Rice University spinout lands $500K NSF grant to boost chip sustainability

cooler computing

HEXAspec, founded by Tianshu Zhai and Chen-Yang Lin, has been awarded an NSF Partnership for Innovation grant. Photo courtesy of Rice

HEXAspec, a spinout from Rice University's Liu Idea Lab for Innovation and Entrepreneurship, was recently awarded a $500,000 National Science Foundation Partnership for Innovation grant.

The team says it will use the funding to continue enhancing semiconductor chips’ thermal conductivity to boost computing power. According to a release from Rice, HEXAspec has developed breakthrough inorganic fillers that allow graphic processing units (GPUs) to use less water and electricity and generate less heat.

The technology has major implications for the future of computing with AI sustainably.

“With the huge scale of investment in new computing infrastructure, the problem of managing the heat produced by these GPUs and semiconductors has grown exponentially. We’re excited to use this award to further our material to meet the needs of existing and emerging industry partners and unlock a new era of computing,” HEXAspec co-founder Tianshu Zhai said in the release.

HEXAspec was founded by Zhai and Chen-Yang Lin, who both participated in the Rice Innovation Fellows program. A third co-founder, Jing Zhang, also worked as a postdoctoral researcher and a research scientist at Rice, according to HEXAspec's website.

The HEXASpec team won the Liu Idea Lab for Innovation and Entrepreneurship's H. Albert Napier Rice Launch Challenge in 2024. More recently, it also won this year's Energy Venture Day and Pitch Competition during CERAWeek in the TEX-E student track, taking home $25,000.

"The grant from the NSF is a game-changer, accelerating the path to market for this transformative technology," Kyle Judah, executive director of Lilie, added in the release.

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Don't miss these March events — from CERAWeek to the Ion's Mardi Gras block party. Image via houston.org

10 can't-miss Houston business and innovation events for March

where to be

Editor's note: March is here, and that means the return of some of Houston’s signature innovation events, as well as insightful talks and a Mardi Gras block party. Here are the Houston business and innovation events you can't miss in March and how to register. Please note: this article might be updated to add more events.

March 5 – SheSpace Women’s Day Open House

Connect with like-minded women during a free day of coworking at SheSpace. And while you're there, take a break and enjoy a floral arranging class, complimentary breakfast, pop-up shops, happy hour and raffle prizes. Space is limited.

The event is Wednesday, March 5, from 9 a.m.–7 p.m. Click here to register.

March 5 — Science and the American Presidency

Hear from former presidential science advisors—Kelvin Droegemeier who served under President Trump, Neal Lane who served under President Clinton and Alondra Nelson who served under President Biden—as they discuss their experiences leading the White House Office of Science and Technology Policy and how science is used to address issues from climate change and public health to national security and economic competitiveness. An exhibit inside Baker Hall will complement the event. The Baker Institute Science and Technology Policy Program and Rice Innovation will host the talk.

This event is Wednesday, March 5, from 5:30–8 p.m. at James A. Baker Hall. Click here to register.

March 6 — Ion Block Party - Mardi Gras Edition 

Let the good times roll this week while networking with potential collaborators, mentors and investors at the Ion. Food and drink will be available while supplies last and the Ion will provide drink tickets for one free drink at Second Draught upon check-in.

This event is Thursday, March 6, from 4–7 p.m. at the Ion. Click here to register.

March 10-14 — CERAWeek 2025

The foremost annual gathering in the energy sector returns to Houston March 10-14, 2025. Themed "Moving Ahead: Energy strategies for a complex world," CERAWeek 2025 will focus on the challenges ahead for energy security, supply, and climate ambitions. More than 10,000 participants from over 2,050 companies across 80 countries will convene in Houston for this ambitious event. CERAWeek comprises three platforms: the Executive Conference, the Innovation Agora, and Partner Programs. We'll dive into comprehensive CERAWeek recommendations in future articles.

This event begins Monday, March 10. Click here to register.

March 11 — Energy Venture Day at the Ion

Preview pitches from 40-plus energy ventures competing at CERAWeek's Energy Venture Day and Pitch Competition, co-hosted by the Rice Alliance, Ion, HETI, and TEX-E. This free, fast-paced pitch event offers an alternative to the CERAWeek event, which requires an Agora pass.

This event is Tuesday, March 11, from 9 a.m.–2:30 p.m. Click here to register.

March 13 — Code4Y'allMeetup

Connect with fellow coders at Code4Y’all's meetup at the Ion. Andrew Baines, Founder of No Experience Jobs, will present "How I Built a Job Board to Help Entry-Level Tech Talent (And What I Learned)." Hear from Baines and learn lessons from job seekers.

This event is Thursday, March 13, from 6–7 p.m. Click here to register.

March 13-14 — Veterans Business Battle

Hear pitches from veterans and entrepreneurs as they compete for $5 million in investments at Rice Businesses' 11th annual Veterans Business Battle. This year, the two-day event will also feature a Small Business Expo which invites Houston-based, veteran-owned businesses to participate in education, networking, and the opportunity to showcase their business.

This event begins Thursday, March 13, at 11:30 a.m. at McNair Hall on Rice's campus. Click here to register.

March 17 — Women in Innovation 

Celebrate Women's History Month with an engaging panel discussion hosted by the University of Houston's Division of Energy and Innovation. UH's Tanu Chatterji, Stacey Gorniak and Chrysa Latrick will discuss the achievements of trailblazing women across various industries, as well as share challenges and experiences. Lunch will be provided.

This event is Monday, March 17, from noon–1 p.m. at UH's Faculty Cafe. Find more information here.

March 24-28 — H-Town Roundup 2025

Celebrate innovation, entrepreneurship and collaboration this month during Houston Exponential's H-Town Roundup. During the fifth-annual free event series, previously known as Houston Tech Rodeo, attendees can expect insightful talks, workshops and networking events at venues across the city like the Ion, Greentown Labs, University of Houston and more.

This event begins Monday, March 24. See the full schedule of events here.

​March 27 — NASA Tech Talks

Every fourth Thursday of the month, NASA experts, including longtime engineer Montgomery Goforth, present on technology development challenges NASA’s Johnson Space Center and the larger aerospace community are facing and how they can be leveraged by Houston’s innovation community. Stick around after for drinks and networking at Second Draught.

This event is Thursday, March 27, from 6-7 p.m. at the Ion. Register here.

Here's what student-founded startups are leaving CERAWeek with fresh funding. Photo courtesy of HETI

Houston clean tech startup pitch competition names winners at annual CERAWeek event

pitch perfect

For the third year, the Greater Houston Partnership's Houston Energy Transition Institute hosted its startup pitch competition at CERAWeek by S&P Global. A dozen startups walked away with recognition — and three some with cash prizes.

HETI joined partners Rice Alliance for Technology and Entrepreneurship and TEX-E for the 2024 Energy Venture Day and Pitch Competition at CERAWeek on Wednesday, March 20. Forty-two companies, which have collectively raised over $265 million in investment funding already, pitched to judges. Nine startups won awards across three tracks.

TEX-E, a Texas nonprofit that supports student-founded upstarts, had five of its companies pitch and three winners walked away with monetary prizes. Teams that competed in the TEX-E Prize track, many of which come from Houston universities, include:

  • AirMax, University of Texas at Austin
  • BeadBlocker, University of Houston
  • Carvis Energy Solutions, Texas A&M University
  • Coflux Purification, Rice University
  • Solidec, Rice University

Solidec, which is working on a platform to produce chemicals from captured carbon, won first place and $25,000. The company also recently scored a $100,000 grant from Rice's One Small Step Grant program, as well as a voucher from the DOE. Coflux Purification, which has a technology that destroys PFAS in filtration, won second place and$15,000. The company also secured a One Small Step Grant to the tune of $80,000. AirMax, which focuses on optimizing sustainability for air conditioning equipment, won third place and $10,000.

Last year, Houston-based Helix Earth Technologies took home the top TEX-E price and $25,000 cash awards. The venture, founded by Rawand Rasheed and Brad Husick from Rice University, developed high-speed, high-efficiency filter systems derived from technology originating at NASA.

The rest of the companies that pitched competed for non-monetary awards. Here's what companies won:

  • Group A (CCUS, oilfield solutions, analytics and minerals):
    • First place: Ardent
    • Second place: Vaulted Deep
    • Third place: Mitico
  • Group B (batteries, renewables, water, and grid technology):
    • First place: SungreenH2
    • Second place: FeX Energy
    • Third place: Mercurius Biorefining
  • Group C (Mobility, Materials, and hydrogen solutions)
    • First place: Thiozen
    • Second place: Power2Hydrogen
    • Third place: Arolytics
HETI, Rice Alliance, and TEX-E celebrated the winners at a private reception on Wednesday evening.
The GHP and HETI announced that it has signed a memorandum of understanding with Argonne National Laboratory, a a federally-funded research and development facility in Illinois. Photo by Natalie Harms/InnovationMap

Houston organization announces major partnership with DOE lab to spur energy innovation commercialization

R&D teammate

A new partnership between the Greater Houston Partnership and Argonne National Laboratory has been established to spur development of commercial-scale energy transition solutions.

The GHP and the Houston Energy Transition Initiative, or HETI, announced that it has signed a memorandum of understanding with Argonne National Laboratory, a federally-funded research and development facility in Illinois. The lab is owned by the United States Department of Energy and run by UChicago Argonne LLC of the University of Chicago.

“The U.S. Department of Energy’s national laboratories have long been the backbone of research, development, and demonstration for the energy sector," Bobby Tudor, CEO of Artemis Energy Partners and Chair of HETI, says in a news release. "The Partnership and HETI, working with our industry members, business community and top research and academic institutions, in collaboration with Argonne, will work across our energy innovation ecosystem to drive this critical effort for our region.”

The partnership, announced at HETI House at CERAWeek by S&P Global, is intended to provide resources and collaboration opportunities between Houston's energy innovation ecosystem — from corporates to startups — to "accelerate the translation, evaluation and pre-commercialization of breakthrough carbon reduction technologies," per the news release.

“A decarbonization center of excellence in Houston is the missing link in the region’s coordinated approach to advancing critical energy transition technologies needed to mitigate the risks associated with climate change, while also promoting economic growth and job creation for the region,” Tudor continues.

Established in 1946, Argonne works with universities, industry, and other national laboratories on large, collaborative projects that are expected to make a big impact on the energy transition.

“Partnerships are essential to realizing net zero goals,” Argonne Director Paul Kearns adds. “We are pleased to extend DOE national laboratory expertise and work with HETI to focus the region’s considerable energy and industrial assets, infrastructure, and talent on broad commercial deployment of needed technologies.”

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This article originally ran on EnergyCapital.

The Rice Alliance for Technology and Entrepreneurship identified eight startups that are best suited for disrupting energy tech and innovation. Photo courtesy of Rice Alliance

Rice Alliance pitch event identifies 8 most-promising energy tech startups

ones to watch

In honor of CERAWeek, the Rice Alliance for Technology and Entrepreneurship hosted its annual Energy Venture Day.

After over 50 startup pitches and more than 300 meetings, venture investors identified eight startups that are the most-promising companies on a path to innovate and disrupt the energy ecosystem.

The 2023 Energy Venture Day's Most-Promising Startup winners were:

AeroShield Materials

Graphic via aeroshield.tech

Hyde Park, Massachusetts-based AeroShield Materials is creating thermally insulating transparent inserts. The inserts are only four millimeters of AeroShield's material and, when placed inside a double-pane window, provides 65 percent more energy efficiency.

Columbia Power Technologies (C-Power)

Image via cpower.co

C-Power, based in Charlottesville, Virgina, has a technology that harnesses the power of the ocean.

"C-Power delivers this renewable energy resource to the world, both through low-power solutions that bring energy and the cloud to the sea and large-scale solutions that help decarbonize terrestrial grids," the company's website reads.

EarthEn

Graphic via earthen.energy

Chandler, Arizona-based EarthEn is focused on long duration energy storage solutions that use CO2 in a closed loop to store 4 to 100 hours of energy at a low cost. The SaaS tools — with artificial intelligence and machine learning — optimize peak demand pricing and use predictive analysis to enable grid resiliency.

Group1

Photo via Twitter

Group 1, based in Austin, is focused on the commercialization of potassium-ion batteries. The core technology originates from the labs of University of Texas at Austin professor JB Goodenough, co-inventor of the lithium-ion battery.

Ionada Carbon Solutions

Photo via ionada.com

Houston-based Ionada, a member of Halliburton Labs, has created a technology that can remove up to 99 percent of the carbon dioxide emissions for the energy, marine, and e-fuels, according to the company.

"Our engineers have more than a century of combined expertise in reducing emissions for the power generation, chemical, road, rail, air and marine industries. We are here to help you find the best sustainable solution to reduce your emissions," reads the website.

H Quest Vanguard

Photo courtesy of Halliburton

Another Halliburton Labs member H Quest Vanguard, headquartered in Pittsburgh, has developed an electrically powered chemical conversion platform that leverages Microwave Plasma Pyrolysis to liberate zero-CO2 hydrogen from natural gas using only a quarter of energy required by electrolysis, while coproducing a high-value carbon or petrochemical coproduct.

Pressure Corp

Photo by Anton Petrus/Getty

Houston-based Pressure Corp is developing waste pressure power systems to help midstream gas companies solve how they reduce emissions by providing the technology, capital and expertise required to achieve their environmental, social and governance goals.

STARS Technology

Photo via starsh2.com

Based in Richland, Washington, STARS Technology Corp. is commercializing advanced micro-channel chemical process technology that originally was designed for NASA and the Department of Energy. The company's reactors and heat exchangers are compact, energy-efficient, and more.

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW, HETI House at CERAWeek, and taking the city on tour to spread awareness of the ecosystem. Photo via houston.org

Tapping into CERAWeek, SXSW to showcase and convene Houston tech

Houston innovators podcast episode 176

Every year, one of the biggest tech conferences in the world convenes right down the road from Houston in downtown Austin. That's a huge opportunity for the Greater Houston Partnership to showcase and congregate Housto's tech innovators.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership, shares on the Houston Innovators Podcast how the GHP has made an effort to increase Houston's presence at SXSW over the past few years. This year, the third year for Houston House, the GHP and the Houston Energy Transition Initiative are convening over 20 Houston innovators for two days of programming.

"We want to further the development of our ecosystem," Davenport says on the podcast. "Houston is so uniquely place for this — we have such well-developed industry sectors and a customer base. ... All entrepreneurs want to showcase their products and talk about what their doing. We'll have people there to answer questions and, most importantly, invite them to Houston."

Currently, the GHP is also hosting its second year of involvement at CERAWeek with its HETI team. HETI House, which is open at CERAWeek showcases unique energy transition technology originating in Houston. Returning this year is HETI's startup pitch competition on March 8 from 10 am to 3 pm.

SXSW and CERAWeek are just two examples of the GHP's mission of putting Houston tech on display. Davenport shares how every year, the GHP's team embarks on a handful of domestic and international mission trips to bring Houston to other major cities — as well as bring back ideas from other ecosystems.

"We go to these conferences to provide a glimpse into what we're doing and have an opportunity to connect, but we also take that message around the globe," Davenport says. "We believe we have a great story. We believe Texas has a great backdrop, and we put all this together and take it on the road."

She shares more about these trips and on what people can expect from Houston House at SXSW on the podcast. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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