Houston Methodist has doled out $4.8 million to Houston nonprofits. Photo via TMC.edu

Houston Methodist has awarded $4.8 million to 50 Houston-area nonprofits as part of its Diversity, Equity & Inclusion Grant Program, the hospital announced this month.

The funds go toward "addressing the root causes of health inequities experienced by social, racial and ethnic minorities," according to the hospital. An estimated 51,000 Houstonians are expected to be impacted by these dollars.

Of the nonprofits selected, 24 are healthy neighborhood programs, 16 are educational empowerment programs and 14 are economic programs.

The grant program is broken up into two types of funding: The Social Equity Grant and the DEI Grant. Now in its third year, the program has for the first time selected recipients of the Social Equity Grant that all support economic empowerment.

"We know there is a direct correlation between economic stability and health outcomes," Ryane Jackson, vice president, community benefits at Houston Methodist said in a statement. "Without livable wages or employer backed insurance, access to health care can be limited. If we can help those in underserved communities obtain employment and increase their wages in a short amount of time, then we can provide immediate and meaningful change that can potentially be felt for years to come.”

Capital IDEA Houston is a local nonprofit that’s received the Social Equity Grant. The organization helps low-wage workers find living-wage careers. Capital IDEA plans to use the funds to support Black and Hispanic Women in health care professions and launch a pilot program that will assist women with an associate degree who are interested in pursuing a bachelor’s degree in nursing.

Another recipient, Compudopt, will focus on digital literacy training to low income African American and Hispanics, while Montrose Center will use the funds to support its Seniors Preparing for Rainbow Years program at the Law Harrington Senior Living Center. Other recipients include Avondale House, BakerRipley, Interfaith Caring Ministries, Kids Meals Inc., and the Tejano Center for Community Concerns. Click here to find a full list.

DEI is at the forefront of Houston Methodist's vision for the future of health care. In a recent interview with InnovationMap, Arianne Dowdell, vice president and chief diversity, equity and inclusion officer at Houston Methodist, shared how linked diversity and innovation are to her.

"I think we're in a very interesting time when we think about how health care looks. It's changing drastically and so people have a lot more options for where they choose to get their health care and who their providers are," she tells InnovationMap. "So I think that the thought of the patient comes first is really going to be the key of understanding how do we tackle health equity."

Since launching Houston Methodist's DEI Grant Program has awarded more than $11 million to 83 Houston-area nonprofits. Last year it awarded $4.6 million to 59 organizations. Click here to see who else has been awarded funding through the program.
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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.