Houston tech company receives corporate investment, HX names new board members, and more innovation news

short stories

From new board members at Houston Exponential to startups receiving funding, here are the latest short stories of Houston innovation. Photo by Zview/Getty Images

Houston's innovation ecosystem has been booming with news, and it's likely some might have fallen through the cracks.

For this roundup of short stories within Houston innovation, a startup snags funding from a new corporate venture group, a blockchain startup gets major kudos, CTV's latest investment, and more.

HX names newest board members

HX has five more members of its board. Photo courtesy

Houston Exponential has announced five new members to its governing board. Joining the group is:

  • Stephanie Campbell, managing director of the Houston Angel Network and general partner at The Artemis Fund
  • Martha Castex-Tatum, Houston City Council member
  • Gordon Daugherty, co-founder and president of Capital Factory
  • Emily Keeton, CFO of Mercato and co-founder of Station Houston
  • Roberto Moctezuma, founder and CEO of Fractal River
The board is chaired by Barbara Burger of Chevron and Chevron Technology Ventures. She will continue on as chair until the end of next year, when Blair Garrou of Mercury Fund will take over.

New corporate venture fund makes first investment

Houston-based SmartAC emerged from stealth mode this summer. Photo courtesy of smartac.com

Pinnacle Ventures, a corporate venture fund created by Pinnacle based just outside of Houston in Pasadena, announced the company has invested in Houston-based SmartAC.com, a member-based technology platform that monitors the health of air conditioning systems.

The deal is Pinnacle Ventures' first investment and will help SmartAC.com expand their service offerings to homeowners and top-level HVAC service providers.

"We are excited to have Pinnacle Ventures invest in our company and to have Ryan Sitton, founder and CEO of Pinnacle, join our board," says Josh Teekell, founder and CEO of SmartAC.com, in a news release. "The capital provided by Pinnacle Ventures will help us accelerate the growth required to meet our customer demand, which has scaled quickly since our launch in June.

"Additionally, this capital will help us power a new residential connected service economy for a $30 billion industry while offering our service partners a way to increase loyalty through improved transparency and customer experience," Teekell continues. "We're very much aligned with Pinnacle Ventures' focus on improving reliability through innovation and are confident that this investment will help us support our end users."

Data Gumbo recognized as an innovative blockchain company

CB Insights ranked 50 blockchain companies and one Houston startup made the cut. Photo via CB Insights

CB Insights released its inaugural Blockchain 50 ranking and named Houston-based Data Gumbo among the top blockchain companies in the world.

"The Blockchain 50, which we've created in conjunction with Blockdata, was born out of a desire to reduce that uncertainty and recognize the pioneering companies using the blockchain," says CB Insights CEO Anand Sanwal in the study. "This inaugural class of the Blockchain 50 is tackling a range of use cases across trade finance, capital markets, exchanges and more and are being used by banks, governments and major retailers."

Combined, the 50 companies included in the ranking have raised over $3 billion across 113 deals since 2017.

"Being named to this CB Insights' list is an honor and testament to the power of Data Gumbo's blockchain network GumboNet," says Andrew Bruce, CEO and Founder, of Data Gumbo in a news release. "Our smart contracts enable companies to leverage blockchain technology across the global business infrastructure to capture critical cost savings and value, forging a new foundation for commercial transactions: one based on trust, transparency, speed and visibility."

Currux Vision is deploying its technology in California

The Houston company's technology has been tested in California. Photo via currux.vision

Houston-based Currux Vision, which uses infra-tech artificial intelligence and machine learning solutions for smart city infrastructure, has conducted testing with the city of San Jose, California, and its department of transportation.

According to the tests, Currux Vision's SmartCity ITS can operate at 99 percent accuracy in the city. Moreover, Currux Vision can achieve high resolution results with older legacy digital and analog camera systems that offer lower resolution. Testing included but was not limited to vehicle detection and classification, turning movement counts, pedestrian counts, bicycle discrimination, stopped vehicles, and speeding, according to a press release.

"Increasing urbanization, traffic, mode shift, and increasing focus on safety drive the urgent need for a next-generation traffic management solution like our SmartCity ITS," says Alex Colosivschi, founder and CEO of Currux Vision, in the release. "We believe that efficient mobility and being able to do more with less creates economic opportunities, enables trade, improves quality of life, and facilitates access to markets and services effectively leveraging resources. ... We are happy to have worked with a great partner like San José's Department of Transportation to prove these transportation solutions."

Chevron Technology Ventures invests in software company

Chevron Technology Ventures, led by Barbara Burger, has announced its latest investment. Courtesy of CTV

Houston-based Chevron Technology Ventures has invested in a Denver-based container platform company's latest round. Nubix today announced it has closed $2.7 million in seed financing led by Tuscan Management with strategic investment from Chevron Technology Ventures, in addition to participation from other new investors.

"Businesses worldwide are investing in digital transformation initiatives with IoT-based solutions," says Rachel Taylor, Nubix co-founder and CEO, in a news release. "Our unique innovation in container and services technology enables unprecedented agility and safety when building, deploying and managing applications at the edge.

"We're delivering on digital transformation's requirements for agile compute at the edge, empowering organizations to analyze data in real-time where the data is actually created. This is a massive market opportunity for Nubix and we look forward to working hand-in-hand with our new investors as we drive agility and intelligence to the edge."

Golden Section Ventures invests in Austin startup

GSV has invested in Accelerist's impact-driven software. Image via accelerist.com

Austin-based Accelerist Inc. raised a $1 million investment round led by Houston-based Golden Section Ventures to catalyze the company's growth plans. Accelerist specializes in social impact partnership technology that nonprofits use to prospect, screen, access and measure the efficacy of their relationships with each other.

"We are very impressed with what Brittany (Hill, CEO and founder) and her team have built and are excited to join the journey," says Dougal Cameron, General Partner at GSV. "We are confident that Accelerist can be the standard of excellence for social impact partnership technology. This solution is more needed than ever."

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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