$1.5M donation secures new alliance for disaster resilience in Houston

supporting the Bayou City's future

Enbridge and Phillips 66 have made a commitment to making sure Houston has the support it needs to be resilient. Photo via Getty Images

Disaster resilience and recovery efforts in the Houston area are getting a boost.

Thanks to a combined $1.5 million commitment from natural gas company Enbridge and energy company Phillips 66, the Greater Houston Community Foundation, and United Way of Greater Houston have formed the Greater Houston Disaster Alliance.

Enbridge and Phillips 66 are each donating $250,000 annually for three years to finance the alliance. The alliance says it will seek additional funding and partnership opportunities to help ensure the organization’s longevity.

The alliance aims to bolster year-round disaster preparedness in the region. It builds on a partnership worked out two years ago between the foundation and the United Way to coordinate philanthropic responses to Houston-area disasters.

The alliance hasn’t yet named a director. However, it already has begun searching for someone to fill the post, a process that could take several months.

Among the initiatives that the alliance will undertake are:

  • Solidifying infrastructure for directing community-wide philanthropic responses following disasters.
  • Pursuing partnerships with nonprofits to improve disaster relief..
  • Accelerating disaster fundraising and providing seed funding for ongoing resilience and recovery innovations.
  • Establishing a council of public and private leaders to mesh disaster resiliency and recovery strategies.

In the event of a major disaster, the alliance will form a separate leadership council to support fundraising.

“When it comes to disasters, it’s only a matter of time before the Houston region will be impacted again, and the Greater Houston Disaster Alliance gives us the opportunity to take a more proactive and effective approach to disaster recovery and resiliency,” Stephen Maislin, president and CEO of Greater Houston Community Foundation, says in a news release.

Every disaster in the Houston area highlights the struggles faced by residents who already were struggling to meet basic needs, according to Amanda McMillian, president and CEO of the United Way of Greater Houston.

“Recognizing the economic peril that many in our community face when disaster strikes compels us to develop the most effective and equitable social service response that we can now. That is why the work of the Greater Houston Disaster Alliance is so important,” says McMillian.

Houston is certainly no stranger to natural disasters. For example, Hurricane Harvey ranks among the worst U.S. natural catastrophes in the 21st century. The 2017 storm caused an estimated $125 billion in damage in Texas and Louisiana, damaged over 200,000 homes and led to more than 100 deaths.

“Harvey was a wake-up call to all of us who set a course for the city’s future,” Houston Mayor Sylvester Turner said in 2018.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.