Houston clean tech startup pitch competition names winners at annual CERAWeek event

pitch perfect

Here's what student-founded startups are leaving CERAWeek with fresh funding. Photo courtesy of HETI

For the third year, the Greater Houston Partnership's Houston Energy Transition Institute hosted its startup pitch competition at CERAWeek by S&P Global. A dozen startups walked away with recognition — and three some with cash prizes.

HETI joined partners Rice Alliance for Technology and Entrepreneurship and TEX-E for the 2024 Energy Venture Day and Pitch Competition at CERAWeek on Wednesday, March 20. Forty-two companies, which have collectively raised over $265 million in investment funding already, pitched to judges. Nine startups won awards across three tracks.

TEX-E, a Texas nonprofit that supports student-founded upstarts, had five of its companies pitch and three winners walked away with monetary prizes. Teams that competed in the TEX-E Prize track, many of which come from Houston universities, include:

  • AirMax, University of Texas at Austin
  • BeadBlocker, University of Houston
  • Carvis Energy Solutions, Texas A&M University
  • Coflux Purification, Rice University
  • Solidec, Rice University

Solidec, which is working on a platform to produce chemicals from captured carbon, won first place and $25,000. The company also recently scored a $100,000 grant from Rice's One Small Step Grant program, as well as a voucher from the DOE. Coflux Purification, which has a technology that destroys PFAS in filtration, won second place and$15,000. The company also secured a One Small Step Grant to the tune of $80,000. AirMax, which focuses on optimizing sustainability for air conditioning equipment, won third place and $10,000.

Last year, Houston-based Helix Earth Technologies took home the top TEX-E price and $25,000 cash awards. The venture, founded by Rawand Rasheed and Brad Husick from Rice University, developed high-speed, high-efficiency filter systems derived from technology originating at NASA.

The rest of the companies that pitched competed for non-monetary awards. Here's what companies won:

  • Group A (CCUS, oilfield solutions, analytics and minerals):
    • First place: Ardent
    • Second place: Vaulted Deep
    • Third place: Mitico
  • Group B (batteries, renewables, water, and grid technology):
    • First place: SungreenH2
    • Second place: FeX Energy
    • Third place: Mercurius Biorefining
  • Group C (Mobility, Materials, and hydrogen solutions)
    • First place: Thiozen
    • Second place: Power2Hydrogen
    • Third place: Arolytics
HETI, Rice Alliance, and TEX-E celebrated the winners at a private reception on Wednesday evening.
The GHP and HETI announced that it has signed a memorandum of understanding with Argonne National Laboratory, a a federally-funded research and development facility in Illinois. Photo by Natalie Harms/InnovationMap

Houston organization announces major partnership with DOE lab to spur energy innovation commercialization

R&D teammate

A new partnership between the Greater Houston Partnership and Argonne National Laboratory has been established to spur development of commercial-scale energy transition solutions.

The GHP and the Houston Energy Transition Initiative, or HETI, announced that it has signed a memorandum of understanding with Argonne National Laboratory, a federally-funded research and development facility in Illinois. The lab is owned by the United States Department of Energy and run by UChicago Argonne LLC of the University of Chicago.

“The U.S. Department of Energy’s national laboratories have long been the backbone of research, development, and demonstration for the energy sector," Bobby Tudor, CEO of Artemis Energy Partners and Chair of HETI, says in a news release. "The Partnership and HETI, working with our industry members, business community and top research and academic institutions, in collaboration with Argonne, will work across our energy innovation ecosystem to drive this critical effort for our region.”

The partnership, announced at HETI House at CERAWeek by S&P Global, is intended to provide resources and collaboration opportunities between Houston's energy innovation ecosystem — from corporates to startups — to "accelerate the translation, evaluation and pre-commercialization of breakthrough carbon reduction technologies," per the news release.

“A decarbonization center of excellence in Houston is the missing link in the region’s coordinated approach to advancing critical energy transition technologies needed to mitigate the risks associated with climate change, while also promoting economic growth and job creation for the region,” Tudor continues.

Established in 1946, Argonne works with universities, industry, and other national laboratories on large, collaborative projects that are expected to make a big impact on the energy transition.

“Partnerships are essential to realizing net zero goals,” Argonne Director Paul Kearns adds. “We are pleased to extend DOE national laboratory expertise and work with HETI to focus the region’s considerable energy and industrial assets, infrastructure, and talent on broad commercial deployment of needed technologies.”

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This article originally ran on EnergyCapital.

The Rice Alliance for Technology and Entrepreneurship identified eight startups that are best suited for disrupting energy tech and innovation. Photo courtesy of Rice Alliance

Rice Alliance pitch event identifies 8 most-promising energy tech startups

ones to watch

In honor of CERAWeek, the Rice Alliance for Technology and Entrepreneurship hosted its annual Energy Venture Day.

After over 50 startup pitches and more than 300 meetings, venture investors identified eight startups that are the most-promising companies on a path to innovate and disrupt the energy ecosystem.

The 2023 Energy Venture Day's Most-Promising Startup winners were:

AeroShield Materials

Graphic via aeroshield.tech

Hyde Park, Massachusetts-based AeroShield Materials is creating thermally insulating transparent inserts. The inserts are only four millimeters of AeroShield's material and, when placed inside a double-pane window, provides 65 percent more energy efficiency.

Columbia Power Technologies (C-Power)

Image via cpower.co

C-Power, based in Charlottesville, Virgina, has a technology that harnesses the power of the ocean.

"C-Power delivers this renewable energy resource to the world, both through low-power solutions that bring energy and the cloud to the sea and large-scale solutions that help decarbonize terrestrial grids," the company's website reads.

EarthEn

Graphic via earthen.energy

Chandler, Arizona-based EarthEn is focused on long duration energy storage solutions that use CO2 in a closed loop to store 4 to 100 hours of energy at a low cost. The SaaS tools — with artificial intelligence and machine learning — optimize peak demand pricing and use predictive analysis to enable grid resiliency.

Group1

Photo via Twitter

Group 1, based in Austin, is focused on the commercialization of potassium-ion batteries. The core technology originates from the labs of University of Texas at Austin professor JB Goodenough, co-inventor of the lithium-ion battery.

Ionada Carbon Solutions

Photo via ionada.com

Houston-based Ionada, a member of Halliburton Labs, has created a technology that can remove up to 99 percent of the carbon dioxide emissions for the energy, marine, and e-fuels, according to the company.

"Our engineers have more than a century of combined expertise in reducing emissions for the power generation, chemical, road, rail, air and marine industries. We are here to help you find the best sustainable solution to reduce your emissions," reads the website.

H Quest Vanguard

Photo courtesy of Halliburton

Another Halliburton Labs member H Quest Vanguard, headquartered in Pittsburgh, has developed an electrically powered chemical conversion platform that leverages Microwave Plasma Pyrolysis to liberate zero-CO2 hydrogen from natural gas using only a quarter of energy required by electrolysis, while coproducing a high-value carbon or petrochemical coproduct.

Pressure Corp

Photo by Anton Petrus/Getty

Houston-based Pressure Corp is developing waste pressure power systems to help midstream gas companies solve how they reduce emissions by providing the technology, capital and expertise required to achieve their environmental, social and governance goals.

STARS Technology

Photo via starsh2.com

Based in Richland, Washington, STARS Technology Corp. is commercializing advanced micro-channel chemical process technology that originally was designed for NASA and the Department of Energy. The company's reactors and heat exchangers are compact, energy-efficient, and more.

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW, HETI House at CERAWeek, and taking the city on tour to spread awareness of the ecosystem. Photo via houston.org

Tapping into CERAWeek, SXSW to showcase and convene Houston tech

Houston innovators podcast episode 176

Every year, one of the biggest tech conferences in the world convenes right down the road from Houston in downtown Austin. That's a huge opportunity for the Greater Houston Partnership to showcase and congregate Housto's tech innovators.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership, shares on the Houston Innovators Podcast how the GHP has made an effort to increase Houston's presence at SXSW over the past few years. This year, the third year for Houston House, the GHP and the Houston Energy Transition Initiative are convening over 20 Houston innovators for two days of programming.

"We want to further the development of our ecosystem," Davenport says on the podcast. "Houston is so uniquely place for this — we have such well-developed industry sectors and a customer base. ... All entrepreneurs want to showcase their products and talk about what their doing. We'll have people there to answer questions and, most importantly, invite them to Houston."

Currently, the GHP is also hosting its second year of involvement at CERAWeek with its HETI team. HETI House, which is open at CERAWeek showcases unique energy transition technology originating in Houston. Returning this year is HETI's startup pitch competition on March 8 from 10 am to 3 pm.

SXSW and CERAWeek are just two examples of the GHP's mission of putting Houston tech on display. Davenport shares how every year, the GHP's team embarks on a handful of domestic and international mission trips to bring Houston to other major cities — as well as bring back ideas from other ecosystems.

"We go to these conferences to provide a glimpse into what we're doing and have an opportunity to connect, but we also take that message around the globe," Davenport says. "We believe we have a great story. We believe Texas has a great backdrop, and we put all this together and take it on the road."

She shares more about these trips and on what people can expect from Houston House at SXSW on the podcast. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


Are you interested in finding the best Houston tech and innovation conversations at CERAWeek this year? Look no further than this guide. Photo by Natalie Harms/InnovationMap

7+ can't-miss innovation events at CERAWeek featuring Houston speakers

where to be

If you're headed out to CERAWeek by S&P Global next week in downtown Houston, you'll want to make the most of it. Scout out Houston tech innovators at this annual energy-focused conference with this list of must-attend panels, presentations, and networking opportunities.

CERAWeek, taking place in the George R. Brown Convention Center and the Hilton Americas Hotel, is focused is on the entire energy industry, and has several themes this year — including shifting geopolitics, supply chain and infrastructure constraints, tech and innovation, future of work, and more.

Most of the innovation-themed events are organized under the Agora track. While CERAWeek is a global affair, you're sure to spot Houston-based executives, companies, and startups. Here are all the events you can't miss if learning more about Houston energy innovation is your goal.

Monday: Scaling Startups: New and efficient financial models

New startups in the energy ecosystem are providing solutions to the grand climate and climate sustainability challenges. But exciting startups need to move beyond the drawing board to eventual commercial success through necessary funding. What financial models are most successful in bringing these startups to scale?

The panel is from 12:30 to 1:10 pm on Monday, March 6. More info.

Tuesday: Chevron | Global Innovation Hubs: Where to grow your startup

The world needs a robust energy innovation ecosystem to realize decarbonization commitments. Learn about how the ecosystem’s parts are interdependent and must work together for the system to thrive and for the world to advance an energy system that’s affordable, reliable and ever cleaner.

The talk is from 2 to 2:30 pm on Tuesday, March 7. More info.

Tuesday: Gulf Coast Hydrogen Hub

With an existing ecosystem of infrastructure, producers, and consumers, the Gulf Coast has ambitions to become a global hydrogen hub. What technologies will be used? How will companies trade low-carbon hydrogen across their shared infrastructure? Join this panel to discuss how the “Energy Capital of the World” plans to lead the low carbon future.

The panel is from 5:30 to 6 pm on Tuesday, March 7. More info.

Wednesday: The Role of Private Capital in Funding the Energy Transition

While public market funds run by institutional investors have been shifting allocations toward cleantech companies, they are often hamstrung by a limited universe of pure-play cleantech equities and index-tracking methodologies that limit their ability to take longer-duration bets. The real action for energy transition investors to date has been in private equity, where funds can take duration risk and have overcome liquidity limitations by successfully raising historically large funds. The pace of private equity dealmaking, which slowed in early 2022, has accelerated sharply again for cleantech since the passage of the Inflation Reduction Act in the United States. How much of the pent-up private equity capital remains to be run through, and how will the even larger universe of public market investors gain access to these growing markets?

The event is from 7:15 to 8:20 am on Wednesday, March 8. More info.

Wednesday: Adaptation and Climate Resilience

We are witnessing a global rise in extreme weather events such as flooding, drought and heat waves. Climate change is having a variety of effects in different regions. Growing attention and investment is being directed to adaptation. What are different countries and regions doing to adapt to climate change? How will technology, policy and smart design combine to make the world more climate resilient?

The event is from 10 to 10:30 am on Wednesday, March 8. More info.

Wednesday: HETI Energy Ventures Pitch Competition

Over 15 startups and entrepreneurs will present to an audience of 1000+ investors, accelerators, and innovators for a chance to win one of many awards sponsored by Houston's energy transition community.

The event is from 10 am to 3 pm on Wednesday, March 8. More info.

Wednesday: Cities Leading the Energy Transition - World Energy Cities Partnership Mayors

Cities are at the forefront for tackling the climate and energy challenges impacting us all. Hear from the cities of Houston, Esbjerg, Perth and Calgary as they describe their visions toward a more sustainable energy plan for their communities.

The panel is from 12:30 to 1:10 pm on Wednesday, March 8. More info.

Thursday: Energy Transition Hubs: How cities are leading the charge

Increasingly, governments are transforming their communities by accelerating energy transition policies and infrastructure. Listen to how these cities are creating the blueprints for a more sustainable habitat for their citizens.

The panel is from 8:30 to 9:10 am on Thursday, March 9. More info.

BONUS: Network at these company houses

CERAWeek's Agora Partner houses exist showcase what companies are most excited about. Find your way to these three houses in between sessions to learn more about each business's tech and innovation.

  • Chevron: Back in its largest space yet, the Chevron house will highlight Chevron Technology Ventures portfolio companies, Chevron New Energies partnerships and tech experts, along with VR experiences and tech exhibits.
  • Oxy: Oxy, an international energy company based in Houston, is featuring its application of new tech, including Direct Air Capture with geologic sequestration and other CO2 utilization technologies.
  • ExxonMobil: ExxonMobil, which recently relocated its HQ to Houston, is talking about a lower-emission energy future — something that requires multiple solutions that can be implemented at scale to address some of the highest-emitting sectors of the economy.

Here's your one-stop shop for innovation events in Houston for March. Photo via Getty Images

10 can't-miss Houston business and innovation events for March

where to be

It's time to look at what's on the agenda for Houston innovators for the month of March — a busy one, from the end of Tech Rodeo and the start of CERAWeek, plus many more things to add to your calendars.

Note: This post might be updated to add more events.


March 2 — CodeLaunch Houston

Improving is hosting CodeLaunch Houston — a high energy startup pitch competition — which will round out Houston Tech Rodeo, which is taking place from Monday, February 17, through Thursday, March 2. Check out the finalists here.

The event is Thursday, March 2, from 6 to 9 pm, at 713 Music Hall. Click here to register.

March 4 — Softeq Chili Showdown

Softeq is hosting its chili cookoff event and official after-party of Houston Tech Rodeo. The event will include the broader Houston community, drive awareness of startup development resources available to the community, demonstrate new technology, feature local culture, and promote local startup job creation, all while benefiting Lemonade Day, a fun, experiential program that teaches youth how to start, own and operate their very own business.

The event is Saturday, March 4, from 10 am to 2 pm, at Truck Yard Houston. Click here to register.

March 6 — Energy Workforce of the Future Summit

At this year's summit, Ally Energy will unveil the Energy Workforce Outlook study on workforce transition and hear from leaders, policymakers, startup CEOs, investors, and innovators about how to take all energy forward.

The event is Monday, March 6, from 8 am to 2 pm, at The Petroleum Club of Houston. Click here to register.

March 6 — Transition on Tap at Greentown Labs

Transition On Tap is Greentown Labs' monthly networking event devoted to fostering conversations and connections among the climate and energy transition ecosystem in Houston and beyond. Entrepreneurs, investors, students, and friends of climatetech are invited to attend, meet colleagues, discuss solutions, and engage with our growing community.

The event is Monday, March 6, at 5 pm, at Greentown Houston. Click here to register.

March 6-10 — CERAWeek by S&P Global

CERAWeek by S&P Global returns to downtown Houston. The annual conference brings energy leaders from around the world to discuss the industry's trends and future. The Agora track focuses on the future of energy, which includes clean energy and innovation.

The conference is Monday, March 6, to Friday, March 10, at The George R. Brown Convention Center. Click here to register.

March 7 — Energy Tech Venture Day

The Rice Alliance Energy Venture Day is a fast-paced event connecting nearly 40 energy ventures with venture capitalists, corporate innovation groups, industry leaders, academics and service provider. Ventures will give 3-minute pitches with a networking reception so you can meet the energy ventures and learn more about their technologies.

The event is Tuesday, March 7, from 3 to 6:30 pm, at Rice University. Click here to register.

March 8 — Navigating Careers: Insights & Inspiration from Women Who Have Done It All

In today’s career landscape for C-level leaders, directors, university innovators, entrepreneurs, and founders, what does success look like? How do women navigate barriers, turn challenges into opportunities, and tackle whatever comes their way with poise and confidence? Join us at the Ion for a panel featuring high-profile women thought leaders, entrepreneurs, and influencers--all on top of their field and all with incredible journeys and stories. These women will share their wisdom and wit in authentic ways. A not-to-miss panel, followed by breakout room discussions with each panelist!

The event is Wednesday, March 8, from 8:30 to 11 am, at the Ion. Click here to register.

March 8 — International Women’s Day Luncheon

This luncheon aims to celebrate womanhood while acknowledging and getting inspired for the challenge of promoting progress.

The event is Wednesday, March 8, from 11 am to 2 pm, at Sesh Coworking. Click here to register.

March 9 — Dream Big Ventures Investor Studio Series: Energizing Latino/a Investors

Join the Ion for a fireside chat with Dream Big Ventures Founder & CEO Staci LaToison, and Angeles Investors CEO & Board President David Olivencia, to discuss trends in venture capital and angel investing, and how they are helping increase access to capital for underrepresented founders.

The event is Thursday, March 9, from 5 to 7 pm, at the Ion. Click here to register.

March 10 — TMC Innovation: Federal Health Innovation Day

TMCi is hosting a Federal Health Innovation Day with participation from various federal government agencies focused on health care and innovation. There will be opportunity for face time with the representatives and food will be provided.

The event is Friday, March 10, from 8 am to 2 pm, at TMC Innovation. Click here to register.

March 10-19 — SXSW (in Austin)

Houston founders, investors, and other tech community members will make their way to Austin for SXSW, an interactive festival that is again bringing startup pitches, thought leadership, and more. The Greater Houston Partnership's Houston House returns on March 13 at the Fairmont Hotel, and will be open to badge holders.

The conference is Friday, March 10, to Sunday, March 19, in Downtown Austin. Click here to register.

March 27-28 — Mission Innovate: Reimagining Space Technology to Solve Today’s Challenges

Innovators from around the greater Houston area will convene for a two-day event to innovate, disrupt, and create commercial space companies. Entrepreneurs will work with licensable intellectual property from NASA’s IP portfolio to solve some of the largest problems facing the industry. Experienced and first-time founders will form teams, ideate, and pitch their ideas to renown technology entrepreneurs, including members of the innovation teams at NASA! As part of the event, teams will be taught critical startup methodologies, advised by experienced business leaders, and network with an entire community that dreams of shaping the commercial space industry.

The event is Monday, March 27, to Tuesday, March 28, at The Cannon West Houston. Click here to register.

March 29 — The Cannon Fish Creek Grand Opening Party

Celebrate the opening of The Cannon Fish Creek, which is located in Montgomery, Texas, within the Woodforest community.

The event is Wednesday, March 29, from 4 to 6 pm, at The Cannon Fish Creek. Click here to register.

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3 things Houston companies need to freshen up when it comes to their HR practices

guest column

Just as we typically look to freshen up our homes this time of year, the same needs to be done for employee handbooks. Employee handbooks streamline HR operations, mitigate risks and set expectations to protect a business from negative workplace behavior by outlining employee policies and procedures.

There are three topics in particular that business owners should refresh and/or make sure they include in their HR policies and employee handbook: in-office attendance, social media and artificial intelligence (AI).

In-office attendance

When taking a closer look at hybrid workplace policies, the in-office attendance policies should align with your organizational goals. Whether you decide to implement hybrid work permanently or eventually return to being in the office completely, the return-to-office (RTO) policies should reflect those goals.

Clear expectations are especially important when defining office attendance rules. When attendance policies are set, employees respond best when they are fair, accessible and easily understood. Detailed policies outlining the nuances and consequences can help reduce noncompliance while supporting accountability.

Policies need consistent enforcement for them to be effective. Hybrid policies set prior to or during the pandemic may now be loosely enforced. The policies may state for employees to be in the office three days a week, but there may be no accountability for not meeting the mandate. Not enforcing attendance policies can give the impression that it is okay to violate other policies, too. Reviewing your policies allows you to course correct and write a policy reflecting your corporate culture and goals. You’ll then be able to reintroduce the attendance policy and enforce it across the board as intended.

Social media

You are hard pressed to find an employee without a social media account, whether it is TikTok or LinkedIn. If your business does not have a social media policy with guidelines surrounding employees’ online behaviors, now is the time to put one in place. If you do have a policy, social media changes quickly enough to warrant an annual review.

Social media policies should set boundaries between personal and professional use of social media. Employee activity on social media outside of work can influence business, as employees are often seen as reflecting the company. It is also important to note that social media policies should be based on input from senior management, HR, legal and IT, not just marketing.

The social media policy should delineate between an employee’s personal and professional use, establish a code of conduct and outline its use as part of crisis communications. Social media can just as easily elevate your brand, and you can potentially ask employees to share positive work experiences online.

Cybersecurity should also be addressed in social media policies. As it has become more common for hackers to infiltrate personal emails and social media accounts, policies can prohibit employees from storing company documents in their personal social media and email accounts for security purposes.

Artificial Intelligence (AI)

AI seems to be changing the way we do business daily. However, the policies surrounding company use of AI are lacking at many organizations. Research from McKinsey states only one in five employers have established policies governing their employees use of AI.

AI technology has already streamlined many business practices, but it can also present major risks. Inaccuracy can threaten your business if employees use generative AI for assistance in completing writing tasks, for instance, and the system may not generate accurate or original information.

As we learn the evolving and complex nuances of AI, creating a policy needs careful attention. You may consider developing an AI team to write a comprehensive, well-researched AI policy tailored to your organization. This working group should gather insights from leaders within the organization, including frontline managers, to fully understand how employees use, or might use, AI. This team should be charged with considering the ethical aspects of AI’s use and ensuring the policy aligns with company values.

One of the most critical elements of the policy is an accountability process or system. The policy should clearly outline any corrective action or disciplinary steps associated with using AI in a manner that harms the business and/or its clients. Just as important, the policy should outline how to use and how to avoid misusing AI. Since AI continues to evolve month to month, this is a policy that will require more attention and revisioning throughout the year.

Keeping a critical eye on HR policies is an important part of business success. Setting aside time to review, update and even create new policies now – before being faced with an issue – can potentially mitigate costly challenges down the road.

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Karen Leal is performance specialist with Houston-based Insperity, a provider of human resources offering a suite of scalable HR solutions available in the marketplace.

Texas again improves on annual ranking of most innovative states

making progress

It's another year of slow but steady progress for the Lone Star State on an annual report on the top states for innovation.

Texas ranked No. 14 with a score of 48.43 points on personal finance site WalletHub's Most and Least Innovative States in 2024 ranking. Last year, Texas ranked No. 15. The state has steadily inched up the list — Texas was No.16 on the list in 2022 and No. 17 in 2021.

According to the report, Texas had the following ranking across the following categories:

  • No. 19 – Share of STEM Professionals
  • No. 16 – Projected STEM-Job Demand by 2030
  • No. 25 – Eighth-Grade Math & Science Performance
  • No. 19 – Share of Science & Engineering Graduates Aged 25+
  • No. 13 – Share of Technology Companies
  • No. 31 – R&D Spending per Capita
  • No. 15 – Venture-Capital Funding per Capita
Source: WalletHub

The report analyzed the 50 states and the District of Columbia and how each performed across 25 key metrics and across two key dimensions, “Human Capital” and “Innovation Environment," per the report. The data was pulled from the U.S. Census Bureau, Bureau of Labor Statistics, National Science Foundation, National Center for Education Statistics, United States Patent and Trademark Office, and other records.

“The most innovative states are especially attractive to people who have majored in science, technology, engineering and math, or STEM, as they offer abundant career opportunities and investment dollars, both for jobs at existing companies and for startups," says Cassandra Happe, a WalletHub analyst in the report. "These states also instill young students with the skills they need to succeed in the current workforce, skills which are useful whether or not they pursue a STEM career.”

The report's top 10 included:

  1. District of Columbia with a score of 71.65
  2. Massachusetts with a score of 69.93
  3. Washington with a score of 66.36
  4. California with a score of 65.63
  5. Colorado with a score of 63.93
  6. Maryland with a score of 62.41
  7. Virginia with a score of 59.86
  8. Delaware with a score of 54.58
  9. Utah with a score of 53.66
  10. New Jersey with a score of 53.2

Houston research team invents cost-saving innovation for automated drug dosing

groundbreaking tech

A team of Rice University researchers has built a technology that uses a $20 blood-glucose sensor to potentially automate dosing of practically any drug.

In a paper recently published in Nature, researchers in Caroline Ajo-Franklin’s lab shared that they were able to modify the inexpensive piece of equipment to detect afimoxifene, an estrogen inhibitor that is naturally produced by a patient’s body after taking the chemotherapy drug tamoxifen.

“The dream is to have technology similar to what’s available today for monitoring and treating variations in blood glucose, and have that be true for basically any drug,” said Ajo-Franklin, a bioscientist, cancer researcher and director of the Rice Synthetic Biology Institute in a press release from Rice University. “Millions of people use blood-glucose monitors every day. If we can use that same basic technology to monitor other drugs and biomarkers, we could move away from the one-size-fits-all dosing regimes that we’re stuck with today.”

The lead author of the study was postdoctoral research associate Rong Cai. She and the team tested more than 400 modified versions of the electron-releasing proteins (what creates the current that glucose monitors detect) until they found a version that reacted with afimoxifene. Essentially, they built an afimoxifene sensor that could reliably detect the presence of the drug.

According to Ajo-Franklin, her team is currently at work testing ways to identify drugs other than afimoxifene.

In a press release, Cai said, “The glucometer is the part that’s so well-developed. While our target is different, it’s just a matter of engineering and changing the protein on the inside. On the outside, everything will still be the same. You can still do the test with a strip or on your arm.”

Better still, she went on to say that because the signal is electrical, it can be sent to a phone or computer to be read and stored.

“That’s the part, that marriage between electricity and biology, that is very attractive,” Cai said.

Rice University synthetic biologists (from right to left) Caroline Ajo-Franklin, Chiagoziem Ngwadom and Rong Cai worked with Rice engineer Rafael Verduzco (left) to create and demonstrate a method of universalizing blood-glucose detection technology as a way of rapidly and inexpensively creating sensors that can monitor the dosing of chemotherapies and other drugs in real time. Photo by Jeff Fitlow/Rice University

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