Houston-based Complete Intelligence was just recognized by Capital Factory as the "Newcomer of the Year." Photo via completeintel.com

The business applications of artificial intelligence are boundless. Tony Nash realized AI's potential in an underserved niche.

His startup, Complete Intelligence, uses AI to focus on decision support, which looks at the data and behavior of costs and prices within a global ecosystem in a global environment to help top-tier companies make better business decisions.

"The problem that were solving is companies don't predict their costs and revenues very well," says Nash, the CEO and founder of Complete Intelligence. "There are really high error rates in company costs and revenue forecasts and so what we've done is built a globally integrated artificial intelligence platform that can help people predict their costs and their revenues with a very low error rate."

Founded in 2015, Complete Intelligence is an AI platform that forecasts assets and allows evaluation of currencies, commodities, equity indices and economics. The Woodlands-based company also does advanced procurement and revenue for corporate clients.

"We've spent a couple years building this," says Nash. "We have a platform that is helping clients with planning, finance, procurement and sales and a host of other things. We are forecasting equity markets; we are forecasting commodity prices, currencies, economics and trades. We built a model of the global economy and transactions across the global economy, so it's a very large, very detailed artificial intelligence platform."

That platform, CI Futures, has streamlined comprehensive price forecasting and data analysis, allowing for sound, data-based decisions.

"Our products are pretty simple," says Nash. "We have our basic off the shelf forecast which is called CI Futures, which is currencies, commodities, equities and economics and trade. Its basic raw data forecasts. We distribute that raw data on our website and other data distribution websites. We also have a product called Cost Flow, which is our procurement forecasting engine, where we build a material level forecasting for clients.


completeintel.com

"Then we have a product that we'll launch next year called Revenue Flow, which is a sales forecasting tool that will use balance of both client data and publicly available data to forecast client sales by product, by geography and so on and so forth. So we really only do three things: revenues, costs and raw data forecasts."

Forecasting across industries

Complete Intelligence's Cost Flow and Revenue Flow products are specific to direct clients. They are working with clients in the food and beverage sector, the energy sector, the chemical sector, and the technology sector.

"Anybody that manufactures a tangible good, should use our product," says Nash. "Because we can take their historical data we can configure their bills of material and they can see the exact cost and exact revenue of those products by month over time."

CI is not a consulting firm, so they offer their clients an annual license, which allows them to receive updated forecasts every month to understand how markets will iterate over time.

"We're integrating with the client's enterprise data," says Nash. "Whether it's their ERP system or their procurement system or their CRM, we're integrating with client's enterprise data, and we're creating forecast outlooks that are perfectly contextually relevant for client buying decisions."

Called out by Capital Factory

As a business solution, CI has garnered widespread industry confidence and accolades, such as Capital Factory's coveted "Newcomer of the Year" award, which recognizes innovative companies from a pool of 110 startups in Texas.

"Honestly, I couldn't believe it because with a startup like ours, there's so much hard work that goes into it, there's so much time, there's so much persistence," says Nash.

"And the types of startups that Capital Factory attracts are very competitive startups, so for us to receive this award, it's given us a huge amount of credibility in the market and it's really encouraged the team inside the company to understand that what we're doing is being recognized, it's meaningful and we're really going places."

From consulting to billions of monthly calculations

Nash is no stranger to going places. Before setting up shop in his native Texas, he lived in Singapore for 15 years where he started his career in sourcing and procurement for American retail firms.

"I became very sensitive to costs, cost inflections and I got very involved in global sourcing and international trade and then I did a couple of corporate turnarounds and start ups and so with that you see costs as an issue with those types of firms," Nash says.

He then worked with the Economist running their global research business. There, he grew familiar with how clients and customers use data. At IHS Markit, a global information provider.

"When I was working with those firms, those firms helped companies with planning," says Nash. "The problem is that those firms have very large errors in their forecasts. It is not just the internal forecasts that have a 30 percent or higher error rate in their forecasts, even the industry forecasters typically have around a 20 percent error rates in their forecasts.

"Even the people who should actually know where prices are going are not very good forecasters. With Complete Intelligence, we wanted to use data and use artificial intelligence to machine learning to create a better way to identify where costs and revenues will go for companies."

Every month, CI runs billions of calculations. They test their error rates and record them for clients that request them. With 700 assets that they show publicly, CI their average error rate is 3.7 percent, which is dramatically lower than both corporate procurement professionals and industry experts.

"With us doing billions of calculations, it allows us to run simulations and scenarios that your average analyst just can't do and most companies haven't even thought of. We're able to run a comprehensive view of activities in the world to understand how things directly and indirectly affect a cost. In Houston, for example, that could be crude oil or natural gas or something like that."

Proving its value

Last year, the company tested its platform with a natural gas trader. After reviewing the data, CI revealed to the client that natural gas would fall by 40 percent over the next year.

"They looked at our forecast and said they couldn't work with us because it didn't make sense," says Nash. "A 40 percent fall didn't make sense, so they didn't subscribe to us. That was 2018. What has happened over the past 12 months? Natural gas prices had fallen by 49 percent. You would look at our forecasts and say, 'Wow, that's a dramatic drop over 12 months.' But reality was even more dramatic than that and there weren't analysts out there saying what our model was telling us."

That natural gas trading company never admitted its faux pas, but if they had listened to CI, they could have positioned themselves to negotiate their vendors down for their cost base, which helps the margin of their business.

"Nobody ever admits mistakes," says Nash. "But when you think about the numerous materials that require natural gas, especially things that are manufactured in Houston, it affects a lot of costs."

Houston roots — by way of Asia

The missed opportunity with the natural gas trader notwithstanding, Nash is happy that he brought Complete Intelligence to Houston.

"I went to Texas A&M and grew up in Texas, so I moved back to Texas knowing how good Americans are with planning, with math and with data. I like Houston because people make stuff in Houston," Nash says. "We just found Houston to be perfect after spending 15 years in Asia given the global centrality of Houston. The industry's here and there's a lot of diversity in Houston."

Nash's expectation was that he would be able to work with Western multinationals to improve their analytics and their artificial intelligence processes because he has learned that there is a lot of pressure in American financial markets and analysts communities to really know what is happening within companies.

"We want companies to be able to really tightly plan their costs so they can better improve their profitability," says Nash. "That's what I wanted to do when we moved to the U.S. and we're finding that there's a lot of interest from companies."

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."