Kim Raath, CEO of Topl, and Leslie Goldman, general partner at The Artemis Fund, identified three challenges that female entrepreneurs face while going through the fundraising process. Photos courtesy

It's estimated that women make up only around 10 percent of decision makers in venture capital firms in the United States, and women-led companies only receive of a fraction of venture capital invested. And, stats aside, female entrepreneurs continue to face obstacles in the process that their male counterparts don't always share.

Kim Raath — co-founder and CEO of Topl, a Houston-based blockchain startup — and Leslie Goldman — general partner and co-founder of The Artemis Fund — discussed some of these obstacles at a virtual fireside chat for Dallas Startup Week. Here are the three challenges women face during fundraising, as Raath and Goldman discussed.

Balancing being realist with optimism

It's almost a chiche at this point — yet it still holds a great deal of truth — that women tend to be more honest than men when it comes to applying for jobs, for instance. Goldman says she's seen it plenty of times, especially when she was involved in corporate recruiting at one point in her career. Raath and Goldman agreed, women want to check off all the boxes on a requirements list.

"Men would apply if they could check just one box," Goldman says. "Women tend to be more realistic."

This trait, while noble, can be a disadvantage as it translates to the fundraising process.

Navigating unconscious bias

Raath says she's no stranger to discrimination for being a woman. In the chat, she tells a story of when she was a girl and the woman's track event she was supposed to run was canceled. She had her heart set on getting to nationals, so her father lobbied for her to get a chance to run in the boy's race. Eventually, they let her and she came in second place.

She continued to observe moments like this throughout her schooling, especially when she started studying male-dominated studies like economics and statistics — Raath now has a master's and a Ph.D from Rice University. When recently raising money for Topl's latest round, her observational and statistical mind picked up on something. Raath explains that there are two types of questions a VC might ask you — preventative vs. promotional. An example she gives for each is:

  • Preventative: "How many daily users do you have?"
  • Promotional: "How do you look to acquire users?"

"About three months in, I started realizing that I'm constantly getting these preventative questions. So, I did a little research," Raath says, explaining that she found that women are more likely to get these preventative questions. "Now, every preventative question I got, I started answering with a promotional answer."

It's the same unconscious bias as how a young male entrepreneur might be considered, "young and promising," while a woman with the same resume would be considered, "young and inexperienced."

Creating a supportive network

Raath and Goldman discussed the importance of women surrounding themselves with supportive networks made up of both women and men. On one hand, it's key to have fellow female entrepreneurs or investors who have been in your shoes before or whom you can give advice to — Raath says she created "woke woman wine nights" with her interns this summer.

On the other hand, having men in your network who can act as advocates — like Raath's father was as well as her male co-founders whom she says are great supporters — is crucial too.

"I have been surrounded by some amazing male counterparts," Raath says. "That's the other side of this is finding male champions."

Dallas Startup Week has pivoted to online panels and chats. Here's which ones Houston innovators shouldn't miss. Getty Images

Here's what Dallas Startup Week events Houston entrepreneurs should attend

where to be online

While a 4-hour trip up Interstate 45 might, in years prior, could have caused Houston entrepreneurs pause from attending the annual Dallas Startup Week, this year there's no excuse.

DSW is taking place online this year, and there are more than a couple virtual events Houston entrepreneurs need to attend. Here's which virtual events Houstonians should log on to.

Monday - The State of Fundraising in Texas

A panel of Texas-based venture experts will discuss the state of fundraising in Dallas and Texas as a whole. The panel includes:

  • Bryan Chambers, vice president of Accelerator & Investment Fund at Capital Factory
  • Cindy Revol, principal at Perot Jain
  • Laura Baldwin, managing director at Golden Seeds
  • Mike Marcantonio, principal at Live Oak Venture Partners

The virtual panel is at 9 am on Monday, August 31. More information.

Monday - Women Investing in Women

Two Houston women — Leslie Goldman, co-founder and general partner of The Artemis Fund, and Kim Raath, co-founder and CEO of Topl — are taking the virtual stage to discuss women in investing.

The virtual fireside chat is at 11 am on Monday, August 31. More information.

Monday - Innovating in co-working in a COVID-19 world

Trey Bowles and Delanie Majors from The DEC Network will host CEO and founder of Common Desk, Nick Clark, for a discussion on how COVID-19 affected co-working spaces and the entrepreneurs that used to work out of them.

The virtual panel is at 11:30 am on Monday, August 31. More information.

Tuesday - The Future of Marketing Post COVID-19

In 2020, the world changed as we know it. Hear from these marketing leaders about how the landscape will continue to change, and how you can be equipped to market your business during and after a pandemic. Panelists include:
  • Ramon Mendez, co-founder of Brand Army
  • Phil Lockhart, partner & chief digital officer of Credera
  • Michael Pratt, founder of Digital Fight Club
  • Laci McKinney, founder of The People's Voice Creative Agency
  • Jennifer Cho, executive vice president and general manager if Weber Shandwick

The virtual fireside chat is at 3:15 pm on Tuesday, September 1. More information.

Wednesday - Do You Really Know Your Customer: Customer Segmentation is Key to Success

Learn to keys to customer success from a panel of seven businesswomen, including:

  • Tracey Altman, principal, Altman Consulting
  • Sophia Johnson, founder & president at Alpha Business Images
  • Anjie Vichayanonda, founder & CEO of Leg Up Legal
  • Karen Jenkins, senior director and regional sales executive of Capital One
  • Kristy Alballero, co-founder & COO, IOOGO
  • Kristy Alballero is the co-founder and COO of IOOGO
  • Marty McDonald, CEO of Boss Women Media

The virtual fireside chat is at 10:15 am on Wednesday, September 2. More information.

Wednesday - How Smalls Can Win Big with Department of Defense

Learning to win government contracts can be a challenging task, yet millions of startups in the United States are thriving because of them. As a founder, entrepreneur, or just a curious individual, check out this session to learn about the keys to success in government contracting. Panelists include:

  • David Shaw, co-founder and chief commercialization officer at Astrapi
  • Steve Guengerich, senior adviser at the University of Texas at Dallas
  • Dave Copps, CEO of Hypergiant Sensory Sciences
  • Sam Riehn, business development at Long Capture & Contract Management

The virtual fireside chat is at 11 am on Wednesday, September 2. More information.

Thursday - The State of Corporate Venture

A panel of experts from some of the largest corporations in the world discuss how their companies work with and invest in startups. They will discuss ways to engage with them, what kinds of companies they look to invest in, and how investing has changed during a tumultuous 2020.

  • Duane Dankesreiter, senior vice president of Research and Innovation of Dallas Regional Chamber
  • Aman Sharma, partner of Capital One Ventures
  • Marisa Bertha, senior director at New Business Development & 7-Ventures, 7-Eleven
  • Jim Adler, founding managing director at Toyota Ventures

The virtual fireside chat is at 1:05 pm on Thursday, September 3. More information.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."