3 Houston innovators to know this week

who's who

This week's Houston innovators to know include Nicolaus Radford of Houston Mechatronics Inc. and Sharita M. Humphry and Enrique Castro of BH Ventures. Photos courtesy

Editor's note: This week's roundup of innovators to know in Houston include three self-starting founders — a robotics expert who's job sounds more futuristic that realistic and a duo looking to bridge the gap between Black and Hispanic entrepreneurs while cultivating their business growth.

Nicolaus Radford, CEO, CTO, and co-founder of Houston Mechatronics Inc.

Nicolaus Radford joins the Houston Innovators Podcast to discuss his plans to take his cloud robotics company global. Photo courtesy of HMI

Discussing Nicolaus Radford's career and his current work with his company, Houston Mechatronics Inc., feels like something out of a science fiction movie. But it's real life. HMI is building a fleet of underwater robots, and, before he founded his company in 2014, he worked on humanoid robots for NASA.

Now, there's a growing market need for the type of robots HMI is working on, and he share on the Houston Innovators Podcast that there's a huge international opportunity for him.

"We're absolutely going to be a global company," Radford says, explaining that new clients in these areas are what's calling for the new offices. "The next 12 months of this company are going to be extremely vibrant and dynamic." Read more.

Enrique Castro and Sharita M. Humphry of BH Ventures

Enrique Castro and Sharita M. Humphrey met at an alumni event at UH and decided to work together on an inclusive accelerator program. Courtesy photos

Black and Hispanics tend to fall low on the lists of personal finance and business success, and usually the two communities don't do business together. That's what BH Ventures, a business accelerator program founded by Sharita M. Humphrey and Enrique Castro, is looking to change.

"Enrique and I know that there can sometimes be a barrier between Black and Hispanics doing business together," says Humphrey. "This is why I wanted, as an African American woman, and him, being a Hispanic male, to be able to show that we should be doing business together — especially in the city of Houston."

Humphrey and Castro met at an alumni event for the University of Houston's SURE program, which creates educational programming for entrepreneurs from under-resourced communities. The duo thought that they could create a program that built upon UH's. In February, after building out the curriculum, BH Ventures ran a successful pilot program in collaboration with UH. Read more.

BH Ventures is seeking Black and Hispanic entrepreneurs for its inaugural cohort. Photo via Getty Images

New startup accelerator emerges in Houston to promote collaboration between Black and Hispanic communities

teamwork

Two local business leaders have teamed up to create a Houston-based accelerator focused on Black and Hispanic entrepreneurs.

BH Ventures has applications open for its inaugural cohort until August 21, and co-founders Sharita M. Humphrey and Enrique Castro are looking for founders who have hit the revenue-generating phase with their business but are looking for mentors and support as they grow.

Enrique Castro and Sharita M. Humphrey met at an alumni event at UH and decided to work together on an inclusive accelerator program. Courtesy photos

The seven-month program will launch virtually at the beginning of September and will work with 15 entrepreneurs across the country. Additionally, The Cannon is a partner and a resource for the program.

As of now, the program has over 20 mentors and speakers lined up, and sessions will occur virtually every other Saturday and will be a mix of presentations and Q&As with an emphasis on fostering networking connections.

"Sometimes for a Black or Hispanic entrepreneur, just being able to have that conversation or be able to ask (a mentor) certain questions and get feedback about their particular business — it's better than money," Humphrey says. "The right relationships can open up doors that money can't."

After the programming, Humphrey says BH Ventures will continue to follow each company from the cohort for 90 days in a sort of incubation period to make sure they have support after the accelerator.

"It's a lot to get the information — but how do you execute it? We're going to still follow their path," Humphrey says.

While Houston has been renown for being the most diverse city in the country, Humphrey says she's seen a shift in leadership diversity across the greater Houston area. This has motivated her to do everything she can to promote inclusion and business growth across demographics.

"(Blacks and Hispanics are) not doing as much business together as we could," Humphrey says. "And that makes no sense when we are normally at the bottom of things when it comes to finances — personal, savings, credit, wealth, business. I think that this is something that's going to be amazing for the city."

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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