From advanced computation to robots, Rice University, the University of Houston, and Houston Methodist are all working on using technology for medical innovation. Graphic via Getty Images

Research, perhaps now more than ever, is crucial to expanding and growing innovation in Houston — and it's happening across the city right under our noses.

In InnovationMap's latest roundup of research news, three Houston institutions are working on brain-related health care solutions thanks to technologies.

University of Houston research team focused on brain injury treatment through computation

Badri Roysam and his team at the University of Houston are working with the National Institute of Health to develop tools to treat concussions and brain injuries. Photo via uh.edu

A University of Houston researcher is tapping into technology to better treat brain injuries and conditions that scientists have not yet figured out treatment for. Badri Roysam, the current chair of electrical and computer engineering at UH and a Hugh Roy and Lillie Cranz Cullen University Professor, and his team have created a new computational image analysis methods based on deep neural networks.

"We are interested in mapping and profiling unhealthy and drug-treated brain tissue in unprecedented detail to reveal multiple biological processes at once - in context," Roysam says in a UH press release about his latest paper published in Nature Communications. "This requires the ability to record high-resolution images of brain tissue covering a comprehensive panel of molecular biomarkers, over a large spatial extent, e.g., whole-brain slices, and automated ability to generate quantitative readouts of biomarker expression for all cells."

Roysam's system, which was developed at the the National Institute of Neurological Disorders and Stroke, analyzes the images on UH's supercomputer automatically and can reveal multiple processes at once – the brain injury, effects of the drug being tested and the potential side effects of the drug, per the release.

"Compared to existing screening techniques, using iterative immunostaining and computational analysis, our methods are more flexible, scalable and efficient, enabling multiplex imaging and computational analysis of up to 10 – 100 different biomarkers of interest at the same time using direct or indirect IHC immunostaining protocols," says Roysam in the release.

The open-source toolkit, which was developed thanks to a $3.19 million grant from the National Institute of Health, is also adaptable to other tissues.

"We are efficiently overcoming the fluorescence signal limitations and achieving highly enriched and high-quality source imagery for reliable automated scoring at scale," says Roysam. "Our goal is to accelerate system-level studies of normal and pathological brains, and pre-clinical drug studies by enabling targeted and off-target drug effects to be profiled simultaneously, in context, at the cellular scale."

Houston Methodist and Rice University launch new collaboration to use robotics for clinical solutions

Rice University's Behnaam Aazhang and Marcia O'Malley are two of the people at the helm of the new center along with Houston Methodist's Dr. Gavin Britz. Photos via Rice.edu

Rice University and Houston Methodist have teamed up to create a new partnership and to launch the Center for Translational Neural Prosthetics and Interfaces in order to bring together scientists, clinicians, engineers, and surgeons to solve clinical problems with neurorobotics.

"This will be an accelerator for discovery," says the new center's co-director, Dr. Gavin Britz, chair of the Houston Methodist Department of Neurosurgery, in a news release. "This center will be a human laboratory where all of us — neurosurgeons, neuroengineers, neurobiologists — can work together to solve biomedical problems in the brain and spinal cord. And it's a collaboration that can finally offer some hope and options for the millions of people worldwide who suffer from brain diseases and injuries."

The center will have representatives from both Rice and Houston Methodist and also plans to hire three additional engineers who will have joint appointments at Houston Methodist and Rice.

"The Rice Neuroengineering Initiative was formed with this type of partnership in mind," says center co-director Behnaam Aazhang, Rice's J.S. Abercrombie Professor of Electrical and Computer Engineering, who also directs the neuroengineering initiative. "Several core members, myself included, have existing collaborations with our colleagues at Houston Methodist in the area of neural prosthetics. The creation of the Center for Translational Neural Prosthetics and Interfaces is an exciting development toward achieving our common goals."

The team will have a presence on the Rice campus with 25,000 square feet of space in the Rice Neuroengineering Initiative laboratories and experimental spaces in the university's BioScience Research Collaborative. The space at Houston Methodist is still being developed.

"This partnership is a perfect blend of talent," says Rice's Marcia O'Malley, a core member of both the new center and university initiative. "We will be able to design studies to test the efficacy of inventions and therapies and rely on patients and volunteers who want to help us test our ideas. The possibilities are limitless."

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Houston female-focused health tech pitch competition names top 3 startup founders

A female-focused pitch competition named its top health tech startups for the fifth year running.

Ignite Healthcare Network, a Houston nonprofit founded on the mission of supporting women in health care, hosted its annual Fire Pitch Competition on November 9 at the Ion, crowning the award recipients and doling out cash prizes.

This year, Ignite accelerated 19 female health tech founders through its program that connects entrepreneurs with mentors and industry professionals. The program concludes with a select number of finalists presenting at the Fire Pitch event.

This year, eight finalists presented at the competition for judges and an audience:

  • Suchismita Acharya, CEO of Fort Worth-based AyuVis, an immunotherapy platform that's developing treatments and prevention for inflammatory and infectious diseases, specifically of the lung, kidney, skin, eye, and sepsis.
  • Piyush Modak, co-founder, vice president of research and development of New Jersey-based EndoMedix, a technology platform developing engineered biosurgery devices that address clinical needs. The first device based on this platform is PlexiClotTM Absorbable Hemostat for brain and spinal surgery.
  • Somer Baburek, co-founder and CEO of San Antonio-based HERAbiotech, which is developing a non-surgical, molecular diagnostic test for endometriosis.
  • Melissa Bowley, founder of Flourish Care, a B2B health services platform and network addressing maternal health disparities and improve outcomes. The Boston company works with health systems and insurance companies..
  • Patty Lee, co-founder and CEO of Orbit Health, a Munich-based company that uses AI and sensor technologies to develop digital health solutions for the management of Parkinson's.
  • Tawny Hammett, chief revenue officer of New York-based Paloma Health, a patient-focused technology providing holistic approach to thyroid care all from the comfort of home.
  • Meghan Doyle, CEO and co-founder of Chicago-based Partum Health, a company focused on combining specialty reproductive care, including mental health, lactation, nutrition, physical therapy, birth doula support, and more.
  • Asma Mirza, CEO and co-founder of Houston-based Steradian Technologies, creator of the RUMI, a medical device that's providing diagnostic accessibility.

Ayse McCracken, founder and board chair of Ignite, and her partners presented several prizes and awards, including naming the winners — EndoMedix won first place, Hera Biotech secured second place, and Steradian Technologies was awarded third place.

In addition to naming the three top companies, the following prizes were doled out:

  • Memorial Hermann presented AyuVis with a certificate indicating interest in a potential partnership.
  • Golden Seeds awarded a $1,000 cash prize and three hours of mentoring to Steradian Technologies.
  • Texas Children's Hospital presented Flourish Care with a certificate indicating interest in a potential partnership.
  • Southwest-Midwest National Pediatric Device Innovation Consortium awarded Hera Biotech with $20,000.
  • Houston Methodist awarded each of the three top companies with mentorship from innovation leadership.
  • JLabs presented EndoMedix with a one-year virtual residency.
  • Donna Peters, founder of The Me Suite and mentor for Ignite, presented Hera Biotech with three coaching sessions.

Last year, Joanna Nathan, CEO of Houston-based Prana Thoracic, won the top award for her company. The company went on to raise a $3 million seed round.

Earlier this year, McCracken sat down with InnovationMap to share how she's grown the program over the past five years — and why she's so passionate about what she does.

"Having an impact in the health care industry and finding solutions is important to me," McCracken says on an episode of the Houston Innovators Podcast. "The second aspect of that is there are so many women in health care, and yet you don't see them in leadership roles."

New immersive, live-action gaming venue powers up Houston debut

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Houston is leveling up its gaming scene with the debut of a new high-tech immersive experience. Called Activate, the indoor venue combines technology and physical activity in 75-minute gaming sessions, which can be played in teams up to five people.

Simply put, the whole place is like stepping inside a live-action arcade.

Activate's first Houston-area location opened softly November 2 at 20225 Katy Frwy., Katy. Official grand opening is set for November 16-17. It is the high-tech brand's sixth location across the country, and second in Texas (behind one in Plano, which opened in spring 2023).

According to a release, the Katy facility spans 9,600 square feet, with 11 different activity rooms offering more than 500 unique games across all difficulty levels. Games include Megagrid, Hoops, Press, Hide, Laser, Strike, Portals, Control, Grid, and more. Radio Frequency Identification (RFID) wristbands track participants’ scores and progress.

"Our mission is to fuse technology, movement, and strategy to create a unique interactive gaming experience," says Activate partner Bryce Anderson in the release. "We want guests to bring their closest friends, family, or co-workers and leave with a feeling of achievement, ready to come back for more."

While gaming activities are mostly adult-focused, children aged 13 and younger can participate with adult supervision.

During Activate's soft opening phase through November 15, 10 percent of sales will be donated to Best Buddies International, a nonprofit that provides mentorships for individuals with intellectual and developmental disabilities. (Check the website for limited hours during soft opening.)

After the grand opening November 16-17, Activate will be open daily, 10 am-10 pm. Gaming sessions (75 minutes) are $24.99 Monday-Thursday, and $29.99 Friday-Sunday. Reservations are encouraged.

Activate has been creating live-action gaming experiences for adults since 2019, and has plans for further expansion, they say.

"As we continue expanding Activate across the United States, we are confident our concept will fill a void for interactive entertainment," says Anderson in the release. "We believe the Houston community will embrace this experience and find it both thrilling and challenging."

More information and reservations can be found on the website.

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This article originally ran on CultureMap.