Google has announced its Houston office is expected to deliver in May. Photo courtesy of Google

Mark it on your calendars: In May, Google is expected to complete the buildout of its first office in Houston.

Google will occupy one floor totaling 11,000 square feet in the One Buffalo Heights building at 3663 Washington Ave. The tech giant announced the Houston office last June.

It's unclear how many Google employees will work in the Houston office, which will be a regional hub for Google Cloud's sales team. But if Google adheres to industry standards for office space per person, the Houston office would house roughly 60 to 70 employees.

Google revealed the May timetable for completion of its Houston office on March 18 in conjunction with a broader announcement about investing $50 million in office space and data center space this year in Texas.

"We are excited to see Google expand its presence in Texas and here in Houston," Bob Harvey, president and CEO of the Greater Houston Partnership, says in a Google release. "Google is working closely with Houston companies in energy and healthcare to ensure successful digital transformation in these core industries. At the same time, the company is collaborating with emerging energy 2.0 companies to help usher in the energy transition to a low-carbon future. We believe the future holds more partnership opportunities for Google and the Houston region."

Houston Mayor Sylvester Turner says the Google office will help lay the groundwork for Houston's evolution as Silicon Bayou, a center of tech innovation. Along those lines, Bill McKeon, CEO of the Texas Medical Center, says the medical complex is working with Google on several initiatives designed to capitalize on his organization's health data and intellectual capital.

Google's local office will contribute to a growing tech presence in Houston.

Houston ranks 14th among major U.S. metro areas for hiring of tech workers, according to tech job website Dice.com. That's one spot ahead of San Jose, California, the heart of Silicon Valley. Austin appears at No. 7 on the list and Dallas at No. 9.

Adding to Houston's tech status is that the typical tech salary sits at $91,190, putting it in 24th place for how much higher that pay is among U.S. metro areas than the typical salary for all industries, according to Business.org. On that scale, Dallas-Fort Worth is No. 23 and San Antonio is No. 26.

Tech trade group CompTIA estimates the tech sector contributes $28.4 billion a year to the Houston area's economy. The region ranks 12th in the U.S. for total tech employment (more than 235,800 workers), with tech jobs representing 7.2 percent of the regional workforce.
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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.