10+ can't-miss Houston business and innovation events for December

where to be

Here's your one-stop shop for innovation events in Houston this month. Photo via Getty Images

This month, Houstonians have yet another good batch of in-person and online innovation events, and you and your tech network need to know about them.

Here's a roundup of virtual events not to miss this month — like pitch nights, workshops, conventions, and more.

Note: This post might be updated to add more events.


December 1 — Fall 2021 D2K Showcase

The Rice D2K Lab is a hub for data science education. In the interactive D2K Showcase, you will explore D2K students' end-of-semester projects sponsored by D2K Affiliate members, researchers and community partners. Interact with student teams in the poster session and learn more about their projects. Vote on your favorite project and team as students compete for cash prizes.

The event is on Wednesday, December 1, at 5 pm. It's free and happening at Rice University (Duncan Hall - McMurtry Auditorium). Click here to register.

December 2 — TeeMates Launch Party

Join TeeMates for happy hour in town at The Cannon's new sportstech and media location. DJ, drinks, prizes, local businesses, and golf.

The event is on Thursday, December 2, at 4 pm. It's free and happening at The Cannon Sports + Media (5353 W Alabama St. Ste 450). Click here to register.

December 3 — Thought Leader Series: A Conversation with Houston's Medical Community

The Greater Houston Partnership invites you to the Thought Leader Series: A Conversation with Houston's Medical Community. This virtual event will feature a dynamic panel discussion with some of the region's top minds working to advance health care and medicine for the future. These leaders will discuss topics ranging from the region's health care system including funding, workforce, technology/innovation, equity and living in a post-pandemic world.

The event is on Friday, December 3, at noon. It's free and happening online. Click here to register.

December 5-9 — 23rd Annual World Petroleum Congress

Returning to the United States for the first time in over 30 years, the 23rd World Petroleum Congress will transform Houston into the epicenter of the global energy debate. Recognized as the energy capital of the world, the host city is home to 4,600 energy firms and a hub of technological innovation and entrepreneurship both within the energy sector and across aligned sectors. The Congress will gather together industry and government leaders from across the world to address all aspects of the industry from technological advances in upstream, midstream, and downstream operations to the role of natural gas and renewables, management of the industry and its social, economic, and environmental impact.

The event is from Sunday, December 5, through Thursday, December 9, at George R. Brown Convention center. Click here to register.

December 7 — Latest Trends & Opportunities in Sports Tech

Join DivInc on December 7th for an in depth discussion focused on trends, challenges and opportunities in this city and beyond at the intersection of sports and technology! The panel consists of subject matter experts from HTX Sports Tech, Intel, 2K, and The Cannon. We will also be sharing details and answering questions regarding upcoming Sports Tech accelerator.

The event is on Tuesday, December 7, at 4 pm. It's free and happening at The Ion (4201 Main St). Click here to register.

December 8 — Houston Veterans In Residence Showcase

Bunker Labs’ Veterans in Residence Showcase is a nationwide event spanning across twenty-two cities and 2 virtual cohorts, celebrating the almost two-hundred veteran and military spouse entrepreneurs launching their startups and businesses from our recent cohort. It gives you a chance to network with local participants. Become part of your local business community and learn how you can get involved by patronizing, investing in, or partnering up with veterans and military spouse entrepreneurs.

The event is on Wednesday, December 8, at 6 pm. It's free and happening at WeWork (The Jones Building - 708 Main St.) Click here to register.

December 8 — The Future of Energy Celebration

Join energy tech leaders right after World Petroleum Congress for drinks, live music and startups to celebrate the Future of Energy — powered by Halliburton Labs, Accenture, Greentown Labs and The Ion.

The event is on Wednesday, December 8, at 6 pm. It's free and happening at 8th Wonder Brewery (2022 Dallas St). Click here to register.

December 8 — HTXelerator's Pitch Event

The Pitch for the inaugural cohort is now upon us and you're invited to be a part of the celebration! Hear from the HTXelerator's nine finalists as they deliver a mock campaign speech for city council. Enjoy drinks and light bites in the courtyard of The Cannon Downtown as the judges crown first, second, and third place to close out the inaugural year.

The event is on Wednesday, December 8, at 7 pm. It's free and happening at The Cannon Tower @ Amegy on Main (1801 Main St). Click here to register.

December 10 — Feedback Friday: Strategy Planning for 2022

Join this session with Impact Hub Houston Board Member and startup advisor Brandy Guidry to receive feedback on your business goals for 2022.

The event is on Friday, December 10, at 1 pm. It's free and happening at The Cannon Tower @ Amegy on Main (1801 Main St). Click here to register.

December 14 — UpSkill Works Forum: New Mission, Transferable Talent: What Employers Need to Know About Hiring and Retaining Veterans

With more than 250,000 veterans in residence, Houston has the country's second highest veteran population. Veterans are a diverse, highly skilled talent population that can bring valuable experience to a workplace but can be difficult to effectively access and engage. Join the UpSkill Houston initiative, NextOp Veterans Executive Director Stephanie Drake, and area employers to learn how to attract, hire, support, and retain talented veterans in your workforce.

The event is on Tuesday, December 14, at noon. It's free and happening online. Click here to register.

December 14 — gBETA Houston Fall 2021 Cohort Pitch Night

Pitch Night is a celebration of all of the current gBETA cohorts. It's an exclusive reception during which participating companies have the opportunity to pitch to an audience of entrepreneurs, mentors, investors and community members. Join either in-person or virtually for one or more Pitch Night events.

The event is on Tuesday, December 14, at 5:30 pm. It's free and happening online and at Cannon West Houston (1334 Brittmoore Rd #1327). Click here to register.

Small businesses and startups are likely to hurt — and hurt bad — from COVID-19's affect on the economy. Here are some resources to get support. Photo by Hero Images

Here's a list of resources for Houston startups and small businesses during COVID-19 shutdown

here to help

It's a trying time for the world, and Houston small businesses and startups have been put in a difficult spot. From having to work remotely or being forced to close or scale back operations due to mandates from the government, entrepreneurs are having to figure out their new normals.

However, organizations have leapt at the chance to help their fellow Houstonians, and a number of resources have appeared to provide aid to startups, from advice and resources to grants.

Editor's note: This article originally ran March 25, 2020, but has been updated and republished with more resources.

The Cannon's CERT Program

The Cannon released information about their Cannon Emergency Response Team Program, and Houston startups can apply online. The multi-week program is intended to provide aid and support for startups and small businesses experiencing a crisis caused by external forces — namely COVID-19 and its repercussions, but also natural disasters, market disruption, legislative actions, civil unrest, fraud, or theft.

Click here to apply and learn more.

The Ion's resource center

The Ion has also rounded up resources for its members and the greater Houston innovation ecosystem. It's available online, and has everything from links to national and local resources and financial assistance information to virtual events.

"While we all try and adjust to this new way of life, The Ion will continue to be a resource to our entrepreneurial community the best way we know how, by connecting our community and providing you with opportunities that you need to be resilient during these unstable times. ... We hope this page serves you well and we promise to keep you all up to date on everything innovation taking place in our community," writes Gaby Rowe, executive director of The Ion.

Rowe has also started a video series of interviews with Houston startups — the videos are also available on the webpage.

Click here to access the resource center.

Houston Exponential's virtual event calendar

Houston Exponential worked quickly to turn their online calendar featuring events across the innovation ecosystem in Houston to helpful virtual events. Anyone can submit an event for consideration.

Click here to find the calendar.

To find InnovationMap's curated list of events for April, click here.

The GHP's Greater Houston Business Recovery Center

The Greater Houston Partnership has released a one-stop shop for business help for companies large and small. The amalgamation combines several national and local options, including relevant information about the Coronavirus Aid, Relief, and Economic Security (CARES) Act.

"We know many Houston companies are hurting and do not have the resources to sustain themselves for weeks without help," said Bob Harvey, president and CEO of the Partnership. "The funds provided through the CARES Act are essential to ensure Houston businesses can meet payroll and cover other expenses during this difficult time. "

Click here to visit the Greater Houston Business Recovery Center page.

Fat Finger's procedure app

In an effort to help businesses organize their response, Houston-based tech company Fat Finger has released a procedure app that is available for free. It offers employee agreements, important protocol checklists, and more.

"Our intention is to help teams of all types operate as safe and effective as possible to overcome what we are all going through," writes James McDonough, founder and CEO of the company.

Click here to learn more about the app here.

Houston PR firm to offer free services

Houston-based Paige PR is offering up $5,000 worth of its services to help out a company affected by COVID-19., which includes media relations, influencer relations, media training, employee communication, content development, social media management, corporate event planning, campaign measurement, brand management, community engagement and crisis communication, according to a news release.

"Paige PR's mission is to empower and help businesses tell their unique stories and amplify their messages," says Paige Donnell, Paige PR's founder and CEO, in the release. "Our team wanted to give back and honor a company making a positive difference, despite these uncertain times. Now is not the time to halt your company's marketing and communication efforts. However, we understand that this may be the only option for some businesses. We're in this together, and all of us at Paige PR look forward to offering our services free of charge to one deserving company."

Click here to learn more and enter your company.

Gener8tor's free 1-week response program

Just like most accelerator programs, cohort schedules and plans have been affected by COVID-19, but one new-to-Houston program is making some lemonade out of the lemons they were served. Gener8tor, along with the Downtown Redevelopment Authority, announced a partnership for one week of virtual programming for small businesses affected by the COVID-19 outbreak. It's free and an extension of the gBETA program, which launched in Houston in January.

Interested entrepreneurs must apply to be enrolled by Friday, May 27. The week of virtual assistence begins March 30 and goes until April 3. Participants will have access to virtual office hours with experts.

"We have seen firsthand the impact that entrepreneurs have on a community and we hope to call on our network of mentors, investors, and partners to support these new Emergency Response Programs," says Joe Kirgues, Co-Founder of gener8tor, in a news release.

Click here to learn more and sign up.

Hello Alice's business center

Houston-based Hello Alice is a great digital resource for startups locally and beyond. The organization recently announced its grant program that will focus on funding minority-founded startups and quickly snapped into action to create a COVID-19 Business Center free for entrepreneurs to use.

Alice is offering emergency grants to businesses affected by COVID-19 and has also gathered other resources like mental health information, tips for running a remote workforce, and more.

Click here to access the business center.

The Small Business Administration's webinars and disaster loans

Startups, nonprofits, and small businesses can apply for an Economic Injury Disaster Loans for up to $2 million. For small businesses, the interest rate is 3.75 percent, and for nonprofits, the interest rate is 2.75 percent. The SBA's Houston chapter is available for help as well.

Click here to learn more about the EIDLs.

Impact Hub Houston's comprehensive list

If this list here isn't exhaustive enough, Impact Hub Houston has gone the extra mile on their blog, creating a comprehensive and updated list of resources for small businesses and startups, as well as for people in general. There is everything from information on small business financial help and online education to tips for parents and health-related resources.

Click here to access the guide.

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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