. closed its seed round to the tune of $11.4 million. Photo via Getty Images

A Houston-based, clinical-stage immuno-oncology company has raised an oversubscribed round of seed funding.

Diakonos Oncology Corp. closed its seed round to the tune of $11.4 million. The funding will go toward supporting the company's Phase 2 trial — slated for later this year, following its ongoing Phase 1 study — and operations through late next year. California-based biotechnology investment firm Restem Group Inc. led the round, and existing investors contributed as well.

“We greatly appreciate the support of these investors in sharing our passion for improving the lives of patients suffering from deadly cancers such as glioblastoma,” Mike Wicks, Diakonos CEO, says in a news release. “The fact that this financing is nearly triple our initial target also shows they share our confidence in the effectiveness of our unique cancer therapy.”

Founded in 2016, the company recently received FDA Fast Track designation for its dendritic cell vaccine, DOC1021, which targets glioblastoma multiforme, or GBM, the most common and most lethal malignant brain tumor in adults. Diakonos also received the designation for its pancreatic cancer treatment.

"We are thrilled to invest in this groundbreaking company that is at the forefront of cancer treatment innovation. As a firm deeply involved in the cell therapeutic field, we recognize the immense potential of their pioneering work with dendritic cell therapies and we are confident that this can become a new standard of care for cancer in the future," adds Andres Isaias, executive chairman of Restem Group Inc.

Diakonos Oncology's DOC1021 uses the body’s natural anti-viral immune response to fight GBM. The vaccine mimics viral infection with the patient’s cancer markers. Essentially, DOC1021 uses the body’s own natural ability to detect and eliminate infected cells. According to the company, all of the patients who have tried the treatment have exceeded survival expectations. And DOC1021 appears to be extremely safe, with no serious adverse effects having been reported.

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UTSI's advisory board digs into cybersecurity's challenges, trends + tech

From The Board

In today's digital landscape, the convergence of Information Technology (IT) and Operational Technology (OT) presents both opportunities and challenges for critical infrastructure asset owners and operators.

UTSI, a leading systems integrator of OT technology, has assembled an OT Cybersecurity Advisory Board to address these challenges and highlight standard processes and best practices to evaluate and secure these environments.

“We are excited about the strength of our esteemed Advisory Board and are confident that these strategic alliances will enhance our competitiveness,” says Shaun Six, president of UTSI International.

A few of the drivers of OT and IT convergence include increased efficiency, enhanced data, and improved remote monitoring and control capabilities. It exists to promote the promise of connectivity, data visualization, and to enable AI and better decision-making.

Key challenges
However, there are challenges. Increased attack surface, legacy systems, and infrastructure, as well as differing security requirements and regulatory and compliance challenges are all present.

“As we witnessed our global infrastructure recover from the largest outage on July 19, this is a clear and present example of how the application of technology between IT/OT can have an impact on the underlying interdependencies in critical systems and infrastructure," says Cherise Esperaza, co-founder and president of Security Gate. "Therefore, there is an ever-increasing need for resources to be expended for this endeavor, and understanding the areas of risk alongside business outcomes as it relates to the convergence will be a critical to ensuring optimal availability of these systems.”

Increased monitoring

When it comes to security monitoring and incident response, it's vital to incorporate new tools to monitor, meeting the same standards as legacy assets and reporting vulnerabilities.

"Continuous monitoring is one of the most critical aspects of securing your IT/OT infrastructure," offers Eric Rippetoe, former CISO of Federal Energy Regulatory Commission and UTSI cybersecurity consultant. "Automated tools coupled with mature processes allow organizations to rapidly detect security threats and enable teams to quickly respond to address issues. Having a security incident and not knowing about it could result in huge remediation costs and major long-term reputational damage."

Emerging technology and trends
With the rise of AI, it makes sense now more than ever to follow the principle of "never trust, always verify." A Zero Trust architecture is a strategic approach to cybersecurity that secures an organization by eliminating implicit trust and continuously validating every stage of a digital interaction.

In line with this approach, UTSI International Corporation, as a Gold Partner of ThreatGEN, has been intensively utilizing ThreatGEN's AutoTableTop™ incident response tabletop exercise simulation tool. This advanced technology is helping UTSI provide meaningful tabletop exercises to their client base, particularly in high-risk SCADA and OT environments.

Clint Bodungen, president of ThreatGEN, emphasizes the tool's significance: "This tool is designed to sharpen incident response capabilities for teams operating in critical SCADA and OT environments. In these high-stakes settings, where system availability is paramount and the consequences of failure can be catastrophic, AutoTableTop™ provides an unparalleled platform for realistic, AI-driven tabletop exercises. It allows teams to practice and refine their responses to a wide range of scenarios, with practically zero planning time required, ensuring they're prepared for the unique challenges posed by industrial control systems where even a minor slip-up could have deadly consequences. This application of advanced simulation technology aligns with the industry's move towards more robust and realistic cybersecurity training, especially in sectors where the stakes are exceptionally high."

In conclusion
The convergence of IT and OT presents significant cybersecurity challenges for critical infrastructure. However, by understanding these challenges and implementing effective strategies, organizations can protect their essential systems from cyber threats.

“Maintaining an accurate inventory of assets poses a significant challenge for companies with control system networks," says Derek Harp, chairman, Control System Cyber Security Association International. "As outlined in our 2024 OT Cybersecurity Technology Report, not only is it difficult to identify these assets, but understanding their communication adds an additional layer of complexity. Typically, companies only gain a snapshot of their OT network status and assets' interactions during periodic assessments. Not surprisingly, our research also indicates that the frequency of these critical evaluations is increasing.”

The role of UTSI's OT Cybersecurity Advisory Board, along with the use of advanced tools like Security Gate and ThreatGEN, is pivotal in navigating this complex landscape. As the threat landscape continues to evolve, proactive measures and ongoing investment in cybersecurity will be crucial to safeguarding our most critical assets.

Play it back: Houston therapeutics co. sees momentum with expanded treatment opportunities

houston innovators podcast Episode 253

It's been a busy summer for Houston-based Coya Therapeutics, a clinical-stage biotech company that's creating revolutionary treatments for neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS.

In July, Coya announced that has expanded its collaboration with Houston Methodist Research Institute, or HMRI. The publicly traded company also announced fresh funding from the Johnson Center for Cellular Therapeutics.

Last month, Coya reported that it has expanded its treatment research to see how GLP-1 drugs — a trending drug for weight loss — can enhance the effects of its proprietary therapeutics. By combining the medicines, Howard Berman, co-founder and CEO of Coya Therapeutics, says he thinks Coya can better treat these complex immune-based diseases.

Berman joined the Houston Innovators Podcast in April of 2023 to discuss taking Coya public and his passion for the company's mission.

"I was interested in what I could do for my dad," Berman says on the Houston Innovators Podcast, explaining how he took the meeting with Dr. Stanley Appel, who then presented him with some of his research. "By slide five my jaw had hit the ground.

"He had shown that he could stop the progression in one of his early trials of ALS," Berman says.

Berman shares more of the Coya Therapeutics story on the podcast, as well as how he sees Houston's potential as an emerging hub for biotech.

"The next number of years as we develop this therapeutic regimen for ALS, we have the potential to transform Houston into something more than it is currently," he says. "Our success will be the city's success."

Diversity-focused sports tech accelerator opens applications to Houston innovators for the first time

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A global organization has announced it's opening applications to its equity-focused sports tech accelerator to Houston founders for the first time.

Thanks to a collaboration with Impact Hub and Black Ambition, the adidas Community Lab has expanded its footprint and is now accepting applicants from new markets, including Houston, Toronto, Los Angeles, Atlanta, and New York, for its 2024-2025 cohort.

The initiative, which has been running for three years, has a goal of supporting Black and Latino/a/e founders with mentorship, pitch training, event programming, and networking. The eight-month program also has $75,000 in grant funding to dole out to participants as well.

“As Community Lab enters its third year, we are thrilled to cultivate a larger cohort of social entrepreneurs who share our vision of removing barriers to accessing sport for the communities we collectively serve,” Ayesha Martin, senior director of adidas Purpose, says in a news release.

Both the global organization of Impact Hub and the local group, Impact Hub Houston, are involved in the collaboration.

“Impact Hub is thrilled to partner and support this third iteration of adidas Community Lab, empowering visionary leaders who are advancing SDG3 —Good Health and Wellbeing — and SDG10 — Reduced Inequalities," Michelle Avalos, co-founder of Impact Hub Houston, adds. Together, we’re helping entrepreneurs create equitable access to sports and foster healthier, more inclusive communities for all."

Applications are open online now until September 23.

Founded by Pharrell Williams, Black Ambition will also collaborate with the program this year on key programing sessions. The organization invests funding and resources into Black and Hispanic entrepreneur-founded startups.

"Black Ambition was founded to create the space, bespoke opportunities and relationships needed for underrepresented founders to excel, uninterrupted. We are excited to partner with adidas Purpose to extend elements of our renowned, global founder support model to social impact entrepreneurs positively transforming their communities through sports and wellness," says Jermeen Sherman, managing director at Black Ambition.

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