Sentinel BioTherapeutics is developing cytokine interleukin-2 (IL-2) capsules to fight many solid tumors. Photo via Getty Images.

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

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Houston native picked for 2025 class of NASA astronaut candidates

space crew

NASA has selected 10 new astronaut candidates, including one whose hometown is Houston, for its 2025 training class. The candidates will undergo nearly two years of training before they can assume flight assignments.

The 10 future astronauts were introduced during a recent ceremony at NASA’s Johnson Space Center, whose facilities include an astronaut training center. NASA received more than 8,000 applications for the 10 slots.

“Representing America’s best and brightest, this astronaut candidate class will usher in the Golden Age of innovation and exploration as we push toward the moon and Mars,” said Vanessa Wyche, director of NASA Johnson.

NASA’s 24th astronaut class reported for duty in mid-September at Johnson Space Center. Their training will prepare them for missions to the International Space Station and the moon, among other activities. Graduates will become members of NASA’s astronaut corps.

Among the recently selected candidates is Anna Menon, who was born in Houston and considers it her hometown. She’s married to NASA astronaut Dr. Anil Menon, a flight surgeon who completed his training in 2022.

Most recently, Anna Menon was a senior engineer at Elon Musk’s SpaceX, where she spent seven years managing crew operations for the Dragon and Starship spacecraft. Previously, Menon worked at NASA’s Mission Control Center in Houston, where she supported medical software and hardware aboard the International Space Station.

In 2024, Menon flew into space as a mission specialist and medical officer aboard SpaceX’s Polaris Dawn private spacecraft. A highlight of the low-orbit trip was the first commercial spacewalk.

Texas native Rebecca Lawler, a native of the Dallas-Fort Worth suburb of Little Elm, is one of Menon’s nine classmates.

Lawler, a former lieutenant commander in the Navy, was a Navy P-3 pilot and experimental test pilot who logged over 2,800 flight hours aboard more than 45 aircraft. At the time she was chosen to be an astronaut candidate, Lawler was a test pilot for United Airlines.

The eight other astronaut candidates in the 2025 class are:

  • Ben Bailey, who was born and raised in Charlottesville, Virginia
  • Lauren Edgar, whose hometown is Sammamish, Washington
  • Adam Fuhrmann, who’s from Leesburg, Virginia
  • Cameron Jones, a native of Savanna, Illinois
  • Yuri Kubo, a native of Columbus, Indiana
  • Imelda Muller, whose hometown is Copake Falls, New York
  • Erin Overcash, who’s from Goshen, Kentucky
  • Katherine Spies, a native of San Diego

Meet the judges for the 2025 Houston Innovation Awards

Meet The Judges

Editor's note: Judging is now underway for the 2025 Houston Innovation Awards, and before we reveal this year's finalists, it's time to meet the decision makers.

Our 2025 judging panel comprises past award winners who represent a variety of industries and areas of expertise. They are joined by InnovationMap's editorial leaders, past and present. All are deeply engaged in the Houston innovation ecosystem.

Our judging panel will review all nominee applications submitted across 10 prestigious categories. They will determine the 2025 finalists in all categories, and they will select the winners in all but one category — our people's choice award, Startup of the Year.

Learn more about our esteemed judges below, and stay tuned for the 2025 Houston Innovation Awards finalists announcement, coming in early October!

Phillip Yates, 2024 Ecosystem Builder of the Year

Phillip Yates. Photo courtesy of Equiliberty

Attorney-turned-entrepreneur Phillip Yates is the founder and CEO of Equiliberty Inc., a Houston-based fintech platform that connects users with resources to build wealth. Deeply involved in the Houston innovation sector, he helped establish a pre-venture business incubator at the Houston Area Urban League Entrepreneurship Center in 2011. He has served as general counsel for the Business Angel Minority Association and Direct Digital Holdings Inc., and currently serves as chairman of Impact Hub Houston.

"My favorite part of Houston's innovative ecosystem is the growing network of resources for founders," he said. "Given our racial, ethnic, and culturally diverse population, we have a wider range of experiences and perspectives — and ideas that lead to better problem solving, creative solutions, and understanding of the needs our community."

Mitra Miller, 2024 Mentor of the Year

Mitra Miller. Photo via LinkedIn

Mitra Miller is vice president of Houston Angel Network, a nonprofit organization dedicated to developing the innovation ecosystem by supporting founders and startups with financial resources and mentorship. She is also founder and chair of Eagle Investors, a nonprofit that teaches students about the investment and innovation community, and she serves as an active mentor for numerous Houston organizations.

"Houston has the most friendly, open, collaborative, and inclusive innovation environment anywhere," Miller said. "When I ask individuals and organizations to partner on events and initiatives, they readily agree and give freely of their time and resources. There is a generosity of spirit that is very special to Houston."

Juliana Garaizar, 2024 Investor of the Year

Juliana Garaizar. Photo courtesy of Juliana Garaizar

Juliana Garaizar is founding partner of Houston energy and carbontech ecosystem builder Energy Tech Nexus. "A hands-on investor," Garaizar invests in Houston and beyond with groups such as Portfolia, Houston Angel Network, Business Angel Minority Association, and more.

"Houston has the talent, the corporations, and the great intersection of industries where innovations happen: energy, medical, and space," she said. "Houston knows how to do hard things. We are doers, and we know how to build on our key strengths and are resilient when things don't go according to plan."

Anwar Sadek, Corrolytics, 2024 Minority-founded Business of the Year and Startup of the Year

Anwar Sadek. Courtesy photo

Anwar Sadek is CEO and co-founder of Corrolytics, a technology startup that aims to solve microbiologically influenced corrosion problems for industrial assets. In 2023, Sadek made the bold decision to relocate his startup, which was founded in Ohio, to Houston. It was the winner of two Houston Innovation Awards last year.

"Houston is the energy capital of the world. For the technology we are developing, it is the most strategic move for us to be in this ecosystem and in this city," Sadek said.

Remington Tonar, Cart.com, 2024 Scaleup of the Year

Remington Tonar. Courtesy photo

Remington Tonar is co-founder of Cart.com, a unified commerce and logistics solutions provider for B2C and B2B companies. Founded in Houston in 2020 by CEO/co-founder Omair Tariq and Tonar, Cart.com relocated to Austin in 2021, before returning to its roots and reestablishing its Houston headquarters in late 2023. The fast-growing e-commerce platform was then named Scaleup of the Year in the 2024 Houston Innovation Awards.

"When we think about Houston, we think about access to at-scale infrastructure, amenities, and workforce and talent pools," Tonar said, in regards to the relocation.

Laura Furr Mericas, Interim Editor, InnovationMap

Laura Furr Mericas is interim editor for InnovatonMap.com and EnergyCapitalHTX.com. She is a longtime contributor to both sites and has reported on Houston's innovation ecosystem for InnovationMap since 2020. Previously, she served as web editor and data reporter for Houston Business Journal.

Natalie Harms, Inaugural Editor, InnovationMap

Natalie Harms is the inaugural editor of InnovationMap.com, spearheading its launch in 2018 and shepherding its growth through 2024, as well as overseeing sister site, EnergyCapitalHTX.com. Prior to InnovationMap, Harms was associate editor for Houston Business Journal. She now covers the hotel and tourism industry as a reporter for Hotel News Now.