A concept design rendering of Persona AI's humanoid robot. The company is one of the finalists for the 2025 Houston Innovation Awards in the Deep Tech Business category. Rendering courtesy Persona AI.

Houston is no stranger to technology that's shaping the future. As the longtime location of NASA Johnson Space Center to home base for new ventures disrupting industries with their technology, the Bayou City has had its finger on the pulse of what's new and next for decades.

The Deep Tech Business category in our 2025 Houston Innovation Awards will honor an innovative startup providing technology solutions based on substantial scientific or engineering challenges, including those in the AI, robotics and space sectors.

Six deep tech companies have been named finalists for the 2025 award. They range from a company developing predictive software to accelerate the energy transition to a new venture that's developing humanoid robots.

Read more about these businesses, their founders and their breakthrough technologies below. Then join us at the Houston Innovation Awards on Nov. 13 at Greentown Labs, when the winner will be unveiled.

Tickets are now on sale for this exclusive event celebrating Houston Innovation.

ARIX Technologies

Industrial and robotics company ARIX Technologies is an integrated robotics and data analytics company that delivers inspection services. Its ARIX VENUS robot combines aerospace-grade engineering, advanced non-destructive testing (NDT) and AI-powered analytics to detect hidden corrosion under insulation for the downstream energy, petrochemical, and chemical processing sectors.

ARIX was founded in 2017 by Dianna Liu, a former ExxonMobil engineer. Craig Mallory serves as CEO. The company reports that it is scaling deployments with major Gulf Coast refineries, expanding its analytics platform to include predictive corrosion modeling and growing a global partner program.

Little Place Labs

Space tech company Little Place Labs is developing an AI, machine-learning software across a network of satellites that can provide insights from space in under seven minutes.

The company was founded in 2022 by CEO Bosco Lai and CTO Gaurav Bajaj. The company recently received an award from the U.S. Space Force that will support it in deploying multiple applications and products onto more than 55 satellites over the next 36 months for both national security and commercial use cases. The company won the Security, GovTech & Space competition at the SXSW Pitch showcase last year.

Newfound Materials

Newfound Materials has developed a predictive synthesis software platform for accelerating the discovery of novel materials for critical energy applications, such as batteries, magnets, catalysts, and more. It guides users on the best experiments to try in the lab to optimize the synthesis of their materials.

Newfound Materials was founded in 2024 by CEO Matthew McDermott and participated in the inaugural Activate cohort. The company plans to release a public web app soon. It also has plans to raise a pre-seed or angel round.

Paladin Drones

Paladian develops drone-as-first-responder (DFR) systems for public safety. Its technology gives first responders live aerial video before teams arrive, enabling quicker decisions, better resource allocation and reduced false alarms.

The company was founded in 2018 by Divyaditya Shrivastava and participated in the Y Combinator accelerator that year. The company raised a $5.2 million seed round in 2024 and another round for an undisclosed amount earlier this year. In the future, it plans to expand its DFR deployments into more cities, offer new payload delivery capabilities (like delivering Narcan and life vests), and enhance deconfliction features.

Persona AI

Persona AI is building modularized humanoid robots that aim to deliver continuous, round-the-clock productivity and skilled labor for "dull, dirty, dangerous, and declining" jobs.

The company was founded by Houston entrepreneur Nicolaus Radford, who serves as CEO, along with CTO Jerry Pratt and COO Jide Akinyode. It raised eight figures in pre-seed funding this year and also expanded its operations at the Ion. The company is developing its prototype of a robot-welder for Hyundai's shipbuilding division, which it plans to unveil in 2026.

Tempest Droneworx

Tempest Droneworx provides real-time intelligence collected through drones, robots and sensors. Its Harbinger software platform shares data through a video game engine and aims to provide teams with early warning and insight to help them make decisions faster.

The company was founded in 2021 by CEO Ty Audronis and COO Dana Abramovitz. It participated in the Mass Challenge Air Force Labs and won the Best Speed Pitch at SXSW earlier this year. The company is currently raising a $2.5M seed round.

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Texas A&M University-Fort Worth will be the home of the FAA's new Center for Advanced Aviation Technologies. Photo via Getty Images.

Texas university to lead new FAA tech center focused on drones

taking flight

The Texas A&M University System will run the Federal Aviation Administration’s new Center for Advanced Aviation Technologies, which will focus on innovations like commercial drones.

“Texas is the perfect place for our new Center for Advanced Aviation Technologies,” U.S. Transportation Secretary Sean Duffy said in a release. “From drones delivering your packages to powered lift technologies like air taxis, we are at the cusp of an aviation revolution. The [center] will ensure we make that dream a reality and unleash American innovation safely.”

U.S. Sen. Ted Cruz, a Texas Republican, included creation of the center in the FAA Reauthorization Act of 2024. The center will consist of an airspace laboratory, flight demonstration zones, and testing corridors.

Texas A&M University-Corpus Christi will lead the initiative, testing unstaffed aircraft systems and other advanced technologies. The Corpus Christi campus houses the Autonomy Research Institute, an FAA-designated test site. The new center will be at Texas A&M University-Fort Worth.

The College Station-based Texas A&M system says the center will “bring together” its 19 institutions, along with partners such as the University of North Texas in Denton and Southern Methodist University in University Park.

According to a Department of Transportation news release, the center will play “a pivotal role” in ensuring the safe operation of advanced aviation technologies in public airspace.

The Department of Transportation says it chose the Texas A&M system to manage the new center because of its:

  • Proximity to major international airports and the FAA’s regional headquarters in Fort Worth
  • Existing infrastructure for testing of advanced aviation technologies
  • Strong academic programs and industry partnerships

“I’m confident this new research and testing center will help the private sector create thousands of high-paying jobs and grow the Texas economy through billions in new investments,” Cruz said.

“This is a significant win for Texas that will impact communities across our state,” the senator added, “and I will continue to pursue policies that create new jobs, and ensure the Lone Star State continues to lead the way in innovation and the manufacturing of emerging aviation technologies.”

A new construction-focused drone services company has landed in Texas. Photo courtesy of Helios Visions

Chicago drone company expands in Texas, opens office in Houston

taking flight

A Chicago-based company that provides drone-based infrastructure inspection services has announced new offices in Texas — including Houston.

Helios Visions announced its expansion into Texas earlier this month, and named three new offices in Houston, Austin, and Dallas/Fort Worth. The company specializes in collecting automated and repeatable aerial data via drone technology within the architectural design, engineering design and construction industries.

"Houston, Austin, and Dallas/Fort Worth are large markets, and it is a natural next step of our continuing expansion strategy," says Ted Parisot, co-founder of Helios Visions, in a news release. "Moving into the Texas market allows us to best serve the needs of both existing and new clients in architecture, engineering, construction, and commercial real estate.

"Coupled with the urgent need for infrastructure inspections across the United States, it was the right time to expand our drone services in Texas," he continues. "This also represents the continued growth and value provided by the commercial drone services industry as a whole."

Helios Visions, founded in 2015, will offer its Texas projects drone services in the following areas:

  • Infrastructure Inspection (bridges, overpasses, viaducts, etc.)
  • Building façade inspection
  • Construction progress documentation
  • Commercial real estate

"Given its central location and the high population growth trajectory, we knew that expanding into the Texas market would allow us to best serve the needs of both existing and new clients," says Calvin Gin, co-founder of Helios Visions, in the release. "I am often traveling across Texas for other projects including Luby's Restaurants and Charming Studios, so it is a natural progression for Helios Visions to expand our drone service offerings here."

Amazon Prime Air drones will fly into College Station later this year. Photo courtesy of Amazon

Amazon plans to land drone delivery down the road from Houston

prime spot

A Houston neighbor will be among the first in the nation to test pilot a game-changing delivery system. Amazon has announced plans to deploy its state-of-the art Prime Air drone delivery in College Station, Texas later this year.

The online juggernaut is already reaching out to College Station customers, telling them that they’ll soon receive free and fast drone delivery on thousands of everyday items. The deployment marks the largest selection of items to ever be available for drone delivery, per Amazon. College Station joins Lockeford, California as targeted test sites for drone launch.

“We are impressed with so many aspects of College Station,” notes an Amazon blog post announcing the news. “The innovative research conducted by Texas A&M University, the small-town feel, and the sense of community that is clear from the minute you arrive in town all make it a very special place.”

Jeff Bezos’ empire plans to also collaborate with the Aggies on tech. “We are thrilled about the opportunity to launch this service in College Station and partner with the city and its world-class university on some of the great work they’ve been doing in the area drone technology,” the post adds.

How will it work? Once onboarded, College Station customers can then view Prime Air-eligible items on Amazon, where they can place orders and receive an estimated arrival time with a status tracker for their order.

Amazon Prime Air’s New Delivery Dronewww.youtube.com

Drones will then fly to the designated delivery location, descend to the customer’s backyard, and hover at a safe height. The drones will then safely release the package, rise back up to altitude, and return to base, per Amazon.

Amazon is touting the difference of its drone fleet versus the masses. Prime Air drones fly up to 50 miles per hour, up to an altitude of 400 feet, and carry packages of up to 5 pounds.

Unlike most drones, Amazon notes, Prime Air drones utilize a sophisticated, sense-and-avoid system allowing them to operate at greater distances while safely and reliably avoiding other aircraft, people, pets, and obstacles. That means the drones can identify objects such as aircraft, birds, or static places such as trees and chimneys, avoid them, and select a safe space to land and later, safely leave.

“Being one of the first drone delivery locations for Amazon puts College Station at the forefront of this exciting technology,” said John Sharp, chancellor of The Texas A&M University System, in a statement. “What happens here will help advance drone delivery for the rest of the country and perhaps the rest of the world. We welcome Amazon to our community and stand ready to assist however we can.”

College Station, Amazon promises, will benefit by more than just speedy, environmentally friendly delivery. “We’re bringing more than drone delivery to Lockeford and College Station,” notes the Amazon blog. “Through these Prime Air drone deliveries, we will create new jobs, build partnerships with local organizations, and help to reduce the impact of climate change on future generations.”

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This article originally ran on CultureMap.

Hylio, based just south of Houston, is setting out to bring the agriculture industry into the 21st century. Photo courtesy of Hylio

Houston area drone company on track to revolutionize the agriculture industry

in-flight innovation

Renowned American inventor Thomas Edison once said, "There's a way to do it better, find it."

That timeless adage has been the spark that has ignited countless technological advances over the years and Hylio is no different, applying it to its own mission to disrupt the agricultural technology space.

With rampant systemic inefficiencies with current crop spraying solutions negatively affecting farm economics, Hylio developed its AgroDrone, a precision crop spraying drone system that is revolutionizing ag-tech.

"Our company started about five years ago, when we were delivering in Central America and noticed the way people were doing spraying was extremely inefficient," says Arthur Erickson, CEO and co-founder of Hylio. "They were doing it either by hand or by plane or helicopter. If you are doing it by hand, you are doing it extremely slow and very inaccurate. If you're doing it by plane or helicopter, you're doing it faster, but you're extremely inaccurate."

In most cases, when farmers use traditional crop spraying methods such as helicopter or plane, up 90 percent of the fertilizer or pesticides miss their intended targets or float away.

However, AgroDrone, which was recently accepted into the Capital Factory accelerator, provides for a very precise method of applying those chemicals with its intuitive planning system, which monitors and controls the spray volumes using pre-existing map files or polygons.

"For the past year, we've been our own first customer," says Erickson. "We've used the technology in El Salvador, Honduras and Guatemala on 40,000 acres. We learned the product and what made it more efficient by using it in the field 10 hours a day. We built this from the ground up using it as a farmer would. We worked out all the bugs, optimized it and made it reliable, so when farmers are out there in the mud or in the rain, it still works."

The drone's flight software allows it to be completely turnkey. The electron-based application can be run on any cross platform and gives pilots control over the drone at all times.

Additionally, the redundant critical flight system ensures stable flight.

"Our software was made completely in house," says Erickson. "Like a Google map interface, you can set up your own pre-loaded missions, in different polygon shapes, draw them yourself or import polygon files and generate missions for the drone to fly."

Because of the radar altimeters fitted on the drones, farmers are able to reduce the amount of chemicals they use because the drones maintain optimal height over crops at all times, which minimizes drift and maximizes application quality.

"If you talk to any farmer that has 400 acres of corn, for example, and they want to get it sprayed, it would cost them maybe $400 times 10 for labor times 10 for chemicals, so about $8000," says Erickson. "The problem is they're providing a brute force solution to a problem that is very simple to solve with a drone.

"If they've got weeds on their 400 acres, and the weeds are only on one or two acres, little spots in the field, they just want to eliminate those spots, so they don't need to pay someone to spray their entire field, so they're saving the chemical cost per acre is $10 bucks. So if they run our drone for 10 minutes, they're literally saving $7,000 or more."

The innovators behind Hylio started the company because they were passionate about drones, but saw that the crop spraying system for farmers was broken and inefficient, so they sought to make the process better and more sustainable.

"Farmers are responsible for how we eat, how everyone eats," says Erickson. "The current technologies used in agriculture is outdated and not very cost effective. We looked at the farm economics and wanted to help develop viable solutions. Every farmer has to battle weeds; it is universal. All crop and weeds are different, but it is the same concept. The more you control the weeds, the more money you make at the end of the year. A farmer could lose 20 percent or more of their crops if they do not control their weeds properly. Despite the inefficiencies and razor thin margins, farmers still use helicopters and planes because they have to kill those weeds.

"There's a better way to do it with drones and it comes at a fraction of the price."

The AgroDrone starts at $19,300 and is delivered to the farmer fully tested and assembled. The package includes four pairs of 30,000 mAh 22V LiPo batteries, charging equipment, one handheld GPS tracker unit and access to the Hylio AgroSol Mission Control Software.

The software, which was designed by farmers for farmers, requires a recurring monthly fee that ranges from $100 to $500 depending on the level.

Hylio also provides the central device that can control multiple drones at the same time and service hundreds of acres per day.

"The people that are doing the weed control spraying for farmers literally won't come out because it's not worth their time to just come out and spray one or two acres," says Erickson. "So even if a farmer has a problem that they know is only on one or two acres, they have to spray the whole thing, because they market will only allow people to spray the entire amount. They cannot come out and afford to spray one or two acres. However, if you buy a drone, you can do it yourself with the click of a button. Farmers are saving literally $10,000 per application depending on how big their crop is."

According to the US Department of Agriculture, American farmers received $11.5 billion in subsidies in 2017. That number will be drastically higher in 2019 to offset the market losses farmers will see due to President Donald Trump's trade war with China.

With profits in continual decline, Hylio's mission to improve margins for farmers continues.

"Farming is heavily subsidized now," says Erickson. "None of them are making money, so they desperately need something to increase their bottom lines. We are here to make farmers' lives better and help them feed us better. It's a win win."

Paladin Drones wants eyes in the skies within 30 seconds of an emergency call. Getty Images

Houston drone company creating the next generation of first responders

To the rescue

When 911 is called, first responders usually arrive at the scene around three or four minutes after the call's placed. But Houston-based Paladin Drones wants to have eyes on the ground ­— or eyes in the sky — within the first 30 seconds.

The company's mission is simple: to outfit public agencies and first-responders with drones that can be autonomously deployed to the site of an emergency. Equipped with thermal sensors and flying around 200 feet high, the drones can give police and firefighters near-instantaneous information on a situation underway.

At the beginning of April, Paladin Drones began working with the Memorial Villages Police Department to respond to incidents in Memorial Villages, Hunter's Creek, Piney Point Village, and Bunker Hill.

"(This is) one of the first departments in the country to be testing this technology," says Paladin Drones co-founder Divyaditya Shrivastava. "We're very limited in the area that we cover, and that's just because we're taking baby steps and going as carefully and deliberately as possible."

Paladin Drones was co-founded by Shrivastava and Trevor Pennypacker. In 2018, the company went through a three-month boot camp at Y Combinator, a California-based incubator that's churned out Dropbox, AirBNB, Instacart and more. Through Y Combinator, Paladin Drones was connected with venture capital investors in Houston.

The company's drones capture critical information, such as a vehicle's color and body type, a suspect's clothing, or the direction a suspect fled the scene. And since roughly 70 percent of 911 calls involve witnesses or passerby giving inaccurate information about the emergency's location, these drones will be able to pinpoint the exact location of an emergency, further aiding the arrival of first responders.

"We're working on tracking technology to give the drones the capability to auto-follow (suspects)," Shrivastava says.

Paladin Drones is looking to hire a handful of employees in the coming months, Shrivastava says. He declined to disclose any information on the company's funding plans, but said it's still involved with Y Combinator in California.

Shrivastava began developing Paladin Drones when he was finishing high school in Ohio. The summer before his senior year, a friend's house burned down. While nobody was injured in the fire, the home was destroyed, and Shrivastava spoke with the local firefighters. Tragically, the 911 call that alerted firefighters of the emergency was one of the 70 percent of calls that involved inaccurate location information.

"If they'd known the exact location, the house would've been saved," Shrivastava says. "A fire doubles every 30 seconds."

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5 Houston scientists named winners of prestigious Hill Prizes 2026

prized research

Five Houston scientists were recognized for their "high-risk, high-reward ideas and innovations" by Lyda Hill Philanthropies and the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST).

The 2026 Hill Prizes provide seed funding to top Texas researchers. This year's prizes were given out in seven categories, including biological sciences, engineering, medicine, physical sciences, public health and technology, and the new artificial intelligence award.

Each recipient’s institution or organization will receive $500,000 in direct funding from Dallas-based Lyda Hill Philanthropies. The organization has also committed to giving at least $1 million in discretionary research funding on an ad hoc basis for highly-ranked applicants who were not selected as recipients.

“It is with great pride that I congratulate this year’s Hill Prizes recipients. Their pioneering spirit and unwavering dedication to innovation are addressing some of the most pressing challenges of our time – from climate resilience and energy sustainability to medical breakthroughs and the future of artificial intelligence,” Lyda Hill, founder of Lyda Hill Philanthropies, said in a news release.

The 2026 Houston-area recipients include:

Biological Sciences: Susan M. Rosenberg, Baylor College of Medicine

Rosenberg and her team are developing ways to fight antibiotic resistance. The team will use the funding to screen a 14,000-compound drug library to identify additional candidates, study their mechanisms and test their ability to boost antibiotic effectiveness in animal models. The goal is to move toward clinical trials, beginning with veterans suffering from recurrent infections.

Medicine: Dr. Raghu Kalluri, The University of Texas MD Anderson Cancer Center

Kalluri is developing eye drops to treat age-related macular degeneration (AMD), the leading cause of vision loss globally. Kalluri will use the funding to accelerate studies and support testing for additional ocular conditions. He was also named to the National Academy of Inventors’ newest class of fellows last month.

Engineering: Naomi J. Halas, Rice University

Co-recipeints: Peter J. A. Nordlander and Hossein Robatjazi, Rice University

Halas and her team are working to advance light-driven technologies for sustainable ammonia synthesis. The team says it will use the funding to improve light-driven catalysts for converting nitrogen into ammonia, refine prototype reactors for practical deployment and partner with industry collaborators to advance larger-scale applications. Halas and Nordlander are co-founders of Syzygy Plasmonics, and Robatjazi serves as vice president of research for the company.

The other Texas-based recipients include:

  • Artificial Intelligence: Kristen Grauman, The University of Texas at Austin
  • Physical Sciences: Karen L. Wooley, Texas A&M University; Co-Recipient: Matthew Stone, Teysha Technologies
  • Public Health: Dr. Elizabeth C. Matsui, The University of Texas at Austin and Baylor College of Medicine
  • Technology: Kurt W. Swogger, Molecular Rebar Design LLC; Co-recipients: Clive Bosnyak, Molecular Rebar Design, and August Krupp, MR Rubber Business and Molecular Rebar Design LLC

Recipients will be recognized Feb. 2 during the TAMEST 2026 Annual Conference in San Antonio. They were determined by a committee of TAMEST members and endorsed by a committee of Texas Nobel and Breakthrough Prize Laureates and approved by the TAMEST Board of Directors.

“On behalf of TAMEST, we are honored to celebrate the 2026 Hill Prizes recipients. These outstanding innovators exemplify the excellence and ambition of Texas science and research,” Ganesh Thakur, TAMEST president and a distinguished professor at the University of Houston, added in the release. “Thanks to the visionary support of Lyda Hill Philanthropies, the Hill Prizes not only recognize transformative work but provide the resources to move bold ideas from the lab to life-changing solutions. We are proud to support their journeys and spotlight Texas as a global hub for scientific leadership.”

Investment bank opens new Houston office focused on energy sector

Investment bank Cohen & Co. Capital Markets has opened a Houston office to serve as the hub of its energy advisory business and has tapped investment banking veteran Rahul Jasuja as the office’s leader.

Jasuja joined Cohen & Co. Capital Markets, a subsidiary of financial services company Cohen & Co., as managing director, and head of energy and energy transition investment banking. Cohen’s capital markets arm closed $44 billion worth of deals last year.

Jasuja previously worked at energy-focused Houston investment bank Mast Capital Advisors, where he was managing director of investment banking. Before Mast Capital, Jasuja was director of energy investment banking in the Houston office of Wells Fargo Securities.

“Meeting rising [energy] demand will require disciplined capital allocation across traditional energy, sustainable fuels, and firm, dispatchable solutions such as nuclear and geothermal,” Jasuja said in a news release. “Houston remains the center of gravity where capital, operating expertise, and execution come together to make that transition investable.”

The Houston office will focus on four energy verticals:

  • Energy systems such as nuclear and geothermal
  • Energy supply chains
  • Energy-transition fuel and technology
  • Traditional energy
“We are making a committed investment in Houston because we believe the infrastructure powering AI, defense, and energy transition — from nuclear to rare-earth technology — represents the next secular cycle of value creation,” Jerry Serowik, head of Cohen & Co. Capital Markets, added in the release.

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This article originally appeared on EnergyCaptialHTX.com.

MD Anderson makes AI partnership to advance precision oncology

AI Oncology

Few experts will disagree that data-driven medicine is one of the most certain ways forward for our health. However, actually adopting it comes at a steep curve. But what if using the technology were democratized?

This is the question that SOPHiA GENETICS has been seeking to answer since 2011 with its universal AI platform, SOPHiA DDM. The cloud-native system analyzes and interprets complex health care data across technologies and institutions, allowing hospitals and clinicians to gain clinically actionable insights faster and at scale.

The University of Texas MD Anderson Cancer Center has just announced its official collaboration with SOPHiA GENETICS to accelerate breakthroughs in precision oncology. Together, they are developing a novel sequencing oncology test, as well as creating several programs targeted at the research and development of additional technology.

That technology will allow the hospital to develop new ways to chart the growth and changes of tumors in real time, pick the best clinical trials and medications for patients and make genomic testing more reliable. Shashikant Kulkarni, deputy division head for Molecular Pathology, and Dr. J. Bryan, assistant professor, will lead the collaboration on MD Anderson’s end.

“Cancer research has evolved rapidly, and we have more health data available than ever before. Our collaboration with SOPHiA GENETICS reflects how our lab is evolving and integrating advanced analytics and AI to better interpret complex molecular information,” Dr. Donna Hansel, division head of Pathology and Laboratory Medicine at MD Anderson, said in a press release. “This collaboration will expand our ability to translate high-dimensional data into insights that can meaningfully advance research and precision oncology.”

SOPHiA GENETICS is based in Switzerland and France, and has its U.S. offices in Boston.

“This collaboration with MD Anderson amplifies our shared ambition to push the boundaries of what is possible in cancer research,” Dr. Philippe Menu, chief product officer and chief medical officer at SOPHiA GENETICS, added in the release. “With SOPHiA DDM as a unifying analytical layer, we are enabling new discoveries, accelerating breakthroughs in precision oncology and, most importantly, enabling patients around the globe to benefit from these innovations by bringing leading technologies to all geographies quickly and at scale.”