UH is investing in a nanotechnology developed on its own campus that can help prevent the spread of COVID-19. Photo courtesy of University of Houston

A nanotechnology developed at the University of Houston is about to make a big difference right on campus.

UH's Facilities/Construction Management Preventive Maintenance team is working on a project that will install air filters that are nanocoated with a material that was first developed at the UH Technology Bridge. UH Professor of Physics Seamus Curran has an extensive background in nanotech, and, as he learned more about COVID-19 and how it spreads, he started nano-coating facemasks to make them more resistant to the small particles that enable the spread of the virus.

Originally developed for the construction business, Curran's coating material could also be used to create hydrophobic facemasks, Curran discovered, and he founded a spin off company, Curran Biotech, to develop his next pandemic-proof innovation: nano-coated air filters.

"The big thing for me when we were shut down was that people couldn't go to work or school. The country can't live that way — but you can't send people back to work in a world that's not safe," Curran said last October in an interview for the Houston Innovators Podcast. "How do you create a safer environment? That's the thing that really got me going in the beginning in the summer. We looked at filters."

Listen to Professor Curran on the Houston Innovators Podcast:

Curran, who says he's learned more about air filters than he ever cared to, realized that even the most expensive air filters can only protect from 10 to 25 percent of viruses. And most buildings' HVAC systems would have to be replaced completely to allow for these pricier, more protective filters. But Curran Biotech's Capture Coating can be used on existing filters and HVAC systems.

Air filters coated with Curran Biotech's sealant were then tested at the New York Family Court Building, by DCAS-Energy Management Division, and now, ahead of the fall semester, UH is implementing the innovation in all buildings that have less than MERV-13 rated filters.

Curran Biotech's sealant can be used on existing air filters and HVAC systems. Photo via UH.edu

University of Houston professor and entrepreneur, Seamus Curran, has pivoted amid the pandemic to use his nanotechnology expertise to help reduce the spread of COVID-19. Photo courtesy of Integricote

Houston scientist taps nanotech in masks and air filters to use to prevent COVID-19 spread

HOUSTON INNOVATORS PODCAST EPISODE 52

For over a decade, Seamus Curran, a physics professor at the University of Houston, has worked on his nanotechnology coating substance. He first thought the innovation could be used on fabrics and textile coating, but he realized, once getting acquainted with the industry, he realized there wasn't an interest for a hydrophobic coating that could be used to prevent the spread of germs — at least, not yet.

"Like anything small startup company, one of the things you have to learn is you have to pivot — or you will die," says Curran, who had created his company Integricote (neé C-Voltaics) to take his innovation to market.

So pivot is what he did. Integricote now markets toward coating and sealing materials within the construction industry — wood, concrete, etc. — to protect from water damage and rotting. As Curran shares on this week's episode of the Houston Innovators Podcast, business was growing steadily. That is until COVID-19 hit.

His construction coating business slowed, much like the rest of business across the country, and classes at UH switched to online. Curran used this newfound time at home to dig deeper into the details of the virus, when an idea hit him.

"I learned the virus traveled in a wet medium," Curran says, "(our coating) is hydrophobic, meaning we can stop it from penetrating any fabrics."

Curran worked to create hydrophobic facemasks using his sealant, and the technology was lauded and covered by various news organizations. He created a new company under Integricote, called Curran Biotech, and he started thinking of the next pandemic-proof innovation he could create using his sealant.

"The big thing for me when we were shut down was that people couldn't go to work or school. The country can't live that way — but you can't send people back to work in a world that's not safe," Curran says. "How do you create a safer environment? That's the thing that really got me going in the beginning in the summer. We looked at filters."

Curran, learning more about air filters than he ever cared to, realized that even the most expensive air filters can only protect from 10 to 25 percent of viruses. And most buildings' HVAC systems would have to be replaced completely to allow for these pricier, more protective filters.

"So, you'd have to replace your equipment and your filter prices go up — and you're still not blocking the virus," Curran says.

Curran Biotech's solution is a spray coating that can be used on air filters to make them more protected from COVID-19 spread.

Curran shared more about his nanotechnology innovation — as well as his excitement for being named one of MassChallenge Texas's finalist within the 2020 Houston cohort — in the episode of the podcast. You can listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


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Houston digital health platform Koda lands strategic investment

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Houston-based advance care planning platform Koda Health has added another investor to the lineup.

The company secured a strategic investment for an undisclosed amount from UPMC Enterprises, the commercialization arm of the University of Pittsburgh Medical Center. The funding is part of Koda's oversubscribed series A funding round that closed in October, according to a release.

"UPMC Enterprises’ investment is a meaningful signal, not just to Koda, but to the broader market," Dr. Desh Mohan, chief medical officer and co-founder of Koda Health, said in the news release. "It validates that health systems are ready to invest in infrastructure that makes advance care planning work the way it should: proactively, at scale, and with the human support that these conversations require. Having UPMC Enterprises as a strategic investor puts us in a unique position to prove what's possible."

Koda has raised $14 million to date, according to a representative from the company. Its series A round was led by Evidenced, with participation from Mudita Venture Partners, Techstars and the Texas Medical Center last year. At the time, the company said the funding would allow it to scale operations and expand engineering, clinical strategy and customer success. The company described the round as a "pivotal moment," as it had secured investments from influential leaders in the healthcare and venture capital space.

Koda Health, which was born out of the TMC's Biodesign Fellowship in 2020, saw major growth last year, as well, and now supports more than 1 million patients nationwide through partnerships with Cigna Healthcare, Privia Health, Guidehealth, Sentara, UPMC and Memorial Hermann Health System.

The company integrated its end-of-life care planning platform with Dallas-based Guidehealth in April 2025 and with Epic Systems in July 2025. It also won the 2025 Houston Innovation Award in the Health Tech Business category. Read more here.

New 'living pharmacy' biotech company launches out of Rice venture studio

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Rice University’s biotech venture studio RBL LLC has launched a new “living pharmacy” company, Duracyte, designed to make cancer treatment easier on patients.

Backed by an up to $45 million Advanced Research Projects Agency for Health (ARPA-H) award, Duracyte aims to commercialize implantable biohybrid pharmacy devices that are designed to produce therapeutic proteins inside the human body around the clock, replacing the need for regular injections and infusions for some cancer patients.

The company’s main platform is its Hybrid Advanced Molecular Manufacturing Regulator (HAMMR), a rechargeable, implantable device that can sense biological signals, monitor tumor environments and adjust therapeutic output in real time. HAMMR has wireless communication capabilities, which allow patients and clinicians to remotely monitor results through an app every five minutes and make changes to treatment plans without a hosptial visit. Additionally, the device can generate its own oxygen supply, which is key for the therapeutic cells’ survival.

“Biologic medicines such as monoclonal antibodies, cytokines and metabolic regulators already account for a significant share of modern therapeutics, but the way we deliver them today often requires frequent injections or infusions that can be demanding for patients and lead to inconsistent drug levels,” Daniel Anderson, MIT professor and co-founder of Duracyte, said in a news release. “Our vision is to enable a continuous, stable therapy by producing these medicines directly inside the body, which could improve treatment consistency, reduce side effects and ultimately transform how biologic therapies are delivered across many diseases.”

Duracyte’s first clinical trial is slated to begin by the end of 2026 and will focus on recurrent ovarian cancer. The Phase I study will build upon existing work on encapsulated cytokine pharmacy technology, and the company hopes that within a few years this treatment can reach clinical application.

The development of Duracyte is supported by ARPA-H's Targeted Hybrid Oncotherapeutic Regulation (THOR) project, which supports a multidisciplinary research consortium co-led by Omid Veiseh, a professor of bioengineering at Rice. The consortium also includes others at Rice, The University of Texas MD Anderson Cancer Center, Stanford University, Carnegie Mellon University, Northwestern University and the University of Houston, plus industry collaborators like Chicago-based CellTrans.

“What we are building is the culmination of years of progress in cell engineering, biomaterials and implantable device technology,” Veiseh added in the release. “By combining these advances with real-time sensing and adaptive drug delivery, we are working with the support of RBL to create a true ‘living pharmacy’ that can deliver continuous, precisely controlled biologic therapies and fundamentally change how these treatments reach patients.”

RBL launched in 2024 and is based out of Houston’s Texas Medical Center Helix Park. Duracyte is the third company launched by RBL, including Sentinel BioTherapeutics, a clinical-stage immunotherapy company developing localized cytokine therapies for solid tumors, and SteerBio, a regenerative medicine company targeting lymphedema.

“Duracyte exemplifies the kind of breakthrough that Houston’s ecosystem is built to produce,” Paul Wotton, managing partner of RBL LLC and co-founder of Duracyte, added in the release. “With world-class clinical infrastructure, exceptional engineering talent and initiatives like the Texas Biotech Task Force driving alignment across industry, investment and talent, this region is uniquely positioned to move the most ambitious ideas in medicine from concept to patient, faster than anywhere else.”