Don't miss these March events — from the 25th anniversary Rice Business Plan Competition to the inaugural TEX-E Conference. Photo via rice.edu

Two new conferences will launch while another longtime business competition celebrates its 25th anniversary this month in Houston. Plus, there are networking opportunities, family tech events and more.

Here are the Houston business and innovation events you can't miss in April and how to register. Please note: this article might be updated to add more events.

​Ion Block Party: Art Crawl

Network and socialize with other tech enthusiasts and business-minded individuals while taking in the new gallery at Community Artists’ Collective and experiencing the immersive dome at Omnispace360. See work by Joel Zika, who will showcase his digital sculptures through augmented reality screens, and other public art around the Ion while also enjoying food and drink.

This event is Thursday, April 3, from 4-7 p.m. at the Ion. Click here to register.

​CLA Presents: Raising Capital over Happy Hour

Gain a better understanding of the capital-raising process and various funding opportunities at this educational happy hour. Keith Davidson, the market leader for CLA in Dallas and former CFO of ICS, will present.

This event is Thursday, April 10, from 4-6 p.m. at The Cannon. Click here to register.

Rice Business Plan Competition 

The Rice Alliance for Technology and Entrepreneurship will host the 25th annual Rice Business Plan Competition this month. Forty-two student-led teams from around the world, including one team from Rice, will present their plans before more than 300 angel, venture capital, and corporate investors to compete for more than $1 million in prizes.

This event is April 10-12. Stream the Elevator Pitch Competition and Final Round here.

RSVF Annual Conference

The Rice Student Venture Fund will host its first-ever Annual Conference to celebrate the university's entrepreneurial spirit and the rising generation of student-led innovation. The conference will include live startup demos, an RSVF fund update, a keynote fireside chat, a builder-investor panel and networking. RSVF welcomes students, alumni, investors, faculty and staff, and innovators and community members of the broader tech scene.

This event is Monday, April 14, from 4-8 p.m. at the Ion. Click here to register.

​TEX-E Conference

TEX-E will host its inaugural conference this month under the theme "Energy & Entrepreneurship: Navigating the Future of Climate Tech." The half-day conference will feature a keynote from Artemis Energy Partners CEO Bobby Tudor as well as panels with other energy and tech leaders from NRG, Microsoft, GE Vernova and TEB Tech.

This event is Tuesday, April 15, from 1-4:30 p.m. at the Ion. Click here to register.

Houston Methodist Leadership Speaker Series 

Hear from Dr. Jonathan Rogg, Chief Quality Officer and Vice President of Operations at Houston Methodist Hospital and a a practicing emergency medicine physician, at the latest Houston Methodist Leadership Speaker Series. Rogg will present "Leadership from the Bedside to the Boardroom."

This event is on Wednesday, April 23, from 4:45-6 p.m. at the Ion. Click here to register.

Ion Family STEAM Day– Let's Build a Tripwire Alarm

STEAM on Demand will host a hands-on, family-friendly engineering lesson for young ones on the Ion Forum Stairs. Kids will learn to create and test their own working alarm system. The event is geared toward those ages 7 to 14.

This event is Sunday, April 26, from 10 a.m. to noon at the Ion. Click here to register.

 Greentown Houston Fourth Anniversary Transition On Tap

Climatetech incubator Greentown Labs will celebrate its fourth anniversary with a special edition of its signature networking event, Transition On Tap. Entrepreneurs, investors, students, and friends of climatetech are invited to attend.

This event is Tuesday, April 29, from 5:30-7:30 p.m. at Greentown Labs. Click here to register.

Integrate Space Technology Into Your Small Biz

The SBA Houston District Office and the UH Technology Bridge will host a collaborative event designed to help small businesses leverage space technology for prototype development. Attendees will also hear from industry experts on resources and gain access free technical engineering assistance to help accelerate their businesses.

This event is Wednesday, April 30, from 9:30-11:30 a.m. at UH Technology Bridge Innovation Center. Click here to reserve your spot.

Don't miss these February events — from talks with the hall-of-fame beauty business founders to AI summits. Photo courtesy of Rice University

10+ can't-miss Houston business and innovation events for February

WHERE TO BE

From talks with the hall-of-fame beauty business founders to agtech and AI summits, Houston will host a number of events focused on innovation and innovators in February.

Here’s what not to miss and how to register.

Note: This post might be updated to add more events.

Feb. 7 – SheSpace Offsite: Coffee & Connection

Get out of the office and head over to Midtown network with fellow SheSpace members and working women via coffee and conversation.

This event is Friday, Feb. 7, from 2-4 p.m. at Kefita Coffee. RSVP here.

Feb. 11 – Texas Business Hall of Fame x Ion: Creators Series with Founders Janet Gurwitch (Laura Mercier) and Tiffany Masterson (Drunk Elephant)

Take part in Texas Business Hall of Fame’s launch of its Creators 2025 speaker series. Janet Gurwitch, founder of Laura Mercier, and Tiffany Masterson, founder of Drunk Elephant, will discuss lessons learned while building their global retail brands and their successful exits.

This event is Tuesday, Feb. 11, from 8–10 a.m. at the Ion. Register here.

Feb. 11 – How to Start a Startup

Gain insight from Mercury Fund’s Heath Butler and stick around for a happy hour afterward. This session, originally scheduled for Jan. 21, is geared toward entrepreneurs, small business owners, investors and academic partners

This event is Tuesday, Feb. 11, from 5:30–7 p.m. at the Ion. Register here.

Feb. 15 – Ion Family Tech Day: Youth Entrepreneurship with Lemonade Day University

Bring the whole family out to the Ion for a family-friendly entrepreneurial workshop with Lemonade Day. Kids can compete in a pitch competition to win free supplies, and trained instructors will coach kids on how to set goals, develop a business or marketing plan and budget, create a brand, save and invest money, and more.

This event is Saturday, Feb. 15, from 10 a.m.–12:30 p.m. at the Ion. Register here.

Feb. 18 — Female Founders and Friends

Connect with like-minded female founders, funders, and allies at this recurring event. Female Founders & Friends is open to all industries and coffee is provided.

This event is Tuesday, Feb. 18, at 9 a.m. at Sesh Coworking. Register here.

Feb. 20 — Diaspora Africa Conference

Come together to hear inspiring speakers, participate in interactive workshops and network with others who are passionate about African heritage and the contributions of the African diaspora. This event will showcase African innovation and allow attendees to connect with funding sources actively seeking high-growth opportunities in Africa.

This event is Thursday, Feb. 20, from 9 a.m.–6 p.m. at the Ion. Register here.

Feb 20–21 — TMC AI Summit 2025

The TMC AI Summit aims to translate advanced AI innovations into practical solutions for real-world biomedical and health care challenges by bringing together researchers, clinicians, and industry leaders. The event features various workshops and tracks with keynote speakers from Rice University, UTHealth, Microsoft Health Futures and other organizations.

This event is Thursday, Feb. 20, from noon–7 p.m. and Friday, Feb. 21, from 8 a.m.–5 p.m. at TMC Helix Park in the TMC3 Collaborative Building. Register here.

Feb. 25 — Houston Methodist Leadership Speaker Series at Ion - Tesha Montgomery

Hear from Houston Methodist’s SVP of System Patient Access about how the health care system is approaching improvements to patient access and highlighting women in health care leadership. Audiences can participate in a 30-minute discussion following Montgomery’s remarks.

This event is Tuesday, Feb. 25, from 4:45–6 p.m. at the Houston Methodist Tech Hub at the Ion. Register here.

Feb. 26 — Inaugural HTX AgTech Rodeo Innovation Summit 2025

Network with farmers, founders, startups and investors at the first-ever HTX AgTech Rodeo Innovation Summit. The all-day event will feature panels, fireside chats, a Saddle Up Pitch Competition and reception with live music.

This event is Wednesday, Feb. 26, from 8:30 a.m.–8 p.m. Find more information and register here.

Feb. 27 — NASA Tech Talks

Every fourth Thursday of the month, NASA experts, including longtime engineer Montgomery Goforth, present on technology development challenges challenges NASA’s Johnson Space Center and the larger aerospace community are facing and how they can be leveraged by Houston’s innovation community. Stick around after for drinks and networking at Second Draught.


This event is Thursday, Feb. 27, from 6-7 p.m. at the Ion. Register here.

Feb. 27–28 – QVIDTVM x The Ion: Inaugural Hack Day Competition

Investment firm QVIDTVM and the Ion are calling all data scientists, analysts, developers and innovators to a new hack day. Participants will aim to find the total value of real estate platformed by Airbnb globally and can participate in a Fireside Chat on AI with Nick King, founder and CEO of Data Kinetic. Teams can include up to four people and prizes for first through third place will be awarded.

This event is Thursday, Feb. 27, at 9:30 a.m. until Friday, Feb. 28, at 5 p.m. at the Ion. Register here.


Don't miss these January events — from meetups to scale ups. Photo via Getty Images

10+ can't-miss Houston business and innovation events for January

WHERE TO BE

From networking meetups to tech talks, January is filled with opportunities for Houston innovators. Here's a roundup of events you won't want to miss out on so mark your calendars and register accordingly.

Note: This post might be updated to add more events.

January 3 — Cup of Joey Networking

Create a connected culture of coffee shop-open networking across our region. Every Friday morning, you’ll have the opportunity to meet new people and expand your current networks, talk about tech, inspire innovation, and create community.

This event is Friday, January 3, from 8:30 to 10:30 am at the Ion. Click here to register.

January 7 — Discover Your Creative Goldmine: The Millions are in your Micro-Niche

In this high-energy workshop, you’ll learn how identifying and embracing your unique micro-niche can simplify your business and fast-track your success. Through a dynamic mix of strategy and mindset mastery, you’ll leave equipped with actionable insights to transform your brand. Don’t miss this opportunity to align your business for growth and connect with like-minded creatives.

This event is Tuesday, January 7, from 12:30 to 1:30 pm at SheSpace. Click here to register.

January 15 — Angel Investing 101: Introduction to Angel Investing

Join the Urban Capital Network team for an evening of learning, discussion and possibilities as we explore the basics of angel investing and the role it plays in bringing new products and services to market and the impact it has on wealth and job creation. At this event, you’ll learn the key components to successfully navigate the critical-path of investing in private, early-stage companies.

This event is Wednesday, January 15, from 5:30 to 6:30 pm at the Ion. Click here to register.

January 15 — In the Age of the Humanoid Robot

Persona AI cofounder & seasoned roboticist Nicolaus Radford will discuss the promise of embodied AI and the adoption of humanoid robots—two advancements likely to impact every market sector. Humanoids coupled to artificial intelligence are poised to reshape the global work landscape; to learn more, check out the Q&A, and Second Draught happy hour.

This event is Wednesday, January 15, from 5 to 7 pm at the Ion. Click here to register.

January 16 — NAWBO Houston Conference: The Power of Women in Business 2025

This event is your opportunity to connect with influential speakers, successful entrepreneurs, and industry experts who are shaping the future of business. From inspiring keynotes to thought-provoking panels, this conference is designed to provide attendees with actionable insights and strategies to elevate their careers.

This event is Thursday, January 16, from 9 am to 3 pm at Norris Conference Centers - Houston/CityCentre. Click here to register.

January 16 — Houston Methodist Innovation TechHub Event

Join the Houston chapter of the Healthcare Information and Management Systems Society for a discussion on the Houston Methodist TechHub, innovative ideas, and a tour of the Ion.

This event is Thursday, January 16, from 5:30 to 7:30 pm at the Ion. Click here to register.

January 21 — 2025 Female Founders & Friends

This Sesh Coworking event brings together female founders, funders and allies looking for connections with other like-minded go-getters in the Houston community. Connect over coffee with like-minded individuals

This event is Tuesday, January 21, from 9 to 10:30 am at Sesh Coworking. Click here to register.

January 23 — NASA Tech Talks

Discover NASA’s toughest tech challenges–and apply your skills and expertise to solve them.In these presentations, occurring the fourth Thursdays of the month, Mr. Montgomery Goforth and other aerospace subject matter experts will discuss the technology development challenges faced by NASA’s Johnson Space Center and the surrounding Aerospace community in our ongoing efforts as the hub of human spaceflight. Presentations will focus on the ways in which these challenges, and the associated opportunities, can be leveraged by Houston’s innovation community

This event is Thursday, January 23, from 6 to 7 pm at the Ion. Click here to register.

January 28 — Texas Small Business Expo

Texas Small Business Expo is a premier trade show, educational business to business conference, exhibition, and networking event for entrepreneurs, startups and anyone that owns a business, or looking to start their own business. The focus of the conference is targeted on networking, building new business relationships and learning from Industry Experts on how to enhance your business.

This event is Tuesday, January 28, from 4 to 9 pm at the Bell Tower on 34th. Click here to register.

January 30 —TiE Houston's Investing in the Age of AI

For those involved in AI-driven innovation, building new companies, leading established businesses, or exploring investment opportunities in AI, this event is designed for you. Moderated by Sammy Haroon, founder and CEO of AlphaX Decision Sciences, speakers at this event include Major Tony Cucolo, CEO of PCSI, and Yashwanth Hemaraj, general partner at BGV.

This event is Thursday, January 30, from 6 to 9 pm at the Junior League of Houston. Click here to register.

January 31 — Greater Houston Partnership 2025 Meeting

This signature event brings together business and community leaders from across our region to celebrate achievements and set the course for an even brighter future. The Greater Houston Partnership will welcome incoming Board Chair Gretchen Watkins, President, Shell USA, Inc., and honor the contributions of outgoing chair Eric Mullins, as well as present several prestigious awards that highlight the exceptional leadership driving Houston forward.

This event is Friday, January 31, from 11 am to 1:30 pm at Hilton Americas Houston. Click here to register.


Don't miss these October events — from expos and conferences to panels and pitch days. Photo via Getty Images

10+ can't-miss Houston business and innovation events for October

WHERE TO BE

From networking meetups to pitch competitions, October is lined with opportunities for Houston innovators.

Here's a roundup of events you won't want to miss out on so mark your calendars and register accordingly.

Note: This post might be updated to add more events.

Additionally, mark your calendars for November 14 for the annual Houston Innovation Awards.

October 3 — Texas Venture Fest: Houston Edition

More than 10 cities simultaneously host this statewide phenomenon, as Texans rally to see innovation flourish. Hear from leaders in impact investing, climate tech startups, and sports tech entrepreneurs. This year's event registration asks for your favorite investor, startup, and community leader for the Texan's Choice Awards— the "People's Choice Awards" for statewide innovation.

This event is Thursday, October 3, from 8:30 am to 8 pm at the Niels Esperson Building. Click here to register.

October 4 — 15th Annual Yatsu Day Symposium

This year’s symposium, “Reviving Hope: AI Innovations and Emerging Technologies in Stroke Recovery,” will unpack life-changing research into emerging stroke recovery technology and methods. This comprehensive program will explore critical topics such as artificial intelligence in healthcare, cognitive recovery post-stroke, stroke rehabilitation and recovery, tele-health, pediatric stroke recovery, and more.

This event is Friday, October 4, from 8 am to 4 pm at the Cooley Center. Click here to register.

October 9 — Future of Global Energy Conference

This premier event convenes industry leaders, policymakers, innovators, and academics to explore Houston's pivotal role in addressing the dual challenge of meeting growing energy demands while reducing carbon emissions. This conference delves into Houston's unique position to lead in this effort, driving innovation, collaboration, and investment towards a sustainable, low-carbon future.

This event is Wednesday, October 9, from 8:15 am to 5:30 pm at Hilton Americas. Click here to register.

October 9 — Houston Methodist & Ion Digital Innovation Reverse Pitch Info Session

Innovators, engineers, students, start-ups, developers, experts, and community members alike can take part in Houston Methodist and Ion's first reverse pitch event. During this session, attendees will hear from Houston Methodist leaders about the problem statement, goals & objectives, program guidelines and timeframe to develop a unique digital solution to help advance the healthcare industry into the future.

This event is Wednesday, October 9, from 4 to 6 pm at the Ion. Click here to register.

October 10 — Fall 2024 TIEEP Energy Forum

The mission of the Texas Industrial Energy Efficiency Program (TIEEP) is to provide thought-leadership, sharing ideas, technologies, opportunities and timely information to Texas industries on ever-improving energy intensity, reduced environmental impact, resilience, and enhanced social and economic development. In this forum experts and attendees will discuss how the cost of decarbonization can be lowered, by examining both technical and financial strategies, as the industrial sector strives to meet increasingly aggressive goals.

This event is Thursday, October 10, from 4 to 6 pm at University of St. Thomas Center for Science and Health Professionals. Click here to register.

October 14-15 — IMPACT 2024: Cognite’s AI and Industrial Data Conference

This global data and AI conference will bring together digital-first innovators and leaders across energy, manufacturing, and power and renewables, from around the world and will showcase real-world success stories, case studies, and state-of-the-art digital transformation strategies. The focus will be on the latest industrial Data and AI trends, hands-on practitioner sessions, proven success sharing, and peer networking.

This event begins Sunday, October 13, from 6 to 10 pm at Norris Conference Center. Click here to register and for the full schedule of events.

October 16 — Houston Methodist Clinician Speaker Series - Dr. Jonathan Rogg

Head to the Houston Methodist Tech Hub at Ion for another clinician speaker series presentation by Dr. Jonathan Rogg.

Jonathan Rogg, MD, MBA is an Emergency Physician, Vice President and Incoming Chief Quality Officer at Houston Methodist Hospital. Dr. Rogg will speak about emergency room operations from a clinical and administrative lens and the innovations being implemented in this unique hospital setting.

This event is Wednesday, October 16, from 4:45 to 6 pm at the Ion. Click here to register.

October 19 — Energy Day

Energy Day is Houston’s largest annual free family festival showcasing science, technology, engineering, and mathematics (STEM). Energy Day has nearly 70 interactive demonstrations and exhibits that teach students and their families about the various forms of energy through STEM fields, along with efficiency, conservation, and other related STEM industries.

This event is Saturday, October 19, from 11 am to 3 pm at Sam Houston Park. Click here to register.

October 22 — The Greentown Labs Climatetech Summit 2024

Greentown Labs invites you, your colleagues, and all the climate champions in your life to step into their incubators for a day of hands-on exploration with our 200+ startups and their climatetech solutions; keynotes and sessions featuring leaders across climatetech, finance, policy, and equity; and networking with key climate-action trailblazers.

This event is Tuesday, October 22, from 8 am to 7 pm at Greentown Labs. Click here to register.

October 23 — TiE Women Houston Showcase

TiE Global is a nonprofit venture devoted to entrepreneurs in all industries, at all stages, from incubation, throughout the entrepreneurial lifecycle. Meet this years TiE Women Houston finalists, program co-leads, and community partners. There will be panels, pitches, awards, and networking.

This event is Wednesday, October 23, from 4 to 6 pm at the Ion. Click here to register.

October 28 — October Odyssey: Start Ups in Space

The final event in TMC's October Odyssey speaker series will feature innovative discussions at the intersection of space and healthcare. Hear from the visionary founders of TMC Innovation startups as they share how space has played a pivotal role in their entrepreneurial journeys. Moderated by Emily Reiser, Ph.D., Strategy and New Ventures at TMC, this engaging session will explore how these startups are revolutionizing healthcare on Earth and pushing the boundaries of what’s possible in space.

This event is Monday, October 28, from 9 to 10:30 am at TMC Helix Park. Click here to register.

Houston innovators — put these August events on your radar. Photo via Getty Images

10+ can't-miss Houston business and innovation events for August

WHERE TO BE

From networking meet-ups to expert startup showcases, August is filled with opportunities for Houston innovators.
Here's a roundup of events you won't want to miss out on so mark your calendars and register accordingly.

Note: This post may be updated to add more events.

August 1 — 7th Annual Summer Science Symposium

The 7th Annual MAPTA Summer Science Symposium will showcase work from research trainees, postdoctoral fellows, and medical residents. The symposium will feature all fields of translational, basic science and clinical research. This two-day in-person event will include both poster and oral presentations.

Keynote Speakers:

Brijesh S. “Billy” Gill, MD, FACS
Corina Rosales, PhD

This event is Thursday, August 1, from 9 am to 4 pm at Houston Methodist Research Institute. Click here to register.

August 1 — Bayou Startup Showcase

The Bayou Startup Showcase is a dynamic celebration of entrepreneurship, spotlighting the newest startups and small businesses from Rice University’s OwlSpark and the University of Houston’s RED Labs accelerators. Attendees can listen to pitches, discover ways to support and grow these businesses, and engage with founders during the showcase.

This event is Thursday, August 1, from 4 to 8 pm at The Ion. Click here to register.

August 8 — Out In Tech Mixer

Out in Tech Houston provides an inclusive networking space for LGBTQ+ people and allies working in tech. Check out this relaxed, social-mixer event, hosted on the second Thursday of every month.

This event is Thursday, August 8, from 7 to 8:30 pm at Second Draught. Click here to register.

August 13 — Software Day at The Ion: An Intro to Central Texas Seed Stage VCs

Software Day is a monthly series driving the support, inspiration, and connections needed to help startups on their path to rapid, sustainable growth. Each month, Software Day will include office hours (by application), a keynote session, and networking.

Speakers include:

  • Eric Engineer, S3 Ventures
  • Rajiv Bala, Clutch Ventures
  • Cat Dizon, Active Capital
  • Mike Marcantonio, LiveOak
  • Moderator: Aziz Gilani, Mercury
This event is Tuesday, August 13, from 3:30 to 7 pm at The Ion. Click here to register.

August 15 — TMC Lunch ‘n’ Launch: Phiogen

This monthly event series hosted by TMC Innovation highlights TMC community companies and provides them with a platform to share their journey, current progress, and future goals. This month the lunch features Phiogen, a specialized phage therapy corporation founded by by Baylor College of Medicine.

This event is Thursday, August 15, from 12 to 1 pm at at TMC Innovation Factory. Click here to register.

August 15 — SPRINT Workforce Forum

This two-day event brings together industry, universities, and government entities to discuss the workforce challenges that arise from the rapidly advancing AI and robotics technologies in the energy sector. It has a special emphasis on inspiring students to become advocates of AI and robotics, enabling them to help the energy industry’s digital transformation.

This event is Thursday, August 15, starting at 12 am at Student Center South and UH Hilton. Click here to register.

August 22 — Transition On Tap

Transition On Tap is Greentown Labs’ monthly networking event devoted to fostering conversations and connections among the climate and energy transition ecosystem in Houston and beyond. Entrepreneurs, investors, students, and friends of climatetech are invited to attend, meet colleagues, and discuss solutions.

This event is Thursday, August 22 from 5:30 to 7:30 pm at Greentown Houston. Click here to register.

August 23 — 2024 Cardiometabolic Syndrome Conference: A Population Health Crisis

The Cardiometabolic Syndrome Conference is designed to provide attendees with the most contemporary knowledge about the syndrome, including the epidemiology, treatment strategies, and knowledge gaps. There will be a specific focus on high-level discussions that dissect the current shortcomings in the overall management of CMS at the individual and community level and begin to consider new and innovative treatment strategies.

This event is Friday, August 23 from 7 am to 5 pm at The Texas Heart Institute. Click here to register.

August 28 — TMCi Cappuccino Connections

Network with the diverse TMC Innovation Community while enjoying a cup of joe.

This event is Wednesday, August 28, from 8:30 am to 10:30 am at TMC Innovation Factory Lobby. Click here to register.

August 28 — Bayou City Bio Pulse: Pearland

Hear from some of the region’s largest commercial life science manufacturers. This panel discussion will examine the obstacles and potential avenues for the growth of commercial life science firms. Tours of Lonza’s and Millar’s manufacturing facilities will follow the program.

This event is Wednesday, August 28, from 11 am to 2 pm at West Pearland Library. Click here to register.

August 29 — SaaStock Local: Scalability in the Age of AI, Building for Growth in SaaS

Attendees will explore innovative strategies and cutting-edge technologies designed to enhance scalability, ensuring that cloud computing environments remain robust, flexible, and capable of supporting dynamic and complex AI workloads. The session will cover best practices for optimizing resource allocation, managing data efficiently, and maintaining high performance as demand increases.

This event is Thursday, August 29, from 5:30 to 8 pm at The Ion. Click here to register.

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CultureMap Emails are Awesome

Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.