5 Houston innovators who made headlines in August 2025

Featured Innovators

M.A.S.R. Saadi, Rice University. Photo courtesy of Rixe University

Editor's note: Innovators hailing from both Rice University and University of Houston made headlines in August by developing a new biomaterial that could replace plastic and deploying a new flood scale to help Houstonians stay safe. Plus, one local innovator has a big move on the horizon.

Here are five Houston innovators to know right now.

​M.A.S.R. Saadi and Muhammed Maksud Rahman, Rice University and University of Houston

A team led by M.A.S.R. Saadi and Muhammad Maksud Rahman has developed a biomaterial that they hope could be used for the “next disposable water bottle." Photo courtesy Rice University.

Collaborators from two Houston universities are leading the way in engineering a biomaterial into a scalable, multifunctional material that could potentially replace plastic. The research was led by Muhammad Maksud Rahman, an assistant professor of mechanical and aerospace engineering at the University of Houston and an adjunct assistant professor of materials science and nanoengineering at Rice University. M.A.S.R. Saadi, a materials science and nanoengineering doctoral student at Rice University, was first author on the study. The study introduced a biosynthesis technique that aligns bacterial cellulose fibers in real-time, which resulted in robust biopolymer sheets with “exceptional mechanical properties,” according to the researchers. Learn more.

Paul Cherukuri, Rice University

Paul Cherukuri, Rice’s first vice president for innovation and chief innovation officer, will leave his post next month. Photo via Rice.edu

Paul Cherukuri, Rice University's top innovation executive, responsible for some of Rice’s major innovative projects like the Rice BioTech LaunchPad and Rice Nexus, will leave the university at the end of September to accept a position at the University of Virginia. Cherukuri, Rice’s first vice president for innovation and chief innovation officer, will become the University of Virginia’s Donna and Richard Tadler University Professor of Entrepreneurship and the school's first chief innovation officer. Learn more.

Steven Paul Woods (pictured) and Natalie C. Ridgely, University of Houston

Steven Paul Woods, professor of Psychology, at UH. Photo courtesy of UH

University of Houston Professor of Psychology Steven Paul Woods and doctoral student Natalie C. Ridgely recently partnered with the Space City Weather (SCW) blog to create a new flood alert scale for the trusted weather site. “My lab does work on how people access, understand, and use health information, so I thought we could adapt some of that ongoing work and our expertise in psychological science to answer questions about weather communication, and help keep Houstonians informed and safe,” said Woods. Learn more.

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Memorial Park Conservancy's renovations include some projects that are rare or never been done before. Photo courtesy of MPC

These were Houston's top impact innovation stories this year

2019 IN REVIEW

When it comes to the impact that innovation has had on Houston, a number of things stand out for 2019. And, so many of these top stories from this past year are just beginning.

InnovationMap's most read articles in its impact category include new technologies for flood resiliency, The Ion's development, Memorial Park renovations, and more.

These Houston entrepreneurs and startups are searching for flooding solutions

From a water-absorbing tower to sensor-enabled rubber ducks, here are some flooding solution ideas coming out of Houston. Courtesy of Gensler's ByDesign

The feeling is all too familiar for Houstonians. Tropical Storm Imelda hit Houston with devastating flood waters just two years after Hurricane Harvey did its damage.

With any obstacle or challenge, there is room for innovation. Over the past year, InnovationMap has covered various flood tech startups in Houston. Here are six innovations that can make a difference the next time a storm decides to take its toll on Houston. Continue reading.

Memorial Park Conservancy plans to deliver its first project of its master plan redevelopment next year

Memorial Park Conservancy is gearing up to unveil one if its first projects within its 10-year master plan redevelopment. Photo courtesy of MPC

Memorial Park Conservancy has until 2028 to deliver on its master plan redevelopment project, but if MPC president and CEO Shellye Arnold has anything to say about it, the plan will be completed way ahead of that.

The project is a collaborative effort between MPC, Uptown Houston TIRZ, and Houston Parks and Recreation Department to redevelop the 1,500-acre park. In 2011, a major drought decimated the park and areas saw losses of 50 to even 90 percent of the canopy of trees.

"As tragic as it was, it made people take action," says Arnold.

Following the drought, these organizations looked to the people to see what was needed and wanted by the 3 million visitors and residents of the 170 ZIP codes that frequent the park annually.

"There was a huge outcry to do something," Arnold says. "That something became an effort to define the future of the park in a way that would be powerful, bold, thoughtful, innovative, and very resilient. It would consider Houstonians of the future and Houstonians today. It would consider soils, storm water treatment, the wildlife, and what people want." Continue reading.

Overheard: The Ion breaks ground in Midtown's former Sears building

The Rice Management Company has broken ground on the renovation of the historic Midtown Sears building, which will become The Ion. Natalie Harms/InnovationMap

The Ion — a to-be entrepreneurial hub for startups, universities, tech companies, and more — is, in a way, the lemonade created from the lemons dealt to the city by a snub from Amazon.

In 2018, Amazon narrowed its options for a second headquarters to 20 cities, and Houston didn't make the shortlist.

"That disappointment lead to a sense of urgency, commitment, and imagination and out of that has come something better than we ever could have imagined," David Leebron, president of Rice University, says to a crowd gathered for The Ion's groundbreaking on July 19.

However disappointing the snub from Amazon was, it was a wake-up call for so many of the Houston innovation ecosystem players. The Ion, which is being constructed within the bones of the historic Midtown Sears building, is a part of a new era for the city.

"Houston's on a new course to a new destination," says Mayor Sylvester Turner. Continue reading.

Third Ward community expresses concerns with The Ion project that's underway

The local community has raised some concerns about Rice Management Company's Ion project's effect on the Third Ward. Courtesy of Rice University

The city of Houston has been buzzing about Rice Management Company's Ion Innovation Hub — a 270,000-square-foot coworking and innovation hub project expected to deliver in 2021 — but there's one group isn't so thrilled with the plans: The Third Ward community.

In a public community meeting on November 12, community members gathered at the Wesley AME Church to plan a Community Benefits Agreement that would legally bind The Innovation District's development team and the Rice Management Company to move forward with the local residents' indicated best interests. According to the Houston Coalition for Equitable Development without Displacement, a newly formed group to work on the CBA, it would be the first of its kind in Houston.

The coalition is supported by Third Ward is Home Civic Club, the Emancipation Economic Development Council, the Texas Coalition of Black Democrats - Harris County, and the Houston Society for Change. Continue reading.

4 things you need to know from the Greater Houston Partnership's annual report as it pertains to innovation

downtown houston

The Greater Houston Partnership has the facts. Nick Bee/Pexels

Every year, the Greater Houston Partnership — the city's economic development arm — gathers up data and reports to paint a full picture of the Bayou City. In the past few editions, innovation has been a key component.

The GHP's innovation coverage spans three pages under the top industry and sectors category. From tech startup growth to money raised, here's what you need to know from the 2019 Houston Facts. Continue reading.

A Houston entrepreneur has brought in a technology to prevent major flood damage. Photo courtesy of HAR

Houston startup is providing self-deploying flood damage prevention technology

Rain rain, go away

Tasha Nielsen was on a trip to Denmark when she came across a Danish company making strides in flood prevention techniques.

"We were visiting family one day when we turn on the news and see FloodFrame's brand launch," Nielsen says. "The inventors live in Denmark, and they've done installations in Denmark, Germany and England, and they've been very successful."

That company partnered with the Danish Technological Institute and the Danish Hydraulic Institute and worked for years perfecting their flood prevention system. After Nielsen asked whether she could contract FloodFrame to install their system at her home back in Houston, she learned the founders weren't interested in coming over themselves to expand their business to the United States.

So, Nielsen took the reins to create the U.S. iteration of FloodFrame. The company provides flood protection to any building, including your home or business. And while it definitely takes inspiration from its European counterpart, Nielsen used her degree in civil engineering from Texas A&M — specifically her speciality in hydraulics, hydrology and storm design — to launch the business in one of the most flood-ravaged cities in the United States: Houston.

FLOODFRAME USAVideo via youtube.com

FloodFrame works by using buoyancy. A lightweight cloth is wrapped around a tube is installed underground outside the perimeter of your home or business. One end of that cloth is attached to a box that is also installed underground. As flooding begins, an automatic system will release the lids to deploy the inflation of the tube that will protect the structure. When the flood comes in, the system will float on top of the flood — kind of like a pool noodle — and protect the structure from the water.

FloodFrame adds a level of security during flooding events and can be considered more cost-effective when compared to the high cost of renovating or rebuilding after flooding.

"Right now we are focused on residential but I think there's a huge potential for it to go commercial. A lot of commercial buildings are self insured, and commercial developers, industrial developers, this would be a drop in the bucket for the overall cost of the entire project," Nielsen tells InnovationMap. "For homeowners, it's kind of a bigger expense, but I think there is the potential for homebuilders to include it as an option in the entire package of a new house because when you put it in to a mortgage, it's only another like $0.50 a month."

Nielsen and the company are wrapping up their time in MassChallenge Texas' inaugural Houston cohort, which concludes early September.

Two years after Harvey, Nielsen thinks the city of Houston is doing the right thing by having workshops and meetings in order to work on ways to redesign the city so flooding isn't an issue.

"I do think there needs to be a better plan for what happens next year, instead of trying to prevent what happens in 20 years," she says. "They're already doing that part; they're working on it. I think there just needs to be more of an emphasis on 'what can we actually do to help people right now.'"

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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