From advanced computation to robots, Rice University, the University of Houston, and Houston Methodist are all working on using technology for medical innovation. Graphic via Getty Images

Research, perhaps now more than ever, is crucial to expanding and growing innovation in Houston — and it's happening across the city right under our noses.

In InnovationMap's latest roundup of research news, three Houston institutions are working on brain-related health care solutions thanks to technologies.

University of Houston research team focused on brain injury treatment through computation

Badri Roysam and his team at the University of Houston are working with the National Institute of Health to develop tools to treat concussions and brain injuries. Photo via uh.edu

A University of Houston researcher is tapping into technology to better treat brain injuries and conditions that scientists have not yet figured out treatment for. Badri Roysam, the current chair of electrical and computer engineering at UH and a Hugh Roy and Lillie Cranz Cullen University Professor, and his team have created a new computational image analysis methods based on deep neural networks.

"We are interested in mapping and profiling unhealthy and drug-treated brain tissue in unprecedented detail to reveal multiple biological processes at once - in context," Roysam says in a UH press release about his latest paper published in Nature Communications. "This requires the ability to record high-resolution images of brain tissue covering a comprehensive panel of molecular biomarkers, over a large spatial extent, e.g., whole-brain slices, and automated ability to generate quantitative readouts of biomarker expression for all cells."

Roysam's system, which was developed at the the National Institute of Neurological Disorders and Stroke, analyzes the images on UH's supercomputer automatically and can reveal multiple processes at once – the brain injury, effects of the drug being tested and the potential side effects of the drug, per the release.

"Compared to existing screening techniques, using iterative immunostaining and computational analysis, our methods are more flexible, scalable and efficient, enabling multiplex imaging and computational analysis of up to 10 – 100 different biomarkers of interest at the same time using direct or indirect IHC immunostaining protocols," says Roysam in the release.

The open-source toolkit, which was developed thanks to a $3.19 million grant from the National Institute of Health, is also adaptable to other tissues.

"We are efficiently overcoming the fluorescence signal limitations and achieving highly enriched and high-quality source imagery for reliable automated scoring at scale," says Roysam. "Our goal is to accelerate system-level studies of normal and pathological brains, and pre-clinical drug studies by enabling targeted and off-target drug effects to be profiled simultaneously, in context, at the cellular scale."

Houston Methodist and Rice University launch new collaboration to use robotics for clinical solutions

Rice University's Behnaam Aazhang and Marcia O'Malley are two of the people at the helm of the new center along with Houston Methodist's Dr. Gavin Britz. Photos via Rice.edu

Rice University and Houston Methodist have teamed up to create a new partnership and to launch the Center for Translational Neural Prosthetics and Interfaces in order to bring together scientists, clinicians, engineers, and surgeons to solve clinical problems with neurorobotics.

"This will be an accelerator for discovery," says the new center's co-director, Dr. Gavin Britz, chair of the Houston Methodist Department of Neurosurgery, in a news release. "This center will be a human laboratory where all of us — neurosurgeons, neuroengineers, neurobiologists — can work together to solve biomedical problems in the brain and spinal cord. And it's a collaboration that can finally offer some hope and options for the millions of people worldwide who suffer from brain diseases and injuries."

The center will have representatives from both Rice and Houston Methodist and also plans to hire three additional engineers who will have joint appointments at Houston Methodist and Rice.

"The Rice Neuroengineering Initiative was formed with this type of partnership in mind," says center co-director Behnaam Aazhang, Rice's J.S. Abercrombie Professor of Electrical and Computer Engineering, who also directs the neuroengineering initiative. "Several core members, myself included, have existing collaborations with our colleagues at Houston Methodist in the area of neural prosthetics. The creation of the Center for Translational Neural Prosthetics and Interfaces is an exciting development toward achieving our common goals."

The team will have a presence on the Rice campus with 25,000 square feet of space in the Rice Neuroengineering Initiative laboratories and experimental spaces in the university's BioScience Research Collaborative. The space at Houston Methodist is still being developed.

"This partnership is a perfect blend of talent," says Rice's Marcia O'Malley, a core member of both the new center and university initiative. "We will be able to design studies to test the efficacy of inventions and therapies and rely on patients and volunteers who want to help us test our ideas. The possibilities are limitless."

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Houston biopharma company launches equity crowdfunding campaign

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A clinical-stage company headquartered in Houston has opened an online funding campaign.

FibroBiologics, which is developing fibroblast cell-based therapeutics for chronic diseases, launched a campaign with equity crowdfunding platform StartEngine. The platform lets anyone — regardless of their net worth or income level — to invest in securities issued by startups.

The funding, according to a press release, will be used to support ongoing operations of Fibrobiologics and advance its clinical programs in multiple sclerosis, degenerative disc disease, wound care, extension of life, and cancer.

"We're excited to partner with StartEngine on this campaign. StartEngine has over 600,000 investors as part of their community and has raised over half a billion dollars for its clients," says FibroBiologics' Founder and CEO Pete O'Heeron, in the release.

"This is an exciting time at FibroBiologics as we continue progressing our clinical pipeline and developing innovative therapies to treat chronic diseases," he continues. "This new funding will fuel our growth in the lab and bring us one step closer to commercialization."

The campaign, launched this week, already has over 100 investors, at the time of publication, and has raised nearly $2 million, according to the page. The minimum investment is set at around $500, and the company's indicated valuation is $252.57 million.

In 2021, FibroBiologics announced its intention of going public. Last year, O'Heeron told InnovationMap on the Houston Innovators Podcast of the company's growth plans as well as the specifics of the technology.

Only two types of cells — stem cells and fibroblasts — can be used in cell therapy for a regenerative treatment, which is when specialists take healthy cells from a patient and inject them into a part of the body that needs it the most. As O'Heeron explains in the podcast, fibroblasts can do it more effectively and cheaper than stem cells.

"(Fibroblasts) can essentially do everything a stem cell can do, only they can do it better," says O'Heeron. "We've done tests in the lab and we've seen them outperform stem cells by a low of 50 percent to a high of about 220 percent on different disease paths."


Texas ranks as a top state for female entrepreneurs

women in business

Texas dropped three spots in Merchant Maverick’s annual ranking of the top 10 states for women-led startups.

The Lone Star State landed at No. 5 thanks in part to its robust venture capital environment for women entrepreneurs. Last year, Texas ranked second, up from its No. 6 showing in 2021.

Merchant Maverick, a product comparison site for small businesses, says Texas “boasts the strongest venture capital scene” for women entrepreneurs outside California and the Northeast. The state ranked fourth in that category, with $6.5 billion invested in the past five years.

Other factors favoring Texas include:

  • Women solely lead 22 percent of all employees working for a business in Texas (No. 4).
  • Texas lacks a state income tax (tied for No. 1).

However, Texas didn’t fare well in terms of the unemployment rate (No. 36) and the rate of business ownership by women (No. 29). Other Texas data includes:

  • Average income for women business owners, $52,059 (No. 19).
  • Early startup survival rate, 81.9 percent (No. 18).

Appearing ahead of Texas in the 2023 ranking are No. 1 Colorado, No. 2 Washington, No. 3 California, and No. 4 Arizona.

Another recent ranking, this one from NorthOne, an online bank catering to small businesses, puts Texas at No. 7 among the 10 best states for women entrepreneurs.

NorthOne says Texas provides “a ton of opportunities” for woman entrepreneurs. For instance, it notches one of the highest numbers of women-owned businesses in the country at 1.4 million, 2.1 percent of which have at least 500 employees.

In this study, Texas is preceded by Colorado at No. 1, Nevada at No. 2, Virginia at No. 3, Maryland at No. 4, Florida at No. 5, and New Mexico at No. 6. The rankings are based on eight metrics, including the percentage of woman-owned businesses and the percentage of women-owned businesses with at least 500 employees.