The Rice Alliance has named its second annual cohort. Photo via Getty Images

The Rice Alliance for Technology and Entrepreneurship has announced the 17 companies joining its second accelerator — and the program didn't have to venture very far for some of them.

The Rice Alliance Clean Energy Accelerator named the early- to mid-stage startups that will participate in its second annual class — five of which are based in Houston:

  • CLS Wind is developing a unique system to lift any size wind turbine component to any height using smaller-capacity cranes, an efficient, safe and economical solution to a lack of available high-capacity cranes and vessels.
  • Dsider is developing a low code solution for climate minded organizations to visualize and analyze their carbon pathways to plan, prioritize and operate sustainably and economically.
  • Emission Critical is developing carbon accounting and management software as a service to help enterprises solve end-to-end carbon footprinting with minimum effort
  • NanoTech is developing advanced materials to help businesses and individuals solve fireproofing and thermal insulation challenges with new world particles.
  • Pressure Corp is developing waste pressure power systems to help midstream gas companies solve how they reduce emissions by providing the technology, capital and expertise required to achieve their environmental, social and governance goals.

The 10-week program kicks off at the university’s Rice Alliance Energy Tech Venture Forum in September, and concludes on Demo Day on Nov. 17. While mostly virtual, the program will welcome the complete cohort to Houston three times throughout the accelerator.

The full cohort of companies — which come from seven states and four countries — has already collectively raised more than $54.5 million. Over the 10 weeks, the companies will receive support and mentorship to help them raise funding, launch pilots, win adoption into the marketplace, and more.

The 2022 cohort specializes across the spectrum of clean energy, including advanced materials, digital technology for energy, energy efficiency, energy storage, geothermal energy, hydrogen, waste heat to power, wave energy, and wind energy. The rest of the cohort includes:

  • Atargis Energy, based in Colorado, is developing an innovative twin hydrofoil-based wave energy converter technology combined with a proprietary feedback control system that combines real-time sensors, predictive algorithms and machine learning to make possible the first predictable, low-cost, utility-scale baseload electricity sourced from ocean waves for utilities and other electricity providers.
  • Based in Somerville, Massachusetts, Eden GeoPower Inc. is developing electrical reservoir stimulation technology to help geothermal, petroleum and mineral resource developers solve issues with low-permeability reservoirs by effectively increasing permeability in a way that uses less water and emits less CO2 than traditional stimulation methods.
  • FuelX has developed solid-state hydrogen power systems to help transportation manufacturers meet their customers’ growing performance requirements by using high-energy-density systems that outperform batteries and other pure hydrogen solutions. When coupled with a green hydrogen raw material, FuelX systems provide zero-carbon power.
  • GeoGen Technologies — a Canadian company — is developing a new kind of geothermal that allows oil and gas companies to convert end of life oil and gas wells to economic geothermal.
  • Durham, North Carolina-based GOLeafe uses organic materials and non-energy or capital-intensive equipment toproduce graphene oxide — the world's strongest, thinnest and most conductive material — through a process that’s 10 times more cost efficient and eco-friendly using readily available materials such as hay, sugar and wood chips.
  • LiNa Energy is commercializing safe, sustainable, solid-state sodium batteries that contain no lithium or cobalt.
  • Luminescent, based in the United Kingdom, is building an isothermal expansion heat engine for waste heat recovery along gas transmission pipelines.
  • Nobel improves fuel efficiency for gas-fired power plants with drop in, reliable supersonic combustion technology.
  • Quino Energy — based in California — produces low-cost, long-lifetime aqueous organic flow batteries for grid storage applications. The charge is stored in specially designed organic molecules called quinones, which are produced from cheap chemical precursors in a proprietary, zero-waste process.
  • Viridly, based in Texas,is developing geothermal power plants with patent-pending generator technology alongside geothermal greenhouses to provide the first financially viable way to confidently deliver and scale up the development of baseload geothermal electricity.
  • Another Canadian company, Volta Technique’s compressed air storage and management technology addresses the unpredictable and ever-increasing cost of energy for large commercial and industrial electricity users while enabling decarbonization of the electricity grid through higher integration of renewable energy.
  • Wootz, another Texas company, is developing a scalable manufacturing process to produce sustainable, cost-effective, high-performance carbon nanotube materials at commercial scale to replace or enhance traditional metallic conductors.

Twelve companies participated in Class 1 of the Rice Alliance Clean Energy, which was delivered virtually last summer. The 12 startups in that inaugural class have raised a combined $6.5 million in funding, identified and launched pilots, met investors, hired staff and moved their offices to Houston.

The program is supported by founding sponsor Wells Fargo and supporters: BP, Baker Botts, Chevron, ExxonMobil, Halliburton Labs, Equinor, Microsoft, NRG, Saudi Aramco Energy Ventures, Shell Ventures, Sunnova, TotalEnergies, Tudor Pickering Holt, Canadian Consulate, TC Energy, Phillips 66, and ENI Next.

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.