The TMC Innovation Institute has been tapped by the government to collaborate on illness-detecting technology. Courtesy of TMC

The Texas Medical Center has been identified as a key partner for a national health-focused initiative. TMCx has been selected as one of eight accelerator programs to be a part of the program that focuses on identifying emerging health security threats, according to a release from TMC.

The United States Department of Health and Human Services has provided TMCx a $96,500 to conduct research and provide solutions for two different challenges within mitigating these risks.

"The first is 'pre-symptomatic' detection of illness, or detecting illness in patients and suggesting treatment before they even begin to show symptoms," the release reads. "The second is addressing sepsis, a life-threatening reaction to infection."

Sepsis, which is one of the most costly illnesses hospitals treat, affects 1.7 million patients a year.

HHS' Biomedical Advanced Research and Development Authority, or BARDA, has a new entity called DRIVe, which stands for Division of Research, Innovation, and Ventures. The effort will be lead by the new organization, which comes at a result of the 21st Century Cures Act that was enacted to spur health security within technology.

In July, HHS officials toured the TMC Innovation Institute campus before deciding to work with the accelerator. TMCx is no stranger to the national spotlight. In November, the organization was lauded for its accelerator program with a national award.

The accelerator has announced its eighth cohort of startups this spring. The 21 companies will be focused on digital health. Last cohort, TMCx accelerated 23 companies that raised $73 million by demo day.

In December, Erik Halvorsen, who had lead the Innovation Institute for a few years, abruptly left his position as director. Lance Black, associate director of TMCx, has been named the interim director.

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CultureMap Emails are Awesome

Why founders need to be prioritizing problem-solution fit, according to this Houston innovator

guest column

Over the past 10 years I have been so incredibly fortunate to work for and with dozens of startup ecosystems, startup development organizations, competitions and accelerators.

Through these interactions I have mentored, advised and coached over 500 startups and as I've reflected back on these interactions and relationships I have observed some crucial insights that I am humbled to be able to share here with you — starting with the importance of problem-solution fit.

My top observation is that the success of founders often hinges on their focus on a specific problem, from the perspective of the problem holder (which is not always their customer) and particularly a problem set they care deeply about. This focus is far more impactful than merely having a great idea. Founders with a laser focus on a problem, showed remarkable advantages. These founders were:

  • Quicker in Validating Assumptions: Their problem-centric approach allowed them to more rapidly test and validate their hypotheses about market needs and solutions.
  • Focused on Data-Driven Decision Making: They were more receptive to letting data guide their strategic decisions, leading to more grounded and effective strategies.
  • Agile in Pivoting: When confronted with challenges or new information, these founders could pivot more efficiently, as their commitment was to solving the problem, not just to their solution.

This problem-focused mindset proved to be a significant differentiator in their journey from ideation to success.

For these reasons, the philosophy that problem-solution fit leads development, has become a cornerstone in my approach to fostering innovation. It underscores the need for startups and organizations alike to delve deeper into understanding the real challenges they face, the first order problems, which in turn opens doors to more impactful and sustainable solutions.

Most recently, In my time at MassChallenge, my approach to problem identification diverged significantly from industry norms. The crux of my strategy was to shift the founders' focus from their innate bias towards their innovation or the allure of monetary gain to a deeper connection with the underlying problem — transforming the innovator's bias into the innovator's gift.

In my interactions, I often met two predominant types of founders:

  • Technical Founders: These individuals were deeply enamored with the technology or product they created. Often coming from the research world or a technical / engineering background within one industry. Their passion was more about the innovation itself rather than its impact or the problem it aimed to solve.
  • Profit-Oriented Founders: These founders were driven primarily by the potential for financial success. Often coming out of Business school, consulting firms or investment / banking background. Their focus was often on the market opportunity, timing, size and scale rather than the problem needing a solution.

I am not a believer that anyone fits into a box but these were broad commonalities I observed over time. While neither mindset is inherently flawed, it became evident that a third type of founder, those who developed a passion for solving a specific problem — often tied to a personal or emotional connection — tended to achieve greater success.

The challenge lay in transforming the mindset of founders who initially did not have this problem-centric focus. To do this, I employed a series of exercises and mental experiments that anyone can do aimed at uncovering the true purpose behind their ventures. Two pivotal tools in this process was Simon Sinek's Golden Circle, which helped delve into the why behind their companies and Ash Maurya’s Problem Discovery process that he details in Lean Mastery.

These exercises were transformative. Founders typically developed a stronger attachment to these newly framed problem statements than to their initial motivations. It aligned their endeavors with a purpose that was emotionally significant to them, thereby enhancing their commitment and effectiveness in addressing the problem.

This approach to problem identification was not just about finding a market fit; it was about aligning the founders' core values and motivations with the problems they aimed to solve, thereby unleashing the true potential of their innovations.

One of the most significant challenges was persuading founders to shift their mindset from their initial focus to a problem-oriented approach. This transition was often difficult, as change is inherently challenging, especially when founders have invested months or years in developing something they feel deeply connected to. The key was to reframe and redirect their passion towards understanding and solving the core problem for the problem holders that were most affected. This shift in focus wasn't always successful, but when it did take effect, it markedly increased the founders' likelihood of success.

Part of the difficulty in effecting this founder mindset shift stemmed from the overwhelming amount of content directed at startup founders, emphasizing the immediate need for customer feedback and early creation of MVP’s. While these aspects are crucial (at the right time), there is a noticeable gap in guiding founders towards the critical step of identifying problem-solution fit earlier in the process. As a result, many founders fell into the trap of building upon untested assumptions, believing that once they've created a product or identified a revenue model, the journey was set on the right path.

This challenge wasn't confined to startup founders alone, it is prolific across the innovation economy. Corporates, governments, and universities also displayed resistance in identifying their core, underlying problems. They often focused on surface-level issues or immediate technological needs without recognizing the structural problems causing these more visible issues.

As a founder, an innovator, or anyone passionate about bringing new solutions to the masses, this shift in perspective is crucial. It allows founders and organizations to understand their challenges more deeply, leading to more effective and sustainable solutions. It isn’t just about solving the problems they could articulate, but about uncovering the first principles issues that needed addressing.

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Jon Nordby is managing partner at Anthropy Partners, a Houston-based investment firm, and professor of entrepreneurship at the University of Houston.

Rice names inaugural recipients of new grant program that's doling out $360,000

Four Houston research projects are splitting hundreds of thousands of dollars in grant funding from Rice University.

After announcing the One Small Step Grant program in September to support Rice-developed, lab-stage innovations, the university has named its inaugural recipients. After receiving nearly 30 applicants, four research projects were selected to share $360,000 in grant funding.

“Being able to fund near-commercial projects represents a leap forward in our mission of supporting the cutting-edge work of our faculty and students and helping bring those to market,” Adrian Trömel, assistant vice president for strategy and investments, says in a news release. “Feedback from industry and investors show that they’re excited on how the One Small Step grants help derisk these technologies, getting them ready to launch. Watch this space for the next generation of leading deeptech companies.”

The selected projects include:

  • PerisBio, developed by Samira Aglhara Fotovat and Samantha Fleury from Rice Professor Omid Veiseh's Lab, focuses on novel, hydrogel-encapsulated engineered "cell factories" for the minimally invasive treatment of endometriosis. The project received a $100,000 award.
  • Solidec, founded by Ryan Duchanois and Yang Xia from Rice Professor Haotian Wang's Lab, is a room temperature, solid-state direct air capture technology. The project received a $100,000 award.
  • HornetX, led by Rice Professor Aditya Mohite's Lab, aims to produce highly stable green hydrogen using a perovskite-based photoelectrochemical cell with leading efficiency. The project received a $80,000 award.
  • Coflux, developed by Jeremy Daum and Alec Ajnsztajn from the labs of Rice Professors Rafael Verduzco and Pulickel Ajayan, focuses on covalent organic framework-based photocatalysts for instream remediation of PFAS (per- and polyfluoroalkyl substances) from water. The project received a $80,000 award.

The Office of Innovation created an investment advisory committee — made up of entrepreneurs, investors and corporate executives across industries — to select these recipients. The grant program was funded by the Office of Innovation, with support from Breakthrough Energy Fellows for climate and energy projects

“The inaugural winners of the One Small Step Grant represent the innovative spirit and dedication to excellence that defines our students and faculty," Rice Chief Innovation Officer Paul Cherukuri says. "We are proud to support these groundbreaking projects on their journey from lab to market."

Innovative Texas hardtech startup secures award to test in space

ready for liftoff

A Houston-area startup and Greentown Houston member has secured a prestigious space prize.

College Station’s FluxWorks, which develops and commercializes non-contact magnetic gearboxes for use in extreme environments, was one of two startups to receive the Technology in Space Prize, which is funded by Boeing and the Center for the Advancement of Science in Space, or CASIS, manager of the International Space Station National Laboratory. Los Angeles-based Symphony Bio also received the honor.

Through the MassChallenge startup accelerator program, the two companies now get to utilize the research environment available through the ISS National Lab. CASIS and Boeing awarded Symphony Bio and FluxWorks more than $630,000 in total through the contest. Approximately $20 million has been awarded for more than 30 projects, which have already launched to the space station, since the event’s beginning.

"Boeing is excited to partner with CASIS to support the advancement of cutting-edge research using the unique environment of the orbiting laboratory,” says Scott Copeland, director for ISS research integration at Boeing, in a news release. “Enabling research that can help millions diagnosed with cancer and advancing mechanical innovations of non-contact magnetic gear technology will benefit human life in both the harsh environment of space and terrestrial environments.

"There are many smart people out there with great ideas who can leverage the space station to advance innovation, and these two companies serve as an inspiration to them all,” he continues.

FluxWorks, which won the 2023 Rice Business Plan Competition, will use the space station to test performance of a new gear. The magnetic gear will be tested to assess its startup behavior, dynamic operation, vibrational characteristics, and seal and bearing behavior in microgravity. Gearbox's goal is to reduce the mass of motors required in a variety of applications, but the lubricant needed to make them work is not designed for use in extreme environments, like space. Magnetic gears do not require lubricant, which makes them an alternative.

Symphony Bio will use the orbiting laboratory to develop a new cancer treatment that hopes to harness the immune system to fight tumors.