With Southwest and Allegiant doubling down on Hobby Airport, the travel hub continues to grow. Image via fly2houston.com

In the estimation of frequent flier Chris Martin, Houston's continually expanding William P. Hobby Airport soars as an "exciting and excellent" hub for business travelers.

Martin is senior vice president of global business development in the Houston office of travel agency Wings Travel Management and one of the leaders of the Houston-based Texas Business Travel Association. He says Hobby Airport's location — seven miles southeast of downtown Houston — and its low-cost flight options hold great appeal for business travelers, especially those with tight travel budgets. And that appeal continues to grow, thanks in part to initiatives at Hobby undertaken by Southwest and Allegiant airlines.

On January 8, Dallas-based Southwest, the No. 1 carrier at Hobby as measured by passenger traffic, unveiled a $125 million, 240,000-square-foot maintenance complex at the airport. It's the largest maintenance facility in Southwest's network. The complex includes a 140,000-square-foot hangar for aircraft maintenance.

"The new hangar continues to showcase our dedication to Houston," Southwest spokesman Dan Landson says. "We've grown continuously over the last several years, and we see more growth in our future, which the hangar will help facilitate."

Southwest's new maintenance complex speeds up airline operations in Houston and helps "get travelers on their way more quickly," Landson says.

At the public debut of the maintenance complex, Southwest Chairman and CEO Gary Kelly told reporters that the airline plans to add a "significant" number of flights at Hobby over the next five to 10 years. He suggested that Houston's beefed-up flight schedule could include brand-new routes to South America.

"We see a lot of opportunity to continue growing," Landson says, "and linking Houston to the places that our customers want to go — whether domestically or internationally."

Today, Southwest offers nearly 200 flights a day from Hobby to almost 70 destinations in the U.S., Mexico, the Caribbean, and Latin America. Hobby opened a $156 million, five-gate international concourse in October 2015.

Six days after Southwest took the wraps off its new maintenance complex, low-cost airline Allegiant said that beginning this May, it's launching seasonal twice-weekly service at Hobby with nonstop flights to Asheville, North Carolina; Destin-Fort Walton Beach, Florida; Knoxville, Tennessee; and Savannah, Georgia. No airlines at Hobby currently serve those destinations.

Allegiant will become the fourth airline to operate at Hobby. Aside from Southwest, American and Delta airlines currently fly out of Hobby, but Southwest is the only one with international service. Last year, JetBlue shifted its Houston operations from Hobby to the larger George Bush Intercontinental Airport.

In 2018, Hobby served almost 14.48 million passengers, up 7.7 percent from 2017 and surpassing 14 million for the first time. Figures for 2019 aren't available yet.

Any increase in passenger traffic at Hobby would certainly be propelled by time-constrained business travelers. In a ranking released January 29 by personal finance website FinanceBuzz, Hobby flies into the top spot on the list of the best U.S. airports if you're running late for a departing flight. To come up with the ranking, FinanceBuzz looked at data for the country's 45 busiest airports.

FinanceBuzz says Hobby's low average wait time at security checkpoints, just under 14 minutes, contributed to its No. 1 ranking.

"The chances of catching Hobby at its busiest are pretty low, and its relatively small number of departing passengers each day helps the airport from getting bogged down with too many travelers," FinanceBuzz reports. "While it's lower percentage of on-time flights might hinder those who are punctual, [this] can be the difference between catching or missing a flight for those running late."

By comparison, Bush Intercontinental ranked eighth on FinanceBuzz's list of the worst U.S. airports if you're running late. It's weighed down by an average 25-minute wait at security checkpoints, according to FinanceBuzz.

"Once you get through security, you've got the sixth-largest terminal on our list to navigate, which puts this airport as one of the worst for late travelers," FinanceBuzz reports of Bush Intercontinental.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”