Houston startup founder is reinventing medical devices by thinking outside the pillbox

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Regina Vatterott is thinking outside the traditional pillbox. Courtesy of Regina Vatterott

One day in college on her way to lunch with some friends, Regina Vatterott fainted on the sidewalk. It wasn't anything serious, but she had a few vitamin deficiencies and hadn't eaten in a while. After that, she started taking her daily supplements more seriously.

She tried using the traditional pillbox, but it would take her forever to organize. And she hated how her friends would call it, in a loving, playful way, her "old people pillbox."

She joined forces with a few like-minded individuals at her school to create a health and wellness accessory, rather than a medical device. They bought craft supplies and hand-glued LED lights to the first prototype of what would become EllieGrid, a smart pillbox that syncs with an app on your phone so that you can easily program your medicinal schedule and receive alerts of when to take what.


EllieGrid is a smart pillbox that syncs with your phone.Courtesy of Regina Vatterott

Vatterott, who was interning at a company that did social media marketing for independent pharmacies nationwide, saw an underserved market of adults who have a need for a product like this. EllieGrid targets the Baby Boomer age and younger, usually between ages 35 and 55.

Now, EllieGrid is growing from its initial presale phase to setting a system in place where Houstonians can find EllieGrid in stores or online.

InnovationMap: You and your team were only college students when you started. How did you get funding?

Regina Vatterott: We started pitching business plan competitions all over the country — even as far as Barcelona. We raised money — and some of it wasn't even money, but resources, like access to 3D printers or free office space. It was an amazing tool for us, and it helped validate us and helped us perfect our business plan. We ended up raising like $200,000 just in business plan competitions.

After that, we knew we had to prove it in market. Last year, we ran a crowdfunding campaign on IndieGoGo. Our goal was to raise $40,000, and we raised around $167,000. In January of this year, we shipped all the products that were preordered on IndieGoGo to 37 different countries.

IM: What's been the biggest challenge?

RV: The very beginning, the challenge was affording our legal fees — it's not something you want to skimp on, but was incredibly expensive. After that, it was simply manufacturing. It's never easy. It's always going to cost three times as much and take three times as long as you expect. With our plastics, we use a process called injection molding, and if the temperature is off, the plastics will dry in a different way and the pieces won't fit together. It's an obnoxious challenge that we're still facing today.

IM: What's next for you or your company?

RV: Right now, we are making that transition from pre-selling products to just regular sales. It's easier said than done because we are making sure that supply chain is efficient and on time. We are finishing up a batch of 1,000 units to work with that we'll just sell on our website. Once we have information on how we can sell these units, we want to work with distributors, so we are working on creating those relationships now.

IM: How has being headquartered in Houston been?

RV: This is a very affordable place and has a lot of resources for startups. I will say our one struggle is there's not a lot of funding for hardware startups — especially for consumers — like ours. That's more in California or New York.

IM: Thinking more long term, what do you have in mind for EllieGrid and your team?

RV: For EllieGrid, we want to implement artificial intelligence. We want to be able to take the data of how the user is interacting with the device and be able to predict when people will forget to take their meds to prevent any issues with medication.

For us, Ellie is just the start. We want to develop more health and wellness accessories that are traditionally known to be medical devices. One example we give is how eyeglasses used to be medical devices, and now glasses are a fashion accessory. We want to do more and more with medical devices because we think that people are always people before they are patients.

IM: What's the worst piece of advice you've received?

RV: In the beginning when we'd pitch this idea to doctors, they would tell us we were wasting our time because patients don't care what a product looks like as long as it works. I don't really get that anymore, because we're proving that wrong now.

The product is available online on the EllieGrid website, and the app is available for download. Courtesy of Regina Vatterott

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Portions of this interview have been edited.

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Houston's Ion District to expand with new research and tech space, The Arc

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Houston's Ion District is set to expand with the addition of a nearly 200,000-square-foot research and technology facility, The Arc at the Ion District.

Rice Real Estate Company and Lincoln Property Company are expected to break ground on the state-of-the-art facility in Q2 2026 with a completion target set for Q1 2028, according to a news release.

Rice University, the new facility's lead tenant, will occupy almost 30,000 square feet of office and lab space in The Arc, which will share a plaza with the Ion and is intended to "extend the district’s success as a hub for innovative ideas and collaboration." Rice research at The Arc will focus on energy, artificial intelligence, data science, robotics and computational engineering, according to the release.

“The Arc will offer Rice the opportunity to deepen its commitment to fostering world-changing innovation by bringing our leading minds and breakthrough discoveries into direct engagement with Houston’s thriving entrepreneurial ecosystem,” Rice President Reginald DesRoches said in the release. “Working side by side with industry experts and actual end users at the Ion District uniquely positions our faculty and students to form partnerships and collaborations that might not be possible elsewhere.”

Developers of the project are targeting LEED Gold certification by incorporating smart building automation and energy-saving features into The Arc's design. Tenants will have the opportunity to lease flexible floor plans ranging from 28,000 to 31,000 square feet with 15-foot-high ceilings. The property will also feature a gym, an amenity lounge, conference and meeting spaces, outdoor plazas, underground parking and on-site retail and dining.

Preleasing has begun for organizations interested in joining Rice in the building.

“The Arc at the Ion District will be more than a building—it will be a catalyst for the partnerships, innovations and discoveries that will define Houston’s future in science and technology,” Ken Jett, president of Rice Real Estate Company, added in the release. “By expanding our urban innovation ecosystem, The Arc will attract leading organizations and talent to Houston, further strengthening our city’s position as a hub for scientific and entrepreneurial progress.”

Intel Corp. and Rice University sign research access agreement

innovation access

Rice University’s Office of Technology Transfer has signed a subscription agreement with California-based Intel Corp., giving the global company access to Rice’s research portfolio and the opportunity to license select patented innovations.

“By partnering with Intel, we are creating opportunities for our research to make a tangible impact in the technology sector,” Patricia Stepp, assistant vice president for technology transfer, said in a news release.

Intel will pay Rice an annual subscription fee to secure the option to evaluate specified Rice-patented technologies, according to the agreement. If Intel chooses to exercise its option rights, it can obtain a license for each selected technology at a fee.

Rice has been a hub for innovation and technology with initiatives like the Rice Biotech Launch Pad, an accelerator focused on expediting the translation of the university’s health and medical technology; RBL LLC, a biotech venture studio in the Texas Medical Center’s Helix Park dedicated to commercializing lifesaving medical technologies from the Launch Pad; and Rice Nexus, an AI-focused "innovation factory" at the Ion.

The university has also inked partnerships with other tech giants in recent months. Rice's OpenStax, a provider of affordable instructional technologies and one of the world’s largest publishers of open educational resources, partnered with Microsoft this summer. Google Public Sector has also teamed up with Rice to launch the Rice AI Venture Accelerator, or RAVA.

“This agreement exemplifies Rice University’s dedication to fostering innovation and accelerating the commercialization of groundbreaking research,” Stepp added in the news release.

Houston team develops low-cost device to treat infants with life-threatening birth defect

infant innovation

A team of engineers and pediatric surgeons led by Rice University’s Rice360 Institute for Global Health Technologies has developed a cost-effective treatment for infants born with gastroschisis, a congenital condition in which intestines and other organs are developed outside of the body.

The condition can be life-threatening in economically disadvantaged regions without access to equipment.

The Rice-developed device, known as SimpleSilo, is “simple, low-cost and locally manufacturable,” according to the university. It consists of a saline bag, oxygen tubing and a commercially available heat sealer, while mimicking the function of commercial silo bags, which are used in high-income countries to protect exposed organs and gently return them into the abdominal cavity gradually.

Generally, a single-use bag can cost between $200 and $300. The alternatives that exist lack structure and require surgical sewing. This is where the SimpleSilo comes in.

“We focused on keeping the design as simple and functional as possible, while still being affordable,” Vanshika Jhonsa said in a news release. “Our hope is that health care providers around the world can adapt the SimpleSilo to their local supplies and specific needs.”

The study was published in the Journal of Pediatric Surgery, and Jhonsa, its first author, also won the 2023 American Pediatric Surgical Association Innovation Award for the project. She is a recent Rice alumna and is currently a medical student at UTHealth Houston.

Bindi Naik-Mathuria, a pediatric surgeon at UTMB Health, served as the corresponding author of the study. Rice undergraduates Shreya Jindal and Shriya Shah, along with Mary Seifu Tirfie, a current Rice360 Global Health Fellow, also worked on the project.

In laboratory tests, the device demonstrated a fluid leakage rate of just 0.02 milliliters per hour, which is comparable to commercial silo bags, and it withstood repeated disinfection while maintaining its structure. In a simulated in vitro test using cow intestines and a mock abdominal wall, SimpleSilo achieved a 50 percent reduction of the intestines into the simulated cavity over three days, also matching the performance of commercial silo bags. The team plans to conduct a formal clinical trial in East Africa.

“Gastroschisis has one of the biggest survival gaps from high-resource settings to low-resource settings, but it doesn’t have to be this way,” Meaghan Bond, lecturer and senior design engineer at Rice360, added in the news release. “We believe the SimpleSilo can help close the survival gap by making treatment accessible and affordable, even in resource-limited settings.”
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